Proceedings and Program - 21st International "Stress and Behavior" Neuroscience and Biopsychiatry Conference, St-Petersburg, Russia (May 16-19, 2014)
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21st International "Stress and Behavior" Neuroscience and Biopsychiatry Conference, St-Petersburg, Russia (May...
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IN PARTNERSHIP WITH: The Russian Society for BioPsychiatry (RSBP) The Ukrainian Society for Biological Psychiatry (USBP) Journal BRAIN, BEHAVIOR AND IMMUNITY The International Zebrafish Neuroscience Research Consortium (ZNRC)
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The International Stress and Behavior Society (ISBS) Centre for Physiology and Biochemical Research (CPBR) Institute of Experimental Medicine (IEM RAMS) The Russian Society for Biopsychiatry (RSBP The Ukrainian Society for Biological Psychiatry (USBP) ZENEREI Institute
Proceedings and Program 21st Multidisciplinary International Neuroscience and Biological Psychiatry
“Stress and Behavior” Conference
St-Petersburg, Russia Mayst 16-19, 2014
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CONFERENCE PROGRAM Day 1. Fri, May 16, 2014 Oktiabrskaya Hotel, Grand hall (2nd floor), 10 Ligovsky Prospect, St-Petersburg, Russia 08.00-18.00
Conference registration
Morning session 09.00-09.20 09.20-10.00
10.00-10.40
OPENING CEREMONY AND WELCOMING ADDRESSES. AV Kalueff (Conference Chair and ISBS President), VM Klimenko (Program Committee Chair) SPECIAL ISBS LECTURE: GENETIC DISRUPTION OF THE STRESS AXIS CAUSES A DEPRESSIONLIKE DISORDER IN ZEBRAFISH: FROM GENETIC TO CHEMICAL SCREENS IN A SMALL VERTEBRATE. H Baier, Max Planck Institute of Neurobiology, Munich, Germany ISBS LECTURE: LINGUISTIC ANALYSIS OF PRE-COMPETITION INTERVIEWS REVEAL ANXIETY STATES AND PREDICT THE OUTCOME OF PROFESSIONAL BOXING BOUTS. JE Warnick (ISBS Fellow), Arkansas Tech University, Russellville, AR, USA
10.40-11.00
Coffee break
11.00-11.40 11.40-12.20
SALIVA AS DIAGNOSTIC MEDIUM IN STRESS RESEARCH. A Ernst, Salimetrics LLC, Newmarket, UK A REVIEW ON BEHAVIORAL EQUIPMENT EXISTING TODAY TO MONITOR BEHAVIORAL CHANGES IN RODENTS. J Fehmer, TSE Systems GmbH, Bad Homburg, Germany ANIMAL MODELS FOR STUDYING PTSD: THE NEED FOR MULTI-MODAL AND MULTI-FUNCTIONAL MEASUREMENT SYSTEMS IN LABORATORY ANIMAL RESEARCH AND MATRIX ANALYSIS. L Bachdasarian, R Bulthuis, E Molenwijk, M Boscaro and P Meuth, Metris BV, Netherlands; Data Sciences International, St. Paul, MN, USA; Institute of Physiology I, Department of Neurology - Inflammatory Disorders of the Nervous System and Neurooncology, Westfalische Wilhelms-Universitat Munster, Germany
12.20-13.00
13.00-14.00
Lunch Break and Exhibition
Afternoon session 14.00-16.00
SYMPOSIUM I. ADVANCES IN MONOAMINERGIC NEUROTRANSMISSION Chair: R Gainetdinov (Italy, Russia), presentations 30 min
THE ROLE OF DIFFERENT DOPAMINE RELEASE PATTERNS IN ALCOHOL DRINKING BEHAVIORS. EA Budygin (ISBS Fellow), Wake Forest School of Medicine, Winston-Salem, NC, USA BEYOND THE DOPAMINE TRANSPORTER: DISCOVERING A NEW AMPHETAMINE TARGET. L Carvelli, Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA DISCOVERY AND CHARACTERIZATION OF SELECTIVE TAAR1 AGONISTS AS POTENTIAL THERAPEUTIC DRUGS IN THE FIELD OF MENTAL ILLNESS. MC Hoener, A Harmeier, RD Norcross, TL Wallace, C Risterucci, J-L Moreau and JG Wettstein, F. Hoffmann-La Roche, Basel, Switzerland; SRI International, Menlo Park, CA, USA CHRONIC SSRI TREATMENT EXACERBATES SEROTONIN DEFICIENCY IN HUMANIZED TPH2 MUTANT MICE. WB Siesser, BD Sachs, AJ Ramsey, TD Sotnikova, JM Beaulieu, X Zhang, MG Caron and RR Gainetdinov (ISBS Fellow), Department of Neuroscience and Brain Technologies, Italian Institute of Technology, Genova, Italy
16.00-16.15
Coffee break
16.15-16.55 16.55-17.35
PRESENTATION: NEUROBOTICS Trading (Russia) ISBS PRESIDENTIAL LECTURE: PSYCHIATRY OF ZEBRAFISH: FROM TANK TO BEDSIDE. AV Kalueff (ISBS Fellow), M Nguyen and AM Stewart, ZENEREI Institute, New Orleans, LA, University of Pittsburgh, Pittsburgh, PA, USA PRODUCTIVE LITERATURE MANAGEMENT WITH PAPERS I. C Buske, Papers, Springer, London, UK
17.35-18.00
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SOCIAL EVENTS 18.00-19.00 19.00-22.00
Welcoming Reception (sponsored by ISBS and Papers/Springer). Induction of ISBS Fellows City Tour (admissions)
Day 2. Sat, May 17, 2014 Oktiabrskaya Hotel, Grand hall (2nd floor), 10 Ligovsky Prospect, St-Petersburg, Russia 09.00-18.00
Conference registration
Morning session 09.00-09.20
09.20-09.40
09.40-10.00
10.00-12.20
SYMPOSIUM II. THE ROLE OF IMMUNE CELLS IN NEURAL AND NEURODEVELOPMENTAL DISORDERS Chairs: J Kipnis, KW Kelley (USA), presentations 30 min
NEUROINFLAMMATION, DEPRESSION AND AGING. KW Kelley and RM McCusker, Laboratory of Immunophysiology, University of Illinois at Urbana-Champaign, IL, USA THE ROLE OF MICROGLIA AND PERIPHERAL MACROPHAGES IN NEURODEVELOPMENTAL DISORDERS: LESSONS FROM RETT SYNDROME. J Kipnis, University of Virginia Medical School, Charlottesville, VA, USA
11.00-11.20
