Pharmaceutical Calculations

 

PHARMACEUTICAL CALCULATIONS

C

1. How many milliliter milliliter of U-100 insulin should be used tto o obtain 50 unit units s of insulin? a. 5 mL b. 50 mL c. 0.5 mL d. 500 mL

A

2. How many drops would be prescribed in each dose of a liqu liquid id med medicine icine if 20 mL contained 60 doses? The dispensing dropper calibrates 35 gtts per mL. a. 12 gtts b. 15 gtts c. 8 gtts d. 23 gtts

B

3. How many milligrams of a drug w will ill be n needed eeded to prepare 74 dosage forms if each is to contain contain 1/10 grain? a. 58 mg b. 480 mg c. 4800 mg d. 4.8mg

D

4. If a pint of a certain liquid w weighs eighs 9200 grains, what is the specific gravity of the liquid? a. 1.0 b. 1.32 c. 1.276 d. 1.26

B

5. How many gram grams s of dextrose are required tto o prepa prepare re 4500 L of a 5% solution?

B

a. 80,000 g b. 225,000g c. 4 f3 d. 8 f3 6. How many grams of a drug substance should be dissolved in 250 mL of water to make a 5% (w/w) (w/w) solution? a. 9.6 g b. 13.16 g c. 60 g d. 10 g

A

7. Convert 5% to mg/mL: a. 50 mg/mL b. 500 mg/mL

c. 5000 mg/mL

d. 5 mg/mL

B

8. In what proportion should alcohols of 90% and 50% strength strengths s should be mixed mixed to make 70% alcohol? a. 3 parts / 5 parts b. 1 part / 1 part c. 5 parts / 4 parts d. 4 parts / 5 parts

A

9. How many milliliters of two liquids with specific gravities of 0.950 and 0.875 should be used to prepare 1500 mL of a liquid having a specific gravity of 0.925? a. 1000 mL (sp gr 0.950) c. 500 mL (sp gr 0.950) 500 mL (sp gr 0.875) 1000 mL (sp gr 0.875) b. 2250 mL (sp gr 0.950) 1125 mL (sp gr 0.875)

d. 1125 mL (sp gr 0.950) 2250 mL (spgr 0.875)

A

10. Zinc chloride iis s a three-ion electrolyte, electrolyte, dissociating 80% in a certain concentration. concentration. Calculate its dissociation dissociation fa factor ctor (I): a. 2.6 b. 1.6 c. 2.9 d. 3

A

11. If 10 mg of a drug are added to a 500 mL large-volume parenteral fluid, what should be the rate of flow, flow, in mL/hour, mL/hour, to deliver 1 mg of drug per hour? a. 50 mL/hour b. 20 mL/hour c. 500 mL/hour d. 5 mL/hour

B

12. How many milliequivalents ar are e there in 15 mL of a 50% M MgSO4 gSO4 solution? (mol. Wt. 246) a. 6.097 mEq b. 60.97 mEq c. 6.96 mEq d. 69.7 mEq

B

13. You are directed to weigh 10 grams of a substance so as tto o limit the error to 0.2%. Calculate the maximum potential potential error, in terms of grams, that you would not be permitted to exceed. a. 0.05 g b. 0.02 g c. 0.002 g d. 0.2 g

B

14. A prescription is to be taken as follows: 1 tablet q. q.i.d. i.d. the ffirst irst day; 1 tablet t.i.d. the second day; 1 tablet b.i.d. x 5 d; and 1 tablet q.d. thereafter. How many tablets should be dispensed to equal a 3-day supply? a. 18 tablets b. 40 tablets c. 22 tablets d. 47 tablets

B

15. Tetracycline has has been shown to form a calcium complex in bone-formi bone-forming ng tissue in infants given oral tetracycline in doses of 0.011 g/lb body weight every 6 hours. Express the dose in terms of milligrams per kilogram of body weight. a. 5 mg/Kg b. 24.2 mg/Kg c. 25 mg/Kg d. 11 mg/Kg

A

16. How many colchicines colchicines tablet tablets, s, each containing 600 mcg, may be prepared from 30 g of colchicines? a. 50,000 tablets b. 20,000 tablets c. 20 tablets d. 50 tablets

D

17. Digitoxin is available for parenteral pediatric use in a concentration of 0.1mg 0.1mg/mL. /mL. How many milliliters would would provide dose of 40 mcg? a. 0.04 mL b. 40 Ml c. 40 mL d. 0.4 mL

A

18. Nitrostat Sublingual tablets are available as 1/200-gr tablets. What iis s tthe he approximate approximate equivalent in milligrams? a. 0.325 b. 0.077 c. 0.005 d. 0.65

D

19. Four thousand (4000) nanograms equals 4: a. centigrams b. grams c. milligrams

d. micrograms

B

20. If a physician prescribed 4 grams of aspirin to be taken by a patient daily, about how many 5-grain tablets should the patient take each day? a. 10 tablets b. 12 tablets c. 15 tablets d. 8 tablets

B

21. The prophylactic d dose ose of riboflavin is 2 mg. How many micrograms micrograms of riboflavin are in a multiple vitamin capsule containing 1/5 the prophylactic dose? a. 500 mcg b. 300 mcg c. 5000 mcg d. 200 mcg

www.brex.us

113

 

PHARMACEUTICAL CALCULATIONS

A

22. A commercial package contains thirty-six 200-mg tablets of ibuprofen. How many kilograms of ibuprofen were used in the manufacture of 1000 packages of product? a. 7.2 Kg b. 5 Kg c. 7.8 Kg d. 6.9 Kg

B

23. How many grams of ethyl estradiol are needed to prepare 2,500 tablets, each containing 50 mcg of the medicinal substance? a. 1.25 g b. 12.5 g c. 0.125 g d. 125 g

A

24. Pico denotes _____ of the basic unit: -12 -15 a. 10   b. 10  

-18

c. 10  

-10

d. 10  

A

25. 1 milliliter is 1,000x greater than:

C

a. microliter b. picoliter c. nanoliter d. liter 26. Sudafed cough syrup contains 0.09 g of dextromethorphan hydrobromide in each fluidounce. How many milligrams of this agent would be present in each teaspoonful dose? a. 10 mg b. 12 mg c. 15 mg d. 20 mg

D

27. The usual dose of digoxin for rapid digitalizati digitalization on is a total of 1.0 mg, divide into two or more portions at intervals of 6 to 8 hours. How many milliliters of digoxin elixir containing 50 mcg/ mL mL would provide this dose? a. 15 mL b. 10 mL c. 25 mL d. 20 mL

A

28. The dose of beclamethasone, an aerosoliz aerosolized ed inhal inhalant, ant, iis s 200 cg tw twice ice daily. The commercial inhaler de delvers lvers 50 mcg per metered inhalation and contains 200 inhalations. How many inhalers should be dispensed to a patient if a 60-day supply is prescribed? a. 3 b. 2 c. 4 d. 5

B

29. If a physician prescribed Keflex, 250 mg q.i.d. x 10 days, how many millilit milliliters ers of Keflex suspension containing 250 mg per 5 mL should be dispensed? a. 250 mL b. 200 mL c. 150 mL d. 100 mL

A

30. Terpin hydrate and codeine elixir cont contains ains 60 mg of codeine per 30 mL. How much additional additional codeine codeine should be added to 180 mL of the elixir so that each teaspoonful will contain 15 mg of codeine? a. 180 mg b. 200 mg c. 170 mg d. 190 mg

C

31. The directions directions intended for the patient on a prescription read 1 Tbsp a.c. and h.s. for 10 days. What is the minimum minimum volume the pharmacist should dispense? a. 200 mL b. 150 mL c. 600 mL d. 450 mL

A

32. If tthe he cost of hum human an growt growth h hormone is P40/m P40/mg g q 4 h six time times s daily. How many will a 180-lb patient receive daily? a. 12 mg b. 164 mg c. 650 mg d. 980 mg

C

33. The pediatric pediatric dose of cefadroxil is 30mg/K 30mg/Kg/day. g/day. If a child w was as given a daily dose of 2 teaspoonfuls teaspoonfuls of pediatric suspension containing 125 mg of cefadroxil per 5 mL, what was the weight, in pounds, of the c child? hild? a. 19 lbs b. 17.3 lbs c. 18.3 lbs d. 18.5 lbs

A

34. A Ferrous Ferrous Sulf Sulfate ate sy syrup rup contains 220 m mg g of FeSO4.7H2O per tteaspoon easpoon dose. How many milligrams milligrams of elemental iron are present in the dose? (mol wt FeSO4.7H2O = 278; at. Wt. of Fe = 55.9, s = 32.1, O = 16, H = 1.0) a. 44 mg b. 50 mg c. 88 mg d. 100 mg

