Maxwell Quick Medical Reference.pdf

ACLS ADULT EMERGENCY CARDIAC CARE Unresponsive * ACTIVATE EMS * CALL FOR DEFIBRILLATOR Pulse Absent * CPR (follow C-A-B algorithm) * VFib/VTach? VF/PVT algorithm * INTUBATE * CHECK VENTILATIONS * Electrical Activity? Yes, PEA algorithm No, ASYSTOLE algorithm Breathing Absent * GIVE TWO SLOW BREATHS Lamberg Waveform Measurements P wave < 0.11 sec PR interval 0.12 – 0.20 sec QRS interval < 0.10 sec QTc interval 0.33 – 0.47 sec

Responsive * Observe * Treat as indicated Pulse Present * RESCUE BREATHING * OXYGEN, IV, VITALS * INTUBATE * H&P, ECG * Causes: hypotension, shock, acute pulmonary edema, arrhythmia, acute myocardial infarction Breathing Present * Recovery position if no trauma James

One Large Box 0.20 sec One Small Box 0.04 sec Cardiopulmonary Values Central Venous 3-8 mmHg R Atrium (mean) 0-8 mmHg R Ventricle 15-30/0-8 mmHg Pulm Artery 15-30/3-12 mmHg Pulm Wedge (mean) 1-10 mmHg L Ventricle 100-140/3-12 mmHg Aorta 100-140/60-90 mmHg Aa Gradient 5-15 mmHg Pulm Resistance 20-130 d*s/cm^5 Syst Resistance 700-1600 d*s/cm^5 Cardiac Output 3.5-7.5 L/min Cardiac index 2.5-3.5 L/min/m^2 Ejection Fraction 59-75%

Left Axis Deviation: -90 to 0 degrees Normal Axis: 0 (or -30) to 90 degrees Right Axis Deviation: 90 to 180 degrees Mitral Valve 4.0-6.0 cm^2 Aortic Valve 2.6-3.5 cm^2

ANAPHYLAXIS / ALLERGIC REACTION (epinephrine dosing) Adult: epinephrine 1:1,000 0.3-0.5 mL IM; may repeat every 20-30 min Children: epinephrine 0.01 mL/kg 1:1,000 IM up to 0.3 mL; may repeat every 20-30 min Severe Cases: epi infusion, add 1 mL of 1:10,000 epinephrine to 9 mL of NSS to create a 1:100,000 dilution. Infuse over 5-10 minutes to create a 10-20 mcg/min infusion.

ACLS ASYSTOLE * CPR, IV, INTUBATE * CHECK ASYSTOLE IN MORE THAN ONE LEAD Possible Causes(3): Hypoxia, Hypothermia, Hyper/Hypokalemia, Drug OD, Acidosis * Consider IMMEDIATE TRANSCUTANEOUS PACING(5) * EPINEPHRINE 1 mg IV PUSH q3-5 min(1,4) * Consider termination of efforts

ACLS BRADYCARDIA * ABCs, IV, O2, Cardiac Monitor, ECG, Pulse Oximeter, Chest X-Ray, H&P Serious Signs Or Symptoms (< 60 beats/min or relative)(6) * ATROPINE 0.5mg IV up to max total 3 mg(7,8,9) * TRANSCUTANEOUS PACING * EPINEPHRINE 2-10 mcg/min * DOPAMINE 2-10 mcg/kg/min Stable * Type II second-degree AV block or third-degree AV block(10) * Prepare for transvenous pacer, use TCP as a bridge device(11) * Otherwise observe

ACLS ELECTRICAL CARDIOVERSION Tachycardia with related serious signs and symptoms May give brief trial of medication based on specific arrhythmias * OXYGEN SAT, IV, SUCTION, INTUBATION EQUIPMENT * Premedicate whenever possible(13) Ventricular Rate > 150 (VTach(16), Afib, PSVT(17), Aflutter(17)) * SYNCHRONIZED CARDIOVERSION 100, 200, 300, 360 J(14,15) Ventricular Rate < 150, cardioversion GENERALLY NOT NEEDED

