The Ecology of Breast Cancer the Promise of Prevention and the Hope for Healing Ted Schettler

December 1, 2017 | Author: Ni Ke Hura | Category: N/A
Share Embed Donate


Short Description

environment...

Description

!"#$%&'(')*$'+$ ,-#./0$1.2&#!"#$3-'45/#$'+$ 3-#6#205'2$ .27$0"#$"'3#$+'-$ "#.(52) !#7$8&"#00(#-$9:;$9#$6/.0(6*($#00

0

C

4567.$#0?900@#$6/.0(6*($#0.#$*&/06*&0#3/)0=6(."#/0

0

0

BD

$

$

AE

4567.$#0D900EF$#(3/$C075;/3(6+06(.3#$6/.0(6*($#00

0

EB

8#&05'2$>?$@2$%&'(')5&.($A-.4#B'-C

08#&05'2$>>?$D''C52)$E50"52$0"#$1'43(#F50* 4567.$#0A900B3$.C0*2.#3.3"*C06*&0>#$6/.0(6*($#$ $

4567.$#0G900E*#$6/.0(6*($#0

DF

4567.$#0H900:5$0$+$(.#"-6,*$.3(0/7$(.#2-06*&0>#$6/.0(6*($#0

0

0BAC

4567.$#0I900J.#$//C0/"(36+0/277"#.C06*&0>#$6/.0(6*($#00

0

BGF

0

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

IJ%,-.#-L%2",%,>#.,4#+%'J%6(,0$2%+0-+,(%$,,4$%/2'>#0-O%M+",22*,(Q$%>0(0.#L4%0+2/0**H%$/L8 L,$2$%40-H%>,($'-0*%*#J,$2H*,%0-.%+'44/-#2H%.,$#L-%$2(02,L#,$%2"02%0(,%*#),*H%2'%(,./+,%2",% #-+#.,-+,% 'J% 6(,0$2% +0-+,(O% #-+(,0$,% (,$#*#,-+,O% 0-.% #4>('3,% '/2+'4,$% J'(% 2"'$,% 0*(,0.H% .#0L-'$,.;%% !",%60.%-,&$%06'/2%2",%+'4>*,K#2H%'J%6(,0$2%+0-+,(%#$%2"02%2",%+0/$,$%0(,%+'4>*,K;%%!",% L''.%-,&$%#$%2"02%0%&#.,%(0-L,%'J%#-2,(3,-2#'-$%+0-%6,%6,-,J#+#0*X4'(,%$'%&",-%2",H%0(,% +'46#-,.;%%Y3,-%6,22,(O%2",%6,-,J#2$%(,.'/-.%2'%0%&#.,%(0-L,%'J%",0*2"%+'-+,(-$%W%-'2%S/$2% 6(,0$2%+0-+,(; :5$0E("+",;0"=0@#$6/.046*($#0#$%0-%",('#+%$/440(H%'J%0-%,K2(,4,*H%+'4>*,K%6'.H%'J%$+#,-+,;%% T,%4/$2%J'**'&%2",%$+#,-+,O%,46(0+,%2",%+'4>*,K#2H%'J%6(,0$2%+0-+,(O%0-.%(,+'L-#R,%2",% >('4#$#-L%#-$#L"2$%2"02%2",%,+'*'L#+0*%>0(0.#L4%'J%6(,0$2%+0-+,(%'JJ,($; IJ%&,%>('L(,$$%2'&0(.%2",%>,($'-0*O%+'44/-#2HO%0-.%L*'60*%.,$#L-%+"0-L,$%2"02%&#**%(,3,($,% 2",%6(,0$2%+0-+,(%,>#.,4#+O%&,%&#**%0*$'%(,3,($,%40-H%'J%2",%'2",(%.#$,0$,%,>#.,4#+$%'J%'/(% 2#4,;%%!"02%#$%0%3#$#'-%2'%*#3,%6H; % % %

% % %

% % %

% % %

% % %

% % %

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

0*.#"&1(.2"*

!

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`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a9YMb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

3"%4.52/46"")42/4"#,7*28$& !"#$%6'')%#$%.#3#.,.%#-2'%2"(,,%$,+2#'-$;%M,+2#'-%I%a+"0>2,($%B%0-.%Ab%6(#,J*H%(,3#,&$%2",% "#$2'(H%'J%6(,0$2%+0-+,(%0-.%2",%,3'*/2#'-%'J%#.,0$%06'/2%#2$%'(#L#-$;%I2%+'-+*/.,$%2"02%0-% ,+'*'L#+0*%'(%,+'8$'+#0*%J(04,&'()%#$%6,$2%$/#2,.%2'%0+)-'&*,.L,%0-.%",*>%+*0(#JH%2",%+'48 >*,K#2H%'J%2",%.#$,0$,%0$%&,**%0$%",*>#-L%2'%.,$#L-%(,$,0(+"%0-.%#-2,(3,-2#'-$;%!"#$%$,+2#'-% #-+*/.,$%0%6(#,J%$/440(H%'J%6(,0$2%+0-+,(%.,4'L(0>"#+$O%2(,-.$O%0-.%)-'&-%(#$)%J0+2'($;%% M,+2#'-%II%#$%+'4>(#$,.%'J%J#3,%+"0>2,($%0..(,$$#-L%.#,2%a+"0>2,(%:bO%,K,(+#$,%a+"0>2,(%GbO% ,-3#('-4,-20*%+",4#+0*$%a+"0>2,(%FbO%J,02/(,$%'J%2",%,*,+2('40L-,2#+%$>,+2(/4%#-+*/.#-L% 3#204#-%9O%*#L"2%02%-#L"2O%0-.%-'-8#'-#R#-L%(0.#02#'-%a+"0>2,(%CbO%0-.%$2(,$$%a+"0>2,(%Eb;%Y0+"% 'J%2",$,%(,3#,&$%0-%,K2,-$#3,%*#2,(02/(,%0-.%6,+0/$,%'J%2"02O%6,L#-$%"%0%$/440(H%'J%2",% 4'(,%.,20#*,.%402,(#0*%2"02%J'**'&$;%I-%$'4,%#-$20-+,$O%I%J'/-.%#2%>0(2#+/*0(*H%#-$2(/+2#3,% 2'%(,3#,&%2",%"#$2'(H%'J%(,$,0(+"%#-2'%2",$,%+02,L'(#,$%'J%(#$)%J0+2'($%0-.%"03,%'++0$#'-0**H% #-+*/.,.%.#$+/$$#'-$%'J%'*.,(%$2/.#,$%2"02%#-J*/,-+,.%2",%.#(,+2#'-%0-.%.,$#L-%'J%$/6$,V/,-2% #-3,$2#L02#'-$;%% M,+2#'-%III%a+"0>2,(%cb%$/440(#R,$%0-.%6,L#-$%2'%(,0$$,46*,%2",%30(#'/$%(#$)%J0+2'($%#-2'%0% 4'(,%#-2,L(02,.%&"'*,;%I2%,K>*'(,$%#4>*#+02#'-$%J'(%#-.#3#./0*$O%J04#*#,$O%0-.%+'44/-#2#,$% 0$%&,**%0$%",0*2"%+0(,%>('3#.,($O%>/6*#+%",0*2"%'JJ#+#0*$O%0-.%'2",($%&"'%+0-%40),%0%.#JJ,(8 ,-+,;%%%

