Web Sites

Web Sites for Fourth Edition

Chapter 1- Basic laboratory principles and techniques http://microbiology.byu.edu/420/BASICLAB_files/frame.htm Slides of basic glassware etc by Shauna Anderson Brigham Young University http://www.pp.okstate.edu/ehs/HAZMAT/LABMAN/toc.htm Web site for safety for OSU http://physchem.ox.ac.uk/MSDS Oxford University Safety MSDS information on many chemicals www.admiralmetals.com/metric_conv.htm See also the calculation algorithm on CD http://omni.ac.uk/browse/mesh/detail/C0600201L0863683.html BIOME, Greenfield Medical Library, Queens Medical Centre, Nottingham, NG7 2UH Funded by the Joint Information Systems Committee (JISC). Target audience is the UK learning, teaching and research community. http://www.mhhe.com/biosci/genbio/dolphin5e/labprep.mhtml, A number of sections on practical lab technique, including calculations Copyright ©2001 The McGrawHill Companies. http://www.practicingsafescience.org Online Safety Course ©2002 Howard Hughes Medical Institute 4000 Jones Bridge Road Chevy Chase, MD http://www.pp.okstate.edu/ehs/HAZMAT/labman.htm Oklahoma State U LAB SAFETY MANUAL http://www.osha-slc.gov/OshStd_data/1910_1450.html Occupational Safety and Health Administration Regulations (Standards - 29 CFR) Occupational exposure to hazardous chemicals in laboratories. - 1910.1450 www.nccls.org/, National Council for Clinical Laboratory Standards http://www.epa.gov/ US Environmental Protection Agency

Chapter 2 - Laboratory Management http://www.clma.org/index.cfm Clinical Laboratory Management Association (CLMA) Home Page. http://www.cap.org/html/lip/lmip.html College of American Pathologists Laboratory Improvement Program; Laboratory Management Index Program (LMIP)

http://www.ascld-lab.org/aslab015.html The American Society of Crime Laboratory Directors (ASCLD) is a nonprofit professional society devoted to the improvement of crime laboratory operations through sound management practices. Professional and Government Organizations http://www.ascp.org ASCP http://www.asmusa.org ASM http://www.cap.org CAP CDC http://www.cdc.gov CMS http://cms.hhs.gov CLMA http://www.clma.org FDA http://www.fda.gov Federal Register http://www.access.gpo.gov/nara/cfr/index.html HCFA/CMS http://cms.hhs.gov JCAHO http://www.jcaho.org NCCLS http://www.nccls.org NIST http://www.nist.gov OIG http://www.dhhs.gov/progorg/oig OSHA http://www.osha.gov http://www.hep-c-alert.org/links/hippa.html HIPPA Chapter 3 –Sources and control of preanalytical variation http://www.westgard.com/qcapp18.htm Six Sigma - Test Interpretation Guidelines as Tolerance Limits James O. Westgard, PhD http://www.acclc.es/invitroveritas/vol2/art20.html Spanish site: ACCLC Associació Catalana de Ciències del Laboratori Clínic . Les Ciències del Laboratori Clínic agrupen els conceptes i tècniques de les ciències bàsiques que són d'aplicació a l'estudi d'espècimens procedents del cos humà per a la prevenció, diagnòstic, pronòstic i control de les malalties. www.upstate.edu/phlebotomy/ State University of New York-Upstate: A comprehensive overview of blood drawing; http://www.srbr.org/ The Society for Research on Biological Rhythms

www.nccls.org/ NCCLS Approved Guideline: contains guidelines for patient preparation, specimen collection

Chapter 4 - Spectral techniques http://depts.washington.edu/spectral University of Washington Department of Chemistry Spectroscopic and Analytical Instrumentation Facility http://www.nist.gov/srd/analy.htm National Institute of Standards and Ttechnology (NIST) provides a comprehensive set of easy-to-use databases that help the analytical chemist identify unknown materials and, in many cases, once identified, avoid the need to recharacterize a substance. The online NIST Chemistry WebBook contains IR spectra for

over 8700 compounds, mass spectra for over 12,000 compounds, and UV/VIS spectra for over 400 compounds. http://www.aist.go.jp/RIODB/SDBS/menu-e.html Integrated Spectral Data Base System for Organic Compounds; National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan http://www.bertholf.net/rlb/Lectures/Lectures/Review%20of%20Analytical%20Methods%20I.pps Power point lecture by Robert L Bertholf Ph.D. Associate Professor of Pathology Chief of Clinical Chemistry and Toxicology

Chapter 5- Chromatography http://www.accessexcellence.org/TSN/SS/chromatography_background.html Patrick McKay http://www.netaccess.on.ca/~dbc/cic_hamilton/chrom.html Chromatography resources http://www.home4u.de/niven/rn_know1.htm Niven’s Chromatographic terms http://ull.chemistry.uakron.edu/chemsep/chrom_theory/ Univ Akron web site; Site sponsored by Supelco http://www.fda.gov/cder/guidance/cmc3.pdf Center for Drug Evaluation and Research (need Adobe Acrobat) http://www.dq.fct.unl.pt/QOF/hplcts.html Trouble-shooting guide http://www.chromatography.co.uk/TECHNIQS/Default.htm Trouble-shooting guide http://www.metabase.net/docs/unibe/01164.html Columbian gov’t site, in Spanish: www.icfes.gov.co/revistas/recolqui/972601/972601~7.HTM

Chapter 6 – Liquid chromatography http://ull.chemistry.uakron.edu/analytical/LC Liquid chromatography lectures associated with Analytical Chemistry I and II and copyrighted by James K. Hardy and The University of Akron. http://ntri.tamuk.edu/hplc/hplc.html High Performance Liquid Chromatography . Text and pictures. This page is maintained by the Natural Toxins Research Center at Texas A&M University - Kingsville. www.chromatographyonline.com LCGC online publication

http://chirbase.u-3mrs.fr/chirbase/ A molecular database for chiral chromatography ENSSPICAM Chirabase Project Avenue Escadrille Normandie-Niemen 13397 MARSEILLE Cedex 20 - FRANCE www.sciquest.com SciQuest is a software and information Company http://hplc.chem.shu.edu/NEW/HPLC_Book/ Chemiluminescent reactions HPLC http://ull.chemistry.uakron.edu/chemsep/chrom_theory/ Univ Akron web site. Site sponsored by Supelco http://www.fda.gov/cder/guidance/cmc3.pdf Center for Drug Evaluation and Research, need Adobe Acrobat http://www.ntri.tamuk.edu/hplc/hplc.html Introduction to HPLC http://www.home4u.de/niven/rn_know1.htm Niven’s Chromatographic terms

Chapter 7 – Gas Chromatography http://www.chem.vt.edu/chem-ed/sep/gc/gc.html The Chemistry Hypermedia Project at Virginia Tech is exploring new ways to apply computer and network technology to help students learn chemistry, and to help educators teach chemistry

Chapter 8 – Mass Spectometry http://ms.mc.vanderbilt.edu/tutorials/ms/ms.htm Tutorial written by Vanderbilt University Mass Spectroscopy Research Center. by Richard Caprioli and Marc Sutter, revised by Markus Stoeckli http://www3.interscience.wiley.com/cgi-bin/jtoc?ID=6043 Journal for Mass Spectrometry by Wiley Interscience www.asms.org/ American Society for Mass Spectrometry; http://www.organicworldwide.net/mass.html SCI.techniques.mass, spectrometry home page that contains archives and links to related documents and mass spectrometry sites http://www.spectroscopynow.com/Spy/basehtml/SpyH Online resource serving the spectroscopy community http://www.ionsource.com/links/ms_links.htm

Ion Resource Webpage

Chapter 9 –Radioisotopes in Clinical Chemistry http://ntri.tamuk.edu/bio/radiation/radiation.html This page is maintained by the Natural Toxins Research Center at Texas A&M University – Kingsville http://www.niehs.nih.gov/odhsb/biosafe/bio.htm Biological Safety Guidelines Links to Radioisotopes data www.webelements.com/webelements/elements/text/periodic-table/radio.html Links to radioisotopes data http://www.ncrp.com/ National Council on Radiation Protection and Measurements http://www.stanford.edu/dept/EHS/prod/researchlab/radlaser/manual/appendices/reports.htm Stanford University’s Radiation Safety Manual ehs.ucdavis.edu/hp/shi/shi_ndex.html UC Davis Safe Handling of Radioisotopes http://www.ntri.tamuk.edu/bio/radiation/radiation.html Radioisotopes safety (In "General" section there are links to current forms used by the Health and Safety Branch); http://www.niehs.nih.gov/odhsb/biosafe/bio.htm More results from phantom.ehs.uiuc.edu

