TALLER NUMERO 1 INTRODUCCION A LA TOXICOLOGIA Yeraldin

 

ONZXNZKOCß@ \@CQLZ_CVKZCK GC@\VN FL FCN_  -\@CGC@\VNVKIILZ @n. ;2 C@VZNF\O C@VZNF\OOCN@ OCN@ K IK VNTCONINEC VNTCONINECK K @NGJZL2 ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ 

NJBLVCQN EL@LZKI2 Ongprl`flr li flskrrniin dcstÿrcon fl ik Vnxconineçk k trkvãs fli tclgpn glfck`tl li rlon`nocgcl`tn fl sctukocn`ls rlilvk`tls qul fclrn` nrcel` k ik tnxconineçk ongn u`k dlrrkgcl`tk au`fkgl`tki l` ik skiuf noupkocn`ki.

KOVCQCFKFL_ FLI VKIILZ ;.

Fcsl Fcslûk ûkrr u` E EIN IN_K _KZC ZCN N on` on` ;8 ;88 8 (O (Ocl cl`) `) ttãr ãrgc gc`n `nss fn fn`f `fl l sl ccfl fl`t `tcacacq cqul ul u u`k `k rl rliko ikocÿ cÿ` ` fcrlo fcrlotk tk on` on` ik tnxc tnxconi onine neçk çk== ls lstl tl ein einsk skrcn rcn flj fljl l jks jkskrs krsl l l` li fnougl`tn kfbu`tn L@ LI K\IK pkrk flskrrniikr lstk kotcvcfkf.

:. K` K`kic kiczk zkrr ins slc slcss (1) FL FL_K _K_V _VZL ZL_ _ VN VNTC TCON_ ON_ fl flso sorct rctns ns l` ik tkj tkjik ik qul y qul qu l tuvcl tuvclrn` rn` u` cgp cgpko kotn tn `l `lek ektcv tcvn n cgp cgpnrt nrtk`t k`tl l k `cv `cvli li sn snoc ocki, ki, ouitu ouiturki rki,, jcniÿecon y ikjnrki, tl`cl`fn l` oul`tk ins sceucl`tls ksplotns2 \JCOKOCß@

VCLGXN

_\OL_N

(Elnrrlalr (Elnrrl alrl`oc l`ockocÿ` kocÿ` ‟ fÿ fÿ`f `fl l lstë lstë uj ujco cokf kfn n gkpk)

(O (Ouë uë`f `fn n su suol olfc fcÿ ÿ, ujc ujcokr orn`niÿecokgl`tl orn`niÿecokgl` tl ik sctukocÿ`)

(Flsorcjcr in qul pksÿ rlikocn`kfn on` li flskstrl)

Odlr`njyi (\ork`ck)

Li :< y :1 fl kjrci fl ;341 sl pr prn nfub fubn li plnr koocfl`tl `uoilkr fl ik dcstnrck.

Jdnpki (C`fck)

Li rlkotnr `òglrn ouktrn ktrn fl ik ol`trk rkii `uoi `uoilk lkrr fl od odlr lr`n `njy jyii lstkiin, lstk iin, kalotk`f kalotk`fn n tnfn li `nrtl fl uork`ck on` su kitn `cvli fl rlkotcvcfkf okusk`fn ik gulrtl fl ?8 plrsn`ks y rlkiczk`fn ik lvkou lvkouko kocÿ` cÿ` c` c`glf glfck cktk tk fl tnfk li ërlk. nourrcfn li ? fl Ls Lstk tk aëjr aëjrco cokk tu tuvn vn u` fcoclgjrl fl ;346 lsokpl fl ?8 tn`likfks

_\_VK@OCK VNTCOK (Flsorcjcr ik sustk`ock sust k`ock tÿxc tÿxcok ok l` tnfns sus ksplo ksplotns, tns, ongn ik `kturkilzk, `kturkilzk, ongpnscocÿ`, la lalo lotn tnss sn snjr jrl l ik skiuf, l`trl ntrns…)

Xëec ec`k `k ;

(Cf (Cfl` l`o okr kr ouë ouëils ils aul aulrn` rn` iks on` on`slo sloul` ul`ock ockss ak aktk tkils ils qul sl nrcec`krn` pnr li flskstrl tÿxcon).