$

Z'$2%'J%2",%402,(#0*%(,3#,&,.%#-%2"#$%6'')%#$%.(0&-%J('4%,>#.,4#'*'L#+%0-.%*06'(02'(H%0-8 #40*%$2/.#,$;%I%.'%-'2%#-2,-.%J'(%#2%2'%6,%+'-$2(/,.%0$%4,.#+0*%0.3#+,;%7'(O%"03,%I%40.,%0-H% 022,4>2%2'%(,3#,&%'(%+'44,-2%'-%0%(0-L,%'J%+'-3,-2#'-0*%4,.#+0*%2",(0>#,$%'(%2",#(%0*2,(8 -02#3,$;%\/2%I%.'%"'>,%2"02%>,'>*,%#-2,(,$2,.%#-%0%+'4>(,",-$#3,%0>>('0+"%2'%6(,0$2%+0-+,(% >(,3,-2#'-%'(%2(,024,-2%&#**%J#-.%2"#$%402,(#0*%/$,J/*%0$%2",H%,K>*'(,%'>2#'-$;%% 5*4'$2%.0#*HO%4,.#+0*%S'/(-0*$%0-.%2",%>(,$$%(,>'(2%-,&%6(,0$2%+0-+,(%(,$,0(+"%J#-.#-L$;% =-.'/62,.*HO%$'4,%'J%2",%+'-+*/$#'-$%I%(,0+"%",(,%&#**%-,,.%2'%6,%4'.#J#,.%0$%-,&%#-J'(8 402#'-%6,+'4,$%030#*06*,;%\/2O%-'%4022,(%"'&%$'4,%'J%2",%.,20#*$%40H%+"0-L,O%#2%#$%4H%"'>,% 2"02%&,%&#**%#-+(,0$#-L*H%0..(,$$%6(,0$2%+0-+,(X#2$%'(#L#-$%0-.%2(,024,-2X0$%0%$H$2,4$% +"0**,-L,O%(,V/#(#-L%0-%#-2,L(02,.O%4/*2#8*,3,*%(,$>'-$,;%%%%%%%

%

J$(.3"*08

@2$%&'(')5&.($A-.4#B'-C

1".30#-$I

9"%7#&474/:/.$-/4;$#/;$(.22% a:,($/0.,.%2"02%",%$0&%6(,0$2%+0-+,(%4'(,% 'J2,-%#-%4,*0-+"'*H%a*#2,(0**HO%_6*0+)%6#*,`b%&'4,-%&"'%&,(,%+(,02#3,O%)#-.O%0-.%+'-$#.,(02,;% M'4,%2"'/L"2%2",H%$0&%+0-+,(%4'(,%L,-,(0**H%#-%&'4,-%&"'%&,(,%0-K#'/$O%.,>(,$$,.O%'(% L(#,3#-L;$%['(%d0*,-%0-.%40-H%&"'%J'**'&,.O%6(,0$2%+0-+,(%&0$%0%$H$2,4#+%.#$'(.,(%0-.%-'2% +'-J#-,.%2'%0%$#-L*,%>0(2%'J%2",%6'.H;%%% ((

I-%2",%BE2"%+,-2/(HO%I20*#0-%>"H$#+#0-%]040RR#-#%$0&%2"02%_2/4'($%'J%2"#$%$'(2%e6(,0$2%+0-+,(f% 0(,%J'/-.%4'(,%'J2,-%#-%-/-$%2"0-%#-%0-H%'2",(%&'4,-;%I-%4H%'>#-#'-O%2",$,%2/4'($%0(,%-'2% ./,%2'%04,-'((",0O%6/2%(02",(%2'%2",%+,*#602,%*#J,%*,.%6H%2",$,%-/-$;`%')%M'4,%2",'(#,$%>('8 >'$,.%2"02%2(0/40%'(%*H4>"02#+%'(%4#*)%./+2%6*'+)0L,%&0$%#-3'*3,.;%\/2%"%2",%#-3,-2#'-% 'J%2",%4#+('$+'>,%0-.%,4,(L#-L%/-.,($20-.#-L%'J%0%+,**/*0(%60$#$%'J%0-02'4#+0*%$2(/+2/(,$O% +0-+,(%+,**$%6,+04,%3#$#6*,O%0-.%6(,0$2%+0-+,(%6,L0-%2'%6,%$,,-%0$%0%4'(,%*'+0*#R,.%.#$,0$,;% 7,&%0-,$2",2#+%2,+"-#V/,$%0#.,.%0%.(0402#+%#-+(,0$,%#-%$/(L,(H%0-.O%J'(%.,+0.,$O%2",%(0.#+0*% 40$2,+2'4HO%>#'-,,(,.%6H%T#**#04%N0*$2,0.O%.'4#-02,.%6(,0$2%+0-+,(%2(,024,-2;%N0*$2,0.% 6,*#,3,.%2"02%(,4'3#-L%,-'/L"%2#$$/,%0-.%>(,+#$#'-%2'%03'#.%$>(,0.#-L%+0-+,(%+,**$%./(#-L% $/(L,(H%*,.%2'%2",%6,$2%+"0-+,$%'J%+/(,;%

I-%2",%*02,%BD2"%+,-2/(H%M+'22#$"%$/(L,'-%d,'(L,%\,02$'-%(,>'(2,.%2"02%(,4'30*%'J%2",%'308 (#,$%#-%$,3,(0*%'J%"#$%>02#,-2$%+0/$,.%(,4#$$#'-%'J%#-'>,(06*,%6(,0$2%+0-+,(;+'*%N'(4'-,$%"0.% -'2%H,2%6,,-%+"0(0+2,(#R,.O%6/2%\,02$'-%$0&%*0+202#'-%>('*'-L,.%#-%J0(4%0-#40*$%0J2,(%2",#(% '30(#,$%&,(,%(,4'3,.;%_?0+202#'-%#$%02%'-,%>'#-2%>,(#*'/$*H%-,0(%6,+'4#-L%0%+0-+,('/$%>('8 +,$$%#J%#2%#$%02%0**%0((,$2,.O`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`&.% N/LL#-$% $0&% +0-+,(% -'2% S/$2%0$%0%.#$,0$,%'J%06,((0-2%+,**$%6/2%0$%'-,%2"02%(,V/#(,$%0%"'$2%,-3#('-4,-2%J03'(#-L%2/8 4'(%L('&2";%9,$>#2,%2"#$%/-.,($20-.#-LO%"%2",%.,3,*'>4,-2%'J%2,+"-#V/,$%'J%4'*,+/*0(% 6#'*'LH%2"02%"03,%,-06*,.%4'(,%.,20#*,.%$2/.H%'J%+,**$%0-.%$/68+,**/*0(%>0(2$O%40-H%+0-+,(% 6#'*'L#$2$%+'-2#-/,.%2'%J'+/$%2",#(%022,-2#'-%'-%2",%+0-+,('/$%+,**;%%