RAPID SEQUENCE INTUBATION (RSI): 8 P’s Plan B: Induction agents, ET tubes, laryngoscope parts, airways, surgical airway tools Prepare: Dentures out, check lights, difficulty ventilation (BONES) = beard, obesity, no teeth, elderly, snoring. Difficult intubation (LEMONS) = look externally (neck/face), evaluate internally (3-3-2 rule), Mallampati, obstruction, neck mobility, saturation < 85% Pre-Oxygenate: High-flow O2 for 5 mins or 8 full breaths, want FiO2 close to 100% Pre-Treat: LOAD = lidocaine 1.5 mg/kg IV, opiates (fentanyl 2-9 mcg/kg IV), anticholinergic (atropine 0.5-1 mg IV adult, 0.02 mg/kg IV children), defasciculating agent (succinylcholine 0.15 mg/kg, vecuronium 0.01 mg/kg or rocuronium 0.1 mg/kg IV) Put To Sleep: Induction agent. Etomidate 0.3 mg/kg IV, ketamine 1-2 mg/kg IV, or midazolam 0.1 mg/kg IV adult and 0.05-0.1 mg/kg IV children. Paralyze: Succinylcholine 1.5-2 mg/kg IV or rocuronium 0.6-1.2 mg/kg Pass The Tube: Sweep tongue, BURP = backward upward rightward pressure. Prove Placement: Auscultate chest, CO2 detection.

ACLS TACHYCARDIA * ABCs, IV, O2, Cardiac Monitor, ECG, Pulse Oximeter, Chest X-Ray, H&P Serious Signs Or Symptoms (Rate > 150, Unstable Patient)(12) * IMMEDIATE CARDIOVERSION, cardiovert any patient that becomes unstable * Cardioversion seldom needed for rates < 150 Narrow QRS (< 0.12 sec): Regular Rhythm (SVT) * VAGAL MANEUVERS * ADENOSINE 6 mg rapid IV push over 1-3 sec * Adenosine 12 mg IV push in 1-2 min (may repeat once) * Consider expert consultation * Children: 0.1 mg/kg rapid IV push with flush, may double for second dose Narrow QRS (< 0.12 sec): Irregular Rhythm * Possible atrial fibrillation, atrial flutter, multifocal atrial tachycardia * Consider expert consultation * Control rate (diltiazem, beta blockers used with caution) Wide QRS (> 0.12 sec): Regular Rhythm (VT) * Ventricular tachycardia or uncertain rhythm * AMIODARONE 150 mg IV over 10 min, repeat prn to max 2.2 g/24hrs * Prepare for elective synchronized cardioversion Wide QRS (> 0.12 sec): Regular Rhythm (SVT + aberrancy) * Supraventricular tachycardia with aberrancy * ADENOSINE 6 mg rapid IV push over 1-3 sec * Adenosine 12 mg IV push in 1-2 min (may repeat once) * Consider expert consultation Wide QRS (> 0.12 sec): Irregular Rhythm (AF + aberrancy) * Atrial fibrillation with aberrancy * See Irregular Narrow QRS Tachycardia (above) Wide QRS (> 0.12 sec): Irregular Rhythm (AF + WPW) * Pre-excited atrial fibrillation (AF + WPW) * EXPERT CONSULTATION ADVISED * Avoid AV node blocking agents (adenosine, digoxin, diltiazem, verapamil) * Consider antiarrhythmics (e.g. AMIODARONE 150 mg IV over 10 min) Wide QRS (> 0.12 sec): Irregular Rhythm (Poly VT) * Recurrent polymorphic ventricular tachycardia * SEEK EXPERT CONSULTATION Wide QRS (> 0.12 sec): Irregular Rhythm (TdP) * Torsades de pointes * MAGNESIUM load 1-2 g over 5-60 min then infusion