Koocfl`tl `uoilkr

- Xrnjilgks el`ãtcons y psconiÿecons. - Li oë`olr c`ak`tci - Ik on on`t `tkg kgc` c`ko kocÿ cÿ` ` rkfckotcvk - Lalotns kgjcl`tkils

Flskstrl quçgcon

Iks sujt sujtlr lrrë rë`l `lks ks

fl csnock`ktn fl gltcin aëjrcok (GCO) (GC O) k ik kt ktgÿs gÿsal alrk, rk, Fnool` Fn l`ttl2 ALZ@ LZ@K@FN X\L X\L@VL @VL_ OZ\R

ON@_LO\L@OCK_

fl

keuks ls lstk tk` `

on`tkgc`kfks pnr pikeucocfk ki tl`lr u`

 

ONZXNZKOCß@ \@CQLZ_CVKZCK GC@\VN FL FCN_  -\@CGC@\VN-

Bn`lstnw` (Euyk`k)

Vnykgk (Bkpÿ`)

u` eks kitkgl`tl tÿxcon plsocfks y gës fl`sn qul li kcrl, in qul prnvnoÿ qul sl fl flsp spik ikzk zkrk rk ki rk rkss fl flii sulin, flbk`fn gcils fl pl plrsn rsn`k `kss gulrtk gulrtkss k su

kitn `cvli fl glrourcn. Gkianrgkocn`ls el`ãtcoks -Fcsokpkocfkfls plrgk`l`tls, gutcikocn`ls.

pksn.

- Oleulrk. Xrnjilgks `lurniÿe `lur niÿecons cons fninrls fninrls fl okjlzk okjlzk,, prnjilg prnjilgks ks fl lqucicjrcn, flprlscÿ`, aktcek, crrctkjcicfkf. - Fkûns l` ins scstlgks rlspcrktnrcns, rlspcrktnrcns, gusouikr-ÿsln, rlprnfuotcvn l c`gu`niÿecon. Ins `c `cûns ûns,, kfuit kfuitns ns y k`ock` k`o ck`ns ns gurcl gurclrn` rn` k okusk fl ik pnocÿ`. Li `ò `ògl glrn rn fl gulr gulrtn tnss aul l` tntki 388,

;4 fl `nvc `nvclg lgjr jrll fl ;354 l` u` rlgnt gntn iuekr l` li `nrnlstl fl Kgãrcok fli _ur.

Ins sleucfnrls fl lstk nrek`czkocÿ` nrek`c zkocÿ` rlicecnsk y su içfl içflrr bcg bcg bn bn`l `lss sl suc sucocfk cfkrn` rn` ongn ngn u` ko kotn tn rlvn rlvniu iuoc ocn` n`kr krcn cn sucocfë`fnsl 388 pl plrs rsn` n`ks ks sl tn tngk gkrn rn` ` on`bu`tk on`b u`tkgl`t gl`tll arksons arksons fl ock`urn L` ;3;: sl gk`calstÿ Lstl suolsn surecÿ surecÿ pnr pnr pnr pr prcg cglr lrkk vlz vlz u`k u`k ik ongpkûçk gc`lrk qul c`tnxc c`t nxcoko okocÿ` cÿ` gkscvk gkscvk icjlrn erk`fls pnr okfgcn ok`tcfkfls fl okfgcn y ntrns ntr ns gltkil gltkilss pl plskf skfns ns yk qul sl kougu kouguik ikrn` rn` tk`tn l` li ilodn fli rçn ongn l` li keuk okusk`fn l`vl` l`vl`l`k l`kgcl gcl`tn `tn k ik ikss plrsn`ks plrs n`ks lstk rlecÿ` rlecÿ` y pnr sc `n aulrk pnon li krrnz kjsnrjcÿ ins gltkils plskfns, lsplockigl`tl l` okfgcn, y ãstl sl kouguiÿ l` li nrek` nrek`csg csgn n fl ik el el`tl `tl qu qull sl kic kicgl gl`tk `tkjk jk on`

Fnool` Fn l`ttl2 ALZ@ LZ@K@FN X\L X\L@VL @VL_ OZ\R

Xëec ec`k `k :

Gkynr sucocfcn onilovn

On`tkgc`koc ÿ` ouivns fl krrnz

- C`suacocl`ock rl`ki - Kjik`fkgcl`tn slvlrn fl ins dulsns. - Aulrtls l c`snpnrtkjils fninrls prnvnokfns l` iks krtcouikocn`ls y l` ik oniug`k vlrtljrki. - Oleulrk - On`tkgc`kocÿ` k ins kicgl`tns

 

ONZXNZKOCß@ \@CQLZ_CVKZCK GC@\VN FL FCN_  -\@CGC@\VNOdcquc`qucrë (Oningjck)

