PEX-10-04

Exercise 10: Acid-Base Balance: Activity 4: Respiratory Responses to Metabolic Acidosis and Metabolic Alkalosis Lab Report Pre-lab Quiz Results You scored 100% by answering 4 out of 4 questions correctly. 1. An increase in metabolic rate (without compensation) would result in You correctly answered: a. more carbon dioxide in the blood. 2. Excessive vomiting results in You correctly answered: c. loss of acid, metabolic alkalosis. 3. Which of the following is not acidic? You correctly answered: d. antacids 4. Which of the following decreases the rate of metabolism? You correctly answered: b. lowered body temperature

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Experiment Results Predict Question: Predict Question 1: What do you think will happen when the metabolic rate is increased to 80 kcal/hr? Your answer : a. metabolic acidosis Predict Question 2: What do you think will happen when the metabolic rate is decreased to 20 kcal/hr? Your answer : d. Breaths per minute will decrease. Stop & Think Questions: The tidal volume and breaths per minute increased with increased metabolism because You correctly answered: b. there is more carbon dioxide being formed. Which body system is compensating for the metabolic alkalosis? You correctly answered: c. respiratory Experiment Data: Metabolic Rate (kcal/hr) 50 60 80 40 20

BPM (breaths/min)

Blood pH

PCO2

15 17 21 13 9

7.39 7.35 7.25 7.42 7.53

40 45 55 37 31

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[H+] in Blood 40 47 63 38 32

[HCO3-] in Blood 24 20 14.50 26 30

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Post-lab Quiz Results You scored 100% by answering 4 out of 4 questions correctly. 1. What happened to the breathing when metabolism was increased? You correctly answered: d. The breaths per minute and the tidal volume increased. 2. Which of the following is not a cause of metabolic acidosis? You correctly answered: b. constipation 3. If PCO2 in the blood increases, then You correctly answered: a. [H+ ] increases and pH decreases. 4. Which of the following values increased with decreased metabolism? You correctly answered: d. pH and [HCO3- ]

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Review Sheet Results 1. Describe what happened to the blood pH when the metabolic rate was increased to 80 kcal/hr. What body system was compensating? How well did the results compare with your prediction? Your answer: Ante un aumento del metabolismo se genera mas concentracion de PCO2 lo que nos condiciona a un acidosis metabolica . 2. List and describe some possible causes of metabolic acidosis. Your answer: • Cetoacidosis, una acumulación de cetoácidos que pueden deberse a diabetes mellitus. • Intoxicación por salicilato, que puede ser debida a una ingestión excesiva de aspirina o de aceite de gaulteria (una sustancia que se encuentra a menudo en los laboratorios). • La ingestión excesiva de alcohol, que se convierte en ácido acético. • Diarrea, que provoca pérdida de bicarbonato del contenido intestinal. • El ejercicio extenuante, que puede causar una acumulación de ácido láctico procedente del metabolismo muscular anaeróbico. 3. Describe what happened to the blood pH when the metabolic rate was decreased to 20 kcal/hr. What body system was compensating? How well did the results compare with your prediction? Your answer: Al disminuir la tasa del metabolismo , disminuye PCO2 lo que genera una alcalosis metabolica , el sistema respiratorio intenta regular hipoventilandose . 4. List and describe some possible causes of metabolic alkalosis. Your answer: • Ingestión de álcalis, tales como antiácidos o bicarbonato. • Vómitos, que pueden provocar pérdida excesiva de H+ • Estreñimiento, que puede generar una reabsorción importante de HCO3

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