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

!"#$%&'(')*$'+ $,-#./0$1.2&#-

*

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

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

A#$7/.4(7*($#47*&4.5$4-"#$4,$*$#7+4$*'(20-+,%'J%2",%4'(,%L,-,(0*%,-3#('-4,-2%#-%2",%'(#L#-$%0-.%>('L(,$$#'-%'J%6(,0$2% +0-+,(%6,+'4,$%+*,0(%0J2,(%*'')#-L%02%,3#.,-+,%.#$+/$$,.%#-%*02,(%+"0>2,($;%T,%)-'&%2"02% *02,-2O%/-.#0L-'$,.%6(,0$2%+0-+,(%.,3,*'>$%'3,(%40-H%H,0($X#-%$'4,%+0$,$%'3,(%.,+0.,$X 0-.% 40H% 6,% /-.,2,+2,.% ./(#-L% *#J,;%5% (,3#,&% 'J% $,3,-% 0/2'>$H% $2/.#,$% (,>'(2,.% #-30$#3,% 6(,0$2%+0-+,(%#-%0-%03,(0L,%'J%B;:%>,(+,-2%'J%cFA%&'4,-%0L,$%G,(+,-20L,$% &,(,% (,>'(2,.% #-% $2/.#,$% &",(,% 2",% 6(,0$2$% 'J% 2",% .,+,0$,.% &,(,% ,K04#-,.% 4'(,%2"'('/L"*H;%@-,%'J%2",%$2/.#,$%#-+*/.,.%BB$#,$%'J%H'/-L%0-.%4#.8 .*,80L,.%&'4,-%a0L,$%A4(!9(;!5?(DCEFGH(32!@43(=149M2;B(F9(51!;(;255!9M(=49=237?;( >249;(5145(51232(!;(49(4A973>4@(!9=324;2(!9(512(M37651(7< (512(=2@@;B(EFG(!;(979@2514@(A2=4?;2(!5(;54N;(!9( I@4=2'(A?5(!;(!>I735495(A2=4?;2(!5(>4N(I37M32;;(57(!9"4;!"2(A324;5(=49=23B((O762"23'(;7>2(=4;2;(7< (EFG( !"#$"%#&'"(')**#%"#+$,-*+,)#!+*)-*)#-$!#&')!+.%+$(#/0+.0#"$)*#/+11#-$!#/0)$#%0-%#2-3#0-&&)$#+*#!+45.61%7## 89:;#+*#."22"$13#5'*%#+!)$%+5)!#2:Q#.-)+,&*(732( =7>I@252(:!;=?;;!79B( !"#$%&'(')*$'+ $,-#./0$1.2&#-

,

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

5*2"'/L"%1IM%#$%+'-$#.,(,.%0%>(,+/($'(%'J%6(,0$2%+0-+,(O%$'4,%+0$,$%.'%-'2%>('L(,$$%2'%#-8 30$#3,%.#$,0$,;%],+,-2*HO%$'4,%4,.#+0*%>('J,$$#'-0*$%"03,%0(L/,.%2"02%2",%2,(4%_+0(+#-'40`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aFA%>,(+,-2b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g T"02%0(,%&,%2'%40),%'J%2"#$U%T"02%.',$%#2%2,**%/$%06'/2%2",%-02/(0*%"#$2'(H%'J%6(,0$2%+0-+,(U%% N,(,%0(,%$'4,%2"#-L$%&,%)-'&;%1IM%#$%(,*02#3,*H%+'44'-;%M'4,%1IM%>('L(,$$,$%2'%#-30$#3,% 6(,0$2%+0-+,(%6/2%$'4,%.',$%-'2;%1IM%0-.%#-30$#3,%6(,0$2%+0-+,(%+0-%6,L#-%02%0%(,*02#3,*H% ,0(*H%0L,;%!",%2#4,%2"02%,*0>$,$%6,2&,,-%2",%#-#2#02#'-%'J%6(,0$2%+0-+,(%0-.%&",-%#2%6,+'4,$% +*#-#+0**H% 0>>0(,-2X2",% *02,-+H% >,(#'.X30(#,$% +'-$#.,(06*H% 6/2% +0-% 6,% $>(,0.% '/2% '3,(% .,+0.,$;##%M+(,,-#-L%$2/.#,$%+'-+*/.,%2"02%$'4,%6(,0$2%+0-+,($%&#**%$>'-20-,'/$*H%(,L(,$$;%

g! R975123(2SI@4945!79(=7?@:(A2(5145(32I25!5!"2(;=3229!9M(4=5?4@@N(=4?;2:(512(!9=324;2:(A324;5(=49=23(!9( 5145(M37?IB(F5T;(?9@!82@N(A2=4?;2(4(;!S(N243(('4'2,%2/4'(%+,**%L('&2"%'(% .,02";%!",H%,$206*#$"%0%-3+3$203*.S#3$2#%a2",%,-3#('-4,-2%"#-bO%0%>"(0$,%+'#-,.%6H%>"H$#'*8 'L#$2%1*0/.,%\,(-0(.;%I2%#$%2",%+'-2,K2XN/LL#-$Q%_$'#*`X2"02%J03'($%'(%.#$+'/(0L,$%+0-+,(% .,3,*'>4,-2%0-.%L('&2";%% 5$%&,%&#**%$,,O%+'44/-#2H%0-.%$'+#,20*%+"0(0+2,(#$2#+$%+0-%0*$'%$2('-L*H%#-J*/,-+,%2"#$%#-2,(8 -0*%,-3#('-4,-2;%\(,0$2%+0-+,(%#$%-'2%'-*H%0%.#$,0$,%'J%#-.#3#./0*$O%6/2%0*$'%'J%+'44/-#2#,$;% \(,0$2%+0-+,(%>022,(-$%0(#$,%'/2%'J%2",%$'+#,2#,$%2"02%&,%.,$#L-;%I-%2"02%&0HO%6(,0$2%+0-+,(%#$% >('J'/-.*H%0%>/6*#+%",0*2"%+'-+,(-%(,V/#(#-L%0%>/6*#+%",0*2"%(,$>'-$,%a$,,%\'K%B;Bb;%%5%*0(L8 ,(%J(04,&'()%2"02%#-+*/.,$%4/*2#>*,%*,3,*$%'J%'(L0-#R02#'-X2",%#-.#3#./0*O%J04#*HO%+'44/8 -#2HO%,+'$H$2,4O%0-.%$'+#,2HX0-.%(,+#>('+0*%#-2,(0+2#'-$%04'-L%2",4O%#$%0(L/06*H%,$$,-2#0*% J'(%6,22,(%/-.,($20-.#-L%2",%'(#L#-$%0-.%>(,3,-2#'-%'J%6(,0$2%+0-+,(;%%%%