A

35. An antacid antacid tablet contains 80 mg off dried aluminu aluminum m hydroxide gel and 20 g of magnesium magnesium trisilicate. How man many y kilograms of aluminum hydroxide gel are required to manufacture 250000 bottles of the product, each containing 100 tablets? a. 2000 Kg b. 20,000 Kg c. 200 Kg d. 8000 Kg

B

36. An estradiol ttransdermal ransdermal system conta contains ins in each skin patch 4 m mg g of estradiol and 0.3mL of of alcohol. How many liters of alcohol would be required to manufacture a half-million patches? a. 15 L b. 150 l c. 1,500 L d. 300 L

A

37. From the ff. formula: Benzyl benzoate Triethanolamine Purified water, to make

250 mL 5 mL 1000 mL

Calculate the quantity of benzyl benzoate required to make 6 fl. Oz. of benzyl benzoate lotion. a. 45 mL b. 40 mL c. 4.5 mL d. 25 mL B

38. If 150 mL mL of polyethylene glycol 400 weighs 74.1 g g,, w what hat is its specific gravit gravity? y? a. 0.88 b. 0.494 c. 2.35 d. 1.3

C

39. A sunscreen lotion contains 5 g of m methyl ethyl salicylate (sp gr 1.045) p per er 1000 mL. How many milliliters milliliters of methyl salicylate should be used in preparing 1 gallon of the lotion? a. 189.25 mL b. 197.77 mL c. 181.10 mL d. 190 mL

D

40. Cocoa butter, which is solid at room temper temperature ature and melts at 34°C, has a specific gravity of 0.86. If a formula calls for 48 mL of theobroma oil, what would be the corresponding weight of cocoa butter to use? a. 40 g b. 55.81 g c. 50 g d. 41.3 g

www.brex.us

114

 

PHARMACEUTICAL CALCULATIONS

D

41. A formula formula for a mouth rinse contains 1/10% (w/v) of zinc chloride. How many grams of zinc chloride should be used in preparing 25 liters of the mouth rinse? a. 35 g b. 30 g c. 20 g d. 25 g

C

42. If a pharmacist dissolves the contents of 8 capsul capsules, es, each containing 250m 250mg g of clindamycin hydrochloride, hydrochloride, into a sufficient amount of Ionex Astringent to prepare 120 mL of solution, what is the percentage strength (w/v) of clindamycin hydrochloride in the prescription? a. 1% b. 1.5% c. 1.67% d. 2%

B

43. If an intravenous dose of mannit mannitol ol is 1. 1.5% 5% (w/v) sodium chloride solution can be made from 1 lb of sodium chloride? a. 50,444 mL b. 30,000 mL c. 50,400 mL d. 1,000 mL

C

44. If 10 mL f a nitroglycerin injection (5mg of nitroglycerin per millili milliliter) ter) are ad added ded to make a liter of intravenous fluid, fluid, is the percentage of nitroglycerinc.in 0.005% the final product? d. 0.0005% a. what 0.025% b. (w/v) 0.05%

A

45. How many milliliters of resorcinol monoacetate should be used to prepare 1 pint of a 15% (v/v) lotion? a. 71 mL b. 65 mL c. 76 mL d. 69 mL

B

46. How many liters of a mouthwash can be pre prepared pared from 100 mL of cinnamon flavor if its concentration is to be 0.5% (v/v)? a. 10 L b. 20 L c. 15 L d. 18 L

C

47. One pound pound of a fun fungicidal gicidal oint ointment ment contains 9. 9.08 08 g of unde undecylenic cylenic acid. Calculate the percentage (w/w) (w/w) of undecylenic acid in the ointment. a. 1.81% b. 1.5% c. 2% d. 2.5%

B

48. A vaginal vaginal foam foam contains 0.0 0.01% 1% (w/v (w/v)) of dienestrol. Express thi this s concentration as a ratio strength. a. 1:100 b. 1:10,000 c. 1:1,000 d. 1:100,000

A

49. A sample of w white hite p petrolatum etrolatum contains 10 mg of ttocopherol ocopherol per kilogram a as s a preservative. Express the the amount amount of tocopherol as a ratio strength. a. 1:100,000 b. 1:1,000 c. 1:1,000,000 d. 1:10,000

B

50. Hepatitis B immune globulin is preserved w with ith 1:10,000 (w/v) of thimerosal. If the dose of the injection is 0.06 mL/Kg mL/Kg of body weight, how many micrograms of thimerosal would be contained in the dose for a 150-lb patient? a. 400 mcg b. 409 mcg c. 415 mcg d. 450 mcg

C

51. What is the percent concentratio concentration n of cholesterol in a patient’s blood serum if the cholesterol level is determined to be 260 mg%? a. 2.6% b. 26% c. 0.26% d. 0.026%

B

52. If a serum sample is determined to contain 270 mg/dL of cholesterol, what is the concentration concentration of cholesterol (mol wt 386) in terms of millimoles per liter? a. 6.5 mmol/L b. 6.9 mmol/L c. 69.9 mmol/L d. 5.66 mmol/L

A

53. A glucose m meter eter show shows s that a pat patient’s ient’s b blood lood cont contains ains 125mg 125mg% % of glucose. Express this valu value e as mg/mL. a. 1.25 mg/mL b. 12.5 mg/mL c. 125 mg/mL d. 0.125 mg/mL

C

54. If 250 mL of a 1:800 (v/v) solution are dilut diluted ed to 1000 mL, what w will ill be the rratio atio strength (v/v)? a. 1:320 b. 1:3000 c. 1: 3,200 d. 1: 32,000 DNA

B

55. If 400 ml of a 20% (w/v) solution are diluted to 2 liters, what will be the percentage strength (w/v)? a. 8% b. 4% c. 5% d. 2%

C

56. How many milliliters of water must be added to 250 mL of a 25% (w/v) stock solution of sodium chloride to prepare a 0.9% (w/v) sodium chloride solution? a. 6,5100 mL b. 6,600 mL c. 6,694 mL d. 6,490 mL

C

57. How many milliliters milliliters of a syrup containing 85% (w/ (w/v) v) of sucrose should be mixed mixed with with 150mL of a syrup containing 60% (w/v) of sucrose to make a syrup containing 80% (w/v) of sucrose? a. 500 mL b. 550 mL c. 600 mL d. 650 mL

D

58. How many milliliters of 95% (w/w) sulfuric acid having a specific gravity of 1.820 should be used in preparing 2 liters of 10% (w/v) sulfuric acid? a. 110 mL b. 120 mL c. 114 mL d. 116 mL

B

59. How many grams of zinc oxide should be added tto o 3,400 g of a 10% zinc zinc oxide ointment ointment to prepare a product containing 15% of zinc oxide? a. 150 g b. 200 g c. 250 g d. 210 g dipole

A

60. How many grams of petrolatum (d (diluent) iluent) should be added to 925 g of zinc oxide paste to prepare an ointment containing 6% of coal tar? a. 59 g b. 60 g c. 50 g d. 55 g

D

61. Four equal equal am amounts ounts of belladonna extract, containing 1.15%, 1.30%, 1. 1.35% 35% and 1.20% of alkaloids respectively, respectively, were mixed. What was the percentage strength of tthe he mixture? a. 1.2% b. 1.4% c. 1.5% d. 1.25%

www.brex.us

115

 

PHARMACEUTICAL CALCULATIONS

A

62. How many milliliters of a 2% (w/ (w/v) v) solution of lidocaine hydrochloride should be used in preparing 500 mL of a solution containing 4 mg of lidocaine hydrochloride per milliliter of solution? a. 100 mL b. 150 mL c. 250 mL d. 120 mL

D

63. How many milliliters of a 37% (w/v) concentrate of saline solution should be used in preparing 750 750 mL of of a solution such that 10 mL diluted to a liter will yield a 9% solution? a. 225 mL b. 156.5 mL c. 67.5 mL d. 182.4 mL

C

64. How many milliliters of a 23.5% (w (w/v) /v) concentrate of sodium chloride soluti solution on should be used in preparing 650 mL of a stock solution such that 30 mL diluted to a liter will yield a 1:5000 solution? a. 0.2 mL b. 4.33 mL c. 18.44 mL d. 11.75 mL

