David Goukassian is a highly skilled Research Physician / Scientist and Principal Investigator with more than 15 years o...
DAVID GOUKASSIAN, MD, PHD West Newton, Massachusetts 02465 617-480-3890
[email protected]
PROFESSIONAL HIGHLIGHT Highly skilled Research Physician/Scientist and Principal Investigator with more than 15 years of biomedical/translational research experience. Demonstrated research expertise in cancer and cardiovascular disease prevention, biomarker-based diagnostics and therapy development and testing. Extensive experience in Space Radiation Biology research identifying long-term cardiovascular disease risks due to space radiation for NASA Astronauts. Proven and published experience in stem cell and progenitor cell biology including testing and pre-clinical validation of a universal therapy to improve stem cell and gene therapy outcomes in diseased and damaged tissue. Solid record of medical research at reputable academic institutions including Boston University and Tufts University, and also at a none-profit institution. Skilled at developing research funding, preparing grant proposals and providing academic research oversight and mentoring graduate students, post-doctoral research scientists, clinical fellows and medical residents as a Principal Investigator.
PROFESIONAL SKILLS Biomedical Research Cancer Biology Cancer Therapeutics Transnational Medicine Pre-Clinical Validation Clinical Research Patient Derived Xenograft Cancer Models Cardiovascular Research Stem Cell Therapeutics Drug Discovery Immunology Pharmacogenomics Pre-Clinical Research Budget Proposals Intellectual Portfolio Management Program Development Negotiations Proposal Writing Strategic Planning Team Leadership / Motivation Grant Writing NASA NIH Training / Development Public Speaking Fostering Collaborations Progress Reporting Scientific Presentations Manuscript Writing Project Management Communication
PERSONAL TRAITS
Very strong believer in leadership by example and by inspiring team members to challenge themselves to do their best. Multi-talented; vast expertise and experience in basic, translational and clinical research. Innovative, entrepreneurial; strategic, outside-the-box thinker; highly motivated, energetic, analytical, persistent. Excellent writing and presentation skills; multilingual and multicultural. Led and mentored Junior Faculty, Ph.D. candidates, Medical Residents, Clinical Fellows, M.Sc., B.A., undergrads. Established and led multi-disciplinary and multi-institutional research teams and consortiums, including strategic planning, opportunity development and management of activities on scientific and business operation levels. Writing wining proposals for government grants (NIH and NASA), foundations and associations (American Heart Association, American Federation of Aging Research, American Cancer Society, etc.), BigPharma (Merck and Co, Industrial Farmaceutica Cantabria, Shiseido Corp., etc.).
SUMMARY OF EXPERTISE
Therapeutic angiogenesis and tissue regeneration including development of TNF-alpha ligand-receptors interaction-based therapies to improve post-ischemic repair, regeneration and neovascularization processes. Development of novel anticancer therapeutics including anti-cancer therapies based on inhibition of TNF-alpha ligand-receptors interactions. Translational research using transgenic and organ-specific models of human cancer and cardiovascular diseases. Stem and progenitor cell biology (hematopoietic stem and progenitor cells, satellite cells) – development of universal platform therapeutics to improve stem cell and gene therapy outcomes in diseased/damaged tissues. Space Radiobiology - molecular mechanisms of space radiation-induced long-term cardiovascular degenerative risks, development of mouse models for evaluation of space radiation-induced Excess Relative Risks-ERR, development of predictive biomarkers for estimation of ERR, development of countermeasures for NASA’s future long-duration space missions to Moon, near Earth asteroids and Mars.
