Reacciones Adversas A Medicamentos, Mecanismos

 

Yfnddamof fnddamofss ncvfrsns n kfcadnkfotms, kfdnoaskms L.J.. LMYFON I YNZM KFOCMRN L.J

 

Aotrmcuddaôo. Fo fl kfrdncm jnrkndmlôhadm kuocanl fxastfo kfcadnkfotms cf vnlmr tfrnpáutadm pmtfodanl rflnta rfln tavm vm,, cu cucm cmsm sm-o -oul ulm m m ao aond ndfp fptn tnil ilf, f, cf nd nduf ufrc rcm m n ln dl dlns nsaj ajad adnd ndaô aôo o du dunl nlat atnt ntav avnn cf lm lmss kfcadnkfotms, kfcadnkfot ms, safocm dmkfrdanlazncms dmkm saotmkîtadms m fo jmrkn cf dmkiaondamofs n cmsas jabns arrndamonlfs pnrn njfddamofs rfsparntmrans, notaaojfddamsms dmo fxpfdtmr fxpfdtmrnotfs, notfs, psadmjîrkndms dmo notafkátadm notafkátadms, s, notatusav notatusavms-fxpfdtmr ms-fxpfdtmrnotfs-notaeas notfs-notaeastnkëoadms, tnkëoadms, prmv prmvmdncm mdncm dmovul dmovulsamofs samofs tôoadm dlôoadns, dlôoa dns, cast castakan, akan, fx fxdatn datndaôo daôo aosm aosmkoam koam,, eapf eapfrsmk rsmkoan, oan, eapm eapmtfka tfkan, n, nluda nludaondam ondamofs, ofs, trn trnstm stmroms roms dnrcamv dnrc amvnsdul nsdulnrfs, nrfs, efpn efpntmt tmtmxa mxadacnc dacnc,, efkm efkmrrn rrnhan han cah cahfsta fstavn, vn, urta urtadnran dnran,, fcfk fcfknn noha nohamofu mofurôt rôtadm adm y semdg nonjalîdtadm jntnl.

 

Fo lns aovfstahndamofs dlëoadns quf dmkprfocf cf duntrm jnsfs duacncmsnkfotf plnofncns, lns trfs prakfrns tafofo luhnr notfs cf ln dmkfrdanlazndaôo y ln dunrtn sf aoadan uon vfz quf fl jîrkndm en sacm nprmincm pnrn sfr usncm fo tfrnpáutadn. Pnrn lms fstucams cf jnrkndmvahalnodan, tnkiaáo llnkncms cf pmstdmkfrdanlazndaôo tapm AZ, lms dunlfs dmostatuyfo uo dmobuotm cf kátmcms, misfrvndamofs y rfhastrms mitfoacms curnotf fl usm fxtfocacm cf uo kfcadnkfotm fo ln ftnpn cf su dmkfrdanlazndaôo, pnrn cftfdtnr rfnddamofs ncvfrsns y mdnsamonlkfotf fjfdtms fjfdtms jnrkndmtfrnpáutadms jnrkndmtfrnpáutadms ifofjadamsms om prfvastms prfvastms fo lns ftnpns prfvans cf dmotrml y fvnlundaôo cfl kfcadnkfotm.

 

Dmo fl mibftavm cf aovfstahnr fl dmkpmrtnkafotm cfl kfcadnkfotm lufhm cf quf su usm fs nprmincm pmr ln nutmracnc snoatnran, kudems pnësfs eno drfncm Tastfkns cf Jnrkndmvahalnodan, cfstao cfs taoncm ncmss n rfd rfdmh mhfr fr,, non nonlaz laznr nr y cas castra traiua iuarr aoj aojmrk mrknda ndaôo ôo ndf ndfrd rdnn cf lns rfn rfndda ddamof mofss ncv ncvfr frsns sns rfdmkfocncm lns kfcacns quf cfifo ncmptnr.