ACLS VF & PULSELESS VT * ABCs, CPR UNTIL DEFIBRILLATOR ATTACHED, CONFIRM VF/VT * DEFIBRILLATE ONCE (120-200 J Biphasic, 360 J Monophasic) Persistent or Recurrent VF/PVT * CPR, INTUBATE, IV, EPINEPHRINE 1mg IV push q3-5 min(1) (or VASOPRESSIN 40 U IV single dose, one time only(21)) * DEFIBRILLATE 360 J WITHIN 30-60 sec * AMIODARONE 300 mg IV, if recurs 150 mg IV, max total 2.2 g/24h(2,3) * LIDOCAINE 1-1.5 mg/kg IV push q3-5 min to max total 3 mg/kg (Drip: Lidocaine 2 g in 250 mL D5W or NSS at 1-4 mg/min) * Magnesium sulfate 1-2 g IV in torsades de pointes * Procainamide 30 mg/min in refractory VF to max total 17 mg/kg (Drip: Procainamide 2 g in 250 mL D5W (8 mg/mL) at 2-6 mg/min) * DEFIBRILLATE 360 J, 30-60 sec AFTER EACH DOSE OF MEDICATION OR AFTER EACH FIVE CYCLES OF CPR * PATTERN SHOULD BE CPR-DRUG-SHOCK (repeat) * MINIMIZE INTERRUPTIONS IN CHEST COMPRESSION

ACLS SUSPECTED STROKE Immediate Assessment (< 10 min from arrival) * ABCs, VITALS, IV, ECG, OXYGEN by nasal cannula * CBC, ELECTROLYTES, COAGS, BLOOD SUGAR (treat as indicated) Neuro Assessment (< 25 min from arrival) * H&P, NEURO EXAM, TIME OF ONSET * LEVEL OF CONSCIOUSNESS (Glasgow Coma Scale) * STROKE SEVERITY (NIH Stroke Scale or Hunt & Hess Scale) * URGENT NON-CONTRAST CT HEAD SCAN * Lateral cervical spine x-ray if trauma or comatose Positive Intracranial Hemorrhage by CT * CONSULT NEUROSURGERY * REVERSE ANTICOAGULANTS, BLEEDING DISORDERS * Monitor neurologic status, * Treat hypertension in awake patients No Intracranial Hemorrhage By CT(22) * REVIEW FOR CT OR OTHER FIBRINOLYTIC EXCLUSIONS * REPEAT NEURO EXAM for changes or improvements * DETERMINE IF SYMPTOM ONSET STILL < 3 HOURS * IF NO EXCLUSIONS, CONSIDER FIBRINOLYTIC THERAPY (arrival < 60 min) * REVIEW RISKS/BENEFITS with patient and family, get CONSENT * START THERAPY, * Monitor neurological status, urgent CT if deterioration * Monitor vitals, admit to Critical Care Unit * No anticoagulants or antiplatelet treatment for 24 hours No Fibrinolytic Therapy: Consider admission, anticoagulation, treatment of other Dx James Lamberg

ACTIVE SEIZURE Coma Cocktail, benzodiazepines (lorazepam 0.1 mg/kg IV or diazepam 0.2 mg/kg IV), fosphenytoin 15-20 mg/kg IV/IM. Refractory seizures, phenobarbital and midazolam.

ACLS ACUTE MYOCARDIAL INFARCTION * IMMEDIATE ASSESSMENT (< 10 min from arrival) * Vitals, O2 Sat, IV, ECG, Serum Cardiac Markers, Coags, Targeted H&P, * Electrolytes, Fibrinolytic Eligibility, Chest X-Ray (< 30 min from arrival) Treatments (not all may be appropriate) MONA greets all pts: * OXYGEN at 4 L/min * Morphine * ASPIRIN 160-325 mg PO * Oxygen * NITROGLYCERIN SL or Spray * Nitroglycerine * MORPHINE IV (if pain not relived by nitroglycerine) * Aspirin * FIBRINOLYTIC AGENTS * Nitroglycerine IV, Beta Blockers IV, Heparin IV * Glycoprotein IIb/IIIa receptor inhibitors (e.g. abciximab, eptifibatide, tirofiban) * ACE inhibitors (after 6 hours or when stable), Angioplasty Fibrinolytic Contraindications (others may apply) * Prolonged or traumatic CPR * Suspected aortic dissection * Trauma or surgery last 2 months * History of BP > 180/110 * Active internal bleeding * Head trauma or neoplasm * Recent GI or GU bleed * History of CVA * Bleeding disorder or warfarin use * Pregnant state * Diabetic hemorrhagic retinopathy * Liver or kidney dysfunction Time in ED to fibrinolytic therapy should be < 30 minutes

