TMLE_phamaco อาจารย์ ณรงค์กร

26. Oral administration of grapefruit juice increases the bioavailability of a variety of drugs, including felodipine, midazolam, saquinavir, and verapamil. After oral administration of any one of these drugs, which of the following is most likely to be increased in the presence of grapefruit juice? (A) Hepatic CYP3A4 activity (B) Intestinal drug metabolism (C) Peak serum concentration (D) Total body clearance (E) Volume of distribution  C ./0123456 bioavailability 7859:;3