pathophysiology

Predisposing factor Precipitating factor •

Diet (high in fat, low fiber)

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Constipation (>3 days)

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Chew tobacco

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Exposure to asbestos

Colon cancer

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Genetics

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Past tumors

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Chemical mutagen

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Age (older the 50)

Polyps in the Mutation of genetics Formation of Cancer Formation of malignant tumor Obstructs the colon Decrease space for stool passage Lower part of the colon: Feces cannot get Abdomina l fullness

There are impacted feces

Abdominal distention

Imperforation of the colon lining

Abdominal pain in the affected area Loss of appetite Weight loss

Melena; the color of the blood depnds on the area of perforation

Upper part of the colon: Stomach content cannot pass through the colon Ribbon like stool

Constipatio n Over exertion in defecation Rectal perforati on Pain in the rectum

Nausea and vomiting