S12. Ureogénesis. Acción de La Arginasa

 

[27. Adjestrbkiûn adf prekdse ad urdehéndsis?   bkkiûn ad fb brhinbsb J[k. Abnitzb Sfbsdnkib Kdrnb

[2;? QI@ [21? QI@ [24? Dxpe QI@

 

EGODQIPE AD FB SWÂKQIKB Df egodtive ad fb prdsdntd dxpdridn dxpdridnkib kib ds adjestrbr fb bkkiûn ad fb brhinbsb segrd fb brhininb pbrb fb sêntdsis ad urdb.

 

@unabjdntes tdûrikes

 

DQBSB I? Fbs hrbnads jefékufbs ad fes bfijdntes sd `rbhjdntbn mbstb uniabads jâs pdqudòbs.

DQBSB II? Fbs uniabads jâs pdqudòbs sd adhrbabn mbstb unbs pekbs uniabads sijpfds? Bkdtif-KeB.

DQBSB III? Bkdtif-KeB,

Fbs uniabads sijpfds? su`rdn unb exiabkiûn kejpfdtb pbrb `erjb BQS.

 

Adhrbabkiûn ad pretdênbs Bfijdntes Sretdênbs abòbabs figdrbabs fi gdrbabs

Sretdênbs dxûhdnbs

Bjineâkiaes

Sretdênbs dnaûhdnbs

aurbntd fb adstrukkiûn ad aurbntd ad fb kéfufb e, dnzijbs qud yb kujpfidren su `unkiûn.  

[d jbrkbn pbrb su adstrukkiûn ken Tgiquitinb y sd adhrbabn jdaibntd un kejpfdoe adpdnaidntd ad BQS (pretdbsejb).

 

Fb aihdstiûn ad fbs pretdênbs ad fb aidtb (pretdênbs dxûhdnbs) kejidnzb dn df dstûjbhe y sd kejpfdtb dn df intdstine

Fb aihdstiûn kejidnzb dn df dstûjbhe? jdaie âkiae `bverdkd fb adsnbturbfizbkiûn pretdikb, bsê sen jâs bkkdsigfds b fb pretdûfisis kbtbfizbab kbtbfizbab prink. per fb pdpsinb (pM ûptije? 7). Fb adhrbabkiûn kentinub dn df intdstine per dnz. pretdefêtikes figdrbabs per df pânkrdbs. Fbs pretdbsbs qud sd fekbfizbn dn fb f b jdjg. pfbsj. ad fbs kéfufbs intdstinbfds (bjinepdptiabsbs) (bjinepdptiabsbs) kentinÿbn fb aihdstiûn.

 

Adhrbabkiûn ad pretdênbs Bfijdntes Sretdênbs abòbabs figdrbabs fi gdrbabs

Sretdênbs dxûhdnbs

Bjineâkiaes

Sretdênbs dnaûhdnbs

aurbntd fb adstrukkiûn ad aurbntd ad fb kéfufb e, dnzijbs qud yb kujpfidren su `unkiûn.  

[d jbrkbn pbrb su adstrukkiûn ken Tgiquitinb y sd adhrbabn jdaibntd un kejpfdoe adpdnaidntd ad BQS (pretdbsejb).

 

Adhrbabkiûn ad pretdênbs dnaûhdnbs

Tgiquitinb  Jbrkb ad fb judrtd

Aihdrir pretdênbs ugiquitinbabs

 

Adhrbabkiûn ad pretdênbs dnaûhdnbs Fbs pretdênbs ugiquitinbabs sd adhrbabn mbstb `rbhjdntes pdptêaikes

Dfijinbkiûn ad fb ugiquitinb  rdkikfbr

Sretdênbs  bjineâkiaes

 

Adhrbabkiûn ad Bjineâkiaes Df prijdr pbse dn fb adhrbabkiûn ad bjineâkiaes ds fb dfijinbkiûn ad nitrûhdne. Dn fes jbjê`dres? mêhbae ds df prinkipbf kdntre ad adhrbabkiûn ad Bbs

Dsqudfdtes kbrgenbae kbrgenbaess

Trdb

Trdb

 

Df pretdbsejb y etrbs pretdbsbs hdndrbn bjineâkiaes figrds

Trdb

Erinb

 

Kikfe ad fb Trdb Dn fes vdrtdgrbaes tdrrdstrds, fb urdb sd sintdtizb dn df

urdb

kikfe ad fb Brhininsukkinbsb

Brhininsukkinbte Brhininsukkinbt e sintdtbsb

Brhinbsb

Ernitinb trbnskbrgbj trbnskbrgbjifbsb ifbsb

Kbrgbjif`es`bte sintdtbsb

(K. Lrdgs) Sretdênbs

Bjineâkiaes

 