A

65. A 35-mL 35-mL aliquot was obta obtained ined from a mixt mixture ure of 98% un unknown known solution. If half the sample sample is diluted to 100 mL, what its final concentration? a. is17.15% b. 2.94%

c. 280.0%

d. 34.3%

B

66. Prepare 30% alcohol cooling sponge from 1 pint of 70% isopropyl rubbing alcohol using the whole bottle. a. add 500 ml of distilled distilled water to 1 pt of 70% alcohol b. add 656.6 ml of distilled water to 1 pt of 70% alcohol c. add 333.33 m mll of distilled water to 1 pt of 7 70% 0% alcohol d. add 200 ml of distilled distilled water to 1 pt of 70% alcohol

A

67. Rx Procaine hydrochloride Sodium chloride Sterile water for injection Make isoton. Sol. Sig. for injection

1% q.s. ad 100.0

How many grams of sodium chloride should be used in compounding the prescription? (NaCl equivalent of procaine HCl is 0.21) a. 0.690 g b. 0.5 g c. 0.6 g d. 0.65 g A

68. What is the the concentration, in milligram milligrams s per m milliliter, illiliter, of a solution containing 5 mEq of potassium chloride (KCl) per milliliter? a. 372.5 mg

b. 375 mg

c. 370 mg

d. 368.5 mg

C

69. Calculate the the sodium (Na) content, in terms of mE mEq, q, of 1 g of a ampicillin mpicillin sodium sodium (C16H18N3NaO4S, mol wt 371) a. 2.5 mEq b. 2.8 mEq c. 2.7 mEq d. 3 mEq

A

70. Ammonium chloride (NH4Cl, mol wt 53.5) is to be used as a urinary acidifier with with a dose of 150 mEq. mEq. How many many 500 mg tablets should be administered? a. 16 tablets b. 20 tablets c. 15 tablets d. 13 tablets

A

71. A physician physician places a patient on a daily dose of 60 units of u-80 units’ insulin. How many ml should the the patient inject each day? a. 0.75 b. 1.33 c. 0.6 d. 0.5

A

72. Give anti-diphtheria anti-diphtheria serum 6000 U by intramuscular 2injections tto o a patient. The patient stock stock is 10000 U/ 5mL vial. How many mL are you going g oing to inject? a. 3 mL b. 5 mL c. 2 mL d. 1 mL

C

73. A jar of cleansing cream is sold for P7.50, thereby y yielding ielding a gross profit of 60% on the cost. What did it cost? a. P5.00 b. P4.00 c. P4.69 d. P4.50

A

74. A pharmacist pharmacist buys 20,000 tab tablets lets for P4000.00 with discounts of16% and 2%. At what what price per 10 must the the tablets tablets be sold to yield a gross profit of 40% on the selling price? a. P27.50 b. P25.50 c. P27.00 d. P28.00

D

75. A prescription item costs a pharmacist P12 P122.00. 2.00. U Using sing a markup of 25% on the cost plus a professional fee fee of P50.00, calculate the prescription price. a. P200.00 b. P250.00 c. P215.00 d. P202.50

B

76. A saturated saturated solution of sodium chloride boils at 22 227.1° 7.1°F. What is its boiling boiling point on the centigrade scale? scale? a. 100°C 100°C b. 108. 108.24° 24°C C c. 105° 105°C C d. 107 107° °C

A

77. A manufacturing pharmacist received a drawback of P1500 on the alcohol that that was was used during a certain period. period. If the drawback on alcohol is P12.50 per proof gallon, how many wine gallons of95% alcohol were used during the period? a. 63.2 b. 60 c. 58 d. 65

A

78. 160 proof strength alcohol is equivalent to: a. 80% b. 320% c. 100%

D

d. all of the above

79. What is the the solubility of anhydrous chemical if 100 g of a saturated aqueous solution leaves a residue of of 25 g after evaporation? a. 1:5 b. 1:4 c. 1:2 d. 1:3

www.brex.us

116

 

PHARMACEUTICAL CALCULATIONS

B

80. A formula formula for a dermatologic cream calls fo forr a 15 g of an emulsifier blend consisting of Tween 20 and Span 40. If the required HLB is 11.70, how many grams of each emulsifier should be used in emulsifying the the cream? (HLB of Tween 20 is 16.7 and Span 40 is 6.7) a. 5 g Tween 20 and 10 g Span 40 b. 7.5 g Tween 20 and 7.5 g Span 40

c. 2.5 g Tween 20 and 12.5 g of Span 40 d. none of the above

B

81. How many 1-fluidounce 1-fluidounce bott bottles les of lagundi syrup can e prepared form 5 gallons gallons of the syrup? a. 740 b. 640 c. 639 d. 540

B

82. A fformula ormula for a cough syrup contains 1/ 1/8 8 grain f codeine phosphate per teaspoonful. teaspoonful. How many many grams grams of codeine phosphate should be used to prepare a quart of the cough syrup? s yrup? a. 1.75 g b. 1.54 g c. 1.84 g d. 2.54 g

C

83.a.The off amyl nitrite is 0.18 mL.c.Express 4 minhalant dose o b. 2 m 3 m the dose in minims. d. 5 m

A

84. A patient weighing 8 lbs is prescribed 2mE 2mEq/kg/day q/kg/day of pot potassium assium chloride (mol wt 74.5). How many many mg of potassium chloride will be administered to the patient per day? a. 541.8 b. 538 c. 436.4 d. 648

D

85. How many grams of sodium chloride (mol w wtt 58.5) should be used to prepare 1 gallon of an isotonic solution? a. 24 b. 28 c. 32 d. 34.1

A

86. A sterile sterile solution of potassium chloride ( mol wt 74 74.5) .5) contains 2 mE mEq/ q/ mL. If a 20-ml ampoule ampoule of the solution solution is diluted to 1 liter, what is the percentage strength of the resulting solution? a. 0.298 b. 0.124 c. 1.298 d. .3241

B

87. How many milliliters of a 3% (w/ (w/v) v) solution of ammoniu ammonium m chloride (mol wt 53.5) should be administered intravenously to provide 50 mEq? a. 99.2 b. 89.2 c. 69.2 d. 79.2

A

88. An initial initial dose of not less than 150 unit units/kg s/kg of body weight has been recommended for for open heart surgery. How many mL of an injection containing 5000 heparin units per mL should be administered to a 300-lb patient? a. 4.1 mL b. 4.1 microliter c. 5.1 mL d. 5.1 microliter

A

89. Acetazolamide sodium is available in 500-mg vials to be reconstituted to 5 mL with sterile water for injection prior to use. The dose of the drug for children is 5mg/ kg of body weight. How many mL of the the injection should be administered to a child weighing 25 lbs? a. 0.57 mL b. 0.52 mL c. 0.50 mL d. 0.54 mL

A

90. Rx Dextrose anhydrous 25% Sodium chloride q.s. Sterile water for injection ad 1000mL Label: Isotonic Dextrose an and d Saline Sol Solution. ution. How many grams of sodium chloride should be used in preparing the solution? The sodium chloride equivalent of dextrose anhydrous is 0.18. a. 4.7 g b. 4.2 g c. 4.5 g d. 4.0 g

A

91. Rx Zinc sulfate Boric acid Purified water Make isoton. Sol.

0.06 q.s. ad 30.0

How many grams of boric acid should be used in compounding the prescription? The sodium, chloride equivalents of zinc sulfate and boric acid are 0.16 and 0.52, respectively. a. 0.50 g b. 0.45 g c. 0.59 g d. 0.30 g C

92. In using isoproterenol hydro hydrochloride chloride solution (1:5000 w w/v), /v), 1 mL of the solution solution is diluted to to 10 mL with with sodium chloride injection prior to IV administration. administration. What is he percentage concentration of the diluted solution? a. 0.001 b. 0.005 c. 0.002 d. 0.008

B

93. How many grams of lactose should be added to 80 g belladonna extract assaying 2.5% (w/w) (w/w) of alkaloids to reduce its strength to 1.4%? a. 52.5 b. 62.8 c. 42.8 d. 60.2

A

94. If 500 mL of mineral oil which has a specific gravity of 0.87, is used to prepare 2 pints of mineral oil emulsion, how many g of the oil would be used to prepare 1 gallon of the emulsion? a. 1740.4 b. 1430.4 c. 1750.4 d. 1741.4

A

95. A perfume oil has a specifi specific c gravity of 0. 0.960 960 and costs P P776.25 776.25 per kg. How much would would 5 fluidounces cost? a. P110.15 b. P111.15 c. P109.15 d. P 180.15

www.brex.us

117

 

PHARMACEUTICAL CALCULATIONS

A

96. If 800 g of a 5% coal coal tar o ointment intment is mixed with 1200 g o off a 10% coal tar ointment, what is the the concentration of coal tar in the finished product? a. 8% b. 8.5% c. 9% d. 9.5%