USE OF ANTIDEPRESSANTS AND POSTMENOPAUSAL BONE LOSS? A 5-YEAR LONGITUDINAL STUDY FROM THE OSTPRE COHORT. PH Rauma, H-TJ Koivumaa-Honkanen, LJ Williams and RJ Honkanen, BCRU, Clinical Research Center, School of Health Sciences, University of Eastern Finland, Kuopio University Hospital, Finland; School of Medicine, Deakin University, Geelong, The University of Melbourne, Parkville, Australia ANXIOLYTIC EFFECTS OF ENVIRONMENTAL ENRICHMENT ARE MEDIATED VIA HIPPOCAMPAL NEUROPEPTIDE Y. F Reichmann, E Painsipp, C Tam-Amersdorfer, A Kresse, H Herzog and P Holzer, Medical University of Graz, Graz, Austria; Garvan Institute of Medical Research, Sidney, Australia PSYCHONEUROIMMUNOLOGY OF ADDICTION. TI Nevidimova, EI Batukhtina and NA Bokhan, Mental Health Research Institute, Tomsk, Russia
Coffee break
THE ROLE OF THE IMMUNE SYSTEM IN BRAIN FUNCTION. AJ Filiano and J Kipnis, University of Virginia Medical School, Charlottesville, VA, USA THE ROLE OF MICROGLIA IN STRESS-INDUCED DEPRESSION. R Yirmiya, Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel
12.20-13.00
JOURNAL PRESENTATION: BRAIN, BEHAVIOR AND IMMUNITY. KW Kelley, Editor-in-Chief, USA
13.00-14.00
Lunch Break and Exhibition
Afternoon session 14.00-14.30
EFFECTS OF THOUGHT SUPPRESSION ON CONSUMPTIVE BEHAVIOUR. JAK Erskine, GJ Georgiou and L Kvavilashvili, St George’s, University of London, London, University of Hertfordshire, UK
14.30-17.15
SYMPOSIUM III. IMMUNE AND INFECTIOUS FACTORS IN PSYCHIATRIC DISEASE Chair: M Pletnikov (USA), presentations 30 min
MULTIPLE ANTIBODIES TO INFECTIOUS AGENTS AND FOOD ANTIGENS, AND PROTEIN MARKERS OF INFLAMMATION IN WELL-CHARACTERIZED COHORTS OF INDIVIDUALS WITH SCHIZOPHRENIA, BIPOLAR DISORDER, AND NON-PSYCHIATRIC CONTROLS. F Dickerson, Sheppard Pratt Hospital, Baltimore, MD, USA THE MICROBIOME: THE MISSING LINK IN THE PATHOGENESIS OF SCHIZOPHRENIA. R Yolken, F Dickerson, School of Medicine, Johns Hopkins University, Sheppard Pratt Hospital, Baltimore, MD, USA INFLUENCE OF MATERNAL IMMUNE REACTIVITY TOWARDS INFECTIOUS AND DIETARY ANTIGENS ON NEONATAL ACUTE PHASE PROTEINS – INTERACTIONS WITH A FUTURE DIAGNOSIS OF NONAFFECTIVE PSYCHOSIS. A Blomstrom, R Gardner, S Wicks, RH Yolken, C Dalman and H Karlsson, Karolinska Institute, Stockholm, Sweden st
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INFECTIOUS AND IMMUNE FACTORS IN PSYCHIATRIC DISEASE: DIRECT VS. INDIRECT MECHANISMS. G Kannan and M Pletnikov, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
16.30-16.45
Coffee break
IMMUNE-STRESS INTERACTIONS IN THE DEVELOPMENT OF ENVIRONMENTALLY PSYCHOPATHOLOGY. S Giovanoli and U Meyer, ETH Zurich, Zurich, Switzerland
17.15-17.35
17.35-17.50 17.50-18.10
DRIVEN
THE RELATIONSHIP BETWEEN COGNITIVE EMOTION REGULATION AND JOB STRESS: MODERATION ROLE OF SOCIAL SUPPORT. M Ozdevecioglu and O Demirtas, Meliksah University, Talas-Kayseri, Turkey PRESENTATION: VIEWPOINT, OVER 20 YEARS IN THE BEHAVIORAL ANALYSIS FIELD. E Batut, Viewpoint, Lyon, France FOSTERING DOMAIN INTERPLAY-DRIVEN RESEARCH IN BIOLOGICAL PSYCHIATRY: A 2014 UPDATE. AV Kalueff (ISBS Fellow), ZENEREI Institute, Slidell, LA, USA
SOCIAL EVENT 20.00-22.00
Neva River and Canals Boat Trip (admissions)
Day 3. Sun, May 18, 2014 Oktiabrskaya Hotel, Grand hall (2nd floor), 10 Ligovsky Prospect, St-Petersburg, Russia 09.00-18.00
Conference registration
Morning session 09.00-09.40
09.40-10.00
10.00-13.00
ISBS SPECIAL PLENARY LECTURE: THALAMO-CORTICAL CIRCUITS IN CONTROL OF FEAR MEMORY EXTINCTION. H-S Shin and S Lee, Center for Cognition and Sociality, Institute for Basic Science (IBS), Seoul, Republic of Korea REPRODUCIBILITY IN SCIENCE: HOW VIDEO JOURNALS INCREASE RESEARCH VALIDITY AND PRODUCTIVITY. KM Henderson and A Diamond, Journal of Visualized Experiments (JoVE), Cambridge, MA, USA SYMPOSIUM IV: ZUKOWSKA SYMPOSIUM ON TRANSLATIONAL NEUROSCIENCE RESEARCH, Part I Chairs: VM Klimenko (Russia), AV Kalueff (USA), presentations 20 min
ANTIPSYCHOTIC EFFECTS ON ALCOHOL PREFERENCE AND BEHAVIOR IN RATS WITH EXPERIMENTAL SCHIZOPHRENIA. E Kutcher, A Egorov (ISBS Fellow), N Chernikova and M Dorofeikova, Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Medical School, St. Petersburg State University, Petersburg, Russia STRESS REDUCTION IN BATTERED WOMEN USING A COMPUTERIZED BIOFEEDBACK PROGRAM: PHYSIOLOGICAL, PERCEPTUAL AND BEHAVIORAL EFFECTS. LA Zuccarelli, ML Montminy-Danna, Salve Regina University, RI, USA HIGH FIELD MAGNETIC RESONANCE IMAGING STUDY OF THE RELATIONSHIP BETWEEN HIPPOCAMPAL SUBFIELD VOLUMES, CORTISOL, AND MEMORY. NV Malykhin, S Travis, Y Huang, N Coupland, K Hegadoren, P Silverstone, E Fujiwara, P Seres and R Carter, University of Alberta, Edmonton, Alberta, Canada
11.00-11.15
Coffee break ZUKOWSKA SYMPOSIUM ON TRANSLATIONAL NEUROSCIENCE RESEARCH, Part II Chairs: IV Ekimova, YuF Pastuhov (Russia), JE Warnick (USA), presentations 15 min