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BOSTON UNIVERSITY SCHOOL OF MEDICINE Boston, Massachusetts 12/2010 – 2016 Associate Professor of Medicine, Whittaker Cardiovascular Institute - Directed cardiovascular and anti-cancer drug-development research. Established multi-institutional and multidisciplinary collaborations with academic and industry research scientists and investigators. Provided instruction and support to undergraduate and graduate students, medical residents, clinical fellows and junior faculties. Assisted students in preparing and executing research studies, preparing scientific presentations and writing manuscripts. Achievements: Served as principal research investigator managing doctoral and post-doctoral research scientists performing medical research and preparing manuscripts. Resolved first author credit disputes and offered course in Responsible Research Conduct for all research scientists to prevent future authorship disagreements. Served as Faculty Supervisor of Research Laboratory maintaining service contracts for all major equipment. Negotiated long-term contract with professional service company covering the majority of equipment saving $120,000 annually the first year and $600,000 over the next six contract years. Performed research focused on developing a small DNA oligonucleotide-based therapy to reduce sun exposure and increases in skin mutagenesis and cancer development. Published research results in high profile medical journals including PNAS USA, Lancet, and FASEB. Results received national and international media attention including the Nature Publishing Group, Lancet Oncology, ASCO – American Society of Clinical Oncology, The Scientist Journal, WedMD Health, Medline Plus Technology News, Boston Herald, the Boston Globe, Daily Telegraph London, BBC World News UK, Reuters, WolffSystem Germany, Der Spiegel Germany, Pressetext Schweiz Austria. The paper Goukassian et al. Proc Natl Acad Sci USA was cited by Faculty of 1000 a consortium of faculty member of 1000 research universities worldwide that evaluate research papers on monthly basis according to paper’s originality, hypothesis, novelty and applicability in clinical setting.
TUFTS UNIVERSITY SCHOOL OF MEDICINE Boston, Massachusetts 3/2008 – 2016 Associate Professor of Medicine, Division of Cardiovascular Research, Department of Medicine, St. Elizabeth’s Medical Center of Boston - Performed high-value cardiovascular drug-development research projects. Taught and mentored 15 graduate students for their Master of Science research thesis manuscripts. Achievements: Developed research project to improve stem and progenitor cell-therapy effectiveness and outcomes. Created and tested pre-clinical models of cardiovascular disease utilizing a new therapy employing modulation of TNF signaling to improve recovery in damaged tissue through inhibition of apoptosis, inhibition of inflammation, and promotion of angiogenesis and regeneration by increasing survival of the resident differentiated cells and adult stem cells. Created tissue environment for recruitment, incorporation and function of endogenous and exogenous stem cells providing damaged organ regeneration and serving as a universal platform therapy for stem cell and gene therapy. Addressed loss of key investigator in a multidisciplinary project for development of stem cell therapy. Identified expert in stem cell therapy testing and recruited scientist to assist in the testing and validation process. Served as a key member of Executive Strategic Planning Committee and develop intellectual portfolio, fostered new collaborations with academic and industrial partner to develop multi-institutional and multi-specialty consortium.
GENESYS RESEARCH INSTITUTE Brighton, Massachusetts 10/2010 – 9/2015 Director of Cardiovascular Research Center, Chief Scientific Officer Drug-development research projects from conception to pre-clinical testing. Designed in vitro and in vivo experiments leading research team and guiding project clinical direction, pathways and data analysis. Prepared study research presentations for national and international scientific conferences. Wrote executive summaries, investor presentations, scientific manuscripts, and grant proposals for government agencies, private foundations and medical associations. Achievements: Developed new anti-cancer treatment utilizing monoclonal antibodies to block the pro-survival receptor of the Tumor Necrosis Factor Alpha. Potentially offers paradigm changing cancer treatment targeting proliferative and silent cancer cells, cancer associated tumor stroma and endothelial cells providing an effective method to clean tumor cells produce self-destructive cycle for tumors. Published initial pre-clinical proof of concept. Researched cardiovascular disease risks for astronauts from low dose radiation exposures. Assisted NASA in developing heart disease risk estimates and proposed measures to prevent Earth-bound population from radiationinduced cardiovascular diseases in cancer patients receiving “standard of care” conventional and particle radiotherapy. Developed neutralizing antibody mitigation therapy to reduce cardiovascular disease risks.