 

Dnrndtfrëstadns cf lns YNK Aokfcantn, curnotf m trns fl trntnkafotm jnrkndmlôhadm

NPNYADAÔO JYFDVFODA N FZASNILFT M AOEFYFOS FT HYNZFCNC

CMTAT

Sfrnpá páut utaadn m smirfcmsajadndaôo

JNDSMYFT JVOSNKFOSNLFT

 

Dlnsajadndaôo Fl mibftavm cf ln dlnsajadndaôo fo lns rfnddamofs ncvfrsns fs snifr sa fs prfvfoailf y dmkm fvatnrln. Ln dlnsajadndaôo pufcf rfnlaznrsf sfhòo2 Hrnvfcnc2 Fb. Tmkomlfodan fo pndafotf dmocudtmr cf nutmiòs Dnusnlacnc2 Vsm cf nlhmratkms Kfdnoaskm Dlëoadn2 cmsas, tafkpm cf prfsfotndaôo y jndtmrfs cf susdfptaialacnc

 

YFNDDAMOFT NCZFYTNT SAPM N M PYFZATAILFT TMO LNT KNT JYFDVFOSFT TMO CMTAT  — CFPFOCAFOSFT DMOTFDVFODAN CAYFDSN M AOCAYFDSN CFL FJFDSM JNYKNDMLÔHADM PVFCFO MDVYYAY FO

DVNL^VAFY DVNL ^VAFY PFYTMON

 

AKPYFZFTAILFT SAPM I m AKPYFZFTAILFT CFPFOCFO CF LN YFTPVFTSN CFL PNDAFOSF OM FTSN FO YFLNDAÔO DMO LN CMTAT

 

YFNDDAMOFT NCZFYTNT PYFZFTAILFT TMIYFCMTAT PMY

CMTAT FUDFTAZN M FLAKAONDAÔO CATKAOVACN

FJFDSMT DMLNSFYNLFT CFYAZNCMT

CFLN KVLSAPLADACNC CF NDDAMOFT JNYKNDMLÔHADNT CF VO KFCADNKFOSM, OM CFTFNLFT FO VO CFSFYKAONCM DMOSFUSM DLAOADM

TF PYMCVDFO N CMTAT SFYNPÁVSADNT FT FL SAPM CF

YFNDDAÔO NCZFYTN N KFCADNKFOSMT KFCADNKFOSMT KÎT JYFDVFOSFT

 

FJFDSMT TFDVFOCNYAMT JFOÔKFOMT

^VF TVFLFO SFOFY YFLNDAÔO AOCAYFDSN DMO LN NDDAÔO JNYKNDMLÔHADN PYAODAPNL CFL KFCADNKFOSM Q TF KNOAJAFTSN DMKM VON OVFZN FOJFYKFCNC

AOSFYNDDAMOFT KFCADNKFOSMTNT LMT

JNYKNDMT PVFCFO AOSFYNDSVYN FOSYF TA, PYMCVDAFOCM NLSFYNDAMOFT FO TVT JNYKNDMDAOÁSADNT YFTPFDSAZNT (NOSNHMOATKMT  — PMSFODANDAÔ PMSFODANDAÔO) O)

 

AKPYFZFTAILFT AOSMLFYNODAN AKPLADN VO AODYFKFOSM CF VO

FJFDSM JNYKNDMLÔ JNYKNDMLÔHADM HADM DNYNDSFYËTSADM CF LN CYMHN Q ^VF, N KFOVCM, TF PYMCVDF DMO PF^VFÞNT CMTAT CF LN KATKN

YFNDDAMOFT ACAMTAODYÎSADNT2 YFTPVFTSN DVNLASNSAZNKFOSF NOMYKNL, CAJFYFOSF CF LNT NDDAMOFT JNYKNDMLÔHADNT

CFL KFCADNKFOSM

TF

PYMCVDF FO PNDAFOSFT TVTDFPSAILFT, OM PMY KFDNOATKMT AOKVOMLÔHADMT

 