APPLICATION OF CONVENTIONAL AND ADVANCED IMAGING MODALITIES IN EVALUATION OF DEMENTIA. D Kozic, J Ostojic, S Lucic, A Peter and J Konstantinovic, University of Novi Sad School of Medicine, Oncology Institute of Vojvodina, Sremska Kamenica, Novi Sad, Serbia IMMUNE REACTIVITY IN RATS WITH GENETIC PREDISPOSITION TO HIGH AND LOW AGGRESSIVENESS TOWARD HUMANS. GV Idova, EL Alperina, IF Plyusnina, MM Gevorgyan, EN Zhukova, MYu Konoshenko, RV Kozhemyakina and DV Yur’ev, State Research Institute of Physiology and Basic Medicine RAMS, State Research Institute of Cytology and Genetics RAS, Novosibirsk State University, Novosibirsk, Russia st
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IMINODIPROPIONITRILE-INDUCED BEHAVIORAL AND ORGANS TOXICITIES IN RATS. HA Khan, AS Alhomida and KE Ibrahim, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia ADMINISTRATION OF PROBIOTIC ENTEROCOCCUS AMELIORATES EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE) IN RATS. IN Abdurasulova, EN Tarasova, AV Matsulevich, EI Ermolenko, IV Kudrjavtsev, YL Zhitnukhin, VI Lioudyno and VM Klimenko (ISBS Fellow), Institute for Experimental Medicine RAMS, St. Petersburg, Russia EFFECTS OF STRESS AND ALCOHOL ON LEARNING OF CONDITIONED PLACE PREFERENCE OR AVERSION IN RAT PUPS. VN Mukhin, IN Abdurasulova, A Matsulevitch and VM Klimenko (ISBS Fellow), Institute of Experimental Medicine RAMS, St. Petersburg, Russia STRESS-INDUCED COCAINE SEEKING: OREXIN-INDUCED ENDOCANNABINOID RETROGRADE DISINHIBITION IN THE VENTRAL TEGMENTAL AREA. L-W Tung and L-C Chiou, Graduate Institute and Department of Pharmacology, Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan ALTERED EXPLORATORY BEHAVIOR AND COGNITIVE DYSFUNCTIONS IN MATURE RATS EVOKED BY NEONATAL ADMINISTRATION OF PRO-INFLAMMATORY FACTORS ARE ASSOCIATED WITH ABERRANT EXPRESSION OF NEUROPLASTICITY GENES. AN Trofimov, AP Schwarz, EA Veniaminova, MS Sechina, OE Zubareva and VM Klimenko (ISBS Fellow), Institute of Experimental Medicine RAMS, St. Petersburg, Russia EVALUATION OF SUPERIOR LONGITUDINAL FASCICULUS WITH DIFFUSION TENSOR IMAGING (TRACTOGRAPHY). D Kiresi, H Ozbiner, C Simsek, AD Aydin Kabakci, D Akin and M Buyukmumcu, Necmettin Erbakan University, Meram Medicine School, Konya, Turkey
13.15-14.15
Lunch Break and Exhibition
Afternoon session 14.15-14.45
ISBS LECTURE: HUMAN TRYPTOPHAN HYDROXYLASE-2 LOSS OF FUNCTION MUTATION INDUCES COGNITIVE DEFICITS IN MICE. JM Beaulieu, Canadian Research Chair in Molecular Psychiatry, CRULRG, Laval University, Québec, Canada
14.45-16.25
SYMPOSIUM V: LAPIN SYMPOSIUM ON EXPERIMENTAL MODELS IN BRAIN RESEARCH Chairs: AYu Egorov, IV Ekimova (Russia), AV Kalueff (USA), presentations 15 min
DOWN-REGULATION OF GH1 IN DEPRRESIVE-LIKE BEHAVIORAL RAT. Y Yamamoto, A Shiba, T Ito, T Ueyama and Y Tsuruo, Wakayama Medical University School of Medicine, Wakayama, Japan AGE-RELATED AND INDIVIDUAL FEATURES OF VASOPRESSINERGIC REGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN NONHUMAN PRIMATES. ND Goncharova, Research Institute of Medical Primatology RAMS, Sochi, Russia THE NEUROPEPTIDE CORRECTION OF THE CHONIC FATIQUE SYNDROME SYMPTOMS IN PRIMATES. TN Sollertinskaya (ISBS Fellow), MV Shorokhov, Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia DISTURBANCES OF BIOLOGICAL RHYTHMS IN A RAT CHRONIC MILD STRESS ANIMAL MODEL OF DEPRESSION. SL Christiansen, K Hojgaard, O Wiborg, J Fahrenkrug and EV Bouzinova, Institute for Clinical Medicine, Aarhus University, Aarhus, Department of Clinical Biochemistry, Bispebjerg Hospital, Denmark WEAK STATIC MAGNETIC FIELD AS A NEW TYPE OF STRESS AND ITS EFFECTS ON COGNITION. ЕV Savvateeva-Popova, MS Kurochkina, SV Surma, BF Shchegolev, MB Evgen`ev, OA Zatsepina and ЕА Nikitina, Pavlov Institute of Physiology RAS, Herzen State Pedagogical University, St. Petersburg, Engelhardt Institute of Molecular Biology RAS, Moscow, Russia THE OPTIMAL ACTIVITY OF CASPASE-3 IN BRAIN TISSUE IS ESSENTIAL FOR EARLY CORTICAL DEVELOPMENT IN RAT PUPS, EXPOSED TO PRENATAL STRESS. DS Vasilev, NL Tumanova, NM Dubrovskaya, IA Zhuravin, Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia ACTIVITY MEASUREMENT USING CONDUCTIVE POLYMER FLEXIBLE ELECTRODE. K Torimitsu, H Takahashi, T Sonobe, Y Furukawa, Tohoku University, Miyagi; NTT BRL, Atsugi, Japan
16.25-16.45
Coffee break
16.45-17.00
PRODUCTIVE LITERATURE MANAGEMENT WITH PAPERS II. C Buske, Papers, Springer, London, UK
17.00-19.00
GUIDED POSTER SESSION AND EXHIBITION: Posters are on display for the whole day; presenters should be available for mini-presentations (10 min) and questions during the poster session. Moderators will be guiding delegates through the posters.
