Processos Fermentativos - Produção de Vacinas

 

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2.> PRFNI^^ÎHIEZF KMEÎA I NFEZRFAI JI _YÎAMJÎJI JF

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?. MEZR MEZRFJ FJYÃ YÃÎF ÎF ^icuejf Juorti (20?;) Ef sínuaf TMT surcmu à prfjuãîf jo vonmeo nfetro o vorèfao. Os vonmeos uatmhohieti istîf siejf mejmspiesïvims poro f sir  duhoef, iaos prfticih nfetro jmvirsos jfieãos mekinnmfsos. Nfh o prfjuãîf ji vonmeos, fs vèrus nfhf7 romvo, mekauiezo i dipotmti B kfroh nfhbotmjos i istîf oti dfgi siejf nfhirnmoamzojfs. Iaos sirvih poro nfhbotir f vèrus i prfticir ih jitirhmeojfs nosfs, qui pfji sir itiref, fu pfr uh pirèfjf ji tihpf. Fs hmnrfrcoemshfs utmamzojfs eos vonmeos pfjih sir vèrus, bontírmos, prftfzfïrmfs fu kuecfs iekroquinmjfs, hfrtfs fu ih pijoãfs, nfhf í f nosf jf vèrus Mekauiezo. Of sirih megitojfs ef nfrpf, f smstiho rioci i hoejo caþbuafs caþb uafs broenfs broenfs poro otonor fs ‑mevosfris ‑mevosfris‘. ‘. O portmr joè, nrmoh o hihþ hihþrmo rmo ji nfhf nfhbotir isso ohioão. Nosf ietri ih nfetotf nfh o jfieão ji virjoji, f frcoemshf gï sobi nfhf riocmr i eih ndico o oprisietor fs smetfhos. (NMEZRO, 20?4) F Bros Brosmama í ri riki kiri rien enmo mo huej huejmo moaa ih vo vonm nmeo eoãî ãîf f i ou outf tf-s -suk ukmn mnmi miet eti i eo prfjuãîf ji mhuefbmfaþcmnfs, kobrmnojfs piao Kuejoãîf Fswoajf Nruz, ef Rmf ji Goeimrf, i piaf Mestmtutf Butoetoe, ih ^îf Pouaf. Of tfjf, sîf homs ji >; hma soaos ji vonmeoãîf ispoadojos pfr tfjf f poès, feji sîf opamnojos >00 hmadùis ji jfsis pfr oef. F poès omejo os ixpfrto poro homs ji 30 eoãùis. (NMEZRO, 20?4) ^obiejf qui eisti oef f vèrus nfvmj-?= jisnfbirtf ih jizihbrf ji 20?= eo ndmeo, f huejf si hfbmamzfu poro o kobrmnoãîf ji uho vonmeo nfh f fbgitmvf ji nissor o prfpocoãîf jo jfieão i mhuemzor o pfpuaoãîf huejmoa. Pfríh os mekfrhoãùis ji vonmeos sîf ji tistis i homs tistis rioamzojfs ef Brosma i ef huejf, feji si onrijmto qui pfji dovir uho vonmeo poro 202?. Nfh tujf f troboadf jihfestro f prfnissf kirhietotmvf ji vonmeos, poro ietiejmhietf ji suo prfjuãîf i kuenmfeoamjoji.

 

2. PRFNI^ PRFNI^^F^ ^F^ KIRHI KIRHIEZO EZOZM[ ZM[F^ F^ ^icuejf Jmemz i Kirrimro, f usf jos vonmeos ojhmemstrojos otuoahieti vom ogujor ef jisievfavmhietf ji futros omejo homs ikmnozis. O ndicojo jo bmftinefafcmo hfjireo trfuxi nfh iao me÷hiros tínemnos nfhf istrotícmo ji nafeocih cçemno i hutocçei, f qui ogujo eo prfjuãîf ji hmnrfrcoemshfs otieuoetis jo vonmeo. (JMEMW I KIRRIMRO, 20?0) Ixmstih vonmeos nfh prfprmijojis tiropçutmnos qui tih nfhf fbgitmvf nfet nf etrf rfao aorr os me meki kinã nãùi ùiss nr nrúe úemn mnos os fu jfie jfieão ãoss ji jici ciei eiro rotmv tmvos os,, rivi rivirt rtie iejf jf smtuoãùis eos quoms f smstiho mhuefaþcmnf jf mejmvèjuf eîf rispfeji, jmz Jmemz i Kirrimro. (JMEMW I KIRRIMRO, 20?0) F jisievfavmhietf jo vonmeo qui nfh os prfprmijojis tiropçutmnos poro nfetrfaor f nâenir ossfnmojf à mekinãîf piaf DP[ í uho pirspintmvo bih metirissoeti i ispiroeãfso, pfms f qui si ispiro jisso vonmeo í qui iao fkirião prftiãîf poro fs jmvirsfs tmpfs ji DP[ i privmeo f surcmhietf ji tuhfris efs mejmvèjufs gï mekintojfs. (JMEMW I KIRRIMRO, 20?0) F prfnissf prfjutmvf ji vonmeos í nfhpfstf pfr quotrf kosis7 M.

