Sketchy Pharm

Sketchy Pharm Nafcillin (staph), Oxacillin, Methicillin, Dicloxacillin             

Beta lactam ring – ringed planet. Death Coccocus wall=PPG cell wall with repeating D-alanyl-D-alanine oligopeptidesD-ALA-D-ALA pattern Planetary building project worker: penicillin binding protein form PPG cross-links Inactivated PBP worker: beta-lactam ABx covalently bind PBPs (halting cell and killing) Protective armor: bulky-R groups prevent beta lactase binding. Staff pencil: nafcillin Ox horns: Oxacillin (narrow spectrum) Purple coccoid space station cluster: activity against staphylococci/step Red Hump: empiric Tx for skin and soft tissue infections (i.e. folliculitis, abscesses) Tricuspid pyramids: Txs Staph endocarditis Fish bones: Txs Staph osteomyleitis MRSA: altered PBP’s o Altered wall builder: altered PBPs resistant to beta-lactams Merciless dark lord MRSA: methicillin resistant staph aureus.

Summary- Antistaph penicillins more resistant to beta lactamases. Can be used for localized and system infection but not active against MRSA.

X1.3 Ampicillin, Amoxicillin, Pipercillin, Ticarcillin           

Ringed planet- Beta lactam ring Unfinished death coccus: binds PBPs halting PPG wall synthesis Purple coccoid space station cluster: activity against staphylococci/step Red color : improved activity against g- bacteria. Prism: broad spectrum Ammo box: amoxicillin Open mouth: amoxicillin – oral availability Red bandana: amoxicillin and ampicillin treats streptococcal pharyngitis Plugged ears: amoxicillin treats otitis media and sinusitis caused by Step Pneumo, Haemophilus Influenza, Moraxella catarrhalis. Rusty chest plate: amox and amp treat pneumonia caused by Step Pneumo and Haemoph. Influenza H wing ship: activity against Haemophilus Infuenzae.

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Helicopter: amoxicillin is part of a triple therapy (with clarithromycin and a PPI) for Helicobacter pylori infection. Robin of Ixodes: amoxicillin treats Lyme diseases caused by Borrelia burgdorefi. Amp: Ampicillin Ivy: ampicillin- IV administration Gas Mask : ampicillin treats anaerobic infections (aspiration pneumonia) Purple Diplococcus rock drums: ampicillin treats Enterococcus infections Knocked over amp: ampicillin resistant strains of Enterococcus due to beta-lactmase production. Set List: ampicillin treats meningitis caused by Listeria monocytogenes Bar spouts: Activity against GI and UTI gram negative rods (E. coli) Beta bouncer: sensitivity to beta lactmases Distracting clarinet: clavulanate –beta-lactamase inhibitor Tambourines back to back: tazobactam and sulbactam – betalactamase inhibitors