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NOVELTY STRESS, ODOR AND SOUND DIFFERENTLY AFFECT INSECT GROOMING. MI Zhukovskaya, AM Lunichkin and AN Knyazev, Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia RELATION OF EMOTIONAL INTELLIGENCE AND STUDENTS’ ADJUSTMENT TO STRESSFUL CONDITIONS OF NEW METHOD OF EDUCATIONAL SUCCESS ASSESSMENT. ES Dmitrieva, VYa Gelman, KA Zaitseva and AM Orlov, Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia EFFECT OF 17β-AMINOESTROGENS IN ANXIETY AND DEPRESSION MODELS OF OVARIECTOMIZED RATS. C Lemini, B Cruz-Lopez, E Garcia-Albor and L Martinez-Mota, Medical School, Universidad Nacional Autonoma de Mexico, Instituto Nacional de Psiquiatría Ramon de la Fuente Muniz, Mexico, Mexico MICROANATOMICAL AND TOPOGRAPHICAL INVESTIGATION OF THE COMMON PERONEAL NERVE (FIBULAR) IN HUMAN FETUS. D Akin, MT Yilmaz, AD Kabakci Aydin, M Buyukmumcu and AE Cicekcibasi, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey EFFECTS OF BIOACOUSTICS ON COGNITIVE BEHAVIOR OF INTACT AND STRESSED RATS. NK Apraksina, TV Avaliani, KV Konstantinov and SG Tsikunov (ISBS Fellow), Institute of Experimental Medicine RAMS, St. Petersburg, Russia EARLY BEHAVIORAL AND BIOCHEMICAL EFFECTS OF UNILATERAL ADMINISTRATION OF LACTACYSTIN INTO THE RAT SUBSTANTIA NIGRA. J Konieczny, T Lenda and A Czarnecka, Institute of Pharmacology PAS, Krakow, Poland ANATOMIC COURSE OF SURAL NERVE IN HUMAN FETUSES. AD Aydin Kabakci, M Buyukmumcu, D Akin, MT Yilmaz and M Seker, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey CREATIVITY AS REFLECTION OF NERVOUS REGULATION UNDERLYING ADAPTIVE REACTION ON HYPOXIC STRESS. OM Razumnikova, LT Kovtun and SG Krivoshchekov, Research Institute of Physiology and Fundamental Medicine RAMS, Novosibirsk, Russia PSYCHOPATHOLOGY, TEMPERAMENT AND ATTACHMENT STYLES OF PARENTS WHOSE CHILDREN AND ADOLESCENTS HAVE BEEN SEXUALLY ABUSED. A Yenel, FSM Research and Training Hospital, Istanbul, Turkey ARIPIPRAZOLE REDUCES PALIPERIDONE INDUCED HIPERPROLACTINEMIA: A CASE REPORT. D Sarikaya Varlik and C Varlik, Bakirkoy Mazhar Osman Mental Health and Neurological Diseases Education and Research Hospital, Istanbul, Turkey CASE OF SCHIZOPHRENIA LIVING IN THE HOUSE OF GARBAGE: COMMUNITY MENTAL HEALTH CARE PROJECT. C Varlik and D Sarikaya Varlik, Bakirkoy Mazhar Osman Mental Health and Neurological Diseases Education and Research Hospital, Istanbul, Turkey DEPRESSION, SELF-ESTEEM AND LIFE SATISFACTION IN PATIENTS WITH SCHIZOPHRENIA. NA Charfi, DO Trigui, JI Ben Thabet, SA Ellouze, NA Zouari, LO Zouari and MO Maalej, Psychiatry C Department, Hedi Chaker University Hospital, Sfax, Tunisia EPIDEMIOLOGICAL IMPACT OF THE TUNISIAN REVOLUTION ON THE POST-TRAUMATIC STRESS DISORDER. JB Thabet, M Maalej, S Yaich, S Ellouze, N Charfi, L Zouari, N Zouari, J Damak and M Maalej, Psychiatry C Department, Hedi Chaker University Hospital, Sfax, Tunisia PSYCHOPATHOLOGICAL DISORDERS IN A POPULATION OF SCHOOL AND UNIVERSITY STUDENTS THROUGH A PSYCHIATRIC CONSULTATION. R Masmoudi, N Halouani, M Ben Elkaroui, F Smaoui, G Mtibaa, J Aloulou and O Amami, Psychiatry Service B, Hedi Chaker University Hospital, Sfax, Tunisia PREVALENCE AND CLINICAL ASPECTS OF THE CAREGIVER BURNOUT: A TUNISIAN STUDY. J Aloulou, F Smaoui, N Halouani, R Masmoudi, M Ben B Elkaroui, F Masmoudi, O Amami, Psychiatry B Department, Hedi Chaker University Hospital, Sfax, Tunisia THYMIC HORMONE THYMULINE ACCELERATES CONDITIONED MEMORY FORMATION FOLLOWING THYMECTOMY. AV Novoseletskaya, NM Kiseleva, AN Inozemtsev, IV Zimina, VYa Arion, Lomonosov Moscow State University, Pirogov Russian National Medical University, Research Institute of Physical-Chemical Medicine, Moscow, Russia HYPERACTIVITY, LEARNING DEFICIT AND ALTERATIONS IN THE BRAIN IN MICE LACKING THE DNA METHYLATION-DEPENDENT TRANSCRIPTIONAL REPRESSOR KAISO. VS Shumskaya, AS Sokolov, NA Zhigalova, AV Kulikov and EB Prokhortchouk, Centre "Bioengineering" RAS, Moscow, Russia EFFECTS OF IMMOBILIZATION AND DIFFERENT TYPES OF RADIATION ON RAT BEHAVIOR IN THE OPEN FIELD TEST. EM Kadukova, DG Stashkevich, MA Bakshaeva, FI Kutz, AD Naumov, Institute of Radiobiology NAS, Gomel, Belarus IMPROVING DEMENTIA CARE USING EARLY COUNSELING AND SUPPORT FOR CAREGIVERS (DEMCAREGIVER TRIAL). A Montedori, N Vancore, R Chattat, G Giovannini, P Iannizzi, A Trequattrini, M Maiotti, G Morini, S Amici, Italy OREXINS INDUCE ANALGESIA VIA THE ENDOCANNABINOID-CB1R SIGNALING IN THE PERIAQUEDUCTAL GRAY: A MECHANISM CONTRIBUTING TO STRESS-INDUCED ANALGESIA. HJ Lee, LY Chang and LC Chiou, Graduate Institute of Pharmacology, Department of Pharmacology and Graduate Institute of Brain and Mind, College of Medicine, National Taiwan University, Taipei, Taiwan GALANIN IN THE ADAPTATION TO PSYCHOLOGICAL STRESS. VI Lioudyno, SG Tsikunov (ISBS Fellow), TS Aksenova, IN Abdurasulova, VM Klimenko (ISBS Fellow), Institute for Experimental Medicine RAMS, St. Petersburg, Russia A CHRONIC DECREASE IN EXPRESSION OF STRESS-INDUCIBLE CHAPERONE HSP70 IN THE SLEEP “CENTER” PROLONGS THE RECOVERY PERIOD FOLLOWING PSYCHO-EMOTIONAL STRESS. VV