Chapter 10 – Electrophoresis www.aesociety.org The Electrophoresis Society http://www.ntri.tamuk.edu/ce/ce.html Capillary electrophoresis Natural Toxins Research Center Texas A & M University www.chemsoc.org/chembytes/ezine/2000/altria_nov00.htm Chemsociety website www.ceandcec.com Capillary electrophoresis and capillary electrochromatography www.life.uiuc.edu/molbio/geldigest/electro.html Gel electrophoresis of DNA www.uct.ac.za/microbiology/sdspage.html SDS polyacrylamide gel electrophoresis (SDS-PAGE) www.nal.usda.gov/pgdic/Probe/v2n3/puls.html Pulsed field electrophoresis for separation of large DNA

http://ntri.tamuk.edu/electrophoresis/home.html This page is maintained by the Natural Toxins Research Center at Texas A&M University - Kingsville Written by Cynthia Sanchez http://www.ehs.berkeley.edu/pubs/helpsheets/04electro.html Guidelines for Safe Use of Electrophoresis Equipment, The Office of Environment, Health & Safety (EH&S) University of California Berkeley. http://www.bertholf.net/rlb/Lectures/index.htm Power point lecture by Robert L Bertholf Ph.D. Associate Professor of Pathology Chief of Clinical Chemistry and Toxicology

Chapter 11- Immunological Reactions http://www.kcom.edu/faculty/chamberlain/Website/MSTUART/lect4.htm Kirksville College of Osteopathic Medicine www.whfreeman.com/immunology/CH06/kuby06.htm W. H. Freeman & Co. and Sumanas, Inc.Immunology, January, 1997 http://www.cig.salk.edu/The_specificity_of_IR.pdf The Salk Institute: The specificity of Immunologic Reactions. http://www.asehaqld.org.au/pblctns.htm Allergy, Sensitivity & Environmental Health Association http://allergy.mcg.edu/home.html American College of Allergy, Asthma & Immunology Arlington Heights, IL http://www.niaid.nih.gov/default.htm The National Institute of Allergy and Infectious Diseases (NIAID)

Chapter 12- Immunochemical Techniques http://www.indstate.edu/thcme/micro/imm-tech.html IMMUNOLOGICAL TECHNIQUES Copyright © 1999, Indiana State University, all rights reserved Indiana State University, Terre Haute, IN 47809 USA, 812-237-6311

Chapter 13- Principles for Competitive-Binding Assays www.med.unc.edu/wrkunits/2depts/pharm/receptor/side5.htm Course on Theory and Practice of Receptor Characterization and Drug Analysis by Dr. Richard Mailman Ph.D. and Dr. Jose Boyer Ph.D. www.m.ehime-u.ac.jp/~yasuhito/Elisa.html Enzyme –Linked Immunosorbent Assay Homepage

www.biology.arizona.edu/immunology/activities/elisa/main.html The Biology Project by the University of Arizona, Introduction to ELISA activity www.curvefit.com/how_to_fit.htm How to fit standard curves http://www.med.unc.edu/wrkunits/2depts/pharm/receptor/side5.htm Theory and practice of receptor characterization and drug analysis by Richard B. Mailman, Ph.D. and Jose Boyer, Ph.D. North Carolina State University,

Chapter 14 – Measurements of Colligative Properties http://www.chem.uidaho.edu/~honors/collig.html Description of colligative properties University of Idaho Honors Chemistry by Prof. Tom "Doc" Bitterwolf and Kevin Rider, TA extraordinar http://dbhs.wvusd.k12.ca.us/ColligProp/ColligativeProp.html Description of colligative properties University of Idaho Honors Chemistry; Copyright © 1996 by John L. Park; Diamond Bar High School Diamond Bar, CA http://www.columbia.edu/cu/chemistry/edison/gallery/Lab3/collig_prop.html College course Chemistry 1500 Department of Chemistry Columbia University New York, NY

Chapter 15 – Electrochemistry: Principles and Measurements http://electrochem.cwru.edu/ed/dict.htm Electrochemistry dictionary http://www.bath.ac.uk/~chsacf/solartron/electro/html/int.htm University of Bath http://jcbmac.chem.brown.edu/baird/Chem22I/lectures/Electrochemistry/ElectroChem.html Electrochemistry via Adobe Acrobat http://www.cranfield.ac.uk/biotech/chinap.htm Cranfield University, Biosensers: Past, Present, and Future, Anthony P F Turner http://www.bertholf.net/rlb/Lectures/index.htm Power point lecture by Robert L Bertholf Ph.D. Associate Professor of Pathology Chief of Clinical Chemistry and Toxicology http://www.funsci.com/fun3_en/electro/electro.htm Experiments in electrochemistry http://learn.chem.vt.edu/tutorials/electrochem/ Electrochemistry help file by theChemistry Learning Center at the Virgina Tech Chemistry Department

Chapter 16 – Automation

http://labautomation.org/ The Association for Laboratory Automation (ALA) is a not-for-profit organization whose vision is to provide the premier educational opportunities in the field of laboratory technologies. http://marc.med.virginia.edu/library.html The Medical Automation Research Center is a research, development, and consulting organization. It provides its industrial partners with solutions to medical automation problems. MARC's mission is to: Develop automation and robotic systems to reduce the cost and improve the quality of health care. Apply process control, scheduling and optimization tools to health care delivery. Improve use of diagnostic information using innovative information processing and informatics. Apply advanced imaging and visionguided robot control to health care delivery. Provide and educational center where investigators learn the use of advanced automation techniques and provide robotics education to hospital faculty and staff. http://medizin.li/_mt_index/_ja/ja_000035382.html JACLA Japanese Association for Clinical Laboratory Automation 113-0033 Tokyo Japan

Chapter 17- Point-of-Care Testing http://www.aacc.org/divisions/poct/ AACC Division of Point of Care Testing http://www.aacc.org/divisions/poct/latest_news.stm Online Newsletter sponsored by the AACC for pont of care testing www.ascls.org/position/point.htm ASCLS, Position on point-of-care testing www.pointofcare.net http://www.cpsa.ab.ca/qoc/Point-of-Care%20Testing.doc Accreditation survey document for laboratories by the College of Physicians and Surgeons of Alberta

Chapter 18- Laboratory Information Systems http://www.informatics-review.com The Informatics Review is an Online journal electronic serial for medical and information system professionals and describes academic developments in clinical informatics and computing. Published as the e-journal of the Association of Medical Directors of Information Systems. www.imia.org International Medical Informatics Association www.amia.org American Medical Informatics Association www.nacb.org National Academy of Clinical

Biochemistry

Chapter 19- Laboratory Statistics http://nimitz.mcs.kent.edu/~blewis/stat/scon.html This is an informal guide to elementary inferential statistical methods used in the laboratory by B. Lewis Department of Mathematics and Computer Science Kent State University Kent OH http://www.ruf.rice.edu/~lane/rvls.html Rice University, Houston, TX ; Rice Virtual Lab in Statistics copyright © 1993-2000 David M. Lane http://www.math.uah.edu/stat/index.html University of Alabama at Huntsville Mathematics Department; http://www.math.yorku.ca/SCS/StatResource.html University of York Mathematics Department with a statistical resource link in their Statistical Consulting Service area; http://www.statistics.com A general web page detailing a myriad of statistical resources.

Chapter 20 –Reference Intervals and Clinical Decision Limits http://www.cche.net/usersguides/decision.asp Centres for Health Evidence: How to use a clinical decision analysis http://www.westgard.com/essay8.htm Medical decision limits by Westgard http://www.analyse-it.com/products/clinical/diagnostic-testing.htm Trial software that works with Excel Analyse-It Software, Ltd,Leeds, EnglandUnited Kingdom http://130.189.200.66/Flow%20Lab%20manual/1.%20Policy%20statements/refrange.html by Marc Langweiler Flow Cytometry Laboratory at Mary Hitchcock Memorial Hospital Dartmouth -Hitchcock Medical Center New Hampshire.

Chapter 21 – Quality Control for the Clinical Chemistry Laboratory www.nccls.org National Committee for Clinical laboratory Standards www.vh.org/Providers/CME/CLIA/CLIAHP.html NIST www.iso.ch/ International Organization for Standardization www.cap.org College of American Pathologists (CAP)

www.jcaho.org Joint Commission on Accreditation of Healthcare Organizations (JCAHO) http://cms.hhs.gov Centers for Medicare and Medicaid Services (formerly HCFA http://www.multiqc.com/ Multivariate QC in clinical laboratories, MultiQC is a software application for laboratory quality control. The program implements the traditional Shewhart charts, but also calculates multivariate QC for routine work.