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EDUCATION Medical Doctor, Internal Medicine Yerevan Medical University, Yerevan, Republic of Armenia
PhD in Genetics, Immunology, Dermatology Central Advanced Training Institute for Physicians, Moscow, Russia
POSTDOCTORAL TRAINING – CLINICAL Internship Cardiology, Nephrology, Endocrinology Yerevan Medical Institute, Yerevan, Armenia Residency, Specialization in Dermatology Belorussian Advanced Training Institute for Physicians, Minsk, Belarus Clinical Fellowship, Dermatology for Primary Care Physicians Belorussian Advanced Training Institute for Physicians, Belarus
POSTDOCTORAL TRAINING – RESEARCH Post-Doctoral Fellowship: Aging, Photo-aging, Gerontology, Cutaneous Oncology, Molecular and Cell Biology Boston University School of Medicine, Boston, MA / National Institute of Aging T32 Training Grant Post-Doctoral Fellowship: Aging, Endothelial Progenitor Cell Biology, Ischemia-induced Neovascularization, Tissue Repair and Regeneration Caritas St. Elizabeth’s Medical Center of Boston, Division of Cardiovascular Research, Boston, Massachusetts / National Heart, Lung and Blood Institute 2010 NASA Space Radiation Summer School / Professional Auditor NASA Space Radiation Laboratory, Brookhaven National Laboratory, Upton, New York
CERTIFICATIONS Medical Doctor Philosophy Doctor of Genetics, Immunology, Dermatology Professional Auditor for NASA, Space Radiobiology
AWARDS AND RECOGNITION World Congress Fund Award of the American Academy of Dermatology Japanese Society of Investigative Dermatology International Fellowship Shiseido Award Dermatology Foundation Research Award The Skin Cancer Foundation Research Award American Cancer Society Research Award American Federation for Aging Research Award Merck and Company, Inc., Research Award American Cancer Society Research Award Industrial Cantabria Farmaceutica, Research Award American Heart Association, Scientist Development Award NIH/NIA R21 Exploratory Developmental Research Grant Industrial Farmaceutica Cantabria, Research Award NASA Human Research Program Award, Ground-Based Studies in Space Radiobiology, 2011-2015 American Heart Association, Grant-in-Aid, 2014-2016 NASA Research and Technology Development to Support Crew Health and Performance in Space Missions, 2016-2017
AFFILIATIONS American Federation for Aging Research, National Scientific Advisory Council Center for Integration of Medicine and Innovative Technology Brigham and Woman’s Hospital Massachusetts Institute of Technology Draper Laboratory American Heart Association Radiation Research Society
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PEER-REVIEW ACTIVITY 2000 – 2002 – 2003 – 2003 – 2004 – 2005 – 2005 – 2006 – 2006 – 2011 – 2013
Reviewer for Journal of Investigative Dermatology Reviewer for Circulation Reviewer for Circulation Research Reviewer for Atherosclerosis Thrombosis and Vascular Biology Reviewer for Journal of Cellular Physiology Reviewer for FASEB Journal Reviewer for Journal of Biological Chemistry Reviewer for Proceeding of National Academy of Sciences, USA Reviewer for Cancer Research and American Association of Cancer Research related 3 other Journals Reviewer for Radiation Research Reviewer for American Journal of Physiology – Heart and Circulatory Physiology
GRANT PEER-REVIEW ACTIVITIES 2007 – 2008 2008 – 2005 –
Invited Program Project Grant reviewer for NIH/NHLBI, Special Emphasis Panel. Reviewer for Basic and Translational grants, Italian Ministry of Health. Reviewer for International Grant Review Committee, Russian Academy of Sciences and Ministry of Health, Russian Federation.
2000 – 2003 – 2010 –
American Association for the Advancement of Science. American Heart Association. Radiation Research Society.