YFNDDAMOFT PFTVCMNL PFTVCMNLÁYHADNT2 ÁYHADNT2 NTFKFBNO

VO KFDNOATKM AOKFCANSM SAPM A, PFYM OM TMO KFCANCNT PMY NOSADVFYPMT AhF. TAKVLNO VON YFNDDAMÔO NLÁYHADN YFNDDAMOFT NLÁYHADNT M CF EAPFYTFOTAILAC EAPFYTFOTAILACNC NC

YFTPVFTSN

NOMYKNL N VO KFCADNKFOSM PYMCVDACN PMY KFDNOATKM AOKVOMLÔHADM, EVKMYNL M DFLVLNY

 

DYASFYAMT PNYN CFSFYKAONY FL HYNCM HYNCM 0 PNDAFOSF

Q DMOTVKACMY ACFOSAJADNILF

NL KFOMT VON TYNK, FZ, YNK, FTNZA KFCADNKFOSM

M ZNDVON TMTPFDEMTM

CNSMT CFL OMSAJADNCMY

 

HYNCM > AODLVQFO

LMT CFL HYNCM 0

JFDEN CF AOADM CF LN

TYNK, FN, YNK M FTN FTNZA ZA JFDEN CF AOADAM CFL SYNSNKAFOSM JFDEN CF SFYKAOM CFL SYNSNKAFOSM (CAN, KFT Q NÞM)

 

HYNCM 92 AODLVQF LMT CNSMT CFL HYNCM > CFOMKAONDAÔO

HFOÁYADN

CFOMKAONDAÔO

CATSAOSAZN

PMTMLMHËN ZËN

CF NCKAOATSYNDAÔO

KMSAZM

C FPYFTDYAPDAÔO

DMOTFDVFODAN

CFL FZFOSM

CNSMT AKPMYSNOSFT CF LN EATSMYAN DLAOADN PNYN FL DNTM OVKFYM

CF LMSF

OMKIYF

CFL LNIMYNSMYAM CFL JNIYADNOSF

 

HYNCM 4 AODLVQF LMT CNSMT FL HYNCM9 FL

YFTVLSNCM CF LN YF-NCKAOATSYNDAÔO CFL KFCADNKFOSM M ZNDVON

 

DYASFYAMT CF HYNZFCNC HYNZFT (TFYANT)2 SMCN KNOAJFTSNDAÔO DLËOADN ^VF TF PYFTFON DMO LN NCKAOTASYNDAÔO CF DVNL^VAFY CMTAT CF VO KFCADNKFOSM AODLVQFOCM ZNDVONT. DNVTNY

LN KVFYSF

PMOFY FO

PFLAHYM LN KVFYSF CFL PNDAFOSF FO FL KMKFOSM KATKM ^VF TF PYFTFOSNO

ENDFO OFTNYAM EMTPASNLARNY M PYMLMOHNY LN FTSNODAN EMTPASNLNYAN TMO DNVTN C FAOZNLACFR M CF AODNPNDACNC PFYKNOFOSF M TAHOAJADNSAZN TMO DNVTN CF NLSFYNDAMOFT M KNLJMYKNDAMOFT KNLJMYKNDAMOFT FO FL

OM HYNZFT

YFDAFOSF ONDACM

 

TFZFYACNC LFZFT. PYFTFOSNO TAHOMT Q TËOSMKN JNDALKFOSF SMLFYNCMT, OM OFDFTASNO SYNSNKAFOSM KMCFYNCNT2 AOSFYJAFYF NDSAZACNCFT ENIASVNLFT NKFONRNO LN ZACN CFL PU, YF^VAFYFDMO CF SULNT JNYKNDMLÔHADM Q PVFCF M(OM OM YF^VFYAY LNCAYFDSNKFOSF TVTPFOTAÔO CFL KFCADNKFOSM DNVTNOSF

TFZFYNT2 AOSFYJAFYF DMO LNT NDSAZNCFT ENIASVNLFT, YF^VAFYF SU JNYKNDMLÔHADM Q LN TVTPFOTAÔO CFL KFCANKFOSM DNVTNOSF. DNVTNOSF.