Chapter 22- Evaluation of Methods http://www.westgard.com Westgard QC, Tools Technology and Training for Health Care Laboratories http://www.dgrhoads.com David G. Rhoads Associates Inc., Specialty Software for the Clinical Laboratory http://www.krouwerconsulting.com Krouwer Consulting Homepages and services provided http://www.asq.org American Society for Quality http://www.nccls.org NCCLS is a voluntary consensus standards – developing organization that enhances the value of medical testing through development and dissemination of standards, guidelines, and best practices www.access.gpo.gov Use this site for the latest updates to Code of Federal Regulations (CFR) information www.fda.gov The Food and Drug Administration’s homepage www.cms.gov The Centers for Medicare and Medicaid Services homepage

Chapter 23 – Interferences in Chemical Analysis http://bashful.chem.washington.edu/abstracts/Stand-abst.htm Standardization of Second-Order Chromatographic/Spectroscopic Data for Optimum Chemical Analysis, The Synovec Group at UW http://courses.chem.ukans.edu/Fall2000/516/LectureNotes/Overview%20of%20Chemical%20Analysis.htm An Overview of Chemical Analysis X http://www.caeal.ca/Simplified%20Uncertainty.pdf A Suggested Method for Calulation of Uncertainty in Environmental Chemical Analysis by Mohammad Foroutan

http://www.edie.net/Library/Features/IEI9825.html Contaminated Land and Ground Water, jargon-busting Chemical analysis

SECTION 2 Pathophsiology http://www.ut.edu.co/fcs/ University of Tolim, Columbia, lots of information from the medical course. In Spanish

Chapter 24 - Physiology and Pathophysiology of Body Water and Electrolytes\ http://family.georgetown.edu/welchjj/netscut/fen/fluids_intro.html Introductory information on fluid and electrolytes http://www.morinlabs.com/electandyou.html Morin Laboratories

Chapter 25- Acid-Base Control and Acid-Base Disorders http://www.foodallergy.org The Food Allergy and Anaphalaxis Network http://www.aaaai.org American Academy of Allergy and Asthma and Immunlogy http://www.asthmainamerica.com/ Asthma in America , a landmark survey www.acid-base.com Acid-base balance http://www.science.ubc.ca/~chem/tutorials/pH pH tutorial www.madsci.com/manu/indexgas.htm Blood gases manual www.int-med.uiowa.edu/education/abg.htm Introduction to interpreting arterial blood gases www.mtsinai.org/pulmonary/books/abg/preface.html All you really need to know to interpret arterial blood gases http://www.home.eznet.net/~webtent/acidbase.html The Drug Monitor, Acid Base Disorders http://cnserver0.nkf.med.ualberta.ca/cn/Schrier/Volume1/chap6/ADK1_06_4-6.pdf

Disorders of Water, Electrolytes, and Acid Base notes

Chapter 26- Renal Function www.kidney.org National Kidney Foundation (US) www.kidney.ca Canadian Kidney Foundation www.kidney.org.au Australian Kidney Foundation http://www.fpnotebook.com/FamilyPracticeNotebook.com Family Practice Notebook www.isn-online.org International Society of Nephrology www.asn-online.org American Society of Nephrology http://www.fpnotebook.com/REN63.htm Family practice Notebook http://www.kcl.ac.uk/teares/gktvc/vc/lt/rtg/sbdl18.pdf Scientific Basis of Disease

Chapter 27- Liver Function www.aasld.org American Association for the Study of Liver Disease (AASLD) www.childliverdisease.org Children’s Liver Disease Foundation http://cpmcnet.columbia.edu/dept/gi/disliv.html An extensive technical medical site from Columbia University www.niddk.nih.gov/health/digest/summary/pricir/pricir.htm A look at primary biliary cirrhosis: what it is, its causes, symptoms, diagnosis, and treatment http://www.ikp.unibe.ch/lab2/Laieen.html The Liver and Liver Diseases by J. Reichen

Chapter 28- Bone Disease

http://pathophysiology.uams.edu University of Arkansas Department of Pathology www.ectsoc.org European Calcified Tissue Society www.meddean.luc.edu Loyola University Medical Education Network www.well.ox.ac.uk Wellcome Trust Centre for Human Genetics www.nof.org National Osteoporosis Foundation www.osteo.org NIH Osteoporosis and Bone Related Disease www.learn-about-osteoporosis.com Osteoporosis & Women's Health www.nos.org.uk National Osteoporosis Society http://uwcme.org University of Washington CME credits for a fee www.nlm.nih.gov NIH MEDLINE plus Medical Encyclopedia http://www.ectsoc.org/review.htm Reviews on Bone Disease and Bone Biology

Chapter 29 – The Pancreas: Function and Chemical Pathology http://www.pancreasfoundation.org/ The National Pancreas Foundation http://arbl.cvmbs.colostate.edu/hbooks/pathphys/digestion/pancreas/ Colorado State University, The Pancreas: Introduction and Index http://www.teaching-biomed.man.ac.uk/student_projects/2000/mnby7lc2/pancreas.htm University Of Manchester , The Pancreas http://www.udel.edu/Biology/Wags/histopage/colorpage/cp/cp.htm University of Delaware, The Pancreas

Chapter 30 –Gastrointestinal Function and Digestive Disease

http://www.pituitary.com/Articles/MEN1Article1.htm Pituitary Network Association http://www.niddk.nih.gov/health/endo/pubs/fmen1/fmen1.htm National Institute of Diabetes and Digestive and Kidney Disease www.niddk.nih.gov/health/digest/pubs/ulcers/ulcers.htm National Digestive Diseases Clearinghouse www.digestivedisorders.org.uk/leaflets/ulcers.html Digestive Disorders Foundation , Dr. Jeremy Barnes www.faseb.org/opar/pylori/pylori.html Breakthroughs in Bioscience www.bsg.org.uk/clinical_prac/guidelines/malabsorb.htm British Society of Gastroenterology www.ncbi.nlm.nih.gov/disease/ggm.html NCBI Genes and Disease www.niddk.nih.gov/health/digest/pubs/celiac/ National Digestive Disorders Information Clearinghouse, Celiac Disease www.celiac.org Celiac Disease Foundation www.niddk.nih.gov/health/digest/pubs/lactose/lactose.htm National Digestive Disorder Information Clearinghouse, Lactose Intolerance www.carcinoid.org/review.html Carcinoid Cancer Foundation, A Review of Carcinoid Disease http://www.karger.ch/journals/ddi/ddi_jh.htm Karger, Digestive Diseases http://pages.prodigy.com/DVBL86A/drk3-hp.htm Gastrointestinal Web Page http://www.iffgd.org/GIDisorders/GImain.html International Foundation for Functional Gastrointestinal Disorders http://escuela.med.puc.cl/ Chilean Catholic University; In Spanish

Chapter 31- Cardiac and Muscle Disease www.acc.org/ American College of Cardiology

www.acc.org/clinical/guidelines/nov96/1999/ ACC/AHA Guidelines for the Management of Patients with Acute Myocardial Infarction www.acc.org/clinical/consensus/mi_redefined/ American College of Cardiology Foundation: Myocardial Infarction Redefined: A Consensus Document www.escardio.org European Society of Cardiology www.fodsupport.org/cpt2.htm Fatty oxidation disorder website http://medlib.med.utah.edu/WebPath/TUTORIAL/MYOCARD/MYOCARD.html University of Utah tutorial www.nlm.nih.gov/medlineplus/ency/article/000158.htm National Medical Library, Encyclopedia; Heart Failure http://www.cardiac-disease.net/ Altruis Biomedical Network http://www.ynhh.org/cardiac/diagnosis/ Yale New Haven Hospital http://www.ultranet.com/~jkimball/BiologyPages/M/Muscles.html#Muscle_Diseases Dr. John W. Kimball online biology text http://www.cardio.bayer.com/ Bayer Corporation Cardiovascular risk management http://www.bertholf.net/ Go to lecture icon and select it. Power point lecture by Robert L Bertholf Ph.D. Associate Professor of Pathology Chief of Clinical Chemistry and Toxicology

Chapter 32- Diabetes Mellitus http://www.bsc.gwu.edu/bsc/studies/dcct.html A brief summary of the 10-year Diabetes Control and Complications Trial and links pertaining to it from George Washington University http://www.zoomph.net/diabetes.world/dcct.htm American Diabetes Association Position Statement: Implications of the Diabetes Control and Complications Trial http://www.diabetes.org American Diabetes Association http://www.diabetes.org/main/professional/journals/diabcs21_2_898.jsp American Diabetes Association article on gestational diabetes mellitus http://www.cdc.gov Centers for Disease Control and Prevention

http://www.ohsu.edu/cliniweb/C18/C18.452.297.html Oregon Health and Science University http://www.ohsu.edu/cliniweb/C18/C18.452.297.html Oregon Health and Science University http://www.aafp.org/afp/981015ap/mayfield.html American Association of Family Physicians: Diagnosis and Classification of Diabetes Mellitus: New Criteria Jennifer Mayfield, M.D., M.P.H

Chapter 33- Coronary Artery Disease and Disorders of Lipid Metabolism http://www.heartpoint.com/coronartdisease.html HeartPoint http://www.chestx-ray.com/Coronary/CorCalc.html Jud W. Gurney, M.D. FACR Department of Radiology Nebraska Medical Center http://my.webmd.com/content/dmk/dmk_summary_account_1454 WebMD Health http://familydoctor.org/handouts/239.html American Academy of Family Physicians Coronary Artery Disease, How Your Diet Can Help www.ohsu.edu/cliniweb/C18/C18.452.494.html Oregon Health Sciences University Hyperlipidemia http://www.nlm.nih.gov/medlineplus/ Medline plus: Search Health Topics www.indstate.edu/thcme/mwking/lipids.html Indiana State College of Medicine www.indstate.edu/thcme/mwking/cholesterol.html Indiana State College of Medicine www.lipoproteins.net Altruis biomedical network www.indstate.edu/thcme/mwking/lipoproteins.html Indiana State College of Medicine www.acclakelouise.com/acc99/htm/genest2.htm Cardiovascular Genetics Laboratory, Clinical Research Institute of Montreal and the Cardiology Services, Centre Hospitalier de l'Universit de MontrÈal. High Density Lipoproteins in Health and in Disease www.nhlbi.nih.gov/guidelines/cholesterol National Heart, Lung, and Blood Institute (NHLBI) Detection, Evalulation and Treatment of High Blood Cholesterol in Adults www.acsm.org/pdf/certnews/cnwv11n2.pdf

