Pathophysiology of Chronic Renal Failure (condensed) part 1

PATHOPHYSIOLOGY (Chronic Renal Failure)

Predisposing Factors:

Precipitating Factors:

Ages 55 and above

■

■

■

Family History (Diabetes Mellitus, Hypertension)

■

Thickening and/or an in the amount of collagen in the basement membranes of the small vessels

Impaired/sluggish blood flow

Glomerulosclerosis

GFR (Glomerular Filtration Rate) proteinuria

Renal blood

Stage I DIMINISHED RENAL RESERVE GFR 50%

Lifestyle - smoking - alcohol drinking Certain Diseases (Hypertension, (Hypertension, Diabetes Mellitus, Recurrent  infections

Normal BUN, creatinine

More than 75% damage

Stage II RENAL INSUFFICIENCY GFR 20-50% BUN, creatinine levels begin to rise

Remaining nephrons undergo changes to compensate for  those damaged nephrons

Filtration of more concentrated blood by the remaining nephrons

Hypertrophy of  nephrons Intolerance and exhaustion of the remaining nephrons

Further damage of  the nephrons 80-90% damage

Stage III RENAL FAILURE GFR 10-20%

Impaired kidney function and Uremia