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Simonova, MA Guzeev, MV Chernyshev, DV Meshalkina, IV Ekimova (ISBS Fellow) and YuF Pastukhov (ISBS Fellow), Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Institute of Cytology RAS, St. Petersburg, Russia THE ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN PATHOGENESIS OF PARKINSON’S DISEASE: EXPERIMENTAL MODELS. YuF Pastukhov (ISBS Fellow), MV Chernyshev, KV Lapshina and OA Sapach, Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia RELATION BETWEEN DEPRESSION LEVELS AND LIFE EVENTS IN PATIENTS WITH PARTIAL SEIZURE. O Cetinkaya, S Celik and N Ertas, Bakirkoy Psychiatric and Neurological Disorders Hospital, İstanbul, Turkey ARIPIPRAZOL INDUCED HAIR LOSS: A CASE REPORT. U Hamurcu and S Yildırım, Ankara Training and Research Hospital, Psychiatry Clinic, Psychology Unit, Ankara, Turkey POST-TRAUMATIC STRESS DISORDER AMONG SYRIAN REFUGEES IN TURKEY. G Alpak, A Unal, F Bulbul, E Sagaltici, Y Bez, A Altindag, A Dalkilic and HA Savas, Gaziantep University, Faculty of Medicine, Department of Psychiatry, Gaziantep, Marmara University, Faculty of Medicine, Department of Psychiatry, Istanbul; Cooper Medical School of Rowan University, St. Elizabeths Hospital, Washington DC, USA GENDER DIFFERENCES IN ANXIETY DISORDERS SYMPTOMS. A Guclu, Cukurova University, Sarikam, Adana, Turkey THE ROLE OF MOLECULAR CHAPERONE HSP70 IN THE PROTECTION OF DOPAMINERGIC NEURONS IN PROTEASOME DYSFUNCTION OF THE NIGROSTRIATAL SYSTEM. DV Plaksina, DV Meshalkina, IV Guzhova, IV Ekimova (ISBS Fellow), Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, Institute of Cytology RAS, St. Petersburg, Russia
SOCIAL EVENT 20.00-22.00
Conference Dinner (admissions)
Day 4. Mon, May 19, 2014 Oktiabrskaya Hotel, Grand hall (2nd floor), 10 Ligovsky Prospect, St-Petersburg, Russia 09.00-11.00
Conference registration
Morning session 09.00-09.45 09.45-10.00
10.00-10.30
10.30-10.50
10.50-11.10
11.10-11.40
THE PRODUCTIVE LAB: CURRENT CHALLENGES IN RESEARCH MANAGEMENT AND PUBLISHING. C Buske, Papers, Springer, London, UK FORMATION AND FUNCTIONAL ACTIVITY OF HYPOTHALAMUS OREXINERGIC SYSTEM IN POSTNATAL ONTOGENESIS IN RATS. IY Morina, EA Aristakesyan, DM Surzhenko and VV Kuzik, Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia ZNRC LECTURE: THE DEVELOPMENTAL AND BEHAVIORAL FUNCTION OF ENDOTHELINS IN THE ZEBRAFISH BRAIN. WHJ Norton, L Jones, S Colanesi and RN Kelsh, Department of Biology, University of Leicester, Leicester, Centre for Regenerative Medicine, School of Biology and Biochemistry, University of Bath, Bath, UK THE EFFECT OF LED LIGHT SPECTRA ON ANTIOXIDANT SYSTEM BY THERMAL STRESS IN GOLDFISH, CARASSIUS AURATUS. NN Kim, YJ Choi, JY Choi, CY Choi, Korea Maritime and Ocean University, Busan, Republic of Korea THE RELATIONSHIP WITH GONADOTROPIN INHIBITORY HORMONE (GNIH) AND THE GENES RELATED WITH REPRODUCTION BY VARIOUS LED LIGHT SPECTRA IN GOLDFISH, CARASSIUS AURATUS. HS Shin, NN Kim, YJ Choi, CY Choi, Korea Maritime and Ocean University, Busan, Republic of Korea Coffee Break
Afternoon session 11.40-14.20
SYMPOSIUM VI: CLINICAL PSYCHIATRY AND PSYCHOLOGY Chair: VM Klimenko (Russia), presentations 20 min
PAC1 GENE VARIABILITY, TEMPERAMENTAL TRAITS AND BRAIN ACTIVATION DURING SOCIAL STRESS. W Dragan, A Marchewka, P Czerski, J Pruessner, School of Psychology, University of Warsaw; Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Warsaw; Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland; McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Montreal, Canada
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IMPACT OF HIERARCHICAL RANK ON COOPERATIVE BEHAVIOUR AND PHYSIOLOGICAL STRESS REACTIONS IN SOLDIERS. B Siart and B Wallner, Department of Anthropology, University of Vienna, Vienna, Austria ENVIRONMENTAL FACTORS AND ANXIETY-RELATED PERSONALITY TRAITS: THE MODIFYING EFFECT ON NEUROTROPHIC FACTOR AND NEUREXIN FAMILY GENES. A Kazantseva, Yu Kutlumbetova, S Malykh, T Traks, S Koks and E Khusnutdinova, Institute of Biochemistry and Genetics, Ufa Scientific Center RAS, Bashkir State University, Ufa, Psychological Institute RAS, Moscow, Russia; Department of Physiology, Department of Pathophysiology, University of Tartu, Tartu, Estonia COMPLIANCE EFFECTS OF BREATHING MEDITATION PROGRAM ON EEG STRESS QUOTIENT. DK Kim, EM Kim and SW Kang, Data Center for Korean EEG, College of Nursing, Seoul National University, Seoul University of Buddhism, Seoul, Republic of Korea DISABILITY AND ANXIETY-DEPRESSIVE STATES IN PATIENTS WITH CORONARY ARTERY DISEASE. A Yenel, M Sunbul, E Sunbul, FSM Research and Training Hospital, Istanbul, Turkey DEPRESSION AND IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (iNPH): A CASE REPORT. V Rutkauskas, I Kazlauskaite and A Siurkute, Republican Vilnius Psychiatric Hospital, Vilnius University School of Medicine, Vilnius, Lithuania EMOTIONAL REACTIONS OF THE HIGH SCOOL STUDENT’S WITH DIFFERENT ACADEMIC SUCCESS. EI Nikolaeva and EG Vergunov, Herzen State Pedagogical University, St. Petersburg State Transport University, St. Petersburg, Russia EXPERIMENTAL STUDY OF THE SUCCESS OF EMOTION RECOGNITION BY CHILDREN AGED 6 TO 11 YEARS. MN Anderson, Academy of Teachers’ Postgraduate Education, St. Petersburg, Russia
14.20-14.40
CLOSING CEREMONY. ANNOUNCING THE 2015 ISBS CONFERENCES
SATELLITE EVENTS 15.00-16.40 12.00-17.00
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ISBS EXECUTIVE COUNCIL MEETING (2 floor Board Meeting room A) th SATELLITE ISBS/ZNRC SYMPOSIUM: 5 INTERNATIONAL ZEBRAFISH NEUROBEHAVIORAL AND nd NEUROPHENOTYPING WORKSHOP ZB2N-2014 (registrations are required; 2 floor Board Meeting room B)