A

97. How many mL of a 5% (w/v) (w/v) solution o off lidocaine hydrochloride should b be e used in in preparing 500 mL of a solution containing 25 mg of lidocaine hydrochloride per mL of solution? a. 250 mL b. 260 mL c. 240 mL d. 270 mL

C

98. In what proportion should 10% and 2% coal tar oint ointments ments be mixed to prepare a 5% ointment? a. 3:7 b. 2:5 c 3:5 d. 2:3

D

99. How many g of isoflurophate ar are e contained in 15 g of a 1 1:10,000 :10,000 ophthal ophthalmic mic solution of isofluroph isoflurophate ate in peanut peanut oil? a. 1.8 mg b. 1.9 mg c. 1.7 mg d. 1.5 mg

B

100. the Thedifference norm normal al range of specific gravity of urine about 1.003 to 1.03 1.030. 0. Using 5-mL urine sam samples, ples, what would be in weight, in mg, between theseisextremes? a. 145 mg b. 135 mg c. 136 mg d. 155 mg

A

101. What is the single dose for a child weighing 53 lbs if the usual pediatric dose of cefazolin sodium is 25 mg/kg/ mg/kg/day day divided equally into 3 doses? a. 200 mg b. 210 mg c. 200 g d. 220 mg

A

102. The adu adult lt dose of a liquid medicat medication ion is 0.1 mL/kg mL/kg body weight tto o be administered as a single dose. How many many teaspoonfuls should be given to a patient weighing 220 lb? a. 2 tsp b. 2.5 tsp c. 3 tsp d. 2 tbsp

B

103. What is the dose of a drug for a 6-year old child if the average adult dose is 1 ½ grains? a. ½ g b. ½ gr c. ½ mg d. ½ mcg

C

104. If 250 unit units s of an antibiotic antibiotic weighs 1 mg, how many units units are in 25 mg? a. 6,256 b. 6,255 c. 6,250 d. 6,500

D

105. A pati patient ent is t receive 260 mcg of a drug 4 times a day for 14 days. How many 1/250 grain tablets must must be dispensed? a. 66 b. 58 c. 46 d. 56

A

106. A phar pharmacist macist had, on the first m month, onth, 54 gallons of 95% alcohol. During the the month, 35 gallons were used in tthe he manufacture of pharmaceutical products. How many proof gallons of alcohol were on hand at the end of the month? a. 36.1 b. 36.5 c. 36.4 d. 36.3

A

107. Calculate the volu volume, me, iin n wine gallons, represented by 175 proof ga gallons llons of 75% (v/v) (v/v) alcohol. a. 125 b. 135 c. 115 d. 145

B

108. How many proof gallons are contained in 500 wine gallons of Dilut Diluted ed Alcohol NF that contain 49% 49% (v/v) of pure alcohol? a. 480 b. 490 c. 470 d. 489

C

109. Convert C onvert 100° 100°C C to °F. a. 221°F 221°F b. 312° 312°F F

c. 212° 212°F F

d. 215 215° °F

C

110. What is the molarity of a solution that is prepared by dissolving 10 g of KCl (mol wt 74.5) in enough water to make 500 mL of solution? a. 0.288 b. 0.258 c. 0.268 d. 0.168

C

111. A pain reliever tablet is listed at P P100 100 per dozen, less a discount of 33. 33.5%. 5%. The manufacturer offers offers 12 tablets free for every 6 dozens purchased. What is the net cost per tablet when the drug is bought on the deal? a. P4.25 b. P4.35 c. P4.75 d. P4.50

B

112. 12 bottles of 100-tablet multivitamins cost P3000 when bought on a promotional deal. If tthe he tablets tablets sell for P450 P450 per bottle, what percent of gross profit p rofit is realized on the selling price? a. 45% b. 44.44% c. 35.44% d. 40.44%

D

113. A prescriptio prescription n item costs P13.50. Using a markup of 50% on the cost, what would would be the selling price for the prescription? a. P20.50 b. P20.35 c. P20.35 d. P20.25

C

114. What is the percent percent concentrati concentration on of cholesterol if a patient patient’s ’s blood serum level level is determined to be 260mg%? a. 26% b. 2.6% c. 0.26% d. 0.26% e. 260%

A

115. Peppermint spirit contai contains ns 10% (w/v) of pepper peppermint mint oil. How m many any mL of peppermint peppermint oil should should be used in preparing 1 gallon of the spirit? a. 379 mL b. 3.79 mL c. 37.9 mL d. 3,785 mL e. 0.400 mL

B

116. The normal body tempera temperature ture is 37° 37°C. C. Express this in °Fahrenhe Fahrenheit. it. a. 96.8° 96.8 °F b. 98.6 98.6° °F c. 28.3° 28.3 °F d. 100° 100 °F

C

117. Number of grams of constituents per 100 mL solution:

www.brex.us

118

 

PHARMACEUTICAL CALCULATIONS

a. % w/w

b. % v/v

c. % w/v

d. none of the given

C

118. Admixture with solutions or mixture of greater st strength rength or by evaporation of the diluent: a. diluted b. saturated c. concentrated d. none

A

119. Dilutions of potent medicinal substances: a. triturations b. diluents c. extracts

d. extractives

120. 2 solutions that have the same osmotic pressure: a. hypotonic b. hypertonic c. isoosmotic

d. isotonic

C B

121. What does 0.5mg/ 500 g capsule mean when expressed in %w/w? a. 0.5% b. 0.1% c. 5% d. 1%

e. none

e. none

C

122. If the ampules of amyl inhalant each4000 contain 0.3 mL of amyl nitrate, having a sp gr of 0.87, how many grams of drug would benitrate used in preparing ampules? a. 4401 g b. 4014 g c. 1044 g d. 1404 g e. 1440 g

A

123. ______ grams is also equivalent to 10 milliliters of water. a. 10 b. 100 c. 1.00

d. 0.01

e. 0.01

C

124. In preparing 250 m mL L of a certain lotion, a pharmacist us used ed 16 mL of liquefied phenol. What was the percentage percentage of liquefied phenol in the lotion? a. 15.63% b. 0.064% c. 6.4% d. none

C

125. Using a v vial ial containing 200,000 units of Pen G sodium, how many mL of solvent should be added to to the dry powder in preparing a solution s olution having a concentration of 25, 000 units/mL? a. 5 mL b. 10 mL c. 8 mL d. 12 mL e. 15 mL

B

126. Paregoric acid contains the equivalent pf 0.4% opium. How many mg of opium are rrepresented epresented in a tablespoon dose of equal parts of paregoric and kaopectate? a. 20 mg b. 25 mg c. 15 mg d. 30 mg e. 28 mg

B

127. White o ointment intment has a label claim of 5 g/ 1000g. When expressed in % w/w, this is eq equal ual to: to: a. 5% b. 0.5% c. 0.05% d. 50% e. 0.005%

B

128. Number of mL of constituents per 10 mL of solution: a. percent weight per volume d. % w/w b. % v/v e. none of the given c. percent volume in weight

B

129. An instrument for measuring temperature, or intensity of heat: a. barometerq b. thermometer c. pycnometer

d. spectrophotometer

B

130. The term expresses the number of milligrams of a substance in 100 mL of liquid: liquid: a. milligram percent c. both b. mg % d. none

B

131. How many mL of water should be added to 300 mL of 1:750 (w/v) solution of benzalkonium chloride to make a 1:2500 (w/v) solution? a. 997.5 mL b. 700 mL c. 90.23 mL d. 60000 mL

D

132. Methotrexate sodium iin n action contains 25 mg of m methotrexate ethotrexate sodium pe perr mL. Express the % concentration concentration of methotrexate in the injection. a. 0.25% b. 25% c. 0.025% d. 2.5% e. 0.0025%

D

133. Expression of taking 50% (v/v) alcohol or pro proof of s spirits pirits as 100 proof: a. 50% v/v alcohol b. 50% proof spirit c. proof spirit

A B

134. 90% of alcohol is how many proof? a. 180 proof b. 45 proof

c. 135 proof

135. Aqueous solution containing 50% (v/v) of absolute alcohol. a. proof solution b. proof spirit c. % proof

d. proof strength

e. none

d. none d. %solution

e. none

B

136. How many mL of 1:16 solution of sodium hypochlorite should be used in preparing 5000 mL of a 0.5% solution of sodium hypochlorite for irrigation? a. 200 mL b. 400 mL c. 600 mL d. 800 mL e. 100 mL