 

DLNTAJADNO Ln dlnsajadndaôo kîs utalazncn y ndfptncn fs ln prmpufst prmpufstnn fo >11> pmr Ynwlaos y Semkpsmo, fo ln quf sf cfsdraifo cms hrnocfs dntfhmrëns dntfhmrëns cf fjfdtms aocfsfncms2

 

Sapm N nukfotncns Nqufllns quf hunrcno rflndaôo dmo fl kfdnoaskm cf nddaôo cfl jîrkndm y sf cfifo n ln prmpan ndtavacnc jnrkndmlôhadn jnrkndmlôhadn cf ln kmláduln. Dmosfdufodan

SAPM N

cf l

fjfdtm

FJFDSM TFDVOCNYAM

jnrkndml jnrkn dmlôha ôhadm dm iusd iusdncm ncm,, pfr pfrm m om sf cfifo n ln nddaôo jnrkndmlôhadn praodapnl

FJFDSM DMLNSFYNL

Dmosfdufodan carfdtn cf ln nddaôo jnrkndmlôhadn cfl kfcadnkfotm

SMUADACNC TMIYFCMTAT YFLNSAZN

Caden nddaôo tmxadn pufcf cfsfkpfþnrln fl kfcadnkfotm m sus kftnimlatms n cmsas dmrrfdtns

 

Sapm I Ynrns Tmo nqufllns rfnddamofs fxtrnþns, jnrkndmlôhadnkfotf akprfvasailfs. Fl kfdnoaskm akpladncm suflf sfr cfsdmomdacm cfravncm cf ln eapfrsfosaialacnc m acamsaodrnsan y sakuln eniatunlkfotf uon fo fojf jfrk rkfcn fcnc c mr mrhî hîoad oadnn dun dunlat latnt ntav avnkf nkfot otff caj cajfr frfot fotff cf lms fj fjfdt fdtms ms jn jnrkn rkndml dmlôha ôhadms dms qu quff dnrndtfrazno nl kfcadnkfotm. Eniatunlkfotf, suflfo om cfpfocfr cf ln cmsas, sfr akprfcfdailfs dmo insf fo lns nddamofs jnrkndmlôhadns cfl kfcadnkfotm, tfofr tnsns flfvncns cf kmrtnlacnc y inbns cf kmrialacnc y omrknlkfotff sfr fvacfodancns dunocm fl prmcudtm fs dmkfrdanlazncm. omrknlkfot dmkfrdanlazncm.

 

Yfnddaôo Acamsaodrîsadn

Tfosaialac Tfosaia lacnc nc aoca aocavacu vacunl nl pnrtadulnr n lms fjfdtms cf uo jîrkndm

>.- nlt >.ltfr frnd ndaô aôo o fo fl kftnimlaskm cfl kfcadnkfotm 9.- rfspufs rfspufstn tn nltf nltfrncn rncn cfl mrhnoaskm

Sapm I

Yfnddaôo nlárhadn m eapfrsfosaialacnc

Aotmlfrnodan

Yfnddaôo Yfnd daôo aokuoml aokuomlôhadn ôhadn qu f npnrfdf pmr ontu on turn rnlf lfzn zn no nota tahá háoad oadnn cfl jîrkndm

Tu npnradaôo fstn nsmdancm n nltfrndamofs hfoátadns

 

Dlnsa Dlnsajad jadndaô ndaôo o H Hfll fll y Dmmkis Dmmk is Ln rfspufstn nlárhadn sf pufcf dlnsajadnr fo 3 tapms castaotms cf rfnddamofs cf eapfrsfosaialacnc, ntfocafocm n lms dmkpmofo dmkpmofotfs tfs cfl sastfkn aokuof ncnptntavm quf ln aoadano (eukmrnl-AhF (eukmrnl-AhF m AhH, m dflulnr-laojmdatm S) y n ln onturnlfzn cfl nlárhfom quf lns prmvmdn (smluilf m nsmdancm n kfkirnons)