Summary of the National Cholesterol Education Program (NCEP) , American College of Sports Medicine www.americanheart.org/presenter.jhtml?identifier=4764 Step I and Step II Diets from The American Heart Association www.medal.org/ch13.html The Medical Algorithms Project, Treatment of Hypercholesterolemia. NCEP Adult Treatment: Panel III (ATP III) www.americanheart.org The American Heart Association, www.nlm.nih.gov/medlineplus/coronarydisease.html Medline Plus, Coronary Disease http://www.heartpoint.com/coronartdisease.html Heartpoint Gallery http://locus.umdnj.edu/nigms/nigms_cgi/cells.flat.cgi?id=2&query=LP&display=diags Coriell Cell Repositories

Chapter 34 – Alcoholism http://alcalc.oupjournals.org/ Oxford Journals Online, Alcohol and Alcoholism http://www.nlm.nih.gov/medlineplus/alcoholism.html Medline Plus, Alcoholism , National Library of Medicine http://www.nmha.org/infoctr/factsheets/02.cfm National Mental Health Association http://www.alcoholismtreatment.org/ Alcoholism Treatment www.niaaa.nih.gov/ National Institute on Alcohol Abuse and Alcoholism; www.ncadd.org/ National Council on Alcoholism and Drug Dependence - NCADD www.aca-usa.org/ American Council on Alcoholism (ACA) www.medicouncilalcol.demon.co.uk/ The Medical Council on Alcohol

Chapter 35 – Iron, Porphyrin, and Bilirubin Metabolism www.med.monash.edu.au/biochem/thcme/bilirub.html /

Mirror of Medical Biochemistry / Terre Haute Center for Medical Education / Michael W. King, Ph.D Disorders in Bilirubin Metabolism http://www.umanitoba.ca/faculties/medicine/units/biochem/coursenotes/blanchaer_tutorials/Frank_II/biliO verview.html Bilirubin metabolism notes www.porphyriafoundation.com American Porphyria Foundation http://www.medic.med.uth.tmc.edu/path/00000884.htm Porphyrias (in Development) , MedIC Medical Education Information Center http://sickle.bwh.harvard.edu/menu_iron.html Harvard University, disorders of iron metabolism http://medlib.med.utah.edu/WebPath/TUTORIAL/IRON/IRON.html University of Utah, diseases of iron metabolism www.americanhs.org American Hemochromatosis Society www.cdc.gov/genomics/info/perspectives/hemo.htm Centers for Disease Control and Prevention, hereditary hemochromatosis http://www.smbs.buffalo.edu/med/hem/iron.html State University of New York at Buffalo, iron metabolism and deficiency Dr. Bruce M. Small M.D. http://www.med.unibs.it/~marchesi/heme.html Medical Biochemistry / Terre Haute Center for Medical Education/ Michael W. KING, Ph.D / Heme and Porphyrin Metabolism http://www.dentistry.leeds.ac.uk/biochem/thcme/hememetabolism.pdf Leeds Dental Institute Division of Oral Biology Online Biochemistry Series, Heme Metabolism www.stargine.com/porphyrins/Mediporph/_mediporphome.html Medical topics of porphyrias

Chapter 36 –Hemoglobin http://www.hematology.org/ American Society of Hematology http://www.cooleysanemia.org/ Cooley’s Anemia Foundation, for patients with thalassemia http://www.emory.edu/PEDS/SICKLE/ The sickle cell information center at the Grady System The Georgia Comprehensive Sickle Cell Center at Grady Health System http://sickle.bwh.harvard.edu/ Joint Center for Sickle Cell and Thalassemic Disorders Harvard Medical School http://www.people.virginia.edu/~rjh9u/hemoglob.html

University of Virginia , A Molecule to Breathe with , Hemoglobin http://web.indstate.edu/thcme/mwking/ Indiana State University School of Medicine The Medical Biochemistry Page http://omlc.ogi.edu/spectra/ Oregon Medical Laser Center Optical Properties Spectra http://cpmcnet.columbia.edu/texts/gcps/gcps0053.html Congenital disorders: screening for hemoglobinopathies. In U.S. Preventive Services Task Force Guide to Clinical Preventive Services, ed 2, Washington, DC, 1996, U.S. Department of Health and Human Services, Office of Disease Prevention and Health Promotion http://www.slh.wisc.edu/newborn/guide/disorders6.html The Wisconsin State Laboratory of Hygiene Health Professionals’ guide to newborn screening for hemoglobinopathies

Chapter 37-Human Nutrition www.nutrition.org.uk British Nutrition Foundation www.nutrition.uu.se/studentprojects/group98/micronut/micronut.html Micronutrient Malnutrition notes www.who.int/nut/pem.htm World Health Organization: Nutrition www.who.int/inf-fs/en/fact119.html WHO fact sheet on childhood malnutrition http://www.aces.uiuc.edu/~fshn/ University of Illinois Champaign Urbana Department of Food Science and Human Nutrition http://www.gfhnrc.ars.usda.gov/hnrcnews.htm USDA/ARS Grand Forks Human Nutrition Research Center http://www.nps.ars.usda.gov/programs/programs.htm?NPNUMBER=107 USDA Agricultural Research Service http://www.nutritionperspectives.com/flash.html Dade Behring nutrition articles http://www.ars.usda.gov/ U.S. Department of Agriculture: Agriculture Research Service (Click on Search, type in Nutrition) www.iotf.org/ WHO International Obesity Task Force www.cdc.gov/nccdphp/dnpa/obesity/ National Center for Chronic Disease Prevention and Health Promotion: Obesity and Overweight www.nhlbi.nih.gov/guidelines/obesity/ob_home.htm

National Heart, Lung, and Blood Institute Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults www.cdc.gov/brfss National Center for Chronic Disease Prevention and Health Promotion Behavioral Risk Factor Surveillance System

Chapter 38 –Trace Elements General http://www.nal.usda.gov/ National Agricultural Library Recommended Dietary Allowances (RDA) http://www.nap.edu/ National Academy Press Division of the National Academy of Sciences www.toxlab.co.uk Regional Laboratory for Toxicology: British Health Service http://hsl.mcmaster.ca/tomflem/nutrition.html McMaster University Nutrition health care information links http://cchs-dl.slis.ua.edu/ University of Alabama Health Sciences digital library research topics. To find information, type name of element into the search engine. http://www.lhsc.on.ca/lab/metallab/ London Health Sciences Center of Canada Trace elements laboratory http://www.aruplab.com/guides/clt/tests/clt_idx_trace.htm ARUP's Guide to Clinical Laboratory Testing. Trace Elements Index http://www.geo.berkeley.edu/geology/labs/epma/trace.htm Electron Probe Microanalysis Laboratory Department of Earth and Planetary Science University of California at Berkeley Chromium http://www.nap.edu/books/030906354X/html/index.html National Academy Press Division of the National Academy of Sciences The Role of Chromium in Animal Nutrition (1997) book online Copper www.nutrition.org American Society for Nutritional Sciences To find information, type name of element into the search engine. Wilson’s disease

http://www.wilsonsdisease.org/ Wilson's Disease Association International http://www.niddk.nih.gov/ National Institutes of Diabetes &Digestive & Kidney Diseases To find information, type Wilsons Disease into the search engine. http://www.ninds.nih.gov/ National Institute of Neurological Disorders and Stroke To find information, type Wilsons Disease into the search engine. Menkes’ syndrome http://www.ncbi.nlm.nih.gov/ National Center for Biotechnology Information Click on OMIM (online Mendelian Inheritance in Man) Type Menke’s Syndrome into the search engine http://dmoz.org Open Directory Project Type Menke’s Syndrome into the search engine for website links. Lead http://www.cdc.gov/nceh/lead/guide/guide97.htm Centers for Disease Control and Prevention: Screening Young Childrenfor Lead Poisoning: Guidance for State and Local Health Officials http://www.aap.org/ American Academy of Pediatrics. Type lead into search engine. http://www.slh.wisc.edu/ Wisconsin State Laboratory of Hygeine. Lead proficiency testing program. Type lead into the search engine www.wadsworth.org Wadsworth Center New York State Department of Health. Certification for Lead Proficiency Mercury http://www.aap.org/ American Academy of Pediatrics. Type mercury into search engine. http://www.epa.gov/ Environmental Protection Agency. Type mercury into search engine. Manganese http://www.tldp.com/ Townsend letter for alternative medicine Selenium www.cc.nih.gov NIH Clinical Center. Type selenium into search engine.

www.cce.cornell.edu Cornell Cooperative Extension. Type selenium into the search engine Zinc http://www.tamu.edu/ Texas A & M University Type zinc into search engine.