PROFESSIONAL SOCIETIES
HOSPITAL, MEDICAL SCHOOL, OR UNIVERSITY COMMITTEE ASSIGNMENTS 2013-2015 2010 – 2013 2005-2010 2006-2009 2001 – 2007
Chair, Institutional Animal Care and Use Committee, GeneSys Research Institute, Brighton, MA, USA Executive Member, Strategic Planning Committee, Steward Research and Specialty Projects Corporation, Brighton, MA, USA Member of Institutional Review Board, St. Elizabeth’s Medical Center of Boston, MA, USA. Member, Committee on Faculty Affairs, Boston University School of Medicine, Boston, MA, USA Executive Faculty Supervisor of Research Labs, Department of Dermatology, BUSM, Boston, MA, USA
TRAINING OF MDs, PhDs, GRADUATE STUDENTS and POST DOCTORAL FELLOWS 2015 2014 2013 2013 2013 2013 2013 2013 2012 2012 2012 2012 2011 2011 2010 2008 2007-2008 2004-2007 2006-2007 2006 2006 2005-2006 2005-2006 2004-2005 2003-2004
John Schwab, Masters Student, BUSM, GMS Division Adam Taleb, MD, - Post-Doctoral Fellow, Medicine, Steward St Elizabeth’s Medical Center Radu Hagau, MD, - Clinical Fellow, Steward St Elizabeth’s Medical Center Begona Quintana, MD, – Post-Doctoral Fellow, Visiting Scholar, Assistant Professor of Medicine, Universidad Complutence, Madrid, Spain Layla Rahimi - Masters Student, BUSM, GMS Division, (Honors for MS). Jin Song – Masters Student, BUSM, GMS Division, (Honors for MS). Brittany Garrety – Undergraduate Intern, UMASS, Worchester Albert Kiladjian – Undergraduate Intern, Trinity University Raman Mehrzad, MD – Cardiac Fellow, Steward St Elizabeth’s Medical Center Sanggyu Bae, MD, - Clinical Resident, Medicine, St Elizabeth’s Medical Center Hannah Gee – Masters Student, BUSM, GMS Division, (Honors for MS) Akhil Aggarwal – Medical Student (USMI) class of 2016 –summer Internship. st Justin Wage – Medical Student, TUSM (1 year), Summer Internship. Daniel Park – Senior Internship, School-To-Career, Weston High School. Daniel Park – High School Internship, Weston High School. rd Danielle Levine – Medical Student, TUSM (3 year), Research Rotation. Joanna Rhodes – Master Student, BUSM, GMS Division (Honors for MS). Simin Arad, MD – Post-Doctoral fellow, BUSM, GMS Division. Christina Coleman – Masters Student (Honors for MS), BUSM, Graduate Medical Sciences (GMS) Division. Edoardo Zattra, MD – Medical Resident, Post-Doctoral Research, University de Padova, Italy. st Danielle Levine – Medical Student TUSM (1 year), Research rotation. rd Alexandra Guillermo – Medical Student TUSM (3 year), Research Rotation. Hu-Ya Chen, MD – Post-Doctoral Research Fellow, Taiwan. Sepideh Bagheri, MD – Post-Doctoral Research Fellow. Laila El-Keeb, MD – Post-Doctoral Research Fellow.
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TEACHING RESPONSIBILITY 2006 2001 – 2010 1999 – 2006
Graduate Faculty, Primary Mentor of Graduate Student, Clinical and Translational Science Institute, BUSM, Boston, MA, USA Lectures (2/semester), within the course of “Special Topic in Pathology”, GMS Division, BUSM. Course of Integrated Clinical Problems/Evidence-Based Medicine for M.D./Ph.D. students, and of 1st and 2nd year Medical School students, BUSM.
BIBLIOGRAPHY #
(#denotes corresponding and or primary author, selected since 2005)
1. Goukassian D.A. Mending the Rift: DNA Repair and Aging. Geriatrics and Aging. 8(8): 57-60, 2005. 2. Kishore R, Qin G, Luedemann C, Bord E, Hanley A, Silver M, Gavin M, Yoon YS, Goukassian D.A., Losordo DW. The Cytoskeletal Protein Ezrin Regulates EC Proliferation and Angiogenesis via TNF-alpha-induced Transcriptional Repression of Cyclin A. J Clin Invest. Jul;115(7):1785-96, 2005. 3. Luedemann C, Bord E, Qin G, Zhu Y, Goukassian D.A., Losordo DW, Kishore R. Ethanol Modulation of TNF-alpha Biosynthesis and Signaling in Endothelial Cells: Synergistic Augmentation of TNF-alpha Mediated Endothelial Cell Dysfunctions by Chronic Ethanol. Alcohol Clin Exp Res. Jun;29(6):930-8, 2005. # 4. Marwaha V, Chen YH, Helms E, Arad S, Inoue H, Bord E, Kishore R, Sarkissian RD, Gilchrest BA, Goukassian DA. T-oligo Treatment Decreases Constitutive and UVB-induced COX-2 Levels Through p53- and NFkappaB-dependent Repression of the COX-2 Promoter. J Biol Chem. 280(37):32379-88, 2005. 5. Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, Thorne T, Takenaka H, Aikawa R, Goukassian D.A., von Samson P, Hamada H, Yoon YS, Silver M, Eaton E, Ma H, Heyd L, Kearney M, Munger W, Porter JA, Kishore R, Losordo DW. Sonic Hedgehog Myocardial Gene Therapy: Tissue Repair Through Transient Reconstitution of Embryonic Signaling. Nature Medicine. 11(11):1197-204, 2005. 6. Qin G, Ii M, Silver M, Wecker A, Bord E, Ma H, Gavin M, Goukassian DA, Yoon YS, Papayannopoulou T, Asahara T, Kearney M, Thorne T, Curry C, Eaton L, Heyd L, Dinesh D, Kishore R, Zhu Y, Losordo DW. Functional Disruption of {alpha}4 Integrin Mobilizes Bone Marrow-derived Endothelial Progenitors and Augments Ischemic Neovascularization. J Exp Med. 203(1): 153-63, 2006. 7. Qin G, Kishore R, Dolan CM, Silver M, Wecker A, Luedemann CN, Thorne T, Hanley A, Curry C, Heyd L, Dinesh D, Kearney M, Martelli F, Murayama T, Goukassian DA, Zhu Y, Losordo DW. Cell Cycle Regulator E2F1 Modulates Angiogenesis via p53-dependent Transcriptional Control of VEGF. PNAS. 103(29): 11015-20, 2006. # 8. Arad S., Konnikov N., Goukassian D.A. Gilchrest B.A. T-oligo Augment UV-induced Protective Responses in Human Skin. FASEB J, 20(11): pp. 1895-7, 2006. 9. Rajasingh J., Bord E., Luedemann C., Asai J., Thorne T., Qin G., Goukassian D.A., Zhu Y., Losordo D.W., Kishore R. IL-10-induced TNF-alpha mRNA Destabilization is Mediated via IL-10 Suppression of p38 MAP Kinase Activation and Inhibition of HuR Expression. FASEB J, 20(12): pp. 2112-4, 2006. # 10. Goukassian D.A., Qin G., Dolan C., Murayama T., Silver M., Curry C., Eaton E., Luedemann C., Ma H., Asahara T., Zak V., Mehta S., Burg A., Thorne T., Kishore R., Losordo D.W. Tumor Necrosis Factor-alpha Receptor p75 is Required in Ischemia-induced Neovascularization. Circulation 115(6): pp. 752-62, 2007. 11. Rajasingh J., Bord E., Qin G., Ii M., Silver M., Hamada H., Ahluwalia D., Goukassian D.A., Zhu Y., Losordo D.W., Kishore R. Enhanced Voluntary Alcohol Consumption After Estrogen Supplementation Negates Estrogen-mediated Vascular Repair in Ovariectomized Mice. Endocrinology 148(8): pp. 3618-24, 2007. # 12. Arad S., Konnikov N., Goukassian D.A., Gilchrest B.A. Quantification of Inducible SOS-like Photoprotective Responses in Human Skin. J of Investigative Dermatology, 127(11):2629-36. 2007. 13. Astner S, Wu A, Chen J, Philips N, Rius-Diaz F, Parrado C, Mihm MC, Goukassian D.A., Pathak MA, Gonzalez S. Dietary Lutein/ Zeaxanthin Partially Reduces Photoaging and Photocarcinogenesis in Chronically UVB-Irradiated Skh1 Hairless Mice. Skin Pharmacol Physiol, 20: pp. 283-91, 2007. 14. Aprahamian T, Takemura Y, Goukassian D.A., Walsh K. Ageing is Associated with Diminished Apoptotic Cell Clearance in Vivo. Clin Exp Immunol 152(3): 448-55, 2008. # 15. Arad S, Zattra E, Hebert J, Epstein EH, Jr, Goukassian DA, Gilchrest BA. Topical pTT Treatment Reduces UVinduced BCC Development in Ptch-1 +/- Mice. American Journal of Pathology. 172(5):1248-55.2008. 16. Zattra E, Coleman C, Arad S, Helms E, Levine D, Bord E, Guillaume A, El-Hajahmad M, Zwart E, van Steeg H, # Gonzalez S, Kishore R, Goukassian DA. Polypodium Leucotomos Decreases UV-induced Cox-2 Expression and Inflammation, Enhances DNA Repair, Decreases Mutagenesis in Hairless Mice. Am J Pathol. 175(5):1952-61, 2009. # 17. Coleman C, Levine D, Kishore R, Qin R, Thorne T, Lambers E, Sasi SP, Yaar M, Gilchrest BA, Goukassian DA. Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides. J of Oncology, 2010: 2010:928628. 18. Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, #Goukassian D.A. Breaking the 'Harmony' of TNF-α Signaling for Cancer Treatment. Oncogene, 567, pp 1-11, 2011. 19. #Goukassian D.A., Gilchrest B.A. Topical Application of Thymidine Dinucleotide to Newborn Mice Reduces and Delays Development of UV-Induced Melanomas. Journal of Investigative Dermatology, 132: pp. 2664-6, 2012.