 

Yfnddaôo cf eapfrsfosaialacnc tapm A Fs aok aokfca fcant ntn, n, kfc kfcanc ancnn pmr Ah AhF, F, nt ntôpa ôpadns dns m nlá nlárh rhadn adns, s, smo rf rfndd nddamo amofs fs aoj aojlnk lnknt ntmra mrans ns quf sf prmcudfo fo kaoutms prmcudfo kaoutms n trn trnvás vás cf knstmdatm knstmdatmss y insôj insôjalms. alms. Ln kmláduln kmláduln fjfdtmr fjfdtmrnn fs ln AhF y su rfdfptmr JdѓYA cf nltn njaoacnc. Tf prmcudf uon cfhrnoulndaôo cfhrnoulndaôo cf cadens dálulns fo ôrhnoms radms fo fllns,, dmk fllns dmkm m pafl, npnr npnrntm ntm rfsp rfsparn arntmra tmram, m, npnr npnrntm ntm cahf cahfstav stavm, m, npnr npnrntm ntm dard dardulnt ulntmram mram y sast sastfkn fkn ofrvamsm.

 

Kfdnoaskm Fl mrhnoaskm rfnddamon jrfotf n notëhfoms smluilfs (nlárhfoms) kfcanotf uon rfspufstn cf tapm AhF-Jd cfpfocafotf quf sf cfsnrrmlln fo sfhuocm m kaoutms. Ln rfnddaôo aokfcantn cfpfocf cf ln sfd sfdrfd rfdaôo aôo cf sus sustn tnoda odans ns vn vnsmn smndta dtavn vnss pr prfj fjmrk mrkncn ncnss y nlk nlkndf ndfonc oncns ns fo lms hr hrîou îoulms lms cf lms knstmdatms, dmkm ln eastnkaon y ln ytraptnsn, cfravncms cf su kfkirnon dmkm lfudmtrafom, prmstnhlnocaons fl jndtmrkfcancmrfs ndtavncm cflapëcadms lns plnquftns. Ln rfnddaôo tnrcën sf prmcu pr mcudf df pmr ln sëo sëotfs tfsas as aoc aocuda udacn cn cf ouf oufvm vmss kf kfcan cancmr cmrfs fs dmk dmkm m lfu lfudm dmtra trafom fomss y ouk oukfr frmsn msnss quakamdaons y datmsaons datmsaons dmkm AL-3, AL-6, AL-1, AL->4 SOJ-ξ

 

Yfnddaôo cf eapfrsfosaialacnc tapm AA Tmo rfnddamofs datmlëtadns quf sf prmcudfo fo emrns n trnvás cf ln ndtavndaôo cfl dmkplfkfotm y jnhmdatmsas pmr ofutrôjalms. Ln kmláduln fjfdtmrn fs ln AhH m AhK y sus rfdfptmrfs Jd n oavfl cf efkntëfs y plnquftns. Tf prmcudfo uon lasas m rmturn cf ln kfkirnon cf fstms flfkfotms jmrkfs cf ln snohrf.

 

Kfdnoaskm Fo fstns rfnddamofs, fl nlárhfom fs tnkiaáo uon kmláduln smluilf, pfrm sf uof n ln supfrjadaf cf lns dálulns m cf ln kntraz fxtrndflulnr, hfofrîocmsf ofmnotëhfoms quf smo rfdmomdacms pmr notadufrpms cfl tapm AhH. Fstms notadufrpms AhH ndtavno fl dmkplfkfotm y rfnddamofs kfcancns pmr Jd uoacm (jnhmdatmsas f eastôlasas dflulnrcfl kfcancn pmr notadufrpms), cfstruyfocm lns dálulns quf llfvno fl nlárhfom. Ln uoaôo notadufrpm AhH dmo ln supfrjadaf dflulnr m ln kntraz fxtrndflulnr ndtavno ln dnsdncn cfl dmkplfkfotm y cf lns dálulns datmlëtadns dmo rfdfptmrfs Jd pnrn AhH, buotm dmo jnhmdatmsas. Lms efkntëfs smo lms flfkfotms jmrkfs kîs njfdtncms nl dnrfdfr cf kfoms prmtfëons rfhulncmrns cfl dmkplfkfotm fo su supfrjadaf quf mtrms flfkfotms m dálulns cf ln snohrf.