ACLS PULSELESS ELECTRICAL ACTIVITY * CPR, IV, INTUBATE, ASSESS BLOOD FLOW WITH: * Doppler Ultrasound, End-Tidal CO2, ECHO, or Arterial Line * EPINEPHRINE 1mg IV push q3-5 min(1) * ATROPINE 1mg IV q3-5 min to max total 0.04 mg/kg(4), if HR < 60 bpm Possible Causes & Treatments(2,3) * Hypoxia (oxygen, ventilation) * Hypovolemia (volume infusion) * Hyper/Hypokalemia (CaCl and others) * Hypothermia (see hypothermia algorithm) * Hydrogen Ion (buffer for acidosis, ventilation) * Tamponade, cardiac (pericardiocentesis) * Tension pneumothorax (needle decompression) * Thrombosis, pulmonary embolism (fibrinolytics, surgery) * Thrombosis, acute myocardial infarction (see AMI algorithm) * Tablets, overdose (i.e. tricyclic, digitalis, Ca channel, or beta blockers)

IMPLANTED DEVICES (Pacemakers & ICDs) Management: ABCs, IV, O2, cardiac monitor, pacer pads in place Inappropriate Shocks: Placing a donut magnet over the device will temporarily disable defibrillation, but will not disable the pacing function (sets to default pace)

ACLS HYPOTHERMIA * Maintain horizontal position * Avoid rough movement and excess activity * Remove wet garments * Monitor core temperature * Monitor cardiac rhythm(18) * Protect against heat loss and wind chill (blankets, insulating equipment) Pulse & Breathing Present * Core 34-36 ºC: Passive rewarming and active external rewarming * Core 30-34 ºC: Passive rewarming and active external rewarming of trunk only(19) * Core < 30 ºC: Active internal rewarming sequence (see below) Pulse & Breathing Absent * CPR, DEFIBRILLATE VF/PVT up to 3 shocks (200, 200-300, 360 J) * INTUBATE, VENTILATE WARM HUMID OXYGEN (42-46 ºC)(20) * IV, INFUSE WARM NORMAL SALINE (43 ºC)(20) Core Temperature < 30 ºC * Withhold IV medications, Limit shocks for VF/VT to 3 max * Transport to hospital, Active internal rewarming sequence (see below) Core Temperature > 30 ºC * Give IV medications as indicated (but at longer than standard intervals) * Repeat defibrillation of VF/VT as core temperature rises * Active internal rewarming sequence (see below)

ACTIVE INTERNAL REWARMING SEQUENCE(20) * Warm IV fluids (43 ºC) * Warm, humid oxygen (42-46 ºC) * Peritoneal lavage (KCl-free fluid) * Extracorporeal rewarming * Esophageal rewarming tubes * Continue active internal rewarming until core temperature > 35 ºC or * Continue until spontaneous circulation returns or * Continue until resuscitation efforts cease

FOCUSED ASSESSMENT WITH SONOGRAPHY FOR TRAUMA * FAST exam 4 views: peri-hepatic, pericardial, peri-splenic, posterior cul de sac. * Anechoic fluid appears as a black stripe, assumed to be blood in trauma. * Sub-xiphoid depth 22cm, supra-pubic depth 10-12 cm, flank depth 14-16 cm. * Morison’s pouch (RUQ) most sensitive for free fluid. * Left kidney rarely has free fluid, fluid collects sub-diaphragmatic or peri-splenic.