B

137. How many gallons gallons of 95% (v/v) alcohol w would ould contain 91.2 proof gallons? a. 137 b. 48 c. 173.28 d. 52

e. none

B

138. How many liters of 2% (w/v) iodine tin tincture cture can be ma made de from 123 g of iodine? iodine? a. 6150 L b. 6.15 L c. 61.15 L d. none of the given

C

139. How m many any mil milligrams ligrams o off a certified red color should be used in preparing 5 L of a 0.1% solution? a. 0.005 g b. 0.5 g c. 5 g d. 0.05 g

A

140. What is the percentage percentage of alcohol in a mix mixture ture of 4000 mL of 60% and 3000 mL of 30% alcohol?

www.brex.us

119

 

PHARMACEUTICAL CALCULATIONS

a. 47%

b. 3666%

c. 82.5%

d. 110%

B

141. A gal gallon lon of a certai certain n lotion contains 946 mL of benzyl benzoate. Calculate the % v/v of benzyl benzoate in the lotion. a. 20% b. 25% c. 18% d. 28% e. 15%

E

142. How many grams of a dug substance should be dissolved in 1800 mL of water to make 10% (w/w) (w/w) solution? a. 100 g b. 50 g c. 300 g d. 25 g e. 200 g

E

143. Lidocaine HCl syringe contains 100 m mg g per 5 mL injection. Express this concentration in % (w/v). (w/v). a. 0.2% b. 20% c. 10% d. 1.0% e. 2%

A

144. Expression of concentrations of weak solutions or liquid preparations: a. strength per se b. ratio concentrations c. strength volume

B A

d. all concentration e. of the givengradient

145. If the dose of the drug is 100 mg how many doses are there in 100 mg? a. 100 b. 1000 c. 10000 d. 100000

e. 1000000

146. 1.5 mg/ 5 mL of echothipate acetonide ointment is al also so equivalent to: a. 0.3% b. 30% c. 0.003% d. 0.03%

e. none

D

147. How many of a g grams rams of a drug, tannic acid should be d dissolved issolved in 320 mL of glycerine having a specific specific gravity of 1.25 to make a 20% (w/w) solution? a. 8 g b. 0.8 g c. 80 g d. 100 g e. 0.008 g

B

148. If the specific gravity of alcohol is 0.812, what is the w weight eight in kilograms o off 10 L? a. 2.81 kg b. 8.12 kg c. 2.18 kg d. 1.82 kg

e. 8.21 kg

A

149. The draw drawback back on alcohol is $11.50 per proof gallo gallon. n. If an eligible claimant us used ed 18 gallons of 95% alcohol, how much drawback will be allowed? a. 2941 mL b. 850 mL c. 11765 mL d. 85 mL

D

150. Convert 6:1000 (w/v) to mg/mL: a. 60 mg/ 10 mL

b. 6 mg/ mL

c. 600 mg/ 100 mL

d. all of the above

A

151. How many grams of opium containing 15% (w/w) of morphine and how many grams of lactose should be used to prepare 150 g of opium containing 10% of morphine? a. 50 g b. 5 g c. 0.5 g d. 500 g e. none

B

152. If 50 tablets contai contain n 0.625 g of an active ingredient, how many tablets can e prepared prepared from 31.25 g of the ingredient? a. 1000 tablets b. 2500 tablets c. 3030 tablets d. none of the above

C

153. How m many any flui fluidounces dounces of a 7% solution can be made fro from m 142 grains of potassium iodide? a. 4.6 b. 5 c. 4.5 d. 4.4

A

154. ss is equal to: a. one half

b. one whole

c. one

d. none of the above

D

155. If 2 tabl tablets ets contain contain 550 mg of paracetamol, how many tablets tablets shou should ld contain 3000 mg? a. 10 b. 12 c. 8 d. 11

B

156. How many grams of water are needed to make 300 g of an 8% w/w solution of lime water? water? a. 275 g b. 276 g c. 300 g d. 277 g

C

157. A 250 mL infusion bottle contains 2.0 mEq of calcium per mL. How much calcium in grams does it contain? Ca: mol wt = 40.0 a. 3.0 g b. 5.0 g c. 10.0 g d. none of the above

C

158. If the ratio 1:250 is expressed as %, the result is: a. 0.004% b. 0.04% c. 0.4%

d. 0.004%

e. 0.05%

D

159. How many mL of 1:5000 (w/v) solution of phenyl mercuric nitrate can be made from 125 mL of a 0.5% solution? a. 1050 b. 5 c. 80 d. 3125 e. none

B

160. How much cod liver oil is necessary to m make ake 250 2500 0 capsules, each containing containing 0.33 0.33 mL? mL? a. 7.57 mL b. 825 mL c. 757 mL d. 0.0012 mL

A

161. How many chloramphenicol chloramphenicol capsules, each cont containing aining 250 mg of chloramphenicol, are needed needed to provide 25 25 mg/kg of body weight per day for 1 week for a person weighing 132 lb? a. 42 b. 24 c. 6 d. 10

D

162. How many fluidounce-bottles can be packed ffrom rom a 33-gallon gallon bottle of antipyretic syrup? a. 90 b. 70 c. 85 d. 96

C

163. q.s.

www.brex.us

120

 

PHARMACEUTICAL CALCULATIONS

a. pint C

b. right eye

164. How many mg are there in 3/8 grains? a. 23 mg b. 23.5 mg

c. a sufficient quantity

c. 24 mg

d. when required

d. 24.5 mg

B

165. How many grams of a drug substance are requir required ed to m make ake 160 mL of a solution, each tsp of which contains 2 mg of the drug substance? a. 64 g b. 0.064 g c. 0.015 g d. 0.64 g

A

166. Roman numeral for 1050: a. ML b. MC

A

b. 16

c. 22

d. 10

168. How many mL of 1:50 stock solution of ephedrine sulfate w would ould be needed to prepare 30 mL of the prescription? prescription? Rx Ephedrine sulfate 0.25% Normal saline q.s. 10 Ml a. 1.25

A

d. DC

167. If one tablespoonful is prescribed as the dose, approx approximately imately how many doses will be contained in one pint of the a. medicine? 32

B

c. MD

b. 3.75

c. 4

d. 7.5

e. 12.5

169. The rratio atio expressed decimally of tthe he weig weights hts of a substance chosen as a standard. a. specific gravity b. percentage c. ratio d. density

e. percent

B

170. A vit vitamin amin capsule contains 6.25 mcg of Vit B B12. 12. How many capsules can be prepared from 1 g of vit B12? a. 106000 b. 160000 c. 100600 d. none

A

171. Unit of weight of metric system: a. gram b. scruple

c. dram

d. grain

172. The dose that can kill the patient: a. lethal dose b. toxic dose

c. therapeutic dose

d. maintenance dose

A

e. liter

B

173. The average body surface area 2 2 of an adult is: a. 1.76 m   b. 1.73 m   c. 1.7 v

B

174. B.i.d. means: a. once a day

b. twice a day

c. three times a day d. four times a day

175. Ung means: a. cream

b. cataplasm

c. cerate

D B C B

d. 1.73 cm

d. ointment

176. 100 proof strength of alcohol is equivalent to: a. 100% b. 50% c. 70%

d. 45%

177. One kilogram is equivalent to: a. 1000 mg b. 2.5 lb

c. 1000 g

d. 5.432 gr

178. One avoirdupois pound is equivalent to: a. 373.2 g b. 454 g

c. 28.35 g

d. 31.1 g

B

179. What is the specific gravity of a liquid having a specific v volume olume of 0.825? a. 0.825 b. 1.212 c. none of the choices

A

180. How many mL of a 0.5% gentian violet sto stock ck solution are needed to prepare one gallon of a 1:500 solution? solution? a. 151.4 b. 15.14 c. 9.46 d. 94.6

C

181. What is the percentage of alcohol in a mixture of 400 mL of 95% v/v alcohol, 100 mL of 70% v/v alcohol and 0.6 L of 50% v/v alcohol? a. 75% b. 7.5% c. 68% d. 69% e. 72.7%

C

182. An elix elixir ir is to conta contain in 250 mcg of an alkaloid in each teaspoon do dose. se. How many many g of the alkaloid will will be required to prepare 5L of the elixir? a. 25 g b. 2.5 g c. 0.25 g d. 5 g e. 0.5 g

D

183. If alcohol is taxed at P12.50 per proof gallon, what is the tax on 30 wine gallons gallons of 95% v/v alcohol? a. P197 b. P57 c. P16 d. P712.50 e. P85

