Mediadores químicos de la inflamación -1

April 29, 2019 | Author: Alfonsoalonso2 | Category: Inflammation, Anatomy, Cell Biology, Clinical Medicine, Ciencias de la vida y de la tierra

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Mediadores químicos de la inflamación

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Acciones principales de los mediadores de la inflamación 

VASODILATACIÓN:: prostaglandinas, óxido nítrico. VASODILATACIÓN



AUMENTO DE LA PERMEABILIDAD VASCULAR: aminas vasoactivas, C3a C5a, bradicinina, leucotrienos, E4, PAF, sustancia P.



QUIMIOTAXIS,ACTIV.LEUCOCITOS:: C5a, leucotrienoB4, quimiocinas. QUIMIOTAXIS,ACTIV.LEUCOCITOS

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Mediadores químicos de la inflamación Características generales de los mediadores  Origen :plasma o células.  

Se unen a receptores específicos situados en las células diana. Actúan sobre uno o algunos tipos de células diana o sobre múltiples tipos de células.

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Mediadores químicos de la inflamación AMINAS VASOACTIVAS SEROTONINA Origen : Mastocitos, basófilos y plaquetas.

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Mediadores químicos de la inflamación HISTAMINA 5-HT



Acciones similares a las de histamina Se encuentra en Plaquetas, y células enterocromafines.



La liberación de serotonina e histamina en plaquetas es estimulada por:



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Mediadores químicos de la inflamación

PROTEÍNAS PLASMATICAS 

Mediadores derivados del plasma:

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Mediadores químicos de la inflamación Neutrófilos y leucocitos : Gránulos Secundarios

Funciones   

Lisozima Colágenas Gelatinasa Lactoferrina

 

permeabilidad vascular Quimiotaxis Lesión celular

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Mediadores químicos de la inflamación RADICALES LIBRES DERIVADOS DEL OXÍGENO 

O2-



H2O



Radical hidroxilo



Liberados de los leucocitos después de

Efectos 

Lesión de células endoteliales.



Causa aumento de la permeabilidad vascular.



Lesión en múltiples tipos celulares.

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Mediadores químicos de la inflamación NEUROPÉPTIDOS

Sustancia P



Mediador poderoso de la permeabilidad vascular



Transmite señales dolorosas



Regulan la presión sanguínea

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PATRONES MORFOLÓGICOS DE LA INFLAMACIÓN

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Patrones morfológicos de la inflamación aguda

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Mediadores químicos de la inflamación -1

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