ACLS HYPOTENSION, SHOCK, PULMONARY EDEMA * ABCs, IV, O2, Cardiac Monitor, ECG, Pulse Oximeter, Chest X-Ray, H&P Volume Problem * GIVE FLUIDS, BLOOD, CAUSE-SPECIFIC INTERVENTIONS * Consider vasopressors (see Pump Problem below) Rate Problem * See Bradycardia or Tachycardia algorithm Pump Problem (Systolic BP < 70 mmHg, Signs/Symptoms of Shock) * NOREPINEPHRINE 0.5-30 mcg/min IV then dopamine if needed (Drip: Norepinephrine 4 mg in 250 mL D5W at 0.5-1.0 mcg/min, max 30) Pump Problem (Systolic BP 70-100 mmHg, Signs/Symptoms of Shock) * DOPAMINE 5-15 mcg/kg/min IV then dobutamine if needed (Drip: Dopamine 400 mg in 250 mL D5W or NSS at 2-20 mcg/kg/min) Pump Problem (Systolic BP 70-100 mmHg, No Shock Signs or Symptoms) * DOBUTAMINE 2-20 mcg/kg/min IV then nitroglycerine if needed (Drip: Dobutamine 250 mg in 250 mL D5W or NSS (1 mg/mL) at 2.5-20 mg/kg/min) Pump Problem (Systolic BP > 100 mmHg) * NITROGLYCERINE 10-20 mcg/min IV, consider (Drip: Nitroglycerine 50 mcg in 250 mL D5W or NSS at 5 mcg/min, titrate as needed) * NITROPRUSSIDE 0.1-5.0 mcg/kg/min IV then Third Line Actions prn (Drip: Nitroprusside 50 mcg in 250 mL D5W or NSS at 0.3 mcg/kg/min, max 10) Acute Pulmonary Edema: First Line Actions * OXYGEN, INTUBATION prn * NITROGLYCERINE SL * FUROSEMIDE IV 0.5-1.0 mg/kg * MORPHINE IV 2-4 mg Acute Pulmonary Edema: Second Line Actions * Nitroglycerine/Nitroprusside if BP > 100 mmHg * Dopamine if BP 70-100 mmHg and shock signs/symptoms * Dobutamine if BP > 100 mmHg and no shock signs/symptoms Acute Pulmonary Edema: Third Line Actions * Identify and treat reversible causes * Pulmonary artery catheterization * Intra-aortic balloon pump * Angiography and percutaneous coronary intervention (PCI) * Additional diagnostic studies * Surgical interventions * Additional drug therapy

NEXUS Criteria For Imaging The C-Spine (clear c-spine if none present) Intoxication, midline neck tenderness, distracting injury, ∆ LOC, neurologic deficit

ACLS ENDNOTES Class I: Definitely helpful Class IIb: Acceptable, possibly helpful Class IIa: Acceptable, probably helpful Class: III: Not indicated 1) Recommended dose is 1 mg IV push every 3-5 min. If this approach fails, higher doses of epinephrine (up to 0.2 mg/kg) may be used but are not recommended. 2) Sodium bicarbonate 1 mEq/kg is Class I if pt has known preexisting hyperkalemia. 3) Sodium bicarbonate 1 mEq/kg IV is Class IIa if known preexisting bicarbonateresponsive acidosis, in tricyclic antidepressant overdose, to alkalinize urine in aspirin or other drug overdoses; Class IIb intubated and ventilated patients with long arrest interval, on return of circulation after long arrest interval; Class III hypercarbic acidosis. 4) Atropine not recommended for PEA/asystole. 5) To be effective, transcutaneous pacing must be performed early combined with drug therapy. Evidence does not support routine use of TCP for asystole. 6) Serious signs or symptoms must be related to the slow rate. Clinical manifestations include symptoms (chest pain, shortness of breath, decreased consciousness) and signs (low BP, shock, pulmonary congestion, congestive heart failure). 7) If patient is symptomatic, do not delay transcutaneous pacing while awaiting IV access or for atropine to take effect. 8) Denervated, transplanted hearts will not respond to atropine. Go at once to pacing, catecholamine infusion, or both. 9) Atropine should be given in repeat doses every 3-5 min up to a total of 0.03-0.04 mg/kg. Use the shorter dosing interval (3 min) in severe clinical conditions. 10) NEVER treat the combination of third degree heart block and ventricular escape beats with lidocaine (or any agent that suppresses ventricular escape rhythms). 11) Verify patient tolerance & mechanical capture. Use analgesia/sedation as needed. 12) Unstable condition must be related to the tachycardia. Signs and symptoms may include chest pain, shortness of breath, decreased level of consciousness, low BP, shock, pulmonary congestion, CHF, acute MI. 13) Effective regimens have included a sedative (e.g. diazepam, midazolam, barbiturates, etomidate, ketamine, methohexital) with or without analgesic agent (e.g. fentanyl, morphine, meperidine). Many experts recommend anesthesia if services readily available. 14) Note possible need to resynchronize after each cardioversion. 15) If delays in synchronization occur and clinical condition is critical, go immediately to unsynchronized shocks. James Lamberg 16) Treat polymorphic VT (irregular form and rate) like VF: see VF/PVT algorithm. 17) PSVT and atrial flutter often respond to lower energy levels (start with 50 J). 18) This may require needle electrodes through the skin. 19) Methods include electric or charcoal rewarming devices, hot water bottles, heating pads, radiant heat sources, and warming beds. 20) Many experts think these interventions should be done only in-hospital. 21) If there is no response 5-10 minutes after a single IV dose of vasopressin, it is acceptable to resume epinephrine 1 mg IV push q3-5 min. 22) If high suspicion of subarachnoid hemorrhage remains despite negative CT scan, perform lumbar puncture. Fibrinolytic therapy contraindicated after lumbar puncture.