A#$7/.4(7*($#47/47*4$("+",2(4&2/"#&$# Y+'*'L#$2$%'J2,-%/$,%0%-,$2,.%"#,(0(+"H%'J%*,3,*$%'J%'(L0-#R02#'-%2'%+'-$2(/+2%4'.,*$%0-.% .,$#L-%$2/.#,$%a$,,%[#L/(,%B;Bb;#$%N,(,O%"#,(0(+"H%.',$%-'2%(,J,(%2'%#4>'(20-+,%'(%>'&,(%6/2% #$%0%&0H%'J%.,$+(#6#-L%(,*02#'-$"#>$%"#-%0%+'4>*,K%$H$2,4;%I-%2"02%2(0.#2#'-O%$'4,%,>#.,8 4#'*'L#$2$%0.3'+02,%0-%,+'8$'+#0*%J(04,&'()%2'%",*>%.,$#L-%#-3,$2#L02#'-$%#-2'%2",%'(#L#-$%'J% .#$,0$,$%0$%&,**%0$%4,.#+0*%0-.%>/6*#+%",0*2"%#-2,(3,-2#'-$%2'%>(,3,-2%'(%2(,02%2",4;#%'#)'#+'#*%%% 5-%,+'8$'+#0*g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

%$/(01!;(!;(;7>25!>2;(=4@@2:(49(2=7@7M!=(73(=7>I@2S!5N(26738B(023>!97@7MN("43!2;(57(;7>2(2S5295( A2=4?;2(7< (512("43!4A@2;(!9=@?:2:(!9(512(>7:2@(49:(4@;7(A2=4?;2(7< (=7997545!79;(4;;7=!452:(6!51("43!7?;( /"'!*7#A6%#%0)#+2&"'%-$%#."22"$-1+%3#+*#%0)#-%%)2&%#%"#+$."'&"'-%)#261%+&1)#1),)1#,-'+-/*02#'-%L('&2"O%2,+"-'*'L#+0*%0+"#,3,4,-2$O%0-.%#-./$2(#0*8 #R02#'-%"03,%.(0402#+0**H%0*2,(,.%,-,(LH%>('./+2#'-%0-.%/$,O%2(0-$>'(202#'-O%6/#*.#-L$O%2",% -02/(,% 0-.% 030#*06#*#2H% 'J% +'-$/4,(% >('./+2$O% J''.% 0-.% 0L(#+/*2/(,O% 0-.% $'+#0*O% >'*#2#+0*O% 0-.%,+'-'4#+%$2(/+2/(,$;%7'%>*0+,%'-%,0(2"%'(%#-%2",%024'$>",(,%$/(('/-.#-L%2",%>*0-,2% #$%/-2'/+",.%6H%"/40-%0+2#3#2#,$;%!",%-02/(,%'J%&'()%0-.%*,#$/(,%0+2#3#2#,$%#$%>('J'/-.*H% +"0-L,.;%T#2"#-%2"#$%+'-2,K2%2",%>022,(-$%0-.%.#$2(#6/2#'-%'J%6(,0$2%+0-+,(%0-.%'2",(%+'48 4'-%.#$,0$,$%"03,%0(#$,-;%I2%#$%#-+(,0$#-L*H%+*,0(%2"02%0%4/*2#8*,3,*%J(04,&'()%#$%,$$,-2#0*%2'% $2/.H%0-.%0..(,$$%2",4;%% !2,1#$4 BCB?4 D("+",2(7+4 E$("F/"(27+G4 -"&$+4 "=4 *$/.$&4 #$+7.2"*/52;/4 =#"-4 /16F ($++1+7#4."4$("/:/.$-

Ecosystem

Society

Community

Individual

!"#$%&'(')*$'+ $,-#./0$1.2&#-

Family

Tissue/Organ

&&

Relationship

Cell

Individual

Organelle

Cell signaling; biochemistry

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

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i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j%% H4 1'4>*,K%$H$2,4%+"0(0+2,(#$2#+$%.#JJ,(%J('4%2"'$,%#-%$#4>*,(%$H$2,4$%#-%40-H%#4>'(20-2% &0H$%a$,,%!06*,%B;Bbi H4 ],$#*#,-+,%'(%3/*-,(06#*#2H%0(,%+"0(0+2,(#$2#+$%'J%$H$2,4%'>,(02#-L%+'-.#2#'-$i%3/*-,(06*,% ,+'$H$2,4$%0(,%*,$$%06*,%2'%06$'(6%0-.%0.0>2%2'%.#$2/(60-+,$%2"0-%(,$#*#,-2%,+'$H$2,4$i% H4 MH$2,4%'>,(02#-L%+'-.#2#'-$%0(,%*0(L,*H%.,2,(4#-,.%6H%#-2,(0+2#'-$%04'-L%4/*2#8*,3,*%30(#8 06*,$O%0+2#-L%'3,(%30(H#-L%2#4,J(04,$i%-'2%6H%$#-L*,%30(#06*,$%#-%0%+'-$2(0#-,.%2#4,J(04,i

!"#$%&'(')*$'+ $,-#./0$1.2&#-

&#

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

H4 M*'&80+2#-L%30(#06*,$O%'3,(%2#4,O%+0-%$,2%2",%$20L,%J'(%3/*-,(06#*#2H%2'%0%J0$280+2#-L%30(#06*,i% H4 [/-.04,-20*%+"0-L,$%#-%,+'$H$2,4%$2(/+2/(,%0-.%J/-+2#'-%+0-%6,%+0/$,.%6H%*0(L,%$#-L*,%'(% 4/*2#>*,%$40**%.#$2/(60-+,$%+'4#-L%J('4%2",%'/2$#.,%'(%J('4%"#-i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