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20. Klement G.L., Goukassian D.A., Hlatky L., Carrozza J., Morgan J.P., Yan X. Cancer Therapy Targeting the HER2PI3K Pathway: Potential Impact on the Heart. Frontiers in Pharmacology, 3:113, 2012. 21. Shtifman A, Pezone MJ, Sasi SP, Agarwal A, Gee H, Song J, Perepletchikov A, Yan X, Kishore R, #Goukassian DA. Divergent modification of low-dose (56)Fe-particle and proton radiation on skeletal muscle. Radiat Res. Nov;180(5):455-64, 2013. 22. Zhou J, Cheng M, Liao YH, Hu Y, Wu M, Wang Q, Qin B, Wang H, Zhu Y, Gao XM, Goukassian D, Zhao TC, Tang YL, Kishore R, Qin G. Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells. PLoS One. May 21;8(5):e63126, 2013. 23. Bian Y, Silver M, Ho KKL, Marchionni MA, Kang PM, Goukassian DA, Carrozza J, Morgan JP, Yan X. Neuregulin1 Improved Cardiac function in Doxorubicin-Treated Mice with Cardiomyocyte-Specific Overexpression of a DominantNegative PI3Kp110α. J Cardiovasc Dis Diagn 1:120, 2013. 24. Sasi SP, Gee H, Lee J, Yang Y, Song J, Carrozza J, Yan X., #Goukassian DA. Radiation-associated cardiovascular risks for future deep-space missions. J Radiat Res. Mar 1;55 Suppl 1:i37-i39, 2014. 25. TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naive BM-derived TNFR1/p55KO EPCs. Sasi SP, Song J, Enderling H, Yan X, #Goukassian DA. J Radiat Res. Mar 1;55 Suppl 1:i122-i123, 2014. 26. Sasi SP, Yan X, Lee J, Sisakyan H, Carrozza J, #Goukassian DA. Radiation-associated degenerative cardiovascular risks during normal aging and after adverse CV event 10 months post-initial exposure. J Radiat Res. Mar 1;55 Suppl 1:i111-i112, 2014 27. Sasi SP, Bae S, Song J, Perepletchikov A, Schneider D, Carrozza J, Yan X, Kishore R, Enderling H, #Goukassian DA. Therapeutic non-toxic doses of TNF induce significant regression in TNFR2-p75 knockdown Lewis lung carcinoma tumor implants. PLoS One. Mar 24;9(3):e92373, 2014 (18 months after publication there were more than 1870 views and 320 full downloads worldwide). 28. Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, #Goukassian DA. TNF-TNFR2/p75 Signaling Inhibits Early and Increases Delayed Non-Targeted Effects in Bone Marrow-Derived Endothelial Progenitor Cells. J Biol Chem. May 16;289(20):14178-93, 2014. 29. Yan X, Sasi SP, Gee H, Lee J, Yang Y, Mehrzad R, Onufrak J, Song J, Enderling H, Agarwal A, Rahimi L, Morgan J, Wilson PF, Carrozza J, Walsh K, Kishore R, #Goukassian DA. Cardiovascular risks associated with low dose ionizing particle radiation. PLoS One. Oct 22;9(10):e110269, 2014 (one year after publication there were more than 1500 views and 300 full downloads worldwide). 30. Sasi SP, Rahimi L, Yan X, Silver M, Qin G, Losordo DW, Kishore R, #Goukassian DA. Genetic Deletion of TNFR2 Augments Inflammatory Response and Blunts Satellite Cell-Mediated Recovery Responses in Hind Limb Ischemia Model. FASEB J, Apr;29(4):1208-19, 2015. 31. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao TC, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol. Jun;225(3):181-9, 2015. 32. Sasi SP, Park D, Muralidharan S, Wage J, Kiladjian A, Onufrak J, Enderling H, Yan X, #Goukassian DA. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells Int. 2015:496512, 2015. 