B

184. One fl fluidounce uidounce of a cough syrup contains 10 gr of sodium citrate, how many mg are contained in 5 mL? a. 50 b. 109 c. 40 d. 108 e. 30

C

185. Temperature at which specific gravity should be performed according to USP/ NF: a. 4°C 4°C b. -40 -40° °C c. 25° 25°C C d. 25°C 25°C e. -40 -40° °C

B

186. Equivalent to 1:2500: a. 0.4% b. 0.04%

www.brex.us

c. 0.01%

121

 

PHARMACEUTICAL CALCULATIONS

A

187. The number of mL of a lliquid iquid that would provide a patient with 2 teaspoonfuls twice twice a day for 7 days is: a. 140 b. 70 c. 35

C

188. A prescriptio prescription n calls for 0.3 g of phosphoric acid with a sp gr of 1.71. How many mL should be used in compounding the prescription? a. 0..5 b. 5.7 c. 0.18 d. 3

B

189. Express in percentage the fluoride concentration in drink drinking ing w water ater g given iven in 0.6 ppm. a. 0.06% b. 0.00006% c. 0.0006% d. 0.006%

D

190. q.i.d. means: a. once a day

b. twice a day

c. three times a day

d. four times a day

D

191. are represented by wine gallons of 95% alcohol: a. How 51.3 many proof gallons b. 175.93 c. 54 87.9 d. 102.6

B

192. How many grams of silver nitrate should be used in pr preparing eparing 500 mL of a solution such that 10 mL diluted diluted to a liter will yield 1:5000 solution? a. 5 b. 10 c. 15 d. 20

C

193. If 1000 mL of syrup with a specific gravity of 1.313 cont contains ains 850 g of sucrose. What is the % (w/w)? a. 6.5% b. 65.5% c. 64.74% d. 64%

C

194. If a pati patient’s ent’s blood urea nitrog nitrogen en is determined to be 15 mg/ dL, what what is the equivalent equivalent percent concentration? a. 0.015 b. 1.5 c. 15 d. 0.15

E

195. A child weighing 25 25 lbs is to receive 5 mg of phenytoin p per er kg of body weight daily as anticonvulsant. How many mL of pediatric phenytoin suspension containing 30 mg per 5 mL should this child receive? a. 1.5 mL b. 5.5 mL c. 7.5 mL d. 6.5 mL e. 9.47 mL

B

196. Prescription call calls s for 250 mL of a liquid medicine cont contains ains 0.025 g of atropine sulfate sulfate and specific specific dose of 5 mL . Each dose contains ____ mg of atropine sulfate. s ulfate. a. 0.0005 b. 0.5 c. 5 d. 25

E

197. A solut solution ion contains 660 mg of NaF per 120 mL and has a dose of 10 gtts. If the dispensing dropper calibrates 30 gtts per mL. How many mg of NaF are contained in each dose? a. 2.2 b. 0.5 c. 2.75 d. 5.5

e. 1.83

A

198. How many mL of a 3% solution can be made from 27g of ephedrine sulfa sulfate? te? a. 900 mL b. 930 mL c. 850 mL d. 880 mL

B

199. How many mL of 1:50 stock solution of ephedrine sulfate would be needed to prepare 30 mL of the ff. prescription? Rx Ephedrine sulfate 0.25% Normal saline solution q.s. 10 mL a. 1.25 b. 3.75 c. 4 d. 7.5 e. 12.5

A

200. C Conv onvert ert -12° -12 °C to °K. a. 261 K b. 285 K

c. 500 K

d. 48 K

A

201. How many proof gallons are represented y 54 wine gallons of alcoholic beverage with a proof strength of 50? a. 54 b. 27 c. 108 d. 100

A

202. How many capsules of an antibiotic ar are e needed to provide 25 mg/ mg/kg/day kg/day for 6 days for a man weighing weighing 180 lbs if one capsule contains 250 mg of the antibiotic? a. 49 b. 59 c. 58 d. 39 e. 45

E

203. Sixty capsules of atropine, atropine, each to contain 1/250 gram, are to be made. How many tablets of atropine sulfate sulfate 0.5 mg each are needed to make the capsules? a. 32 tab b. 10 tab c. 130 tab d. 25 tab e. NOTA

C

204. A prescriptio prescription n calls for 0.3 g of phosphoric acid with a specific gravity of 1.71. How many mL should be used in compounding the prescription? a. 0.5 mL b. 0.7 mL c. 0.18 mL d. 0.3 mL

C

205. What is the % of alcohol in a mixture of 400 mL of 40% alcohol and 600 m mL L of a 60% alcohol? a. 50% b. 57% c. 52%

B

206. How many grams of glacial acetic acid (99.9% w w/w) /w) must be added to 1 galloon of purified water to obtain a solution containing 0.25% acetic acid? a. 1.2 g b. 9.5 g c. 12 g

C

207. Lanoxin pediatr pediatric ic elixir contains 0.05 mg of digoxin / mL. How many micrograms (mcg) are there in 3 mL of the elixir? a. 1.5 b. 0.0015 c. 150 d. 15 e. NOTA

B

208. One thousand nanograms equals one: a. kilogram b. microgram

www.brex.us

c. milligram

122

 

PHARMACEUTICAL CALCULATIONS

A

209. The concentration of NaF in a commu community’s nity’s di dinking nking w water ater is 0.6 p ppm. pm. Express this this concentration concentration as percentage. a. 0.00006% b. 0.0006% c. 0.006% d. 0.06% e. 0.6%

E

210. A 20 ml vial of a biological solution is labeled 2.0 megaunits. How m many any units of the drug are present in every ml of the solution? a. 100 b. 1000 c. 2000 d. 10000 e. 100000

B

211. A pharmacist adds 120 mL of aluminum acetat acetate e solution US USP P containing 5% aluminum acetate to to one liter liter of sterile water for irrigation. What is the % w/v concentration of aluminum acetate present? a. 0.5% b. 0.54% c. 0.6% d. 1.07% e. 1.20%

E

212. A phar pharmacist macist has 50 mL of 0.5% gentian violet solution. What will be the final ratio if he dilutes the solution solution to a. 1250 1:8 mL with purified b.water? 1:200

c. 1:50

d. 1:1000

D

213. How m many any 8-flu 8-fluidounce idounce bott bottles les can be pa packed cked from a 2-gal 2-gallon lon bott bottle le of cough syrup? a. 15 b. 20 c. 28 d. 32

C

214. If we divide 5L int into o 10 equal part parts, s, w what hat is the v volume olume of 1 part? a. 50 mL b. 0.005 L c. 0.500 L d. 0.05 L

C

215. Express 1:2000 as a percentage strength a. 0.5% b. 5% c. 0.05%

d. 0.0005%

216. One teaspoonful is equivalent to: a. 5 mL b. 10 mL

d. 20 mL

A

c. 15 mL

e. 1:5000

A

217. If 75 pounds of chemical costs P250, what will be tthe he cost of 9 95 5 pounds? a. P316.67 b. P197.37 c. P28.50 d. P400

A

218. 10 pints of a 5% solution are diluted with 30 pints of diluent, w what hat is the percentage strength strength of the dilution? a. 1.25% b. 1.67% c. 60% d. 15%

C

219. If a cough syrup co contains ntains 0.24 g of codeine phosphate in 120 m mL, L, how many milligrams milligrams are conta contained ined in each tsp dose? a. 20 mg

b. 15 mg

c. 10 mg

d. 5 mg

B

220. A pharmacist weighed 800 mg of a substance on a balance of dubious accuracy. When checked on a balance of high accuracy, the weight was found to be 785 mg. Calculate the %error in the first weighing. a. 2% b. 1.88% c. 1.9% d. 1.78%

D

221. A pharmacist pharmacist att attempts empts to weigh 80 mg of sodium carbonate on a balance having a sensitivity sensitivity requirement of 4 mg. Calculate the maximum potential error in terms of percentage. a. 2% b. 3% c. 4% d. 5%

D

222. Peppermint spirit contains 10% (v/v) of pepp peppermint ermint oil. How many mL mL of peppermint oils should be used in preparing 1 gallon of the spirit? a. 390 mL b. 400 mL c. 377 mL d. 378.5 mL

D

223. What is the weight in grams of 4 fluidounces of orange oil with a specific gravity of 0.844? a. 105 g b. 110 g c. 95 g d. 99.83 g

B

224. How many 5 cc doses may be obtained from 1 L of a lliquid? iquid? a. 20 b. 200 c. 2000

d. 2

A

225. How much water should be mixed w with ith 250 grams of 93% solution to make a 10% solution? a. 2 L b. 20 mL c. 9.2 mL d. 200 mL

