Respuestas Funcionales de Linfocitos T-Secreción de Citocinas y Expresión de Receptores para Citocinas

 

_IPXYIPZCP NYB@LKBCAIP - JI AKP ALBNK@LZKP Z CA CBZÍEIBK \ @KIPZLMYAC@LÐB JLCXK ? 

Pi`ri`lðb ji `ltk`lbcs y ixprislðb ji ri`iptkris pcrc `ltk`lbcs Ac lbtiraiu`lbc ? is ub nc`tkr ji `ri`lmlibtk, `r i`lmlibtk, supirvlvib`lc y jlnirib`lc`lðb pcrc aks albnk`ltks Z qui lbtirvlibi ib ac lbju``lðb ji sus rispuistcs lbmubltcrlcs, ac si`ritcb ib pcrtl`uacr aks @J: pkstirlkr ca ri`kbk`lmlibtk jia cbtíeibk qui istlmuac su prkalnirc`lðb ji albnk`ltks Z. Istc c`t÷c ib acs mlsmcs `ìauacs qui ac prkju`ib k albnk`ltks Z cjyc`ibtis (`kmk `ltk`lbc cutk`rlbc k pcrc`rlbc6 is ji`lr, c`t÷c skori ac mlsmc `ìauac qui prkju`i ac prktiíbc k ib `ìauacs `ìa uacs vi`lbcs). \ erc`lcs c su c`tlvc`lðb ji aks albnk`ltks Z si s i istlmuac ac trcbs`rlp`lðb jia eib LA-? y ac síbtisls ji prktiíbc. Dcy qui tibir ib `uibtc qui ac prkju``lðb ji LA-? is rãpljc y implizc ? dkrcs cprkxlmcjcmibti jia ri`kbk`lmlibtk jia cbtíeibk `kb ub mãxlmk c acs 4 c 3? d cprkxlmcjcmibti y ubc ji`albc`lðb c acs ?: d Aks ri`iptkris pcrc ac LA-? sltucjks ib aks a ks albnk`ltks Z tcmolìb tlibjib c ak`cal ak`calzcr zcr ac slbcpsls, ji mcbirc qui ac `ltk`lbc y su ri`iptkr ca`cbzcb `kb`ibtrc`lkbis ak`cais sunl`libtimibti catcs pcrc lbl`lcr acs rispuistcs `iauacris. LA-? is si`ritcjc pkr ubc eau`kprktiíbc eakouacr ji 3:-35 flakJcatkb qui `kbtlibi :   Ac dial`is canc, isti prktktlpk ji dìal`is lbtirc`t÷c `kb aks ri`iptkris ji tlpk L pcrc `ltk`lbcs.

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Isti ri`iptkr (LA-?_) `kbstc ji prktiíbcs csk`lcjcs ji nkrmc bk `kvcaibti qui skb LA-?_ γ  (@J?9), LA-?/39_ ο (@J3??) y` (@J30?). - 

Ia ib`uibtrk lbl`lca `kb cbtíeibks ispi`ínl`ks ib prisib`lc ji ubc sióca `kistlmuacjkrc c`tlvc ac ibtrcjc ji ac `ìauac Z ib ac ncsi E3 jia `l`ak `iauacr6 ca mlsmk tlimpk, tcmolìb lbju`i c ac `cjibc canc `kb cnlbljcj ocgc c ublrsi c ac LA-?, slb prkju`lr caeubc sióca `ltkpaãsml`c, bl rispuistc jiti`tcoai. (istc tcmolìb is `kbk`ljk `kmk @J?9). NLE 4-?8

Ia ri`iptkr ji LA-? tlibi tris `cjibcs7 γ, ο y ΰ.  - 

Acs `ìauacs Z ib ripksk ixpriscb ubc nkrmc ji isti ri`iptkr `kbstltuljc pkr `cjibcs ο y ΰ qui si ubi c LA-? `kb cnlbljcj mkjircjc, ak `uca pirmlti c acs `ìauacs Z ib ripksk ric``lkbcr c `kb`ibtrc`lkbis muy catcs ji LA- ?. Ac ublðb ji ac `cjibc γ `kb ia ditirkjímirk ο y ΰ `ric ub ri`iptkr ri` iptkr `kb mu`dk mcykr cnlbljcj pkr LA -?, ak `uca pirmlti

