Pediatrics - Hematology 1B - Blood Component Therapy

Pediatrics – Hematology 1 (Blood (Anemias) Component Tx) Lecturer: Dr. Montoya

This is an edited version of the transcription made by Katlen of batch 2011 on July 31, 2009. Added some things doc Montoya said during her July 26, 2012 lecture. I also included some additional some stuff from her most recent powerpoint. -Lil

OUTLINE I. II. III. IV.

Definition of Terms A. Blood Component B. Blood Component Therapy Blood Components Available in the Philippines Advantages of Component Therapy Blood Components A. Red Cell Transfusion B. Platelet Concentrates

V. VI.

C. Fresh Frozen Plasma D. Cryoprecipitate E. Cryosupernate F. Plasma Derivatives G. Irradiated Blood Transfusion Related Risks Adverse Effects of Blood Transfusion

HEMATOLOGY 1B: BLOOD COMPONENT THERAPY I.

Definition of Terms A. Blood Component  A constituent of blood separated from whole blood B. Blood Component Therapy  The process of transfusing only the portion of the blood needed by the patient.  Allows a single unit of donated blood to benefit more than one patient.

Remember: a. Single donated blood is up to 450 ml, if this undergoes centrifugation, it will yield packed red cell cells and platelet-rich plasma b. The platelet rich plasma is further centrifugated. This will yield platelet concentrates and plasma o c. The packed red blood cells is kept in the blood bank refrigerator at 4-8 C d. The platelet concentrate is stored at room temperature with frequent continuous agitation to prevent blood clot e. Plasma can be kept in the freezer as fresh frozen plasma, or it could still be centrifuged to yield your cryoprecipitate and cryosupernate

II.

Blood Components Available in the Philippines A. B. C. D.

RBC (Whole blood, PRBC, Washed RBC, Leuko-depleted RC) Fresh Frozen Plasma Cryoprecipitate Cryosupernate – being disposed in other countries, but is still being used in the Philippines, particularly in hemophilia B patients E. Platelets – Random Donor Platelets (RDP) or Apheresed (Single Donor Platelet)

Hematology 1B: Blood Component Therapy Page 1 of 7

Different Blood Components Storage ˚C

Volume (ml) 450 250 Variable 250