33. Coleman MA, P Sasi S, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev Y, Yan X, #Goukassian DA. Low Dose Radiation Affects Cardiac Physiology: Gene Networks and Molecular Signaling in Cardiomyocytes. Am J Physiol - Heart Circ Physiol. Sep 25:ajpheart.00050, 2015 (Podcast) 34. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh K, Yan X, #Goukassian DA. Ionizing particle radiation as a modulator of endogenous bone marrow cell reprogramming: implications for hematological cancers. Front. Oncol., 14 October 2015, http://dx.doi.org/10.3389/fonc.2015.00231 (in one month there were more than 210 views and 65 downloads) Chapters: 1. Suvorova X.N. and #Goukassian D.A.- Textbook for Physicians “Complications of Atopic Dermatitis by Secondary Infection and its Treatment”. -Moscow, 1993. 2. Kishore R,Tkebuchava T, Sasi SP, Silver M, Gilbert H-Y, Yoon Y-S, Park H-Y, Thorne, T, Losordo W, #Goukassian DA. Tumor Necrosis Factor-α Signaling Via TNFR1/p55 is Deleterious whereas TNFR2/p75 Signaling is Protective in Adult Infarct Myocardium. Publisher Springer, Adv Exp Med and Biol 691, Chapter 45: pp. 433-48, 2011. 3. #Goukassian D.A. Morgan J, Yan X. Neuregulin1-ErbB Signaling in Doxorubicin-Induced Cardiotoxicity. Publisher Intech, Ed.: Manuela Fiuza, Book Chapter in: Cardiotoxicity of Oncologic Treatments. pp. 65-88, 2012. (18 months after publication there were more than 1,500 full downloads worldwide). International patent applications (non-provisional): April 2008 – Pub No.: US 2012/0014879 A1 - Use of Tumor Necrosis Factor-α Receptor p75 for Treatment of Ischemia-Induced Neovascularization. Inventors – Losordo, DW, Goukassain DA.
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March 2010 – Pub No.: US 2010/0150841 A1 - Use of Tumor Necrosis Factor-Alpha p75 Receptor for the Reduction of Inflammation. Inventors – Goukassian DA, Kishore R. April 2013 – Pub No.: US 2013/0195896 A1 - Composition and Methods for the Treatment of Neoplasia. Inventor – Goukassian DA. August 2013 – Compositions and Methods for the Treatment of Radiation Exposure. Inventor – Goukassian DA.
Provisional patent applications: January 2015 - Patent Application No.: 62102374; Title - Compositions and Methods for the detecting and treating Cardiovascular Damage associated with ionizing radiation. Inventor - David A. Goukassian, MD, PhD. January 2015 - Patent Application No.: 62102431; Title - Particle radiation-induced non-targeted effects in bone marrow-derived endothelial progenitor cells. Inventor - David A. Goukassian, MD, PhD. January 2015 - Patent Application No.: 62102306; Title - Compositions and methods for diagnosing and/or reducing delayed cardiomyocyte response to total body particle radiation. Inventor: David A. Goukassian, MD, PhD. January 2015 - Patent Application No.: 62102500; Title - Different sequence of fractionated sequential proton and single low dose iron radiation induce divergent biological responses in the heart. Inventor: David A. Goukassian, MD, PhD. January 2015 – Patent Application No.: 62102439; Title – Particle radiation induced long-lasting cyclical decreases in the number of bone marrow progenitor cells is associated with up-regulation of several pluripotent stem cell markers over 10 months post radiation. Inventor: David A. Goukassian, MD, PhD. June 2015 – Patent Application No.: 62185353; Title – TNFR2/p75 neutralizing antibodies and uses thereof. Inventor: David A. Goukassian, MD, PhD.
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