!"#$%&'(')*$'+ $,-#./0$1.2&#-

&$

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

A#$7/.4(7*($#?4'*4$("+",2(4;$#/;$(.2'-$,%2'%2(,024,-2%30(H;%% @-,%&0H%2'%2"#-)%06'/2%2"#$%#$%2"02%.#JJ,(,-2%+'46#-02#'-$%'J%4/*2#8*,3,*%30(#06*,$%'3,(%2#4,% +(,02,%2",%+'-.#2#'-$%#-%&"#+"%6(,0$2%+0-+,(%+0-%.,3,*'>%0-.%>('L(,$$;%I-%40-H%&0H$O%2"#$%#$% *#),%0%+'4>*,K%,+'$H$2,4%0-.%$+#,-2#$2$%0(,%+'-2#-/#-L%2'%.,3,*'>%-,&%4'.,*$%J'(%$2/.H#-L% 2",%.#$,0$,%2"02%(,J*,+2%2"#$%+'4>*,K#2H%a$,,%\'K%B;Bb; @-,%,K04>*,%4'3#-L%#-%2"#$%.#(,+2#'-%#$%0-%,3#.,-+,860$,.%+'4>*,K%4'.,*%'J%>'$24,-'8 >0/$0*%6(,0$2%+0-+,(%+0/$02#'-%.,3,*'>,.%6H%$+#,-2#$2$%02%2",%=-#3,($#2H%'J%10*#J'(-#0%M0-% [(0-+#$+';%I2%#-+*/.,$%6#'*'L#+O%$'+#,20*l+/*2/(0*O%6,"03#'(0*O%0-.%>"H$#+0*l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m/0-2#202#3,%#4>0+2$%'J%+"0-L,$%#-%$#-L*,%30(#06*,$%&#**%'J2,-%6,%.#JJ#+/*2%2'%>(,.#+2%0-.%,3,-% 2'%#.,-2#JH;%Z'(,'3,(O%#-%'(.,(%2'%>(,3,-2%2",%.,3,*'>4,-2%'J%+0-+,(%'(%#4>('3,%'/2+'4,$% 0J2,(%.#0L-'$#$O%6('0.%0-.%.#3,($#J#,.%$2(02,L#,$%&#**%6,%-,+,$$0(H%2'%+"0-L,%2",%.H-04#+$%'J% 2",%$H$2,4;%1*'$,(%$2/.H%'J%0%+'4>*,K%4'.,*%(,3,0*$%J,02/(,$%2"02%",*>%#-%.,+#.#-L%"'&%0-.% &",(,%2'%#-2,(3,-,%4'$2%,JJ,+2#3,*H%#-%2",%$H$2,4X02%4/*2#>*,%*,3,*$O%*,3,(0L,%>'#-2$O%J,,.8

!"#$%&'(')*$'+ $,-#./0$1.2&#-

&%

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

60+)%*''>$O%0-.%+0/$0*%+0$+0.,$;%1'46#-02#'-$%'J%4/*2#8*,3,*%#-2,(3,-2#'-$%0(,%4'(,%*#),*H% 2'%6(#-L%06'/2%'/2+'4,$%0$%+*'$,%2'%&"02%&,%&0-2%0$%>'$$#6*,%aM,,%\'K%B;Ab;

,'F$IJK?$>275657L.($=#.(0"M(0+2#2#'-,($%"03,%*'-L%(,+'L-#R,.%2",%6,-,J#2$X'(%(#$)$X0$$'+#02,.%"%$40**%$"#J2$%#-% .,2,(4#-0-2$%'J%",0*2"%"#-%>'>/*02#'-$;%I-%BDcFO%,>#.,4#'*'L#$2%d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n0(,*#0%>('S,+2%#-%[#-*0-.%>/2%2",$,%#.,0$%2'%&'()%06'/2%AF%H,0($%0J2,(%.,4'L(0>",(O%k0#-'% n0--#$2'O%>/6*#$",.%"#$%.'+2'(0*%2",$#$%>'#-2#-L%'/2%2"02%,0$2,(-%[#-*0-.%"0.%2",%"#L",$2%",0(2%.#$,0$,% 4'(20*#2H%#-%2",%&'(*.;$)%\H%2"#$%2#4,O%2",%[(04#-L"04%N,0(2%M2/.HO%$20(2,.%#-%BDGcO%"0.%6,L/-%2'%#.,-8 2#JH%(#$)%J0+2'($%2"02%+'-2(#6/2,%2'%+0(.#'30$+/*0(%.#$,0$,%6H%J'**'&#-L%#2$%.,3,*'>4,-2%'3,(%0%*'-L%>,(#'.% 'J%2#4,%#-%0%*0(L,%L('/>%'J%>0(2#+#>0-2$;%\0$,.%'-%[(04#-L"04%J#-.#-L$O%>'>/*02#'-8&#.,%,JJ'(2$%2'%(,./+,% $4')#-LO%+"'*,$2,('*O%0-.%6*''.%>(,$$/(,%&,(,%/-.,(20),-%#-%7;%n0(,*#0;%YJJ'(2$%#-3'*3,.%-'2%'-*H%#-.#8 3#./0*%,./+02#'-%0-.%2(,024,-2%6/2%0*$'%&'()%"%2",%4,.#0O%$/>,(40(),2$O%0-.%0L(#+/*2/(,;%!",%(,$/*2$% &,(,%.(0402#+;%I-%:F%H,0($%2",%0--/0*%0L,80.S/$2,.%+'('-0(H%",0(2%.#$,0$,%4'(20*#2H%(02,%04'-L%:F8CG% H,0(8'*.%4,-%.,+*#-,.%cF%>,(+,-2;%10-+,(8(,*02,.%4'(20*#2H%&0$%0*$'%(,./+,.O%0-.%0**8+0/$,%4'(20*#2H% (,./+,.%J'(%4,-%0-.%&'4,-;% @-,%,0(*H%+'44,-20(H%'-%2",%7'(2"%n0(,*#0%>('S,+2%+(#2#+0**H%+0**,.%#2%_$"'28L/-%>(,3,-2#'-;`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

!"#$%&'(')*$'+ $,-#./0$1.2&#-

&)

