Nephron and Renin-Angiotensin

Nephron and Renin Angiotensin System Study online at quizlet.com/_egxar 1.

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Reasons for JGA to secrete renin

low sodium concentration in macula densa or low perfusion pressure in afferent arteriole

Which cells in JGA secrete renin

Granular cells

Immediate function of renin

converts angiotensinogen into angiotensin 1

where ACE is located

endothelial cells especially in lungs

effects of angiotensin II (3)

increased ADH release, Aldosterone secretion, vasococonstriction of systemic arterioles

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Where ADH is released from

anterior pituitary

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where aldosterone is secreted from

adrenal cortex

Effect of increased ADH

increased water reabsorption from collecting ducts which increases total circulatory fluid volume

effect of increased aldosterone secretion

increased sodium and water reabsorption which increases total circulatory fluid volume

effect of vasoconstriction of systemic arterioles

increased systemic blood pressure

Maximum aldosterone secretion causes reabsorption of what % of total filtered load of sodium

2%

how much saline is aquired per day with max aldosterone secretion

3.6 liters

relationship of kidneys and heart during heart failure

left ventricle can't pump enough blood to maintain adequate BP so kidney tries to increase BP but makes heart work even harder and the circuit feeds on itself

glomerular filtration rate

volume of fluid filtered out of glomerular capillaries into the proximal tubule

GFR for both kidneys (numerical value)

100 ml/min

Basic path of renal exretion

filtration, reabsorption, secretion, excretion

where fluid is reabsorbed from and to

from proximal tubule into peritubular capillaries

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what's secreted out of peritubular capillaries into tubular fluid (step 3)

drugs and toxins

equation for final volume of urinary excretion

GFR - reabsorption + secretion

function of macula densa cells

detect tubular fluid and tell granular cells to secrete renin if GFR is inadequate

where macula densa cells are located

wall of thick ascending limb

main effects of reninangiotensin system

increase circulatory fluid volume and raise BP

What detects inadequate afferent arterial blood flow

stretch receptors in walls of afferent arterioles