B

226. A physici physician an prescribes Tetracycline O Oral ral Suspen Suspension sion (125 mg/5mL) ffor or Mr. Dela Cruz to be taken in doses of 2 teaspoons four times a day for four days, and then 1 teaspoonful four times a day for 2 days. How many mL of the suspension should be dispensed to provide the quantity for the prescribed dosage form? a. 250 mL b. 200 mL c. 210 mL d. 150 mL

B

227. How many mL of methyl salicylate should be used to prepare 1 pt of a 5% (v/v) (v/v) solution? a. 24.10 mL b. 23.60 mL c. 23.70 mL d. 24.50 mL

A

228. Rx Potassium permanganate tablets 0.30 g Dispense 50 tablets. Signa: three tablets in 6 pt of water and use as directed. Express the concentration as a ratio strength s trength of the solution prepared according to the direction given in the prescription. a. 1:3153 b. 1:3253 c. 1:3053 d. 1:3000

www.brex.us

123

 

PHARMACEUTICAL CALCULATIONS

C

229. A physician req requests uests that an iso-alcoholic elixir containing 30.0% alcohol be prepared. prepared. How much low alcoholic elixir (10.0% of alcohol) and high alcoholic elixir (78% of alcohol) must be mixed to prepare 1 gallon of iso-alcoholic elixir? a. 1481 mL of low and 953 mL of high c. 1407.35 mL of low and 3377.64 mL of high b. 1520 mL of low and 953 mL of high d. 2925 mL of low and 1450 mL of high

C

230. Convert Conver t 104° 104°F F to centig centigrade. rade. a. 20.0° 20.0 °C b. 30.0 30.0° °C

c. 40.0 40.0° °C

d. 50.0 50.0° °C

A

231. A phar pharmacist macist aide adds 76 mL of strong iodine solution US USP P (5.0%) to 1 L of sterile water for irrigat irrigation. ion. What is the % w/v iodine present? a. 0.35% b. 0.53% c. 0.60% d. 0.375%

C

232. How m many any proof gallons ar are e containe contained d in 3 w wine ine gallons of a 50% (v/v) (v/v) alcohol?

D

a. 5 proof gallons b. 4 proof gallons c. 3 proof gallons d. 2 proof gallons 233. What is the HLB of a mixture of 20.0% of Span 80 and 80.0% of T Tween ween 80? HLB of Span 80=5. 80=5.3; 3; HLB of Tween Tween 80=15.0 a. 6.3 b. 8.9 c. 10.3 d. 12.9

B

234. A fformula ormula for a dermatologi dermatological cal cream calls for 15 g of an emulsive blend consisting of Tween 20 and Span Span 40. If the required HLB is 11.70 how many grams of each emulsifier should be used in emulsifying the cream? a. 5 g Tween 20 and 10 g Span 40 c. 2.5 g Tween 20 and 12.5 g Span 40 b. 7.5 g Tween 20 and 7.5 g Span 40 d. none of the above

B

235. How many teaspoonfuls are there in 3 tablespoonfuls? a. 6 b. 9 c. 12

d. none of the above

236. 2 gr of a drug is equivalent to: a. 129.6 mg b. 127.4 mg

d. 200 mg

A

c. 132.1 mg

B

237. If 5 fluidounce of a 1:1000 (w/v) solution of sterile alcohol diluted to 2 pts what will be the ratio strength w/v of the solution? a. 1:3200 b. 1:6400 c. 1:8000 d. 1:6300

C

238. A method of solving problems that involved tthe he m mixing ixing of solutions or mixture mixture of solids a. alligation medial b. alligation alternate c. both a and b d. none

B

239. How many grams of sucrose are req required uired to prepare 2000 mL of a 4% solution? solution? a. 50 g b. 80 g c. 90 g d. 100 g

A/B 240. A system of measurement used only in compounding of prescriptions a. metric system b. apothecary system c. avoirdupois system

d. all

B

241. Purified water contains not ore than 10 ppm of ttotal otal soli solids. ds. E Express xpress this concentration as a percentage. percentage. a. 1.00% b. 0.001% c. 0.01% d. 10%

D

242. How many mg are there in 3/8 grains? a. 23.5 mg b. 24 mg

c. 23 mg

d. 24.5 mg

B

243. __________ is the fundamental unit for volume of the metric system: a. grain b. liter c. meter d. gram

A

244. Which expression is the largest number? a. 2/4 b. 1/150 c. 1/50

d. 1/300

B

246. In d dosing osing the drug genta gentamicin micin in pediat pediatric ric patie patients, nts, ffor or every 1 mg mg/kg /kg of gentamicin administered, serum drug concentrations are expected to increase by 2.5mcg/mL. What would be the expected serum drug concentration following an administration of a 2.5 mg/kg dose of gentamicin? a. 5 mcg / mL b. 6.25 mcg/ mL c. 10 mcg/ mL d. 2.5 mcg/ mL

C

247. A physician places a patient on a daily dose of 48 units of U-80 insulin. How ma many ny ml should tthe he patient inject each day? a. 0.4 b. 0.5 c. 0.6 d. 0.25

B

248. How many fl.oz. bottles of lagundi syrup can be prepared ffrom rom 5 gallons of tthe he syrup? syrup? a. 639 b. 640 c. 540 d. 740

D

249. A prescriptio prescription n calls for 10 units of a drug to be taken 3 ties a day. How much will tthe he patient have taken after 7 days? a. 21.0 units b. 0.21 units c. 2.10 units d. 210 units

D

250. A physician orders meprobam meprobamate ate 0.2 g. How mu much ch is to be administered iiff the dose on hand is 400 mg in each tablet? a. Do not dispense c. give 1 tablet b. Give 2 tablets d. give 1/2 tablet

B

251. The dose of a dr drug ug for children based on body surface are b based ased on: on:

www.brex.us

124

 

PHARMACEUTICAL CALCULATIONS

a. weight and age

b. weight and height

c. age and height

d. width and height

C

252. The pediat pediatric ric dose of cefadrox cefadroxilil is 30 mg/kg/day. mg/kg/day. If a child is given a daily dose of 2 teaspoonfuls of a suspension containing 125 mg of cefadroxil per 5 mL, what is the weight in lb. of the child? a. 18.5 lbs b. 18.8 lbs c. 18.3 lbs d. 18.1 lbs

D

253. If glycerin (sp gr 1. 1.25) 25) costs P131.00 per pint pint,, ho how w much would 10 lbs cost? cost? a. 105.90 b. 1105.90 c. 1025.90 d. 1005.90

B

254. What is weight of 60 mL of oil whose density is 0.9624 g/mL? a. 5.770 g b. 57.7 g c. 6.0 g

d. 0.577 g

255. Change 1/10% to a common fraction. a. 1/100 b. 1/10

d. 1/.01

C

c. 1/1000

D

256. A pati patient ent is determined to have 0.8 mg of glucose in each mL of blood. Express the the concentration of glucose glucose in the blood as mg%. a. 800 mg% b. 0.8 mg% c. 8 mg% d. 80 mg%

A

257. Calculate the num number ber of kg of a 20% (w/w) solution which can e made from a kg of solute. a. 5.0 b. 5000 c. 0.5 d. 50.0

D

258. If a patient is determined to have 100 g g% % of blo blood od glucose, what is the equivalent concentration in terms of mg/dL? a. 1 b. 10 c. 40 d. 100

D

259. Change to percent the number 1/300. a. 3% b. 33%

c. 3.3%

d. 1/3%

A

260. A phar pharmacy macy aide adds 75 mL of strong iodine solution USP (t.o%w/v) tto o 1 L of sterile water water for irrigation. What is the %w/v of iodine present? a. 0.35% b. 0.375% c. 0.53% d. 0.60%

C

261. Express 0.2% as a ratio strength. a. 1:5000 b. 1:50

A

c. 1:500

d. 1:5

262. A cupric chloride inject injection ion (0.4 mg/mL) is used as an additive to IV solutions for TPN. What is the final final ratio strength of copper in the TPN solution if 2.5 mL of the injection is added to enough of the IV solution to prepare 500mL? a. 1:500 b. 1:5000 c. 1:500000 d. 1:50000

B

263. How many mL of a 1:400 (w/v (w/v)) stock solution should be used to m make ake 4 L of a 1:2000 (w/v) solution? solution? a. 1000 mL b. 800 mL c. 1600 mL d. 200 mL

D

264. You have a stock solution o off 50% sodium nit nitrate rate and you were asked to prepare 300 mL of a 10% solution. How many mL are needed? a. 20 b. 15 c. 30 d. 60