NORMAL LAB VALUES Hematology WBC 4.5-11.0 x 10^3 per mcL

Hemoglobin M 13.5-17.5 g/dL F 12.0-16.0 g/dL

Platelets 150-450 x 10^3 Hematocrit per mcL M 39-49% F 35-45% RBC, M 4.3-5.7 x 10^6/mcL PT 11-15 sec RBC, F 3.8-5.1 x 10^6/mcL aPTT 20-35 sec MCV 80-100 fL Bleeding Time 2-7 min MCH 26-34 pg/cell Thrombin Time 6.3-11.1 sec MCHC 31-37% Hgb/cell Fibrinogen 200-400 mg/dL Reticulocyte Count 0.5-1.5% FDP < 10 mcg/mL Hemoglobin A1c 5.0-7.5% ESR, M < 15 mm/hr Haptoglobin 26-185 mg/dL ESR, F < 20 mm/hr

Chemistries Sodium Chloride 135-145 mEq/L 98-106 mEq/L

BUN 7-18 mg/dL

Potassium 3.5-5.1 mEq/L

Creatinine 0.6-1.2 mg/dL

Bicarbonate 22-29 mEq/L

Calcium, total 8.4-10.2 mg/dL Calcium, ionized 4.65-5.28 mg/dL Phosphate 2.7-4.5 mg/dL >60y, M 2.3-3.7, F 2.8-4.1 mg/dL Magnesium 1.3-2.1 mEq/L Protein, total 6.0-8.0 g/dL Albumin 3.5-5.5 g/dL alpha1-Fetoprotein < 10 ng/dL Bilirubin, total 0.2-1.0 mg/dL Bilirubin, conjugated 0-0.2 mg/dL Lipase 10-140, >60y 18-180 U/L Amylase 25-125 U/L C-peptide 0.70-1.89 ng/mL Total Cholesterol < 200 mg/dL LDL Cholesterol < 130 mg/dL HDL Cholesterol, M > 29, F > 35 mg/dL Triglycerides, M 40-160, F 35-135 mg/dL Lactate, venous 5.0-20.0 mg/dL Uric Acid, M 3.5-7.2, F 2.6-6.0 mg/dL Ammonia Nitrogen 10-50 mcmol/L NOTE: Adult normal values may vary.

Neutrophils: 57-67% Segs: 54-62% Bands: 3-5% Lymphocytes: 22-33% Monocytes: 3-7% Eosinophils: 1-3% Basophils: 0-1% Ca PT PTT INR

Mg

PO4

Anion Gap 7-16 mEq/L Glucose 70-115 mg/dL

Osmolality 275-295 mOsm/kg

Alk Phos, M 38-126, F 70-230 U/L LDH 90-190 U/L Fraction 1, 18-33%; 2, 28-40% 3, 18-80%; 4, 6-16%; 5, 2-13% SGOT/AST 7-40 U/L SGPT/ALT 7-40 U/L GGT, M 9-50, F 8-40 U/L CPK, M 38-174, F 26-140 U/L CPK MB < 5% Iron, M 65-175, F 50-170 mcg/dL TIBC 250-450 mcg/dL Iron Saturation, M 20-50, F 15-50% Ferritin, M 20-250, F 10-120 ng/mL Vitamin B12 100-700 pg/mL Folate 3-16 ng/mL Copper, M 70-140, F 80-155 mcg/dL Zinc 70-150 mcg/dL PSA < 4.0 ng/mL Acid Phosphatase < 0.8 U/L CEA < 2.5, smoker < 5.0 ng/mL CA-125 < 35 U/mL

NORMAL LAB VALUES Arterial Blood Gases pH PaCO2 PaO2 HCO3 O2 Sat Base Excess 7.35-7.45 35-45 mmHg 80-100 mmHg 21-27 mEq/L 95-98% +/-2 mEq/L