Kqucserk` (Kilgk`ck)

fcodn krrnz. Li sëjkfn :< fl Odcq Odcquc` uc`qucr qucrëë sl vcstcÿ vcstcÿ Vnxcon l` L`vl`l`kgcl`tn onilotcvn `nvclgjrl fl ;315 fl iutn y sl l`vnivcÿ l` pk`kflrçk li fnin fninrr, ki plrf plrflr lr ik vcfk 54 plrsn`ks l`trl `cûns y kfuitns y gës

Li aërgkon sl lgplzÿ k vl`flr gkscvkgl`tl l` ;3, Bustcacqul y Lxpicqul su rlspulstk. Ik lvn lvniuo iuocÿ` cÿ` fl ik tnx tnxcon conine ineçk çk tcl tcl`l `l erk erk` ` cgp cgpnrt nrtk`o k`ock, ck, yk qul ouyk fcsocpic`k kjnrfk li lstufcn fl ins lalotns `nocvns snjrl ik skiuf fli trkjkbkfnr prnfuocfns p pnr nr ins on`tkgc`k`tls fli kgjcl`tl kgjcl`tl ikjnrki. Li flso fl son` n`no nocg cgcl cl`t `tn n fl in ins s lalo lalotn tns s fl ik ko kotc tcvc vcfk fkf f ik ikjn jnrk rkii l` oc oclr lrtk tks s c`fustrcks c`ourrclrn` l` ik gk`calstkocÿ` fl slrcks l`alrglfkfls y flolsns nokscn`kfns pnr ik lxpnscocÿ` k quçgcons plicernsns y kel`tls tÿxcon tÿx cons s jkb jkbn n on on`fc `fcocn ocn`ls `ls c`s c`sleu leurks rks fl trk trkjkb jkbn= n= lst lstl l ls li okg okgpn pn fl koocÿ` fl ik tnxconineçk noupkocn`ki. Fl ceuki gk`lrk ik cgpnrtk`ock fl ik tnxconineçk rkfcok l` li on`nocgcl`tn qul sl pulfl tl`lr n fcspn`lr y Fnool` Fn l`ttl2 ALZ@ LZ@K@FN X\L X\L@VL @VL_ OZ\R

Xëec ec`k `k ?

 

ONZXNZKOCß@ \@CQLZ_CVKZCK GC@\VN FL FCN_  -\@CGC@\VNik on`ocl`tczkocÿ`, fl iks sustk`ocks plicernsks qul sl utciczk` l` li kgjcl`tl ikjnrki.

6. ¾[uã on on`olptns `olptns fl in ls lstufckfn tufckfn oon` n` rlsp rlsplotn lotn ki f flskrrnii lskrrniin n dcstÿrco dcstÿrcon n fl ik tnxconineçk sl pulfl` kpicokr l` `ulstrn tclgpn> , Bustcacqul y Lxpicqul su rlspulstk. _kjlgns qul ik tnxconineçk `n snin ik kpicokgns k li ëgjctn ikjnrki, sc`n tkgjcã` l` `ulstrk vcfk ontcfck`k, yk qul k fckrcn `ns l`arl`tkgns k fcalrl`tls sustk`ocks tnxcoks plicernsks. S ouk`fn `n utciczkgns ik prlvl`ocÿ` y iks glfcfks `lolskrcks pnflgns iilekr k u`k c`tnxcokocÿ`  y pnflgns kitlrkr y kalotkr li nrek`csgn fli slr vcvn, pnr l`fl ls cgpnrtk`tl qul tl`ekgns oikrn okfk u`n fl ins on`olptns qul l`oclrrk ik tnxconineçk y li erkfn fl plicernscfkf l` ik qul okfk u`k kjkrok, pkrk ksç pnflr tl`lr u` jul` usn fl liiks sc` `lolscfkf qul skiekgns kalotkfns.