Chapter 39- Vitamins www.asns.org/ American Society for Nutritional Sciences www.faseb.org/ascn American Society for Clinical Nutrition www.asns.org/sinr/index.htm Society for International Nutrition Research http://vm.cfsan.fda.gov/list.html United States Food and Drug Administration Center for Food Safety and Applied Nutrition www.nalusda.gov/fnic/ Food and Nutrition Information Center of the National Agriculture Library http://books.nap.edu/books/ Dietary reference intakes report This site takes you to Crawler List of All NAP Searchable Open Books Go to 0309065542 www.nalusda.gov/fnic/etext/ The National Agricultural Library Food and Nutrition Information Center etext list. Go to 000105 on the Index of /fnic/etext document list. Select Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline http://web.indstate.edu/thcme/mwking/vitamins.html Indiana State University Terra Haute Center for Medical Education. Introduction to Vitamins

Chapter 40 – Pregnancy and Fetal Development http://www.babycenter.com/pregnancy/fetaldevelopment/ “Baby Center” website http://pregnancy.about.com/cs/pregnancy/ The “What You Need to Know About” website http://www.dartmouth.edu/~obgyn/mfm/PatientEd/ Dartmouth-Hitchcock Medical Center, Division of Maternal Fetal Medicine, Patient Education http://www.fpnotebook.com/ Family Practice Notebook

http://www.atlanta-mfm.com/clindisc/vol4no5.html Atlanta Fetal-Medicine PC Clinical Discussion, volume 4, number 5, May 21, 1996 http://www.w-cpc.org/index.htm Westside Pregnancy Resource Center http://www.ibd.nrc.ca/english/s_clinical_fetal.htm Institute for Biodiagnostics, National Research Council of Canada http://www.docboard.org/me/rules/allch078.htm Maine Board of Licensure in Medicine: Medical Board Rules 2. Procedure: Assessment of fetal maturity prior to repeat cesarean delivery or elective induction of labor http://www.acog.org/ The American College of Obstetricians and Gynecologists. Type diabetes into the website’s search engine

Chapter 41 –Extravascular Biological Fluids www.arthritis.org Arthritis Foundation www.niams.nih.gov/ National Institute of Arthritis and Musculoskeletal and Skin Diseases Home page www.arthritis-research.com Arthritis Research www.vh.org/Providers/TeachingFiles/PulmonaryCoreCurric/PleuralEffusion/PleuralEffusion.html — Virtual Hospital: Adult Pulmonary Core Curriculum: Pleural Effusions and Chemical Pleurodesis www.aafp.org/afp/20000415/2391.html American Academy of Family Physicians: Knee Effusions: A Systematic Approach to Diagnosis www.postgradmed.com/issues/1999/05_01_99/rubins.htm Postgraduate Medicine: Evaluating Pleural Effusions www.uwcme.org/courses/rheumatology/rheumlab/synovial.html University of Washington School of Medicine: Synovial Fluid Analysis www.nlm.nih.gov/medlineplus/ency/article/003629.htm National Library of Medicine: Synovial Fluid Analysis

Chapter 42 – Nervous system http://www.ninds.nih.gov/ National Institute of Neurological Disorders and Stroke http://www.nimh.nih.gov/ National Institute of Mental Health http://www.nimh.nih.gov/publicat/depressionmenu.cfm

NIMH publications on depression http://www.mic.ki.se/Diseases/c10.html Karolinska Institute Library, Stockholm, Sweden http://www.vh.org/Providers/TeachingFiles/CNSInfDisR2/IDCNSHomePg.html University of Iowa Virtual Hospital: Infectious Diseases of the Central Nervous System http://www.nda.ox.ac.uk/wfsa/html/u05/u05_010.htm World Federation of Societies of Anaesthesiologists The Autonomic Nervous System http://www.kumc.edu/instruction/medicine/anatomy/histoweb/nervous/nervous.htm Nervous System University of Kansas Medical Center Department of Anatomy and Cell Biology http://weavernt.med.utah.edu/kw/neuro.html Knowledge Weavers Spencer S. Eccles Health Sciences Library at the University of Utah: Neuroanatomy http://www.merck.com/pubs/mmanual/section14/sec14.htm The Merck Manual Section 14 Neurological Disorders http://www.drada.org/ Depression and Related Affective Disorders Association (DRADA)

Chapter 43 – General Endocrinology http://www.slis.ua.edu/dls/cchs/main/clinical/endocrinology/general.htm School of Library Information Studies University of Alabama General Endocrinology Clinical Resources http://www.hormoneproblems.com/Gen_Endo.htm Texas Institute for Reproductive Medicine & Endocrinology, General Endocrinology http://www.vetmed.ucdavis.edu/PHR/Therio/General%20Male%20Endocrinology.pdf University of California Davis Veternary Medicine General Male Endocrinology http://www.mednets.com/sendocri.htm MedNets, Inc. is a Delaware corporation providing healthcare information www.endo-society.org The Endocrine Society Home Page; www.mic.ki.se/Diseases/c19.html Karolinska Institute list of sites providing information on a wide variet of endocrine Disorders http://www.aace.com/ American Association of Clinical Endocrinologists;

Chapter 44 – Thyroid www.nacb.org National Academy of Clinical Biochemistry: Draft Guidelines of Laboratory Support for Diagnosis and Monitoring of Thyroid Disease

www.thyroid.org American Thyroid Association www.endo-society.org The Endocrine Society www.thyroid.about.com About Network Thyroid Disease www.thyroid.ca Thyroid Foundation of Canada www.thyroidmanager.org Thyroid Disease Manager http://the-thyroid-society.org/ The Thyroid Society www.4women.gov/faq/thyroid_disease.htm National Women’s Health Information Center http://www.focusonthyroid.com/ MedicineNet.com Focus on Thyroid http://www.tsh.org Thyroid Foundation of America http://www.aace.com/clin/guidelines/ American Association of Clinical Endocrinologists

Chapter 45 – The Gonads Amenorrhea http://www.advancedfertility.com/amenor.htm Advanced Fertility Center of Chicago Polycystic Ovary Disease www.pcosupport.org/ Polycystic Ovarian Syndrome Association http://www.wdxcyber.com/dxinf001.htm Women’s Diagnostic Cyber Disease Profile Infertility/Fertility http://www.inciid.org/ The InterNational Council on Infertility Information Dissemination, Inc.

http://www.womens-health.com/health_center/infertility/ Women’s Health Interactive http://www.fertilityuk.org/ This site is an on-line version of the book 'Fertility' Premenstrual Syndrome http://www.pms.org.uk/ National Association for Premenstrual Syndrome Klinefelter's Syndrome http://www.akac70.care4free.net/home.html Klinefelter's Syndrome Association UK http://www.e-testicles.com/ Altruis Biomedical Network

Chapter 46- Adrenal Hormones and Hypertension http://www.medhelp.org/nadf/ National Adrenal Diseases Foundation http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/adrenal/index.html Colorado State Hypertextbook: The Adrenal Gland: Introduction and Index http://web.indstate.edu/thcme/mwking/hormone-table.html Indiana University Medical Biochemistry http://www.pslgroup.com/dg/6a3da.htm Doctor's Guide Publishing Limited. Article on hypertension. http://www.wfubmc.edu/hypertension/ Wake Forrest Baptist Medical Center Hypertension and Vascular Disease http://www.cancer.gov/cancer_information/ National Cancer Institute Information: http://www.nlm.nih.gov/medlineplus/adrenalglanddisorders.html Medlineplus adrenal gland disorders. http://www.ash-us.org/ American Society of Hypertension (ASH) http://www.who.int/en/ World Health Organization http://www.medhelp.org/ Med Help International "Virtual Medical Center for Patients"

Chapter 47 – Diseases of Genetic Origin http://www.accessexcellence.org/AB/IWT/Gene_Therapy_Overview.html The National Health Museum: Gene Therapy- An Overview http://www.bioscience.org/atlases/disease/genedis/glossary.htm Human Genome Project Information, glossary text http://www.ornl.gov/hgmis/publicat/primer2001/index.html Genomics and Its Impact on Medicine and Society: A 2001 Primer Accessed 2/8/2002 Human Genome Project US Department of Energy http://www.genome.gov/glossary.cfm Glossary of Genetic Terms National Human Genome Institute National Institutes of Health (US) Accessed 2/8/2002 http://www.ncbi.nlm.nih.gov/disease National Center for Biotechnology Information Genes and Disease page part of the National Library of Medicine Accessed 2/8/2002

Chapter 48 – Molecular Biology in the Clinical Laboratory www.genetests.org Gene Tests and Gene Clinics web page www.hivatis.org US Department of Health and Human Services HIV/AIDS Treatment Information Service http://hivdb.stanford.edu Stanford University HIV RT and Protease Sequence Database www.ncbi.nlm.nih.gov National Library of Medicine National Center for Biotechnology Information www.genet.sickkids.on.ca Department of Genetics, Hospital for Sick Children, Toronto, Canada Cystic Fibrosis Mutation Data Base http://archive.uwcm.ac.uk/uwcm/mg/hgmd0.html Institute of Medical Genetics, Cardiff, Wales Human Gene Mutation Database

Chapter 49- Neoplasia http://www.cancer.org/ American Cancer Society www.cancer.gov/ National Cancer Institute

http://cis.nci.nih.gov/ Cancer Information Service http://medlib.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html The Internet Pathology Laboratory for Medical Education Florida State University College of Medicine http://edcenter.med.cornell.edu/CUMC_PathNotes/Neoplasia/Neoplasia.html Cornell University Medical College HTML by Adam Goldstein http://www.tmc.tulane.edu/classware/pathology/medical_pathology/New_for_98/Neoplasia_new/5t_Answe red/Neoplasia_Cases.html#Case1 Tulane Medical Pathology Course http://www.merck.com/pubs/mmanual_home/sec13/149.htm The Merck Manual of Medical Information--Home Edition Section 13. Hormonal Disorders

