Medicine 6th Le Ay 2011-2012 Onco Part

MEDICINE 6TH LE A.Y. 2011-2012 1. Which of the following is an example of the loss of sensitivity to growth inhibitory signals in the development of cancer? a. Mutations in the ras gene b. Mutations in the p53 gene c. Elaboration of the vascular endothelial growth factors d. DNA amplification of the epidermal growth factor receptor gene 2. Which of the following is associated ONLY with tumor suppressor genes? a. Nowell’s hypothesis b. Knudson’s hypothesis c. Microsatellite instability d. Mendellian cancer syndromes 3. In a patient diagnosed to have lung cancer, which of the following suggests the presence of an aggressive tumor? a. Tumor blood vessels are few in number and of small caliber b. Clubbing of the hands and feet are noted on physical examination c. Hemoptysis of about 1 teaspoon/day is prominent in the patient’s history d. The patient claims to have lost