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c ac `ìauac rispkbjir c `kb`ibtrc`lkbis muy ocgcs ji istc `ltk`lbc. Ac ublðb ji LA-? ca ri`iptkr ji catc cnlbljcj c`tlvc ibtkb`is ia cvcb`i pkr ia ristk jia `l`ak `iauacr. (nl ( nl e. 4?3). Acs `ìauacs Z c`tlvcjcs ji istc mcbirc puijib jlvljlrsi jks k tris vi`is ca jíc jurcbti vcrlks jícs, ak `uca dc`i pksloai qui ubc `ìauac ` ìauac jì krleib c ubc `a `akbc kbc ji mlais ji `ìauacs pkrtib aks mlsmks ri`iptkris ji cbtíeibks. Csí `kmk ac LA-? is ub nc`tkr ji supirvlvib`lc pcrc istcs `ìauacs, su ialmlbc`lðb pkjríc `cuscr su muirti, istc tcmolib prkmuivi su jlnirib`lc`lðb pcrc `kbvirtlrsi ji `ìauacs c`tlvcjcs c `ìauacs ini`tkrcs.

Cquí tcmolib lbtirvlibi ac `kistlmuac`lðb pkr mijlk jia @J?4 qui `kbtrlouyi c ac prkju``lðb ji LA-? ji jks nkrmcs

 

3.  Xrlmirk, acs siócais prk`ijibtis ji @J?4 ubljk c mkaì`uacs ji O5 lb`rimibtcb ac

prkju``lðb ji CX-36 Xrktiíbc C`tlvcjkrc 3 y BNηO6nc`tkr ji trcbs`rlp`lðb ji `ìauacs O, ak qui lb`rimibtc `csl ca trlpai ia lbl`lk ji ac trcbs`rlp`lðb jia m_BC ji LA-?. LA -?. ?.  Xkr ktrc pcrti, si plibsc qui ia sieubjk ini`tk ji ac siócalzc`lðb c trcvìs ji @J?4 is istcolalzcr ia m_BC ji LA-?, ak qui lb`rimibtc ib ?8 c 08 vi`is ac prkju``lðb ji ac prktiíbc LA-?. Ia cumibtk ji jl`dc prkju``lðb pkr istks jks ini`tks gubtks is ji ubcs `lib vi`is. Aks m_BC pcrc `ltk`lbcs tlibi vljc muy orivi, jioljk c ubc si`uib`lc ji ‑lbistcolaljcj” ib su rielðb bk trcju`ljc 0‿. Ia _BC lbistcoai lmplji ac prkju``lðb y aloirc`lðb sk stibljcs ji

`ltk`lbcs, ak `uca pirmlti ac rieuac`lðb istri`dc ji ac c`tlvljcj ji `ltk`lbcs. @ucbjk ubc `ìauac Z ri`kbk`i cbtíeibks ispi`ínl`ks ib cusib`lc ji `kistlmuac`lðb c trcvìs ji su mkaì`uac @J?4, si prkju`i pk`c LA-? y aks albnk`ltks Z bk prkalnirc. Csí, ac nub`lðb mãs lmpkrtcbti ji ac sióca `kistlmuacjkrc is prkmkvir ac síbtisls ji LA-?.

JLCXK 0 

Ixpcbslðb `akbca Ac prkalnirc`lðb jia albnk`ltk Z ib rispuistc ca ri`kbk`lmlibtk jia cbtíeibk istã c trcvìs ji ubc `kmolbc`lðb ji siócais c pcrtlr jia ri`iptkr pcrc ia cbtíeibk, `kistlmuacjkris y nc`tkris ji `ri`lmlibtk cutk`rlbks, skori tkjk ac LA-? - 

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Ia risuatcjk ji istc prkalnirc`lðb ib 3-? jícs bks jc ub cumibtk jia tcmcók ji `akbis ispi`ínl`ks `kbtrc ca cbtíeibk `kbk`ljk `kmk ixpcbslðb `akbca6 eibircbjk ubc ercb `cbtljcj ji `ìauacs dcstc akercr ialmlbcr ia ml`rkolk jisji ubc risirvc ji albnk`ltks víreibis ispi`ínl`ks (istk vc jisji 388 mla- 3 mlaaðb ji albnk`ltks) Jispuìs ji ac ixpksl`lðb ca cbtíeibk aks albnk`ltks Z @J4 lb`rimibtcb ji 3 pkr `cjc 0 ji istks, ixpcbjlìbjkaks mcykr c 98 mla vi`is nribti ca cbtíeibk. Ib `cmolk aks @J: ispi`ínl`ks lb`rimibtcb 3 ji `cjc 388 @J:.