SOCIAL EVENT 20.00-22.00
Theatre (admissions). Tchaikovsky Ballet “The Swan Lake” at Hermitage Theater
POST-CONFERENCE EVENTS:
Tue, May 20, 2014 Institute of Experimental Medicine (12 Pavlov Street, St-Petersburg) 10.00-15.00 Visit to Pavlov Department of Physiology of the Institute of Experimental Medicine: bus to IEM leaves at 10.00 sharp from main entrance of Oktiabrskaya Hotel, and will return to Hotel by 15.00 (FREE for all delegates, but registration required) SOCIAL EVENT 09.30-16.00
Suburban Royal Peterhof Palace Tour (admissions)
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STRESS, BRAIN AND BEVAVIOR, Vol. 1, 2014. 21 International ISBS Conference, St-Petersburg, 16-19.05.2014 Page 10
ABSTRACTS Day 1. Fri, May 16, 2014 Morning session SPECIAL ISBS LECTURE: GENETIC DISRUPTION OF THE STRESS AXIS CAUSES A DEPRESSION-LIKE DISORDER IN ZEBRAFISH: FROM GENETIC TO CHEMICAL SCREENS IN A SMALL VERTEBRATE. H Baier, Max Planck Institute of Neurobiology, Munich, Germany. While chronic stress is a major risk factor for depression in human patients, the exact mechanism of its action still remains elusive. The role of cortisol, in particular, is still controversial. Excessive signaling through the glucocorticoid receptor (GR) apparently causes changes in neurogenesis or synaptic physiology that may underlie depression. On the other hand, cortisol provides a negative feedback signal to the stress systems of the brain and should therefore have an overall protective function. Animal models provide insights into the changes in brain physiology and circuitry that accompany stress responses. In a large-scale forward genetic screen (Muto et al., PLoS Genetics 2005), our group has identified an adult-viable zebrafish mutant with disruption of the GR. Due to abolition of all transcriptional activity of GR, the negative feedback on the stress response is disrupted. Cortisol is elevated, but unable to signal through GR. Target genes of GR, including those that encode the stress hormones corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH), are de-repressed by the mutation. When placed into an unfamiliar aquarium (‘novel tank’), mutant fish become immobile (‘freeze’), show reduced exploratory behavior and do not habituate to this stressor upon repeated exposure (Ziv et al., Molecular Psychiatry 2013). A related syndrome is observed at larval stages of the zebrafish mutant (Griffiths et al., Frontiers in Behavioral Neuroscience 2012). Addition of the antidepressant fluoxetine to the holding water, as well as social interactions, restore normal behavior in this fish mutant, followed by a delayed correction of cortisol levels. Fluoxetine does not affect overall transcription of CRH, the mineralocorticoid receptor (MR), the serotonin transporter Serta, or GR itself. Fluoxetine, however, suppresses the stress-induced upregulation of MR and Serta in both wild type fish and mutants. Our studies show a conserved, protective function of glucocorticoid signaling in the regulation of emotion, and reveal novel molecular aspects of how chronic stress impacts vertebrate brain physiology and behavior. These data have also paved the way for an ongoing in vivo high-throughput small-molecule screen aimed at discovering new therapies for depression. ISBS LECTURE: LINGUISTIC ANALYSIS OF PRECOMPETITION INTERVIEWS REVEAL ANXIETY STATES AND PREDICT THE OUTCOME OF PROFESSIONAL BOXING BOUTS. JE Warnick (ISBS Fellow), Arkansas Tech University, Russellville, AR, USA. Combative sports have roots to the earliest known societies. However, in spite of this rich history, combative sports have received little attention from the behavioral sciences aside a focus on traumatic brain injury. This experiment attempted to begin determining which psychological variables are correlated with the outcome of a professional boxing bout. METHODS: Interviews, press conference quotes, and press release statements given by professional boxers prior to a boxing match were collected from a major combative sports news website (www.fightnews.com). The textual data collected from each fighter were analyzed with the linguistic software LIWC2007 (Linguistic Inquiry and Word Count). The outcome of each fighter’s bout(s) was retrieved from an online database of professional boxing results (www.boxrec.com). RESULTS AND DISCUSSION: Regression and correlation analyses revealed that the pre-bout use of words that convey