Chapter 50 – Laboratory Evaluation of the Transplant Recipient and Donor http://www.a-s-t.org/ American Society of Transplantation http://www.ashi-hla.org/aboutfiles/aboutframe.html American Society for Histocompatibility and Immunogenetics (ASHI) http://www.transweb.org/ TransWeb: All About Transplantation and Donation, a nonprofit educational web site serving the world transplant community. Based at the University of Michigan, http://www.kidneytransplant.org/ University of Southern California, Department of Surgery, Kidney Transplant Program http://worldnet.medbiq.org/clinicalresources/hearttransplant.jsp Heart Transplantation - Questions and Answers William Baumgartner, MD http://www.nlm.nih.gov/ National Library of Medicine’s Medline encyclopedia http://www.kidneyatlas.org/book5/adk5-11.ccc.QXD.pdf Examples of immunosuppressive protocols and mechanisms Angelo M. de Mattos http://cnserver0.nkf.med.ualberta.ca/cn/Schrier/Volume5/ch9/ADK5-09_7-9.pdf Transplant rejection and treatment www.unos.org United Network of Organ Sharing http://www.wadsworth.org/labcert/blood_tissue/ New York State Department of Health, Wadsworth Center, Division of Laboratory Certification, Blood and Tissue Resources http://www-med.stanford.edu/shs/txp/livertxp/livingdonation.html Stanford University Living Liver Donor Program

http://www.hopkinsmedicine.org/cardiology/heart/ Johns Hopkins Cardiomyopathy and Heart Transplant Service

Chapter –51 Toxicology http://www.bertholf.net/rlb/Lectures/index.htm Select the Clinical and Forensic Toxicology lectures in Power Point http://medicine.iupui.edu/flockhart Indiana University’s Cytochrome P450 Drug Interaction Table http://www.aapcc.org American Association of Poison Control Centers http://www.cdc.gov/nchs/datawh/statab/unpubd/mortabs/gmwki.htm National Center for Health Statistics http://www.atsdr.cdc.gov/atsdrhome.html Agency for Toxic Substances and Disease Registry http://www.epa.gov/ US Environmental Protection Agency http://www.ag.ohio-state.edu/ The Ohio State University Pesticide Education Program http://ace.orst.edu/info/nptn/ National Pesticide Information Center http://ntp-server.niehs.nih.gov/ National Institute of Environmental Health Sciences National Toxicology Program http://toxnet.nlm.nih.gov/ TOXNET, US National Library of Medicine http://www.usdoj.gov/dea/concern/concern.htm US Drug Enforcement Agency (DEA) http://www.bioterrorism.slu.edu/ Center for the Study of Bioterrorism and Emerging Infections at Saint Louis University http://www.toxicology-info.com/ Altruis biomedical network http://physchem.ox.ac.uk/MSDS/ The Physical and Theoretical Chemistry Laboratory, Oxford University, Chemical and Other Safety Information

http://www.emedicine.com/EMERG/topic819.htm, Acetaminophen Toxicity Synonyms, Key Words, and Related Terms: paracetamol, N-acetyl-paminophenol, APAP

Chapter –52 Addiction and Substance Abuse http://www.usdoj.gov/dea/ US Drug Enforcement Administrations (DEA) http://www.edc.org/hec/ Higher Education Center for Alcohol and Drug Prevention, a program from the US Department of Education http://www.health.org/ and http://www.samhsa.gov/ Substance abuse and Mental Health Services Administration (SAMHSA), National Clearinghouse for Alcohol and Drug Information http://www.prideusa.org/ National Parents’ Resource Institute for Drug Education (PRIDE) http://www.niaaa.nih.gov/ National Institute on Alcohol Abuse and Alcoholism (NIAAA) http://www.nida.nih.gov/ National Institute on Drug abuse (NIDA) http://www.asam.org/Frames.htm American Society of Addiction Medicine http://www.aaap.org/ American Society of Addiction Psychiatry http://www.casacolumbia.org/newsletter1458/newsletter.htm National Center on Addiction and Substance Abuse at Columbia University

Chapter 53 –Classifications and Descriptions of Proteins, Lipids, and Carbohydrates Nucleotides Lipids http://www.cyberlipid.org/cyberlip/desc0004.htm Cyberlipid Center homepage, description of various natural lipids Carbohydrates http://www.chem.qmw.ac.uk/iupac/2carb/ International Union of Pure and Applied Chemistry and International Union of Biochemistry and Molecular Biology: Nomenclature of Carbohydrates http://ull.chemistry.uakron.edu/genobc/Chapter_17/

General organic and biochemistry This material is copyright (C) 1997 - 2002 James K. Hardy and the University of Akron Proteins http://www.friedli.com/herbs/phytochem/proteins.html FRIEDLI ENTERPRISES Georges-Louis Friedli, PgDip., MSc., Ct.H., R.H., PhD. http://chemistry.gsu.edu/glactone/PDB/Proteins/Classic/classic.html Glactone is a project whose goal is to provide computer based resources for chemistry and biochemistry students and faculty in the State of Georgia. http://www.schoolscience.co.uk/content/5/chemistry/proteins/index.html National Grid for Learning Unilever Education Advanced Series

Nucleotides http://genome.gov/glossary.cfm?=nucleotide National Human Genome Research Institute Talking glossary of Genetic terms

CHAPTER 54 Enzymes http://www.bmb.leeds.ac.uk/ Major metabolic pathways in mammalian liver University of Leeds, School of Biochemistry and Molecular Biology www.chem.qmul.ac.uk Nomenclature Committee of International Union of Biochemistry and Molecular Biology Queen Mary, University of London Department of Chemistry www.genome.ad.jp KEGG metabolic pathways Bioinformatics Center and Institute for Chemical Research Kyoto University, Genome.Net www.biochem.ucl.ac.uk Enzyme structure database UCL Department of Biochemistry and Molecular Biology http://biochem.boehringer-mannheim.com/techserv/metmap.htm Boehringer Mannheim Biochemical Pathways Chart (updated April 27, 2000) http://www.biochem.ucl.ac.uk/bsm/enzymes/index.html Enzyme Structure Database (deposited in the Brookhaven Protein Data Bank – 6562 entries) http://www.expasy.ch/enzyme/ ENZYME Enzyme nomenclature database (ExPASy site Jan 27, 2001 – 3721 entries) http://www.enzim.hu/ Institute of Enzymology Biological Research Center, Hungarian Academy of Sciences

CHAPTER 55 Isoenzymes

http://www.chem.qmw.ac.uk/iubmb/misc/isoen.html IUPAC-IUB Commission on Biochemical Nomenclature (CBN) Department of Chemistry, Queen Mary University, London http://www.biologie.uni-hamburg.de/b-online/e17/17g.htm Botany online The Internet Hypertextbook, Alloenzymes and Isoenzymes http://www.nlm.nih.gov/medlineplus/ency/article/003504.htm Medline plus. This is for CK isoenzymes. One can search for other isoenzymes described in this chapter. http://health.discovery.com/diseasesandcond/encyclopedia/1155.html Discovery Health encyclopedia. CK isoenzymes. One can search for the other isoenzymes described in this chapter.

Chapter –56 Therapeutic Drug Monitoring (TDM) www.iatdmct.org International Association of Therapeutic Drug Monitoring and Clinical Toxicology www.sfaf.org Description of TDM by San Francisco AIDS Foundation www.people.virginia.edu Article describing TDM University of Virginia Information and Technology and Communication http://www.bertholf.net/rlb/Lectures/index.htm Select theTherapeutiv Drug Monitoring lectures in Power Point Robert L Bertholf Ph.D. Associate Professor of Pathology Chief of Clinical Chemistry and Toxicology University of Florida

Chapter 57 Urinalysis http://www.ec.hscsyr.edu/path/Urinalysis/frame.htm Microscopic Evaluation of Urine Sediment, part of a Pathology course offered by the Department of Pathology to second year medical students. Created and maintained by Jannie Woo, Ph.D. [email protected] Department of Pathology 2000 SUNY Upstate Medical University. Copyright ©. http://www.vh.org/Providers/CME/CLIA/UrineAnalysis/UrineAnalysis.html Urinalysis tutorial from the virtual hospital—Ruthanna Hyduke, MA, Department of Pathology, University of Iowa Hospitals and Clinics www3.sympatico.ca/dionrich/Homeng.htm The Microscopic Examination of Urine —by Michael Dion of Rosemont College in Montreal, Canada www.lhsc.on.ca/lab/renal/ Pfizer's urinalysis in perspective, link to microphotographs of urinary casts www.cpmc.columbia.edu/whichis/private/aim/31HEMAT.html

Chapter 31 Microhematuria—Lecture by Dr. Tatyana Z. Morton, MD, Presbyterian Health Care, Columbia University www.kidney.org/ Kidney Foundation www.bayerdiag.com/index_flash.phtml Bayer Diagnostics

Useful web sites Acronyms http://129.79.137.107/cfdocs/libchem/searchu.html Gives definition to 120,000 biomedical acronyms. Indiana University Science Libraries http://gungadin.cs.brandeis.edu/~weiluo/main3.htm AcroMed is a computer generated database of biomedical acronyms and the associated long forms extracted from the last year of Medline abstracts (2001). www.pharma-lexicon.com Medical/Pharma abbreviations search - Pharma companies wordwide search - Drug search - Medical/Pharma associations search - Medical articles search - Merck manual search Look up medical & pharmaceutical acronyms and abbreviations from database of over 56,000 entries. Algorithms http://wwww.medal.org/ Developed by John R. Svirbely, M.D., & M.G.Sriram, Ph.D. The Medical Algorithms Project A Medical Algorithm is any computation, formula, survey, or look-up table, useful in healthcare. The authors have collected over 3000 algorithms spanning major medical domains, organized into 44 chapters. An additional chapter contains algorithms contributed by visitors. To ensure the widest possible audience, the algorithms have been implemented in an Excel workbook which you can freely download to run on your Windows or Macintosh computer. You will need MS Excel, and should be familiar with running spreadsheets.