Aisdòe dxpdrijdntbf

 

Jbtdribfd s Mejehdndizbae mdpâtike bf 73 % dn sbkbresb 3,74 J

(@udntd ad fb Brhinbsb)

([ustrbte) (Dnzijb) (Exiab, aihidrd fes rdstes kdfufbrds, adspretdinizb) (Bhrdhb y prdkipitb fes rdstes pretdikes)

(Adtdrjinb NM₋)

 

 

Egtdnkiûn adf dxtrbkte kruae ad fb dnzijb

+ 43 jF [efukiûn ad sbkbresb 3,74 J

(sefukiûn iseesjûtikb)

Mêhbae

Mejehdnizbaer Mejehdnizba er ad tdoiaes

Sdsbr

[efukiûn mejehéndb mejehéndb bf 73% j/v 23 jF

Dnzijbs? Brhinbsbs

x 24 jin

Srdkipitbae?

Kdntri`uhbr b ;433 rpj per

Inkugbr b 03³K (fb brhinbsb ds

Etres dnzijbs.

23 jin

dstbgfd, fbs etrbs dnzijbs

 

2. Qbgfb 2. [istdjb ad inkugbkiûn? Sreaukkiûn ad urdb utifizbnae brhininb

[ustrbte

Dnzijb Dnzijb

 

Qbgfb 7.

Adtdrjinbkiûn ad fb urdb jdaibntd df rdbktive ad Ndssfdr 

 

Wdbktive ad Nddsfdr •

Adgd su nejgrd b su adskugriaer, df quêjike bfdjân Oufius Nddsfdr.

•

Ds un rdbktive quêjike qud sd utifizb pbrb adtdktbr pdqudòbs kbntiabads ad

•

bjenêbke (NM;) e kbtiûn bjenie (NM1 +). Df yeaejdrkuribte petâsike (rdbktive (rdbktive ad Ndssfdr), Ndssfdr), dn sefukiûn bfkbfinb, `erjb ken df NM; e NM1+ un kejpfdoe ad kefer bjbriffe-nbrbnob (yeaebjiaure) kuyb kubntitbtivbjdntd,, prdvib egtdnkiûn adnsiaba ûptikb b 133 nj pdrjitd vbferbrfe kubntitbtivbjdntd ad unb kurvb pbtrûn. Ne egstbntd pudad utifizbrsd dstb téknikb b jeae ad prudgb kubfitbtivb,, sin utifizbr jdaiab ad bgserkiûn ad fb fuz. kubfitbtivb

Wdbkkiûn -

Wdbkkiûn +

 

Wdsuftbae s

 

Gfbnke

Quge I

Quge II

@ihurb 2. Wdsuftbaes egtdniaes adf sistdjb ad adtdrjinbkiûn ad fb urdb (bjenibke) jdaibntd

df rdbktive ad Ndssfdr. [d pudad rdbfizbr unb dvbfubkiûn kubfitbtivb (dn `unkiûn bf kefer) e fdkturb ad fb bgsergbnkib ad kbab tuge (adtdrjinbkiûn kubntitbtivb, tbgfb ;).

 

Qbgfb ;. Wdsuftbaes egtdniaes adf sistdjb ad adtdrjinbkiûn ad fb urdb jdaibntd df rdbktive ad Ndssfdr    Quges

Fdkturb

Gfbnke

3,32

Quge I

3,30

Quge II

3,32

 

Sbse 2. Kerrdhir fbs fdkturbs ad bgsergbnkib Quges

Fdkturb

Fdkturb kerrdhiab 2

Gfbnke

3,32

-

Quge I

3,30

Quge II

3,32

3,34 Quge I ‛ Gfbnke ad rdbktive

3,33

Quge II ‛ Gfbnke ad rdbktive

 

Sbse 7. Adtdrjinbr fb bktiviaba ad fb urdbsb Bktiviaba ad fb urdbsb (jh NM;/jF) : (Fdkturb kerrdhiab kerrdhiab ad bgsergbnkib) (;8)

Quges

Fdkturb

jh NM;/jF

jh urdb/jF

Quge I

3,34

2,=4

3,974

Quge II

3,33

3,33

-

 

Wdbkkiûn 2

+ DK ;.4.;.2

Wdbkkiûn 7

2,=4 3,974

3,974

DK ;.4.;.2

Tnb jefékufb ad urdb preaukd 7 jefékufbs ad bjenibke

 

µSrdhuntbs5