 

Lms jrnhkfotms Jd cf lns AhH sfrîo rfdmomdacms pmr rfdfptmrfs fspfdëjadms cf nltn njaoacnc (JdδYA) uiadncms praodapnlkfotf fo dálulns kndrmjîhadns. Cf fstf kmcm, lms hlôiulms rmbms, ofutrôjalms m plnquftns sfrîo sndncms cf dardulndaôo dunocm pnsfo n trnvás cfl sastfkn rftëdulmfocmtflanl fo n, fl cfpfocafocm eëhncm y fl inzm. Dlëoadnkfo tf sf trncudarî fo nofkan efkmlëtadn, ofutrmpfoan m plnquftmpfoan, plnquftmpfoa cf lnDlëoadnkfotf dáluln ilnodm.

 

Yfnddaôo cf eapfrsfosaialacnc tapm AAA

Tmo rf Tmo rfnd ndda damo mofs fs ao aojl jlnk nknt ntmr mran anss qu quff sf pr prmc mcud udfo fo fo em emrn rnss n tr trnv nvás ás cf ln nd ndta tavn vnda daôo ôo cf cfll dmkplfkfotm, jmrkndaôo cf aokuomdmkplfbms (AD), quakamtnxas cf ofutrôjalms y laifrndaôo cf fozakns tôxadns. Ln kmláduln fjfdtmrn fs ln jrnddaôo D4i cfl dmkplfkfotm. Tf prmcudf uo cf cfpô pôsa satm tm cf AD fo lm lmss ôr ôrhhno noms ms cf de demq mquf uf,, dm dmkm km pa pafl fl,, vn vnsm smss sn snoh ohuë uëof ofms ms,, hl hlmk mkár árul ulms ms y nrtadulndamofs.

 

Kfdnoaskm

Ta lms notëhfoms smo smluilfs, tnkiaáo sf pufcfo jmrknr AD dmo notadufrpms cf asmtapm AhH. Lms AD nl cfpmsatnrsf dnusno rfnddamofs aojlnkntmrans lmdnlfs Jd-cfpfocafotfs, ndtavîocmsf tnkiaáo fl sastfkn cfl dmkplfkfotm y prmvmdnocm ln cfstruddaôo cf fstms dmkplfbms pmr jnhmdatmsas. Nl ahunl quf lns rfnddamofs tapm AA, tnrcno uons emrns fotrf ln fxpmsadaôo nl notëhfom y fl cfsnrrmllm cfl duncrm dlëoadm

 

Yf Yfndda nddamofs mofs cf cf eapfr eapfrsfosa sfosailac ilacnc nc tapm AZ AZ

Tmo rfnddamofs aojlnkntmrans quf sf prmcudfo fo cëns n trnvás cf ln ndtavndaôo cf laojmdatms S datmtô datm tôxadm xadmss y sfdr sfdrfdaôo fdaôo cf aot aotfrlud frludaons aons (AL) dmkm rfspufstn rfspufstn n uo ofmontëhfom ofmontëhfom.. Ln kmlá kmláduln duln fjfdtmr fs fl jndtmr cf ofdrmsas tukmrnl   ξ  (SOJ-ξ), sf prmcudf uo cnþm tasulnr n oavfl cf pafl y kudmsns. Pnrn lns rfnddamofs kfcancns pmr jîrkndms, sf utalazn uon oufvn dlnsajadndaôo fo ln quf lns rfnddamofs cf tapm AZ qufcno suicavacacns.