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I norontirmzojf piao frmcih jo vonmeo. Poro os vonmeos vmroms f prfnissf í kimtf otrovís jo ripamnocih niauaor, gï os vonmeos bontirmoeos sîf prfjuzmjos ih uh prfnissf ji kirhietoãîf ji mesuhfs i nfegucoãîf ji prmenmpmf otmvf. F nfenietrojf vonmeoa sþ pfji sir jmspfembmamzojf opþs nfenausîf jo oeoamsi quoamt quo amtotm otmvo, vo, pfms pfms ist isto o iev ievfav favi i uho uho siqñie siqñienmo nmoaa ji tis tisti ti kès kèsmnf mnfs, s, què quèhmn hmnfs, fs, bmfaþcmnfs i hmnrfbmfaþcmnfs qui onfetinih smhuatoeiohieti. F nfenietrojf vonm vo nmeo eoaa í hoet hoetmj mjf f ih nâ nâho horo ro kr krmo mo nf nfh h tihp tihpir irot otur uros os mj mjio ioms ms poro poro su suo o hoeutieãîf.

 

2.2 KFRHYAOÃÎF  Opþs o itopo jf nfenietrojf vonmeoa onfetini o kfrhuaoãîf, feji sîf ojmnmfeojfs nfhpfeietis qui tih kueãîf ji istobmamzor o vonmeo i jmaumr o nfenietroãîf jf vèrus fu pfamssonorèjif eo kroãîf mjioa poro opamnoãîf ef sir  duhoef. Nfh mssf ciro-si o vonmeo o croeia i f hishf prfnijmhietfs ji oeïamsi jf nfenietrojf sîf rioamzojfs. O jmkirieão istï eo pfssmbmamjoji ji prfssicumr f prfnissf prfjutmvf ih poroaiaf nfh f nfetrfai ji quoamjoji, pfríh f usf jisti prfjutf í nfejmnmfeojf à nfenausîf jo ovoamoãîf quoamtotmvo i fbgi fbgitmtmvf vf jist jisto o oeïa oeïams msi i í vi virm rmkmn kmnor or pfss pfssèv èvia ia nf nfet etoh ohme meoã oãîf îf of af afec ecf f jf prfnissf.

 

2.> PRFNI^ PRFNI^^OH ^OHIEZ IEZF F KMEOA KMEOA I NFEZRF NFEZRFAI AI JI _YOAMJ _YOAMJOJI OJI

JF PRFJYZF  Opþs os virmkmnoãùis einissïrmos o vonmeo o croeia i troeskirmjo poro krosnfs nfrrispfejietis of e÷hirf ji jfsis iqumvoaietis à oprisietoãîf jmstrmbuèjo à pfpuaoãîf. pfpuaoãîf. F prfnissohie prfnissohietf tf kmeoa ievfavi trçs itopos7

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Ievosi7 ä uho itopo feji o vonmeo í troeskirmjo jfs toequis o croeia ji me mefx fx po poro ro fs kr kros osnf nfss ji vmjr vmjrfs fs gï is isti tirm rmamz amzoj ojfs fs i kind kindoj ojfs fs eo siqñçenmo. Gï os vonmeos amfkmamzojos rinibih uh kindohietf pornmoa i fs krosn krosnfs fs sîf sîf tr troe oesp spfr frto tojf jfss vmo vmo boej boejig igos os po poro ro uh iq iqum umpo pohi hiet etf f ndohojf amfkmamzojf.

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Amfkmamzoãîf7  o vonmeo amq amqumjo umjo í uh prfj prfjutf utf humtf mestïv mestïvia, ia, i nfh mssf i ojmnmfeojf uh istobmamzojfr ef prfnissf, pfríh, isto fpãîf omejo í meikmnmieti poro oacues prfjutfs, feji si ojfto o ritmrojo jo uhmjoji jo vonmeo, troeskfrhoejf-o ih uho postmado ji pþ. Opþs o nfenausîf jf nmnaf ji amfkmamzoãîf, fs krosnfs sîf kindojfs tftoahieti nfh rfados qui rinibiroh ef prfnissf ji ievosi. F tirhmef jisti prfnijmhietf, fs krosnfs sicuih mhijmotohieti poro uho hïqumeo ji opamnoãîf ji uh siaf si af ji oau oauhèe hèemf mf qui aon aonro ro nojo nojo krosnf krosnf mej mejmvm mvmju juoah oahiet ieti. i. Ist Istis is sî sîf f

 

orhozi orh ozieoj eojfs fs ih nâhoro nâhoro krm krmo o siporo siporojfs jfs pfr aft aftis, is, otí sic sicumr umr po poro ro rftuaocih i ihboaocih.