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positive mental states were related to winning a bout. Use of words that convey anxiety and negative mental states were related to losing the athletic contest. This investigation provides further evidence that a combative sport competitor’s psychological state can be revealed through indirect measures and can predict a bout’s outcome. These findings suggest measures of anxiety and mood could be related to performance differences in professional boxing. The use of indirect measures in developing better safety protocols for combative sports will be discussed. RESEARCH SUPPORT: Arkansas Tech University Professional Development Grant. SALIVA AS DIAGNOSTIC MEDIUM IN STRESS RESEARCH. A Ernst, Salimetrics LLC, Newmarket, UK. In 1992 Dr. Irwin Mandel addressed the first New York Academy of Sciences meeting on the topic of Saliva as a Diagnostic Fluid, where he referred to the concept of using saliva as “a mirror of the body.” At that time, the number of researchers who shared Dr. Mandel’s enthusiasm for saliva testing was relatively small, and there were some who felt that saliva could not serve as a reliable testing fluid. After nearly 20 years of subsequent work in this field, however, we are now witnessing a sharp rise in the acceptance of saliva as a valuable testing medium alongside, or as an alternative to, traditional testing fluids like blood and urine. This adoption of saliva has been especially evident in psychology and related fields, where researchers were among the first to recognize the advantages of multiple, non-invasive collections that saliva testing has to offer. Salivary biomarkers can be used to answer a wide range of questions within psychology. Perhaps most pertinent for those who are new to saliva testing, it can offer an objective and fully quantitative result to assess psychological disorders, such as stress, anxiety and depression. Testing can be incorporated into longitudinal study designs to investigate the progression of these disorders, overcoming some of the issues that surround the use of questionnaires and participant recall. Saliva testing is also frequently used to assess the physiological response to psychological stimuli, both in lab and field-based scenarios. Concentrations of salivary biomarkers change within minutes in response to psychological stimuli, allowing researchers to analyse a participant’s response to even the most acute stimuli. One of the main biomarkers used in psychological studies is cortisol. Cortisol is the major glucocorticoid hormone produced in the adrenal cortex and is actively involved in the regulation of many physiological systems. Salivary cortisol has been studied extensively in research on human behavior, emotions, and development; examples include studies involving anxiety, depression, PTSD, and behavioral disorders. The digestive enzyme alpha-amylase (sAA), which is one of the major proteins secreted by the salivary glands, has been one of the analytes most heavily studied in connection with the nervous control of protein secretion. By its use as a marker of autonomic activity, research has revealed that sAA measurements are related to a variety of behavioral, social, health, and cognitive phenomena in human subjects. Many psychobiological studies now routinely include measurements of both cortisol and sAA in order to observe activity in the HPA axis and the ANS, respectively. Here, I will elaborate on the use of saliva as a diagnostic fluid in stress research and incorporate scientific studies performed by the Salimetrics and associated laboratories. It will also include the basic “DOs and DON’Ts” of saliva research and the science behind Salimetrics’ assays. The presentation is aimed at people who are interested to know more about and would like to integrate noninvasive, cost-effective methods to their stress and behavioral studies. A REVIEW ON BEHAVIORAL EQUIPMENT EXISTING TODAY TO MONITOR BEHAVIORAL CHANGES IN RODENTS. J Fehmer, TSE Systems GmbH, Bad Homburg, Germany. A thorough characterization of animal models of human diseases often faces issues of data quality due to non-standardized procedures and equipment, experimenter interference and animal stress. In recent years, TSE Systems has pioneered a home cage based research approach to increase animal welfare, reduce experimenter interference and increase throughput. Despite the flexibility and versatility of complex phenotyping instrumentation such as PhenoMaster or IntelliCage, there are still paradigms that
STRESS, BRAIN AND BEVAVIOR, Vol. 1, 2014. 21 International ISBS Conference, St-Petersburg, 16-19.05.2014 Page 11
could not be tackled with these systems. Therefore, TSE Systems has developed novel systems based on video tracking or observing animals using RFID or telemetry technology. The TSE MotoRater was designed to offer fully automated, comprehensive kinematic analysis of a variety of natural locomotor behaviors, such as walking, swimming or wading by using high-speed video technology. Animal models of diseases in which patients suffer from locomotor coordination deficits, such as stroke, Parkinson, spinal cord injury, Huntington’s disease can be investigated with this new tool. The IntelliCage the only available high throughput behavioral phenotyping tool in which animals can be investigated within their social context, can be now combined with the new Stellar Telemetry system allowing the parallel measurement of behavioral and physiological parameters such as blood pressure, heard rate as well as biopotentials, including EEG under group housing conditions. In conclusion, these unified approaches open new horizons for a large