 

Lms laojmdatms laojmdatms Se> sfdrftno sfdrftno aot aotfrjfrôo frjfrôo   ϙ (AJO-ϙ) quf ndtavn n lms

YFNDDAMOFT SAPM AZ n

kndrôj kndr ôjnh nhms ms/k /kmo momd mdat atms ms y ca cara rahf hfo o ln prmcuddaôo cf notadufrpms jabncmrfs cfl dmkplfkfotm sakalnrfs n lns rfnddamofs tapm ta pm AA y AA AAA, A, pr prmc mcud udfo fo uo uon n rf rfsp spuf ufst stn n prmaojlnkntmran prmaojlnk ntmran n trnvás cf SOJ-ξ f AL->9 y uon rfspufstn kfcancnn ln pmr laojmdatms S DC5+ fbfkplm rfnddaôo tuifrdulaon tuifrdulao n y ln cfrkntatas cf dmotndtm

 

YFNDDAMOFT SAPM AZ i

Lms laojmdatms Se9 sfdrftno AL-3 f VG->4 quf prmkufvfo ln prmcuddaôo cf AhF f AhH3 Ah H3 pm pmrr la laoj ojmd mdat atms ms I y ln nd ndta tavn vnda daôo ôo knstmdatnran, lms laojmdatms Se9 tnkiaáo sfdrftno AL-6 quf prmkufvf rfspufstns kfca kf canc ncns ns pm pmrr fm fmsa saoô oôja jalm lmss fb fbfk fkpl plm2 m2 rfnddamofs cf fxnotfkns kndulmpnpu kndulmpnpulnrfs lnrfs dmo fmsaomjalan y raoatasnskn nlárhadns drôoadns

 

YFNDDAMOFT SAPM AZ d

Lms la Lms laoj ojmd mdat atms ms S nd ndtò tòno no dm dmkm km dá dálu luln lnss fjfd fj fdtmr tmrns ns pmr sa kas kaskns kns,, cfs cfstru truyfo yfocm cm tfbacms tfba cms (efp (efpntmd ntmdatm atm m qufr qufrntao ntaomdat mdatm) m) n trnvás cf lms sastfkns pfrjmraon/hrnozakn I y jns-lahnocm. Pmr fstf fs tf kf kfdn dnoa oask skm m sf pr prmc mcud udf f ln hr hrno no knym kn ymrë rën n cf ln lnss rf rfnd ndda damo mofs fs du dutî tîof ofns ns rcfrkntatas ftnr ft nrcn cnc cns cfpdmotndtm, mr jîr îrkn knd dmk mkm m lms ln dmotndtm , lndms knymrën cf fxnotfkns kndulmpnpulmsms, fojfrkfc foj frkfcncfs ncfs nkpm nkpmllms llmsns, ns, rfnd rfnddamo damofs fs ofutrmjaladns y njfdtndamofs pnrfoquaontmsns

 

YFNDDAMOFT SAPM AZ c

Tmo Tmo rfn fnddda dam mofs of ofu utr trm mjë jëllad adns ns.. Lms laojmdatms S prmkufvfo fl rfdlutnkafotm cf of ofu utr trôj ôjal alm ms n tr trn nvás cf jnd ndtm tmrr fstakulnotf cf dmlmoans cf hrnoulmdatmskmomdatms (HK-DTJ) y ln prfvfodaôo cf su npmptmsas n trnvás cf DUDL5. tnkiaáo sf pr prmc mcud udfo fo pm pmrr fs fstf tf kf kfdn dnoa oask skm m ln fo fojf jfrkf rkfcn cnc c cf Ife Ifeff fftt y ln ps psmra mransa nsass pustulmsn

 

Lms jîrkndms smo lms òoadms nlárhfoms dnpndfs cf prmvmd prmvmdnr nr rfnddamofs cf eapfrsfosaialacnc pmr lms saftf kfdnoaskms (A, AA, AAA, Avn, Avi, Avd, Avc).