Istujlks jimkstrcrkb isti bktcoai `cmolk ib ac ixpcbslðb jurcbti skak ska k ac prlmirc simcbc ji lbni``lðb, ak qui nui bktcoai ib rctkbis ib isti prk`isk ricalzcjk. Xkr ktrk acjk, aks albnk`ltks Z bk ispi`ínl`ks `kbk`ljks ‑ispi`tcjkris¶ nribti ca vlrus bk prkalnircocb.   Ziblibjk ib `uibtc ji qui acs `ìauacs Z @J4 istãb prkercmcjcs jisji su krleib pcrc prkal prkalnircr nircr y jlnirib`lcrsi ib `ìauacs ini`tkrcs @ZAs y ji mimkrlc `ucbjk si ib`uibtrib `kb ia cbtíeibk. Isti prk`isk implizc pkr c`tlvc`lðb ji acs `ìauacs Z @J4 pcribtca, acs `ucais lbstruyib c acs `ìauacs dlgcs pcrc jlvljlrsi y jlnirib`lcrsi ib acs jks suopkoac`lkbis `iauacris slb bi`isljcj ji ac prisib`lc ji ubc nuirti istlmuac`lðb cbtleìbl`c. Isti mkjiak prijl`i qui sl ia cbtíeibk bk is coubjcbti (pkr igimpak, jurcbti `lirtcs lbni``lkbis), ibtkb`is acs `ìauacs Z @J4, qui jivlibib c`tlvcjcs, skb c÷b `cpc`is ji jlnirib`lcrsi ib `ìauacs ji mimkrlc. Ib ia `csk ji acs `ìauacs Z @J:, su rispuistc is mãs ditirkeìbic. Pi dc jimkstrcjk qui ac jlnirib`lc`lðb c `ìauacs Z @J: ji mimkrlc, bk riquliri qui acs `ìauacs víreibis pcsib pkr ub istcjk ini`tkr lbtirmijlk mlibtrcs qui acs `ìauacs Z @J4 víreibis, trcbsltcb c trcvìs ji ub istcjk ini`tkr cbtis ji ac jlnirib`lc`lðb jlnirib`lc`lðb c ubc `ìauac Z ji mimkrlc.

 

JLCXK : 

Jlnirib`lc`lðb Jlnirib`lc` lðb ji aks albnk`ltks Z víreibis ib `ìauacs ini`tkrcs Jispuìs ncsi prkalnirctlvc ji ac rispuistc ji `ìauacs Z lbju`ljc pkr LA-?, auiek ji 0 k : jícs ji `ri`lmlibtk rãpljk, acs `ìauacs Z c`tlvcjcs si jlnirib`lcb ib `ìauacs Z ini`tkrcs `cpc`is ji slbtitlzcr tkjcs acs mkaì`uacs ini`tkrcs bi`iscrlcs pcrc sus nub`lkbis ispi`lcalzcjcs `kmk `ìauacs Z `kacokrcjkrcs k `ltktðxl`cs.

-  Ybc viz qui ubc `ìauac Z si dc jlnirib`lcjk ib ubc `ìauac ini`tkrc, ia ib`uibtrk `kb su cbtíeibk ispi`ínl`k jc pkr risuatcjk ia ctcqui lbmubltcrlk slb ac bi`isljcj ji `kistlmuac`lðb.  Acs `ìauacs Z si jlnirib`lcb ib vcrlks suoerupks ji `ìauacs ini`tkrcs nub`lkbcamibti jlstlbtcs. Istcs si jlvljib c jks ercbjis erupks, ubk ji aks `ucais pkrtc ia `krri`iptkr @J4 ib su supirnl`li y ia ktrk pkrtc ia `krri`iptkr @J:. 

-  Acs `ìauacs Z @J4 si jlnirib`lcb tkjcs ib `ìauacs Z @J4 `ltktðxl`cs (albnk`ltks `ltktðxl`ks k @ZA), qui jistruyib sus `ìauacs oacb`k. Pkb lmpkrtcbtis ib ac jinibsc `kbtrc pctðeibks lbtrc`iauacris, ib ispi`lca vlrus6 acs `ìauacs lbni`tcjcs pkr vlrus ixpkbib nrcemibtks ji prktiíbcs vírl`cs `kmk `kmpaigks pìptljks7 MD@ ji `acsi L ib su supirnl`li, qui skb ri`kbk`ljks pkr acs `ìauacs Z `ltktðxl`cs @J4.  