Spanish http://www.medal.org.ar/ Un esfuerzo para crear software útil para aplicar los algoritmos medicos habituales de la practica diaria, con documentación, referencias y bibliografía, enteramente fundado por sus autores. Los algoritmos han sido recogidos de la litaratura médica, incluyendo libros, publicaciones científicas, journals. ¿Cúal es el objetivo de este proyecto? permitir el uso de calculos automaticos en las ecuaciones y algoritmos que faciliten la tarea medica y profesional diaria. proveer documentación original y bibliografía adecuada sobre esos algoritmos. estandarizar elementos y datos para una automatización del ingreso y resultados. Certification

http://www.amt1.com/ American Medical Technologists, Higgins Road Park Ridge, Illinois is a national agency that certifies health practitioners as: Medical Technologists (MT) Medical Laboratory Technicians (MLT) Certified Office Laboratory Technicians (COLT) Certified Laboratory Consultants (CLC) Registered Medical Assistants (RMA) Registered Phlebotomy Technicians (RPT) Registered Dental Assistants (RDA) Allied Health Instructors (AHI) CLINICAL CHEMISTRY JOURNALS http://www.acb.org.uk/annalsindex.htm Annals of Clinical Biochemistry http://www.clinchem.org/ Clinical Chemistry http://www.degruyter.de/journals/cclm/ Clinical Chemistry and Laboratory Medicine http://www.elsevier.nl/locate/inca/506018 Clinica Chimica Acta http://www.clabmr.com/ Clinical Laboratory Management Review http://www.ascls.org/leadership/cls/index.htm Clinical Laboratory Science http://www.elsevier.nl:80/inca/publications/store/3/9/7/ Current Advances in Clinical Chemistry http://www.elsevier.nl/locate/inca/525463 Clinical Biochemistry http://www.ifcc.org/ejifcc/default.asp Journal of the International Federation of Clinical Chemistry http://www.svls.se/sektioner/sfkk/journals/kliniskkemi.htm Klinisk kemi http://www.tandf.co.uk/journals/titles/15227952.html Pediatric Pathology and Molecular Medicine http://www.seqc.es/publirevi.htm Quimica Clinica Spanish http://www.tandf.co.uk/journals/titles/00365513.html Scandinavian Journal of Clinical and Laboratory Investigation http://www.jr2.ox.ac.uk/bandolier/ Bandolier is a print and Internet journal about health care, using evidence-based medicine techniques to provide advice about particular treatments or diseases for healthcare professionals and consumers. The content is 'tertiary' publishing, distilling the information from (secondary) reviews of (primary) trials and making it comprehensible.

Spanish http://www.infodoctor.org/bandolera/baul/ Bandolier Spanish version. Translated by "Bandoleros Team" Traducción autorizada de Bandolier. Realizada por "Los Bandoleros" Por los Bandoleros: Rafael Bravo Toledo. Área 10 de Atención Primaria. Insalud. Madrid.España Los artículos de Bandolera son traducciones de la revista inglesa Bandolier, la cual da su autorización para reproducirlos en esta web. Son realizadas de forma desinteresada por un grupo de médicos españoles. Se autoriza y alienta la reproducción y copia para usos privados y docentes, siempre que se cite la fuente y no se olvide que el copyright pertenece a los autores de la edición original y de la traducción. The stories of Bandolera are translations of the English Bandolier, which gives its authorization to reproduce them in this Web. The translations are made of disinterested way by a group of Spanish health care professionals. The reproduction and copies is authorized and encouraged for private uses and educational purposes, whenever the source is mentioned and it does not forget that copyright belongs to the authors of the original editing and translation Clinical Chemistry Societies and Associations http://www.aacc.org/ American Association for Clinical Chemistry

http://www.clinical-labs.org/ American Clinical Laboratory Association http://www.ascls.org/ American Society for Clinical Laboratory Science http://www.ascp.org/index.asp American Society of Clinical Pathologists http://www.apfcb.org/ Asian and Pacific Federation of Clinical Biochemistry http://www.acb.org.uk/ Association of Clinical Biochemists http://www.iol.ie/~deskenny/acbi.html Association of Clinical Biochemists in Ireland http://labautomation.org/ Association for Laboratory Automation http://www.aacb.asn.au/ Australasian Association of Clinical Biochemists http://members.aon.at/oegkc/ Austrian Society of Clinical Chemistry (Österreichische Gesellschaft für Klinische Chemie) http://miginfo.rug.ac.be/lab/bvkcsbcc.htm Belgian Society of Clinical Chemistry (Belgische Vereniging http://www.cscc.ca/index.html The Canadian Society of Clinical Chemists (Société Canadienne des Clinico-Chimistes) http://www.csmls.org/ Canadian Society for Medical Laboratory Science (Société Canadienne de Science de Laboratoire Médical) Canadian Society of Laboratory Technologists http://www.acclc.es/ Catalans Society of Clinical Laboratory Sciences (Associació Catalana de Ciències de Laboratori Clínic) http://sbch.conicyt.cl:9090/sociedad/bioqui01.htm Chilean Society of Biochemistry and Molecular Biology (Sociedad de Bioquímica y Biología Molecular de Chile) http://www.clma.org/index.cfm Clinical Laboratory Management Association http://www.clas.org/ Clinical Ligand Assay Society http://www.ifcc.org/ria/COLABIOCLI.html Confederación Latinoamericana de Bioquimica Clinica (COLABIOCLI), http://klinisch.chemicus.ziekenhuis.nl/home/index.html

Dutch Society of Clinical Chemistry (Nederlandse Vereniging voor Klinische Chemie) http://www.uni-oldenburg.de/ec4/ European Communities' Confederation of Clinical Chemistry http://www.dgkc.de/index.html German Society of Clinical Chemistry (Deutsche Gesellschaft für Klinische Chemie) http://wwwlabor.uni-muenster.de/dglm/ German Society of Laboratory Medicine (Deutsche Gesellschaft für Laboratoriumsmedizin) X International Association of Medical Laboratory Technologist http://www.ifcc.org/ifcc.asp International Federation of Clinical Chemistry and Laboratory Medicine http://www.sibioc.it/ Italian Society of Clinical Biochemistry and Clinical Molecular Biology (Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica) http://www.ambc.org.mx/ Mexican Association of Clinical Biochemistry (Asociación Mexicana de Bioquímica Clínica, A.C. México, D.F.) http://www.sacb.org.sg/ Singapore Association of Clinical Biochemists http://www.seqc.es/ Spanish Society of Clinical Biochemistry and Molecular Biology (Sociedad Española de Bioquímica Clínica y Biología Molecular) http://www.svls.se/sektioner/sfkk/eng/index.htm Swedish Society for Clinical Chemistry (Svensk Förening för Klinisk kemi) http://www.aqfu.org.uy/ Association of Chemistry and Pharmacy of Uruguay (Asociación de Química y Farmacia del Uruguay) Members of COLABIOCLI PAIS

SOCIEDAD

ARGENTINA

CUBRA http://www.aba-online.org.ar/ La Asociación Bioquíca

BRASIL COLOMBIA CUBA

SBAC FECODEL SCPC

ECUADOR GUATEMALA HONDURAS

SEBC AQBG CMH

PARAGUAY PERÚ REPÚBLICA DOMINICANA VENEZUELA

ABP SPAByC

Argentina

ADPLC FCBV

Commercial and Newsmagazines http://www.advanceformlp.com/ ADVANCE for Medical Laboratory Professionals is a newsmagazine for all disciplines of laboratory professionals. Published bi-weekly, by ADVANCE Newsmagazines/Merion Publications, Inc. Dr. King of Prussia, PA http://www.emedicine.com/ eMedicine Journal,© Copyright 2002, eMedicine.com, Inc. eMedicine , Inc. St. Petersburg, FL 33707 Review articles http://www.emedicine.com/specialties.htm Algorithms, calculators, decision rules, diagrams, scores and tables http://www.emedicine.com/splash/shared/etools/index.htm Calculators Copyright 2000 eMedicine.com. All Rights Reserved. Courses http://medlib.med.utah.edu/WebPath/webpath.html#MENU Pathology course Florida State University College of Medicine https://www.medialabinc.net/ MediaLab Inc provides a pool of computer based instructional content for health care providers to educate their workers. MediaLab specifically promotes the use of computer-assisted instruction and distance learning in the medical office and clinical laboratory settings. http://www.skillpath.com/ SkillPath Seminars Mission, Comprehensive training and skills improvement provider. Online courses are available. Courses are by subscription only. http://www.dgrhoads.com/ David G. Rhoads Associates, Inc. providing specialty software, training, and consulting services to the clinical laboratory industry. Diseases http://www.cdc.gov/ The Centers for Disease Control and Prevention (CDC) is the lead federal agency for protecting the health and safety of people. CDC, located in Atlanta, Georgia, USA, is an agency of the Department of Health and Human Services. http://www.yahoo.com Type disease and conditions into the search engine. Then click on Health > Diseases and Conditions to reach the index. Hematology