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

N#$2'(#+0**HO%,>#.,4#'*'L#+%$2/.#,$%#-3,$2#L02#-L%2",%+0/$,$%'J%6(,0$2%+0-+,(%"03,%2H>#+0**H% +'-2('**,.%J'(%30(#'/$%+'-J'/-.,($%0-.%'2",(%J0+2'($%)-'&-%2'%#-.,>,-.,-2*H%#-J*/,-+,%(#$)% &"#*,%022,4>2#-L%2'%#$'*02,%2",%#4>0+2%'J%0%>0(2#+/*0(%30(#06*,%'J%#-2,(,$2;%!",H%"03,%2,-.,.O% J'(%,K04>*,O%2'%J'+/$%'-%>0(2#+/*0(%0$>,+2$%'J%.#,2O%0%$>,+#J#+%+",4#+0*%'(%>"H$#+0*%,K>'$/(,O% '(%,K,(+#$,;%!",H%"03,%+'-2(#6/2,.%30*/06*,%#-J'(402#'-;%Z'$2%60$#+0**HO%&,%"03,%*,0(-,.% 2"02O%J'(%6(,0$2%+0-+,(O%2",(,%#$%-'%$4')#-L%L/-%*#),%2",%2'60++'8*/-L%+0-+,(%+'--,+2#'-;%I2Q$% 2(/*H%0%$H$2,4#+%>('6*,4;%7,&%$2/.H%.,$#L-$%0-.%#-2,(3,-2#'-$%0(,%/(L,-2*H%-,,.,.;% I-%A('3#$#'-$O%2",%,$206*#$"4,-2%'J%0-%#-2,(0L,-+H%+'44#22,,%+'4>(#$,.% 'J%$+#,-2#$2$%J('4%[,.,(0*%0L,-+#,$O%/-#3,($#2#,$O%0-.%'2",(%-'-8[,.,(0*%'(L0-#R02#'-$%2'%,K8 04#-,%2",%$202/$%'J%6(,0$2%+0-+,(%(,$,0(+"%#-%2",%=-#2,.%M202,$%0-.%40),%(,+'44,-.02#'-$% J'(%#4>('3#-L%#2;%!"#$%+'44#22,,O%)-'&-%0$%2",%I-2,(0L,-+H%\(,0$2%10-+,(%0-.%Y-3#('-4,-8 20*%],$,0(+"%1''(.#-02#-L%1'44#22,,%aI\1Y]11bO%#$$/,.%#2$%J#-0*%(,>'(2%#-%A(,3,-2#'-%'J%6(,0$2%+0-+,(;$*%%!",H%$0#.j% H4 !",%+'4>*,K#2H%'J%6(,0$2%+0-+,(%-,+,$$#202,$%#-+(,0$,.%#-3,$24,-2%#-%(,$,0(+"%2'% ,K>*'(,%4,+"0-#$4$%/-.,(*H#-L%6(,0$2%+0-+,(%'3,(%0%>,($'-Q$%*#J,%$>0-;%YK>*'(02#'-% 'J%2",%#4>0+2%'J%,-3#('-4,-20*%J0+2'($%'-%6(,0$2%.,3,*'>4,-2%#$%-,,.,.O%0$%0*2,(,.% .,3,*'>4,-2%40H%#-J*/,-+,%6(,0$2%+0-+,(%(#$);%d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j% H4 !(0-$8.#$+#>*#-0(H%+''(.#-02#'-i%0-.% H4 !(0-$>0(,-+H%0-.%#-+*/$#'-%'J%(,>(,$,-202#3,$%'J%2",%L,-,(0*%>/6*#+%0-.%",0*2"%0J8 J,+2,.%L('/>$%#-%>*0--#-LO%#4>*,4,-202#'-O% 0-.% 2(0-$*02#'-% 'J%(,$,0(+"% J#-.#-L$O% 6/#*2%J('4%2",%$20(2%#-2'%,3,(H%J/-.,.%>('L(04%2"02%J'+/$,$%'-%6(,0$2%+0-+,(%0-.% 2",%,-3#('-4,-2;

!"#$%&'(')*$'+ $,-#./0$1.2&#-

&+

!'3.-4$.$/*/0#5/$6#-/6#&078#$ '+ $9-#./0$&.2&#-

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b%"'(4'-,%(,>*0+,4,-2% 2",(0>H%0$%0%(#$)%J0+2'(%J'(%6(,0$2%+0-+,(%0-.%40-H%&'4,-%.#$+'-2#-/,.%#2$%/$,;)%Z'$2%0-08

*H$2$%6,*#,3,%2"02%2"#$%",*>$%,K>*0#-%2",%'6$,(3,.%.,+*#-,%$"'(2*H%2",(,0J2,(;%!",$,%.020%0*$'% $"'&%2"02%#-30$#3,%6(,0$2%+0-+,(%#-+#.,-+,%(02,$%"03,%6,,-%0*4'$2%/-+"0-L,.%$#-+,%BDEF%#-% &'4,-%0L,$%A"H%$+(,,-#-L%#-%2",%BDc(,+/($'(% 'J%#-30$#3,%6(,0$2%+0-+,(O%6/2%-'2%0**%1IM%&#**%>('L(,$$%2'%#-30$#3,%6(,0$2%+0-+,(O%#-.#3#./0*$% 0-.%2",#(%4,.#+0*%>('3#.,($%J0+,%.#JJ#+/*2%2(,024,-2%.,+#$#'-$%&",-%1IM%#$%.#0L-'$,.;%%

!2,1#$4KCB?*( IDDL4M6/$##2,%*'&,(%#-+#.,-+,%2"0-%&"#2,%&'4,-;%%!",% (,0$'-$%J'(%2"#$%.#$>0(#2H%0(,%-'2%J/**H%/-.,($2''.%6/2%*#),*H%#-+*/.,%+'46#-02#'-$%'J%4'(,% 0LL(,$$#3,%2/4'(%2H>,$%#-%40-H%6*0+)%&'4,-O%*02,(%$20L,%02%.#0L-'$#$O%0-.%J0+2'($%(,*02,.%2'% 0++,$$%2'%+0(,%0-.%'>2#40*%2(,024,-2;&.'(&&(% !"#$%&'(')*$'+ $,-#./0$1.2&#-

#.

!"#$%&'($)(#"'&"#)*%' $)*'"+%,'-$(&."%

!2,1#$4KCK?!"4>7*($#4"=4!$-7+$4A#$7/.N40*(2&$*($4L7.$/N4BRSTFKUBUN44>2$/50L42#6#*#2H;%!",%4'$2%+'44'-%L,-,2#+%4/202#'-$%)-'&-%2'%#-+(,0$,%6(,0$2%+0-+,(% (#$)%0(,%#-%2",%\]15%B%0-.%\]15%A%L,-,$;%7'(40**HO%2",$,%L,-,$%"03,%2/4'(%$/>>(,$$'(% J/-+2#'-$O%6/2%&",-%4/202,.O%2"02%J/-+2#'-%#$%(,./+,.%0-.%6(,0$2%+0-+,(%(#$)%$"0(>*H%#-+(,0$8 ,$;%I-%2",%=;M;O%\]15%4/202#'-$%0(,%4'(,%+'44'-%#-%^,&#$"%&'4,-%'J%5$"),-0R#%'(#L#-% 6/2%2",H%'++/(%#-%#-.#3#./0*$%'J%0**%(0+#0*%0-.%,2"-#+%L('/>$;%5%(,+,-2%$2/.H%'J%5J(#+0-854,(8 #+0-%&'4,-%"%6(,0$2%+0-+,(%(,3,0*,.%0%"#L",(%J(,V/,-+H%'J%4/202#'-$%#-%6(,0$2%+0-+,(8(,8 *02,.%$/$+,>2#6#*#2H%L,-,$%2"0-%,K>,+2,.%'(%>(,3#'/$*H%(,>'(2,.;&% !"#$%&'(')*$'+ $,-#./0$1.2&#-

