Regulación y Control de La Expresión Génica

 

Lihsíntcsis `c prhtcínds \coujdaiñn y ahntrhj `c jd cxprcsiñn oéniad7 @urdntc dôhs, jd prhljcmätiad `c jd `ctcrmindaiñn `c jd ndturdjczd `cj mdtcridj ocnétiah mdntuvh cn `isausiñn d jhs aicntíeiahs `c jd éphad. Muabhs arcídn quc jds prhtcínds `clídn scr phrtd`hrcs `c jd inehrmdaiñn ocnétiad `cli`h d quc sc cnahntrdldn cn mdyhr adnti`d` cn cj n÷ajch `c jd aéjujd, sin cmldroh, ordaids d vdrid`hs cxpcrimcnths sc `csaulriñ quc tdj eunaiñn jd hthrodld und sustdnaid ljdnad, dzuadrd`d, jiocrdmcntc äai`d y quc ahntcníd eñsehrh. Cj aicntíeiah Erc`criak Orieeitb ordaids d sus invcstiodaihncs, si licn nh jh cxpush `c mdncrd `ircatd, euc unh `c jhs prcaurshrcs `c jd i`cd `c quc jd inehrmdaiñn ocnétiad sc oudr`dld cn cj D@N. Vhstcrihrmcntc cn jd `éad`d `c 49> y cstä cntrc 5 d ? nuajcñti`hs `cj ah`ñn `c iniaidaiñn. l) Cjh Cjhnod nodaiñ aiñn n `c jd aad`cn d`cnd d pcptí` pcptí`iad iad Snd vcz quc cj rilhshmd sc cnsdmljd cn cj ah`ñn `c iniaidaiñn, ahmicnzd jd ctdpd `c cjhnodaiñn. @urdntc cstd ctdpd, cj sitih D `cj rilhshmd, auyh sitih V cstä haupd`h phr un tD\N ahn jd ad`cnd pcptí`iad cn arcaimicnth h phr cj tD\N iniaid iniaid`hr, `hr, scrä scrä haup haupd`h d`h trd trdnsi nsithr thridm idmcnt cntc c phr sua suacsi csivhs vhs dmi dminhda nhdaijij-tD\ tD\N. N. Jhs dmin dm inhd hdai aijj-tD tD\N \N quc quc hau haupc pcn n cj siti sitih h D scr scrän än dqucjj dqucjjhs hs au auyh yh dn dntitiah` ah`ñn ñn sc scd d ahmpj ahm pjcm cmcnt cntdri drih h dj ah ah`ñn `ñn qu quc c qu quc` c`d d cxp cxpuc ucst sth h cn cs csc c siti sitih. h. Jd cn cntr trd` d`d d `c `cjj dminhdaij-tD\N dj sitih D `cj rilhshmd rcquicrc su uniñn prcvid ahn und prhtcínd jjjjdm dmd` d`d d edathr `c cjhnodaiñn , quc cn su ehrmd dativd cstä uni`d dj OPV. Dj dpdrcdrsc cj tD\N ahn cj mD\N, sc `ispdrd jd bi`rñjisis `cj OPV phr pdrtc `cj edathr `c cjhnodaiñn quc jucoh sc `ishaid, jh audj pcrmitc quc cj dminhdaij-tD\N pcrmdnczad uni`h phr un pcríh`h ahrth dj mD\N. Audn`h tdnth jhs sitihs D ahmh jhs V cstän cstän haupd`hs, haupd`hs, jd pcpti`ij-trdnsecrdsd, auyd dativi`d` rcsi`c cn cj rD\N `c jd suluni`d` mdyhr `cj rilhshmd, adtdjizd jd ehrmdaiñn `c un cnjdac pcptí`iah cntrc jhs `hs dminhäai`hs dahpjdn`h cj primcrh dj scoun`h.

 

Cj primcr tD\N sc `cspjdzd bdaid cj sitih `c sdji`d C y jucoh sc jilcrd. Cj rilhshmd sc mucvc un ahn`ñn d jh jdroh `c jd ad`cnd `c mD\N, cs `cair, sc trdnsjhad; cn ahnscaucnaid, ahnscau cnaid, cj scoun`h tD\N, dj audj dbhrd sc cnaucnt cnaucntrdn rdn dahpjd`hs jd ehrmijmctihnind (h mctihnind cn cuadrihntcs) y cj scoun`h dminhäai`h, sc trdnseicrc `c jd phsiaiñn D d jd V. Sn tcracr dminhdaij-tD\N sc uliad cn jd dbhrd vdadntc phsiaiñn D, dpdrcd`h dj tcracr ahn`ñn mD\N, jd y sc rcpitciniaid`hrd cj prhacsh.csDjilcrd`d mc`i`d quc cj rilhshmd dvdnzd d jh jdroh `c `cj jd ad`cnd, phraiñn pdrd pd rd qu quc c htrh htrh ri rilh lhshm shmd d puc`d puc`d eh ehrm rmdr dr ahn cj cjjd jd ht htrh rh ah ahmp mpjc jcgh gh `c in inia iaid idai aiñn ñn (phjishmd). a) Pcrm Pcrmind indaiñ aiñn n` `c c jd sín síntcs tcsis is Bdaid cj eindj `c jd scaucnaid `c mD\N, bdy un ah`ñn quc dat÷d ahmh scôdj `c tcrmindaiñn. Qc ahnhacn trcs ah`hncs `c tcrmindaiñn -SDO, SDD y SOD- y ahn ercaucnaid bdy mäs `c unh prcscntc bdaid cj eindj `c un mD\N `d`h. Nh cxistc nino÷n tD\N auyh dntiah`ñn sc dpdrc ahn csths ah`hncs, `c mdncrd quc nh cntrdrä nino÷n tD\N dj sitih D pdrd dpdrcdrsc ahn cjjhs. Cxistc Cxis tcn n aicr aicrth thss edat edathr hrcs cs `c jilc jilcrd rdai aiñn ñn qu quc c sc un uncn cn d audj audjqu quic icrr ah`ñ ah`ñn n `c tcrmindaiñn quc djadnzd cj sitih D `cj rilhshmd. Csds prhtcínds djtcrdn jd dativi`d` `c jd pcpti`ij-trdnsecrdsd, jh quc prhvhad quc cj phjipépti`h sc scpdrc `cj tD\N.  Dsí audn`h sc djadnzd un ah`ñn `c tcrmindaiñn sc `cticnc jd trd`uaaiñn, jd ad`cnd phjipcptí`iad sc `csprcn`c y jds `hs suluni`d`cs rilhsñmiads sc scpdrdn. Jhs 1 ed Jhs edat athrc hrcss `c jijilc lcrd rdai aiñn ñn cn pr prhad hadri rihn hntc tcss ah ahnha nhai` i`hs hs sc `cn `cnhm hmin indn dn \E \E-4 -4 (`ctcatd (`ctca td SDD y SDO), \E-< (`ctc (`ctcatd atd SDD y SOD) y \E-1 (unc OPV y dumcntd dumcntd jd dativi`d` `c \E-4 y \E