Gl`tcn` acvl ( ¾[uã sn` ins nrek`csgns tÿxcons> _n` kq _n` kqul uliin iinss ong ongpu pulst lstns ns nreë nreë`co `cons ns qu qul l `n pu pulf lfl` l` slr kcs kcsik ikfns fns pnr flstcik fls tcikocÿ` ocÿ`.. Vnfns ins aërg aërgkon konss l`t l`trk` rk` l` lstk okt oktlenr lenrçk çk ksç ongn iks frne frneks ks fl kj kjus usn, n, ins pik pikeuc eucocf ocfks ks y u` u`k k erk` erk` ok`t ok`tcfk cfkf f fl sust sustk`o k`ocks cks utciczkfks l` sç`tlscs quçgcok y l` c`fustrck kicgl`tkrck :;. Udkt krl Vnxco _ujstk`ols>, k`f wrctl tdrll (?) lxkgpils2 ¾[uã sn` iks sustk`ocks tÿxcoks>, y lsorcjk trls (?) lblgpins2 sn` prnfuotns quçgcons ouyk akjrcokocÿ`, prnolskfn, fcstrcjuocÿ`, usn y licgc`kocÿ` rlprlsl`tk` u` rclsen c`ksugcjil pkrk ik skiuf dugk`k y li glfcn kgjcl`tl. lblgpins Fnol Fn ol`t `tl2 l2 ALZ@ ALZ@K@ K@FN FN X\L@ X\L@VL VL_ _ OZ OZ\R \R

Xëec` ëec`k k ;:

 

ONZXNZKOCß@ \@CQLZ_CVKZCK GC@\VN FL FCN_  -\@CGC@\VNGn`ÿxcfn fl okrjn`n (prnfuotn fl ongjustcÿ`)2 c`oiusn l` ok`tcfkfls plqulûks pulfl okuskr ik gulrtl pnr ksacxck yk qul sustctuyl ki nxçel`n l` ik sk`erl

Ock`urn  (ak (akjrc jrcok okocÿ ocÿ` ` fl tlb tlbcf cfns, ns, pc`tu pc`turks rks,, pië piëstc stcon ons.. s...)2 .)2 ls ilt iltki ki ki cgplf cgplfcr cr ik rlspcrkocÿ` c`trkoliuikr Xikeucocfks2 kitlrkocn`ls `lrvcnsks y dnrgn`kils, oë`olr, c`alrtcicfkf ::. Udkt cs tdl fcaalrl`ol jltwll` _ystlgco Vnxcok`ts k`f Nrek` Vnxcok`ts> Ongpiltl2 ¾Ouëi ls ik fcalrl`ock l`trl ins tÿxcons scstãgcons y ins tÿxcons nreë`cons> Ongpiltkr

tÿxcons scstãgcons \` tÿxcon scstãgcon kalotk tnfn li oulrpn n guodns ÿrek`ns l` iuekr fl u` sctcn lsploçacon. Xnr lblgpin, li ock`urn fl pntkscn ls u` tÿxcon scstãgcon qul kalotk prëotcokgl`tl k tnfks iks oãiuiks y ÿrek`ns fli oulrpn ki c`tlralrcr on` on` ik okpko okpkocfk cfkf f fl iks oãiu oãiuiks iks pkrk uskr nxçel`n.

tÿxcons nreë`cons _n` kquliins ongpulstns nreë nreë`c `con onss qul qul `n pul ulfl fl` ` sl slrr kcsikfns pnr flstcikocÿ`. Vnfns ins aërgkons l`trk` l` lstk oktlenrç oktlenrçk k ksç ongn iks frneks fl kjusn, ins pikeu pikeuco cocfk cfkss y u` u`k k erk erk` ` ok`tc ok`tcfk fkf f fl sustk`ocks utciczkfks l` sç`t sç`tls lscs cs qu quçg çgco cok k y l` c` c`fu fust strc rck k kicgl`tkrck.

:?. Udkt cs yynur nur jceel jceelst st on`trcju on`trcjutcn` tcn` ks k tnxcon tnxconiney iney stu stufl`t, fl`t, tn cgprnvl ttdl dl qukicty na ical na wnrmlrs c` nur rlecn`> Fnol Fn ol`t `tl2 l2 ALZ@ ALZ@K@ K@FN FN X\L@ X\L@VL VL_ _ OZ OZ\R \R

Xëec` ëec`k k ;?

 

ONZXNZKOCß@ \@CQLZ_CVKZCK GC@\VN FL FCN_  -\@CGC@\VNOuëi ls su gkynr on`trcjuocÿ on`trcjuocÿ` ` ongn lstufck` lstufck`tl tl fl tnxconine tnxconineçk çk pkrk glbnrkr ik okicfkf fl vcfk fl ins trkjkbkfnrls l` `ulstrk rlecÿ`>  ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^  ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^  ^   ^^^^^^^^^^^^^  ^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^^^^^^ ^^^^^^^^. ^.

Fnol Fn ol`t `tl2 l2 ALZ@ ALZ@K@ K@FN FN X\L@ X\L@VL VL_ _ OZ OZ\R \R

Xëec` ëec`k k ;6