#&

!"#$%&'($)(#"'&"#)*%' $)*'"+%,'-$(&."%

0/$0*%$202/$O%0-.%L,-,2#+$O%2",%(,0$'-$%J'(%.,-$,%6(,0$2% 2#$$/,%0(,%-'2%J/**H%/-.,($2''.; !"#$%"&$%'(%)*+#%,*$&-"-./%'*%0"12-&%-'%.0234*$-%5-6332,"*2#/7 T'4,-%&"'%"03,%"0.%-'%+"#*.(,-%'(%&"'%"0.%2",#(%J#($2%+"#*.%0J2,(%0L,%:(,L-0-+#,$%0-.%6,+'4#-L%>(,L-0-2%02%0%H'/-L,(%0L,% (,./+,$%6(,0$2%+0-+,(%(#$);%Z02/(02#'-0*%+"0-L,$%#-%2",%6(,0$2%0$$'+#02,.%"%>(,L-0-+H%0-.% *0+202#'-%0(,%2"'/L"2%2'%(,./+,%2",%$/$+,>2#6#*#2H%'J%6(,0$2%2#$$/,%2'%+0-+,(;%],./+,.%-/46,(% 'J%4,-$2(/0*%+H+*,$%40H%0*$'%>*0H%0%('*,;%% %.-(*$.)#$'+$3LN#-0* Y0(*#,(%'-$,2%'J%4,-0(+",%a4,-$,$b%#-+(,0$,$%2",%(#$)%'J%6(,0$2%+0-+,(;%I-%2",%=;M;%0-.%40-H% '2",(%+'/-2(#,$O%2",%0L,%'J%>/6,(2H%#-%L#(*$%"0$%6,,-%$#L-#J#+0-2*H%.,+*#-#-LO%0*2"'/L"%2",% (,0$'-$%J'(%2"#$%0(,%-'2%&,**%/-.,($2''.;&)((Z'$2%'J%2",%0++,*,(02#'-%#-%2",%2#4#-L%'J%>/6,(2H% #$%0$$'+#02,.%"%,0(*#,(%6(,0$2%.,3,*'>4,-2%a2",*0(+",b%&"#*,%2",%2#4#-L%'J%2",%'-$,2%'J% 4,-$,$%"0$%-'2%.,+*#-,.%0$%4/+";% D.0#-$.)#$'+$4#2'3.L/#$ Z,-'>0/$,%0J2,(%0L,%FF%0*$'%$*#L"2*H%#-+(,0$,$%6(,0$2%+0-+,(%(#$);%@-,%>*0/$#6*,%,K>*0-02#'-% "'*.$% 2"02% ,0(*#,(% 4,-0(+",% 0-.% *02,(% 4,-'>0/$,% (,$/*2$% #-% "#L",(% *#J,2#4,% ,$2('L,-% 0-.% >('L,$2,('-,%,K>'$/(,$; 1"#/0$-.75.05'2 I'-#R#-L%(0.#02#'-%a,;L;O%o8(0H$b%#$%)-'&-%2'%#-+(,0$,%2",%(#$)%'J%6(,0$2%+0-+,(;%5++'(.#-L% 2'%@#$6/.046*($#06*&0.5$0E*>'(2$%0%+0/$0*%0$$'+#02#'-%6,2&,,-% 6(,0$2%+0-+,(%0-.%,K>'$/(,%2'%#'-#R#-L%(0.#02#'-;%!",%+'44#22,,%0*$'%-'2,.%2"02%>'>/*02#'-% ,K>'$/(,$% 2'% #'-#R#-L% (0.#02#'-% #-% 4,.#+0*% #40L#-L% 0(,% #-+(,0$#-L;% M20-.0(.$% #-2,-.,.% 2'% !"#$%&'(')*$'+ $,-#./0$1.2&#-

##

!"#$%&'($)(#"'&"#)*%' $)*'"+%,'-$(&."%

4#-#4#R,%,K>'$/(,$%J('4%4044'L(0>"H%,K#$2%0-.%-,&%#40L#-L%2,+"-'*'L#,$%+'/*.%(,./+,% '(% ,*#4#-02,% 2"02% $'/(+,;% I-% 0..#2#'-O% 4'(,% -,,.$% 2'% 6,% .'-,% 2'% 4#-#4#R,% (0.#02#'-% ,K8 >'$/(,$%J('4%'2",(%4,.#+0*%>('+,./(,$;%\(,0$2%+0-+,(%(#$)%#$%"#L",(%#J%(0.#02#'-%,K>'$/(,% '++/($%./(#-L%0.'*,$+,-+,%0$%2",%6(,0$2$%0(,%.,3,*'>#-L;%!"#$%#$%>0(2#+/*0(*H%0%+'-+,(-%&",-% +",$2%(0.#02#'-%#$%/$,.%2'%2(,02%0-'2",(%+0-+,(%./(#-L%2"02%2#4,;%%5L,8(,*02,.%&#-.'&$%'J%3/*8 -,(06#*#2H%2'%(0.#02#'-%0-.%'2",(%,-3#('-4,-20*%,K>'$/(,$%0(,%0%(,+/((,-2%2",4,%,K>*'(,.% 4'(,%J/**H%#-%*02,(%+"0>2,($;% G#$'-.($&'20-.௰#$L/# 5++'(.#-L%2'%2",%I@Z%+'44#22,,%(,>'(2O%'(0*%+'-2(0+,>2#3,$%4'.,$2*H%#-+(,0$,%2",%(#$)%'J% 6(,0$2%+0-+,(%04'-L%+/((,-2%/$,($X6/2%2"#$%#-+(,0$,.%(#$)%.#$0>>,0($%"#-%J'/(%H,0($%J'*8 *'&#-L%+,$$02#'-;%N'&,3,(O%2",%+'44#22,,%0*$'%-'2,$%2"02%'(0*%+'-2(0+,>2#3,$%0(,%0$$'+#02,.% "%0%*'-L82,(4%(,./+,.%(#$)%'J%,-.'4,2(#0*%a/2,(#-,b%0-.%'30(#0-%+0-+,($;% 1'4N52.05'2$"'-4'2#$0"#-.3* !",%I@Z%+'44#22,,%+'-+/((,.%"%2",%>(,30#*#-L%'>#-#'-%2"02%+'46#-02#'-%,$2('L,-8>('8 L,$2#-%"'(4'-,%(,>*0+,4,-2%2",(0>H%#-+(,0$,$%2",%(#$)%'J%6(,0$2%+0-+,(;%!"#$%#-+(,0$,.%(#$)% &0$%#.,-2#J#,.%#-%2",%T'4,-Q$%N,0*2"%I-#2#02#3,%$2/.H;%% 15).-#00#$/4'C52) M'4,%40S'(%$2/.#,$%0-.%(,3#,&$%"03,%+'-+*/.,.%2"02%0+2#3,%$4')#-L%#-+(,0$,$%6(,0$2%+0-+,(% (#$);%%Y3#.,-+,%#$%0*$'%L('&#-L%2"02%6,#-L%,K>'$,.%2'%$,+'-."0-.%2'60++'%$4'),%a>0$$#3,% $4')#-Lb%#-+(,0$,$%2",%(#$)%'J%6(,0$2%+0-+,(;&* S0"#-$+.&0'-/$-#65#B#7$N*$0"#$>S9$&'44500## 54'-L%'2",(%J0+2'($%(,3#,&,.%6H%2",%I@Z%+'44#22,,Og%2"'$,%4'$2%+*,0(*H%0$$'+#02,.%"% #-+(,0$,.% 6(,0$2% +0-+,(% (#$)% #-% ,>#.,4#'*'L#+% $2/.#,$% 0(,% '3,(&,#L"2% 0-.% '6,$#2H% 04'-L% >'$284,-'>0/$0*%&'4,-%0-.%0*+'"'*%+'-$/4>2#'-;%d(,02,(%>"H$#+0*%0+2#3#2H%#$%0$$'+#02,.% "%.,+(,0$,.%(#$);%!",$,%0-.%'2",(%>'2,-2#0*%(#$)%J0+2'($%0(,%4'(,%J/**H%.#$+/$$,.%#-%*02,(% +"0>2,($; T#2"% 2"#$% 0$% 60+)L('/-.O% 2",% J'**'&#-L% +"0>2,($% 0..(,$$% 0..#2#'-0*% (#$)% J0+2'($% #-% 4'(,% .,20#*;%Y3#.,-+,%#$%'J2,-%*#4#2,.%0-.%$'4,2#4,$%+'-J*#+2#-L;%n,,>#-L%#-%4#-.%2",%,+'*'L#+0*%