variety of high-quality in-vivo research in biomedical and preclinical science. ANIMAL MODELS FOR STUDYING PTSD: THE NEED FOR MULTI-MODAL AND MULTI-FUNCTIONAL MEASUREMENT SYSTEMS IN LABORATORY ANIMAL RESEARCH AND MATRIX ANALYSIS. L Bachdasarian, R Bulthuis, E Molenwijk, M Boscaro and P Meuth, Metris BV, Netherlands; Data Sciences International, St. Paul, MN, USA; Institute of Physiology I, Department of Neurology - Inflammatory Disorders of the Nervous System and Neurooncology, Westfalische Wilhelms-Universitat Munster, Germany. Current trends in the pharmaceutical industry require new translational approaches for pre-clinical testing. Those aspects can be achieved by animal experiments in which not only one variable (e.g., Behavior) at the time is analyzed, but rather a multidimensional approach (i.e., Physiology + Behavior) is applied. Therefore, automation and integration of different measuring technologies become the crucial aspects in this process. Behavior = function {internal stimuli / external stimuli}. Furthermore, Behavior = function {dynamic internal stimulus /from drug effects}; if external factors = constant. For example, in our Laboras system, animal freezing behavior is not immobility behavior. ANIMAL MODEL FOR PTSD RESEARCH IS FEAR CONDITIONING PROTOCOL: For this protocol, mouse models are very important. There are two common ways of measuring fear responses in mice: to assess their Startle response and/or Freezing behavior. Metris BV has developed two special algorithms for automated Startle and Freezing detection. Having an automated detection system is not sufficient at the behavioral level for excluding false results (e.g., sleeping phases), therefore, resulting in ‘less movement’ not being confounded and misinterpreted as ‘freezing’). Thus, the behavioral response needs to be integrated and synchronized with physiological parameter (e.g., EEG,ECG, BP, Datasciences Int., The best way to do so would be using Laboras system (for behavioral study), DSI (for assessing Physiological parameters) and Sonotrack (for ultrasounds vocalization study). LABORAS: system for fully automatic recognition, recording and analysis of the behavior and tracking of small laboratory rodents (rats, mice), based on the analysis of force and energy. SONOTRACK: system for recording, playback and visualization of ultrasounds vocalizations in laboratory animals (15KHz-125Khz). DSI: system for measuring physiological parameters remotely (without wire measuring pressure, temperature, ECG, EEG, EMG, identification, activity, respiration). Data Sciences is the leading manufacturer for implantable monitoring devices used in preclinical studies. The devices acquire cardiovascular, CNS and respiratory data from freely moving animals in a stress-free environment. This talk will give an overview and introduction to DSI latest product releases, including new Physiotel Digital Telemetry device L-00 for infection studies with large animals, new implantable devices for continuous monitoring of glucose level in rats, and iPrecio infusion pump series, which reduce stress levels in animals and experimenter’s labor.
Afternoon session SYMPOSIUM I. ADVANCES IN MONOAMINERGIC NEUROTRANSMISSION. Chair: R Gainetdinov (Italy, Russia)
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THE ROLE OF DIFFERENT DOPAMINE RELEASE PATTERNS IN ALCOHOL DRINKING BEHAVIORS. EA Budygin (ISBS Fellow), Wake Forest School of Medicine, Winston-Salem, NC, USA. The dopaminergic projection that extends from the ventral tegmental area (VTA) to the nucleus accumbens plays an integral role in the regulation of motivated behaviors and alterations of this circuit have long been hypothesized to contribute to the etiology of alcohol addiction. Animal and human studies have shown that deep brain electrical stimulation of the nucleus accumbens has an inhibitory effect on alcohol consumption. However, until recently it has been impossible to parse the causal role of different dopamine release patterns in mediating this effect. METHODS: Newly developed optogenetic tools are now providing a means to explore the cause-effect relationship between specific patterns of mesolimbic dopamine release and appetitive and consummatory behaviors. Here, we applied a viral technology to restrict the expression of channelrhodopsin-2 (ChR2) to dopamine cells in the rat VTA, driving ChR2-EYFP expression by a tyrosine hydroxylase promoter. The viral construct was unilaterally microinjected into the VTA of male, Long Evans rats (n=12) habituated to a modified intermittent two-bottle choice procedure in which subjects had access to either 20% ethanol or 3% sucrose and water, three days per week. Using in vivo voltammetric recordings, we confirmed that optical stimulation of VTA dopamine cells can induce tonic and phasic patterns of dopamine release in the nucleus accumbens. RESULTS AND DISCUSSION: We found that tonic VTA stimulation, delivered during the initial 10 min of drinking sessions, significantly (P
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