Pathophysiology of Sepsis

Pathophysiology of Sepsis Predisposing: Age

Precipitating: 1. Sterility of the environment 2. Exposure to bacteria 3. Sterility of Delivery

Organism invades the bloodstream and multiply Triggers pro- inflammatory mediators

Leukotrines Lipoxgenase Histamine Bradykinin

Interleukin 4-10 Cytokines

Results in negative feedback Mechanism

Artries & Arterioles dilate

Production of micro thrombi

Inability to retain IVF

Impairs 02 absorption of epithelial cells

Filing of fluids in the lungs

Impaired removal of CO2 & waste products Epithelial cells tubules slough Loss of functions of nephrons

Collapse alveoli

Acute Renal Failure

Inability for o2 and CO2 exchange

Decrease Blood Supply to brain

Lung Failure Hypoxia of the Heart Irritability and exhaustion of heart muscle

Gross Hypoxia Brain Dysfunction Coma

Heart Failure Death

A. Actual diagram

Predisposing: Unknown

Precipitating: 1. Sterility of the environment 2. Exposure to bacteria 3. Sterility of Delivery

Organism invades the bloodstream and multiply Triggers pro- inflammatory mediators

Leukotrines Lipoxgenase Histamine Bradykinin

Cytokines Interleukin 4-10

Results in negative feedback Mechanism

Production of micro thrombi Increase gastric acid production

Impairs 02 absorption of epithelial cells Loss of functions of nephrons

Disruption of gastric lining

Acute Renal Failure

Gastric infection

1.Amorphous Urate formation

Bloated Abdomen

2. Pus cells formation 3. High Level of Creatinine