An Interactive Hematology Atlas Die Abteilung für Unterrichts-Medien. .ist für die Produktion und das Angebot von Lernmedien an der Medizinischen Fakultät Bern verantwortlich. Die AUM gehört zum Institut für Aus- Weiter- und Fortbildung der Universität Bern Gestaltung: Béatrice Boog - Adresse und Situationsplan AUM -Letzte

Änderungen - medweb NEU: Studien-Unterlagen

German

Laboratory Testing http://www.labtestsonline.org/ Lab Tests Online Sponsored by AACC, ACLA, ASCLS, ASM, CLMA, http://www.ascls.org/labtesting ASCLS - Laboratory Testing Information Consumer Laboratory Testing Information Page http://www.neosoft.com/~uthman/lab_test.html Interpretation of Lab Test Profiles Ed Uthman, MD http://medstat.med.utah.edu/arup/ ARUP lab test guide http://www.sydpath.stvincents.com.au/spec_db/ A database for information on specimen handling ordering.. The content is available via a list of topics, from the test database, or from a hyperlink made from the testname on the intranet results viewing screens. The database is specific for SydPath The Pathology Service of St Vincent's Hospital Sydney, Australia by Graham Jones and colleagues Lectures http://www.aacb.asn.au/educ/lect/index.html Australasian Association of Clinical Biochemists AACB On-Line Lectures Nitty Series (Not In The Textbooks Yet) These presentations are slide-audio talks of about 10 min duration. They are available as both RealPlayer and Windows Media files. Windows Media Files Haemochromatosis Andrew Wootton Royal Melbourne Hospital Quicki Insulin Resistance Ken Sikaris Dorevitch Pathology Soluble Transferrin Receptor Nick Balazs Southern Cross Pathology Platelet Serotonin John Beilby WA PathCentre Breast Cancer Testing Evelyn Koay Singapore National Hospital Markers of Bone Resorption Hans Schneider Alfred Hospital Tandem Mass Spectrometry James Pitt Royal Children's Hospital HDL Cholesterol Methods Derek Rae St Vincent's Hospital Total AntiOxidant Status Peter Vervaart Royal Children's Hospital New Criteria for Myocardial Infarction David Deam Gribbles Pathology

Libraries http://www.nlm.nih.gov/medlineplus/ MEDLINEplus, or http://www.medlineplus.gov. MEDLINEplus contains health information from the world's largest medical library, the National Library of Medicine. MEDLINEplus has extensive information from the National Institutes of Health and other trusted sources on about 500 diseases and conditions. There are also lists of hospitals and physicians, a medical encyclopedia and dictionaries, health information in Spanish, extensive information on prescription and nonprescription drugs, health information from the media, and links to thousands of clinical trials. http://www.nlm.nih.gov/ National Library of Medicine's Medline encyclopedia National Library of Medicine (United States) http://www.nlm.nih.gov/ United States National Library of Medicine

MEDLINEplus Find answers to your health questions MEDLINE/PubMed References and abstracts from 4300 biomedical journals ClinicalTrials.gov Provides information for patients about clinical research studies DIRLINE Directory of health organizations LOCATORplus Catalog of books, journals, and audiovisuals in the NLM collections NLM Gateway A single Web interface that searches multiple NLM retrieval systems PubMed Central A digital archive of life sciences journal literature TOXNET Databases on toxicology, environmental health, and hazardous chemicals Additional Information by Subject AIDS/HIV HIV/AIDS facts, tutorials, clinical trials, etc. provided by NLM's Specialized Information Services Arctic Health Arctic Health, an information portal to issues affecting the health and well-being of our planet's northern most inhabitants Cancer Cancer.gov, the National Cancer Institute's (NCI) many sources of cancer information including CANCERLIT Chemical Substances Chemical information on drugs, pesticides, environmental pollutants and other potential toxins Molecular Biology/Genetics Consult the databases of the National Center for Biotechnology Information for DNA sequences and analysis tools, human genome resources and information on genetic diseases and taxonomy. Public Health Partners in Information Access for Public Health Professionals has information resources and services for those working in the broad field of public health Toxicology Consult the Toxicology and Environmental Health Information Program for information on toxicology, hazardous chemicals, toxicological effects of drugs, etc. http://www-medlib.med.utah.edu Spencer S.Eccles Health Sciences Library one of eight Regional Medical Librariesof the National Library of Medicine. http://nnlm.gov/mcr/ Midcontinental Region, NN/LM-MR! http://www.nlm.nih.gov/medlineplus/encyclopedia.html Medical Encyclopedia The Adam Health Illustrated Encyclopedia includes over 4,000 articles about diseases, tests, symptoms, injuries, and surgeries. It also contains an extensive library of medical photographs and illustrations. Licensure for physicians: example http://www.ohio.gov/chr/ Ohio State Chiropractic Board On-Line License Verification This feature may be used to verify the license of any Ohio licensed chiropractic physician. http://www.state.oh.us/med/

State of Ohio Medical Board Licensee profile and status of physicians in the State of Ohio One can search by name of doctor, Linking Sites http://members.tripod.com/~LouCaru/index-5.html Clinical Laboratory Science Internet Resources © Louis B. Caruana, Ph.D., MT(ASCP) A list of useful websites. http://www.il-st-acad-sci.org/health/clinchem.html links to many Clinical Chemistry sites http://www.pathology.med.umich.edu/links/ Internet Resources for Pathology and Laboratory Medicine Medicare and Centers for Medicare and Medicaid Services http://www.adminastar.com/anthem/affiliates/adminastar/meda/oh/index.html AdminaStar Federal, Inc.’s most significant area of business is the administration of government contracts for Medicare, under the authority of CMS (Centers For Medicare and Medicaid Services). http://www.cms.hhs.gov The Health Care Financing Administration is now the Centers for Medicare & Medicaid Services (CMS). CMS provides health insurance for over 74 million Americans through Medicare, Medicaid and SCHIP, CMS also performs a number of quality-focused activities, including regulation of laboratory testing (CLIA), development of coverage policies, and quality-of-care improvement. CMS maintains oversight of the survey and certification of nursing homes and continuing care providers (including home health agencies, intermediate care facilities for the mentally retarded, and hospitals). http://www.amt1.com/ Compliance http://www.eliresearch.com/ A research and information company with over 60 print and online publications serving our two core markets of health care and financial services. This includes publications on Clinical Laboratory Compliance and Hospital Compliance http://fr.cos.com/ Issued by the U.S. Government Printing Office (GPO), and published on the Web by Community of Science, the Federal Register (FR) lists U.S. federal agency announcements and information Test Complexity http://www.phppo.cdc.gov/clia/testcat.asp CLIA Complexity database maintained by FDA. Search for a particular test. Microbiology http://www.med.sc.edu:85/book/parasit-sta.htm On-line textbook from the Department of Microbiology and Immunology at the University of South Carolina School of Medicine http://www.dpd.cdc.gov/DPDx/HTML/Image_Library.htm DPDx Parasite Image Library DPDx is a Web site developed and maintained by CDC's Division of Parasitic Diseases (DPD). http://www.doctorfungus.org/ A continuously updated electronic textbook that serves as a general reference and guide to mycology copyright © 2002 DoctorFungus Corporation.

Pathology http://www.ascp.org/index.asp The American Society for Clinical Pathology (ASCP) is a not-for-profit medical society. It is concerned with the appropriate application of pathology and laboratory medicine. http://www.cap.org/ College of American Pathologists It is the world's largest association composed exclusively of pathologists Pathology Courses http://medlib.med.utah.edu/WebPath/webpath.html#MENU The Internet Pathology Laboratory for Medical Education Florida State University College of Medicine Standards Organizations http://nccls.org/ or http://www.nccls.org/ National Committee on Clinical Laboratory Standards http://www.ansi.org/ American National Standards Institute Washington, DC Suppliers of reagents instruments (limited list) http://www.bd.com/ BD (Becton, Dickinson and Company) is a medical technology company. BD manufactures and sells a broad range of medical supplies, devices, laboratory equipment and diagnostic products. http://www.beckmancoulter.com/Default.asp?bhfv=0 Beckman Coulter, Inc. is a leading provider of instrument systems and complementary products for the clinical laboratory. http://www.biomerieux.com/home_en.htm, bioMérieux designs, develops, manufactures and markets reagents and automated instruments for medical analyses in the field of in vitro infectious disease diagnostics http://www.dadebehring.com Dade Behring provides diagnostic products, services and expertise http://www.bio-rad.com Bio-Rad Laboratories, Inc is a multinational manufacturer and distributor of life science research products and clinical diagnostics http://www.orthoclinical.com/ocdindex.asp Ortho-Clinical Diagnostics, a Johnson & Johnson company, is a leading provider of diagnostic products