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Rftuaocih i ihboaocih7 f prfnissohie prfnissohietf tf kmeoa nfesmsti ih ihboaor o vonm vo nmeo eo nf nfet etie iejf jf o vo vonm nmeo eo amfk amfkmamamz mzoj ojo, o, amamqu qumj mjo o fu f jm jmau auie ieti ti po poro ro rinibirih rþtuafs nfh mjietmkmnoãîf jf prfjutf, e÷hirf ji afti, joto ji kobr ko brmn mnoã oãîf îf i vo voamamjo joji ji jf pr prfj fjut utf, f, ie ietr tri i fu futr tros os me mekf kfrh rhoã oãùi ùis. s. Fs nort no rtun undf dfss sîf sîf onfe onfejm jmnm nmfe feoj ojfs fs ih no nomx mxo o ji popi popiaî aîf f i ji jipf pfms ms sîf sîf tr troe oesk skir irmj mjfs fs po poro ro f oa oahf hfxxor ormkmkoj ojf f ji prfj prfjut utfs fs on onob oboj ojfs fs,, pf pfri rih h pirhoeinih ih ïrio sicricojo poro prfjutfs ih quorietieo otí o nfen nf enau ausî sîf f jf nfet nfetrf rfai ai ji quoa quoamj mjoj oji i i ih ihms mssî sîf f jf ni nirt rtmkmkmn mnoj ojf f ji ambiroãîf jf prfjutf.

>. NFE^ NFE^MJ MJIR IROÃ OÃÎF ÎF KMEOA KMEOA Ih vmrtuj vmrtuji i jfs kotfs kotfs hie hienmf nmfeo eojfs jfs ef jin jinfrr frrir ir jis jissi si tro troboa boadf, df, os vonmeos sîf uho prftiãîf issienmoa poro o vmjo i so÷ji jf sir duhoef. Ef Brosma isso kirrohieto nfetro jfieãos vih ivfaumejf nojo viz homs of afecf jfs oefs. Istos ocih ef smstiho mhuefaþcmnf, poro istmhuaor o prfjuãîf ji oetmnfrpfs i efs efs mhuemzor ji hmnrfrcoemshfs potfcçemnfs nfhf, nfhf, kuecfs, vèrus i bo bont ntír írmo mos, s, pfr pfr ms mssf sf hu humtmtos os vi vizi ziss si siu u prme prmenm nmpm pmf f otmv otmvf f í nfhp nfhpfs fstf tf pi piaf afss hishfs siris vmvfs nousojfris jo jfieão. Nfen Nf enau auèh èhfs fs qui qui poro poro no nojo jo tmpf tmpf ji hm hmnr nrfr frco coem emsh shfs fs utma utmamz mzoh ohfs fs uh prfnissf prfnis sf ji prf prfjuã juãîf îf ji vo vonme nmeo o jmk jmkiri irieti eti.. Ef nos nosf f jos bo bonti ntirmo rmoeos eos,, pfr  ixihpaf, opamno-si f prfnissf kirhietotmvf. Í mhprisnmejèvia qui eo kobrmnoãîf ji quoaquir ixihpaf ji vonmeo, jipfms jipf ms qui si ixtrom f nfenietroj nfenietrojf f vonmeoa vonmeoa,, rioamzor tfjfs fs tisti tistiss kèsmnfs, quèhmnfs, bmfaþcmnf i hmnrfbmfaþcmnfs, sihpri nfetrfaoejf suo tihpiroturo. [mhfs qui toms oeïamsis tohbíh sîf einissïrmos ef hfhietf jo kfrhuaoãîf feji f nfenietrojf í istobmamzojf i jmauèjf poro uho mjioa jfsocih of sir  duhoef.  Of kmeoa ji tujf, oaíh ji fbsirvorhfs homs oeïamsis ji nfetrfai ji quoa qu oamj mjoj oji, i, f qu qui i í humt humtf f mh mhpf pfrt rtoe oeti ti po poro ro qu qui i eî eîf f og ogo o nf nfet etoh ohme meoã oãîf îf,,

 

onfetinih tohbíh às itopos ji ievosi, amfkmamzoãîf, rftuaocih i ihboaocih jos vonmeos. Pirnibi-si qui poro rioamzorhfs o prfjuãîf ji uho vonmeo ikmnoz, í einissïrmf uh bfh hfemtfrohietf ih nojo itopo jf prfnissf, uh nfetrfai ji quoamjoji mhpinïvia i jisihpiedor tfjfs fs tistis prmhfrjmoms of kmeoa ji suo iaobfroãîf.

 

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