-  acs `ìauacs Z @J: si jlnirib`lcb ib jlvirscs `ìauacs Z ini`tkrcs qui ixpriscb mkaì`uacs ji supirnl`li y si`ritcb `ltk`lbcs qui c`tlvcb ktrcs `ìauacs (albnk`ltks O, mc`rðnceks y `ìauacs jibjrítl`cs).6 ZD3, ZD?, ZD35 y acs `ìauacs Z rieuacjkrcs. NLE 4-?5   Acs ZD3 y ZD? si jlstlbeulirkb prlmirk, slibjk `cpc`is ji `kbtrkacr lbni``lkbis oc`tirlcbcs aiprc). Istcs  Istcs lbtrcvisl`uacris ib aks mc`rðnceks (`kmk ml`koc`tirlcs qui `cuscb tuoir`uaksls y aiprc). oc`tirlcs skb `cptcjcs pkr mc`rðnceks, pirk puijib ivltcr ia mi`cblsmk m i`cblsmk ji ialmlbc`lðb. - 

Ac ZD3  ri`kbk`i cbtíeibks oc`tirlcbks ixpuistks ib ac supirnl`li ji ub mc`rðncek

lbni`tcjk, lbtirc`t÷c `kb ac mlsmc c tca pubtk ji c`tlvcrac, istlmuacbjk ac c`tlvljcj ml`rkol`ljc jia mc`rðncek dcstc `cpc`ltcrak y qui jistruyc acs oc`tirlcs oc` tirlcs jia lbtirlkr ji acs `ìauacs ji nkrmc nkrmc inl`libti. inl`libti. ✐ 

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Ktrc nub`lðb is ac prkju``lðb ji cbtl`uirpks `kbtrc pctðeibks ixtrc`iauacris qui eibircb siócais `kistlmuacjkrcs pcrc albnk`ltks O lbjlnirib`lcjks c`tlvcjks pkr cbtíeibk. Istcs `ìauacs ZD3 lbju`ib tcmolìb ia `cmolk ji ac `acsi ji albnk`ltks O pcrc prkju`lr lsktlpks ji cbtl`uirpk ispi`ínl`k.

Ac ZD?  prkju`ib `ltk`lbcs qui lmpuascb c acs `ìauacs O c jlnirib`lcrsi y prkju`lr

lbmubkeakoualbcs ji ktrks tlpks, ib ispi`lca LeI, y skb rispkbscoais ji lbl`lcr rispuistcs ji `ìauacs O ca c`tlvcr `ìauacs O lbjlnirib`lcjcs lbjl nirib`lcjcs pcrc qui prkalnirib y si`ritib LeM.Ac prkju``lðb ji ac `acsi LeI jia cbtl`uirpk si ib`crec ib `kmoctlr lbni``lðb ji pcrãsltks, tcmolìb isti is ia cbtl`uirpk `cuscbti ji cairelcs. Aks jlvirsks tlpks ji lbmubkeakoualbcs `kbstltuyib ib `kbgubtk acs mkaì`uacs ini`tkrcs ji ac rispuistc lbmubltcrlc dumkrca

 

Zcbtk acs ZD3 y ZD? skb `kbk`ljcs `kmk `ìauacs Z `kacokrcjkrcs (Diapirs) pkr istc rczðb ji prkju``lðb ji cbtl`uirpks. Ktrk suoerupk ri`lìb ri`kbk`ljk ji `ìauacs Z ini`tkrcs @J: skb acs ZD35, qui lbju`ib

c `ìauacs ipltialcais y jia istrkmc ak`cais c prkju`lr qulmlk`lbcs qui ri`autcb biutrðnlaks ib sltlks ji lbni``lðb ca prlb`lplk ji ac rispuistc lbmubltcrlc cjcptctlvc

Zkjcs istcsqui `ìauacs Z ini`tkrcs c`tlvc`lðb ji `ìauacs oacb`k pcrc mkbtcr rispuistcs pirmltcb ialmlbcr`kbtrlouyib ia pctðeibkib jiaac`uirpk. Ia suoerupk ristcbti ji `ìauacs Z ini`tkrcs `kbstc ji acs `ìauacs Z rieuacjkrcs qui si ib`uibtrib ib ac pirlnirlc skb jlstlbtcs nub`lkbcamibti. Xuistk qui suprlmib acs rispuistcs ji `ìauacs Z ib viz ji c`tlvcracs. Istcs lbtirvlibib ib ac c``lðb ji almltcr ac lbmubkrispuistc i lmpljib acs ric``lkbis cutklbmubltcrlcs. Pi ri`kbk`ib ? erupk7 3.  3.  Jistlbcjc c ac c`tlvljcj rieuacjkrc `ucbjk si ib`uibtrc ib ia tlmk (`ìauacs Z rieuacjkrcs bcturcais) ?.  ?.  Ktrc ib ac pirlnirlc ocgk `kbjl`lkbis cmolibtcais ispi`lnl`cs (`kbk`ljcs `kmk `ìauacs rieuacjkrcs cjcptctlvcs). JLCXK 9 

Jiscrrkaak ji aks albnk`ltks Z ji mimkrlc  Ca mibks ia