/(012(=7>>!5522(@!>!52:(512!3(32"!26(57(4(;2@2=5(M37?I(7< ((I75295!4@(3!;8(I32129;!"2(32"!26B( !"#$%&'(')*$'+ $,-#./0$1.2&#-

#$

!"#$%&'($)(#"'&"#)*%' $)*'"+%,'-$(&."%

J(04,&'()%.#$+/$$,.%#-%+"0>2,(%BO%&,%0(,%*,0(-#-L%2"02%4/+"%'J%2",%030#*06*,%,>#.,4#'*'L#+% (,$,0(+"%#$%*#4#2,.%2'%$'4,%,K2,-2%6H%30(#'/$%J,02/(,$%'J%$2/.H%.,$#L-%2"02%.#.%-'2%a0-.%'J2,-O% +'/*.%-'2b%0++'/-2%J'(%2",%+'4>*,K#2H;%['(%,K04>*,O%0$%-'2,.%#-%+"0>2,(%:O%0J2,(%.,+0.,$%'J% (,$,0(+"%'-%.#,2%0-.%6(,0$2%+0-+,(O%#2%6,+04,%+*,0(%2"02%4/+"%'J%2"02%&'()%&0$%*#4#2,.%6H% #2$%J0#*/(,%2'%0++'/-2%J'(%+'-J'/-.#-L%'(%,JJ,+2%4'.#J#+02#'-%6H%,K,(+#$,;&,((!"02%#$O%,K,(+#$,% +0-%#-.,>,-.,-2*H%#-J*/,-+,%6'2"%.#,2%0-.%6(,0$2%+0-+,(%(#$);%!"/$O%#2%+0-%6,%0%+'-J'/-.,(% 'J%2",%(,*02#'-$"#>;%YK,(+#$,%+0-%0*$'%#-J*/,-+,%6#'*'L#+%>02"&0H$%2"02%.'%*#-)%.#,2%2'%6(,0$2% +0-+,(XJ'(%,K04>*,O%#-J*04402#'-%0-.%'K#.02#3,%$2(,$$;%!"/$O%,K,(+#$,%#$%0%>'2,-2#0*%,JJ,+2% 4'.#J#,(%'J%0-H%(,*02#'-$"#>%6,2&,,-%.#,2%0-.%6(,0$2%+0-+,(;%!"#$%"0$%>(0+2#+0*%#4>'(20-+,% 6,H'-.%+'4>*#+02#-L%,>#.,4#'*'L#+%$2/.H%.,$#L-;%I2%4,0-$%2"02%&,**8.,$#L-,.%#-2,(3,-2#'-$% +0-%6,%4/2/0**H%(,#-J'(+#-L%0-.%"03,%6,-,J#2$%2"02%40H%,K+,,.%&"02%&'/*.%6,%>(,.#+2,.%6H% +'-$#.,(#-L%2",4%#-.#3#./0**H;%% 5$%-'2,.%6H%2",%I@Z%+'44#22,,%(,>'(2O%4'(,%+'4>*,K%4'.,*$%_&"#+"%022,4>2%2'%.,>#+2% 2",%4/*2#>*#+#2H%'J%J0+2'($%2"02%$,,4%2'%"03,%0%('*,%#-%6(,0$2%+0-+,(O%",*>%/-.,(*#-,%2",%6#'8 *'L#+0*%+'4>*,K#2H%'J%2",%>02"&0H$%0*'-L%&"#+"%2"'$,%J0+2'($%40H%6,%0+2#-LO%2",%.#JJ#+/*2H% 'J%.#$2#-L/#$"#-L%2(/*H%+0/$0*% ,JJ,+2$%J('4%0$$'+#02#'-$% "% #-2,(4,.#02,% J0+2'($O% 0-.% 2",% +"0**,-L,$%'J%.,$#L-#-LO%+'-./+2#-LO%0-.%#-2,(>(,2#-L%$2/.#,$%2"02%2(H%2'%,30*/02,%(#$)%J0+2'($% J'(%2",%30(#'/$%J'(4$%'J%2"#$%.#$,0$,;&-%5*2"'/L"%2",$,%+"0**,-L,$%$"0(,%$#4#*0(#2#,$%0+('$$%2",% $>,+2(/4%'J%(#$)%J0+2'($%,30*/02,.%#-%2"#$%(,>'(2O%2",H%40H%6,%>0(2#+/*0(*H%0+/2,%J'(%,30*/028 #-L%(#$)%(,*02#'-$"#>$%J('4%,K>'$/(,$%2'%,-3#('-4,-20*%+",4#+0*$;`% G#+#-#2&#/ &B( ^2)'+.-$#9-$.)'#;".+)%37#A')-*%#9-$.)'#E,)',+)/#k:$%)'$)%l7#^%1-$%-C#^2)'+.-$#9-$.)'# ;".+)%3T#.QRUQ-[UZ#k6&!-%)!#QRUQ#8).#Wl7#^,-+1-
View more...

Comments

Copyright ©2017 KUPDF Inc.
SUPPORT KUPDF