D

265. Prepare 1000 mL of KMnO4 1:12000 compresses out of KMnO4 1:8000. a. add 333.3mL water to 1000mL KMnO4 1:8000 b. add 666.6mL water to 333.3mL KMnO4 1:8000 c. add 333.3mLKM 333.3mLKMnO4 nO4 1:8000 and enough water to make a final volu volume me of 1000mL d. add 333.3mL water to 666.6mL KMnO4 1:8000

D

266. How many mL of 24% (w/v (w/v)) concentrate of saline solution shoul should d be used in preparing 600mL 600mL of a solution such that 10 mL diluted to a liter will yield a 0.09% solution? a. 300mL b. 150 mL c. 50.0mL d. 225mL

B

267. How many grams of 10% (w/w) am ammonia monia soluti solution on can be made from 1 1800g 800g of 28% (w/w) (w/w) strong ammonia solution? a. 6428.57 g b. 5050 g c. 50400 g d. 342.86 g

C

268. How many grams of a 1:10 trituration of atrop atropine ine sulfate are required to obtain 25 mg of atropine sulfate? a. 250 b. 25 c. 0.25 d. 2.5

D

269. In w what hat proporti proportion on should alcohol of 9 95% 5% and 50% strength strengths s be mixed to make make 70% alcohol? a. 3 parts and 5 parts c. 5 parts and 4 parts b. 5 parts and 5 parts d. 4 parts and 5 parts

C

270. The injection form of calcium gluconate (Ca(C7H13O8)2 contains 1 g of drug in 10 mL of solution. solution. How many mEq of calcium are present? (Ca=40, (Ca(C 7H13O8)2 =430) a. 0.78 b. 2.3 c. 4.7 d. 503

B

271. Five pints of HCl weigh 2.79 kg. Calculate its specific gravity. a. 0.810 b. 1.180 c. 2.180

A

272. From the following formula, calculate Rx Calcium carbonate Magnesium oxide Sodium carbonate

www.brex.us

d. 3.180

the quantity of sodium carbonate required to make make 1500 g of powder. 5 parts 1 part 4 parts

125

 

PHARMACEUTICAL CALCULATIONS

Bismuth subcarbonate a. 576.9 g b. 461.5 g

3 parts c. 346.2 g

d. 115.4 g

C

273. The USP states that that 1 g of a chemical is soluble in 10mL of al alcohol. cohol. What is the percentage strength of a saturated solution of this chemical if alcohol has a sp gr of 0.80? a. 10.0% w/w b. 11.1% w/v c. 11.1% w/w d. 12.5% w/v

B

274. Reduce 25 mcg to g  –6  –5 a. 2.5 x 10   b. 2.5 x 10  

c. 2.5 x 10

 –4

 

d. 2.5 x 10

 –3

 

A

275. How many gallons gallons of 20% alcohol (v/v) w would ould be equivalent tto o 20 proof gallons? gallons? a. 50 b. 60 c. 75 d. 100

C

276. A pharmacist purchased 5 gallons of alcohol. At different ttimes, imes, 2pints, 2 gallons, gallons, 8 fluidounces, and ½ gallon What volume, fluidounces, fluidounces, remained? a. were 256 used by the pharmacist. b. 264 c. in 280 d. 296

B

277. If some moist crude drug contains 7.2% (w/w) of active ingredient and 21.6% of water, what will be the percentage (w/w) of active ingredient after the drug is dried? a. 7.2 b. 9.2 c. 11.2 d. 13.2

A

278. How many grams of petrolatum should be added to 250 g of a 25% sulfur ointment ointment to make a 5% ointment? a. 1000 g b. 1250 g c. 500 g d. 100 g

C

279. Concentration of a weak solut solution ion of liquid preparation is expressed in terms of: a. proof strength b. percentage strength c. ratio strength d. mEq

C

280. A cough syrup is llabeled abeled as containing 20% alco alcohol hol by volume. Which of the ff. ff. statement is/are true? a. Each 1 100mL 00mL of syrup contains exactly 20mL alcohol USP. b. The proof strength of this product is 40. c. All of these d. There is tthe he equivalent of 20mL of absolute alcohol present in every 100mL of syrup.

B

281. How many mL of a syrup having asp gr of 1.350 should be m mixed ixed with 3000mL of a syrup having having a sp gr of 1.250 to obtain a product having a sp gr of 1.310? a. 3500mL b. 4500mL c. 4600mL d. 5500mL

C

282. If 800g of a 5% coal tar ointment is mixed with 1200 g of a 10% co coal al tar ointment, ointment, what what is the concentration of coal tar in the finished product? a. 8.5% b. 9.5% c. 8% d. 9%

C

283. How many gallons of water are needed to dilute 1 gallon of 6^ conc. O Off antiseptic solution to make 2% final concentration? a. 1 gallon b. 3 gallons c. 2 gallons d. 1.5 gallons

A

284. How much water should be added to 2500mL of 83% (v/v) alcohol to prepare 50% (v/v) alcohol? a. 1650 b. 1660 c. 1550 d. 1560

B

285. An order calls for 500mL of a solution of potassium sulfate to be made so that it contains 10 mEq of potassium sulfate. How many grams of potassium sulfate is required to prepare the solution? a. 0.495 b. 0.870 c. 4.44 d. 0.440

C

286. Concentrations of electrolytes in solution are expressed in terms of: a. g% b. g/mL c. mEq d. millimole

B

287. A solut solution ion contains 10mg% M Mg+2 g+2 (at. Wt. 24). How many mEq are there in a liter? a. 4.33 b. 8.33 c. 6.21 d. 8.55

A

288. How many mg of magnesium sulfat sulfate e (M (MW W 120) should be added to an IV IV solution to provide 5 mEq of Mg+2 per liter? a. 300 mg b. 210 mg c. 307 mg d. 200 mg

A

289. How many mEq of KCl are represented in 15 mL of a 10% (w/v) potassium chloride elixir? elixir? a. 20.1 mEq b. 60 mEq c. 0.06 mEq d. 167 mEq

C

290. How m many any mL of glycerin w would ould be needed tto o prepare 1 lb of an ointment containing 5% w/w glycerin? The density of glycerin is 1.25 g/mL. a. 1.2 b. 22.7 c. 18.2 d. 24

A

291. An antihypert antihypertensive ensive drug lilists sts as P P180.00 180.00 per dozen tablets, less a discount of 33 1/3 % for a purchase of 100 dozens, plus an additional promotional discount of 10%. Calculate the net cost per unit. a. P9.00 b. P9.15 c. P9.25 d. P9.50

B

292. A pharma pharmacist cist receives a bill of goods amounting to P35,400 less a 5% discount for quantity buying and a 2% cash discount for paying the bill within 10 days. What is the net amount of the bill? a. P32,950.40 b. P32,957.40 c. P32,930.40 d. P32,951.60

A

293. Find the difference in the net cost of a bill of goods amounting tto o P100,000 if the bill is discounted discounted at 45% and if it is discounted at 33% and 12%.

www.brex.us

126

 

PHARMACEUTICAL CALCULATIONS

a. P3960

b. P3860

c. P3550

d. P3750

A

294. What is the ratio ratio strength (w/v) of a solution made by dissolving 5 tablets, each each containing 2.25 g of sodium chloride in enough water to make 1800mL? a. 1:160 b. 1:360 c. 1:1000 d. 1:300

B

295. How many grams of reserpine would be required tto o prepare 10,000 ttablets, ablets, each each containing 250 mg of reserpine? a. 2.5 b. 2500 c. 250 d. 25

C

296. Physicians prefer the calculation of doses for children based on: a. age b. weight c. body surface area

d. height

A

297. If the adult dose of a drug is 90 mg, what should be the dose for a child with with a b body ody surface area area of 0.60 sq. m.? a. 31.21 mg b. 54 mg c. 150 mg d. 540 mg

D

298. The draw drawback back on alcohol is P450 per proof gallon. If an eligible clai claimant mant used 8 gallons of 95% alcohol, how how much drawback will be allowed? a. 1,937 b. 3,680 c. 5,275 d. 6,992

D

299. Rx Antipyrine 7% Glycerin ad 60.0 Signa: Five drops in the right eye. How many grams of antipyrine should be used in compounding the prescription? a. 2 b. 7 c. 5.5 d. 4.2

A

300.

How many milligrams of gentian violet should be used in preparing the following solution? Rx Gentian violet (1:10,000) Signa: Instill as directed.

a. 50

www.brex.us

b. 0.05

c. 0.50

50mL d. 500

127