Urine

Cerebrospinal Fluid

Minimum Volume 0.5-1.0 mL/kg/hr Specific Gravity 1.002-1.030 Osmolality 50-1400 mOsml/kg Creatinine, M 14-26, F 11-20 mg/kg/day Creatinine Clearance M 90-136 mL/min/1.73m^2 F 80-125 mL/min/1.73m^2 Urea Nitrogen 12-20 g/day Sodium 40-220 mEq/day Potassium 25-125 mEq/day Calcium 100-300 mg/day Phosphate 0.4-1.3 g/day Uric Acid 250-750 mg/day Amylase 1-17 U/hr Glucose < 0.5 g/day Albumin 10-100 mg/day Protein 10-150 mg/day 5-HIAA 2-6 mg/day 17-Ketosteroids (17-KS) M 8-22, F 6-15 mg/day 17-Ketogenic Steroids (17-KGS) M 5-23, F 3-15 mg/day 17-Hydroxycorticosteroids (17-OHCS) M 3.0-10.0, F 2.0-8.0 mg/day Homovanillic Acid (HVA) 1.4-8.8 mg/day Metanephrine, total 0.05-1.2 mcg/mg cre.

Pressure 70-180 mm CSF supine WBC 0-5 mononuclear cells/mcL Protein 15-45 mg/dL Glucose 40-70 mg/dL

Toxicology Acetaminophen, toxic > 200 mcg/mL COHgb, toxic > 20% saturation Ethanol (mg/dL, non-alcoholic pt) > 100 intoxed, ataxic, slurred speech > 200 lethargy, stuporous, vomiting > 300 coma > 500 respiratory depression, death Ethylene Glycol, toxic > 20 mg/dL Lead, toxic > 100 mcg/dL Methanol, toxic > 200mg/L Salicylate, toxic > 300 mcg/mL (trough) NOTE: Adult normal values may vary.

Synovial Fluid WBC < 200/mcL ( 4000 WBC/mcL Septic > 60,000 WBC/mcL Protein < 3.0 g/dL Glucose > 40 mg/dL Uric Acid < 8.0 mg/dL LDH < Serum LDH

Endocrinology Aldosterone, supine 3-10 ng/dL upright 5-30 ng/dL Cortisol, 0800h 6-23, 1600h 3-15 mcg/dL 2200h < 50% of 0800h value Estrogen, follicular 60-200, luteal 160-400, menopausal < 130 pg/mL FSH, follicular 1-9, ovulation 6-26, luteal 1-9, menopausal 30-118 mU/mL Gastrin < 100 pg/mL Growth Hormone, M < 2, F < 10 ng/mL >60y, M < 10, F < 14 ng/mL LH, follicular 1-12, midcycle 16-104, luteal 1-12, menopausal 16-66 mU/mL Progesterone, follicular 0.15-0.7, luteal 2.0-25 ng/mL Prolactin < 20 ng/mL PTH 10-65 pg/mL Testosterone, M, free 52-280 pg/mL, total 300-1000 ng/dL T4, total 5.0-12.0 mcg/dL T4, free 0.8-2.3 ng/dL T3, total 100-200 ng/dL TBG 15-34 mcg/mL TSH < 10 mcU/mL >60y, M 2-7.3, F 2-16.8 mcU/mL

SERUM DRUG LEVELS Drug

Therapeutic

Toxic

Carbamazepine (Tegretol) Digoxin (Lanoxin) Ethosuximide (Zarontin) Lidocaine (Xylocaine) Lithium (Eskalith) NAPA (N-acetyl procainamide) Phenobarbital

4-12 mcg/mL 0.8-2.0 ng/mL 40-100 mcg/mL 1.5-6 mcg/mL 0.6-1.2 mEq/L 5-30 mcg/mL 15-40 mcg/mL

> 12 > 2.0 > 150 >6 > 1.5 > 40 > 35

Phenytoin (Dilantin) Procainamide (Procan) Quinidine (Quinaglute) Theophylline (Theo-Dur) Valproic Acid (Depakene)

10-20 mcg/mL 3-10 mcg/mL 1.5-5 mcg/mL 10-20 mcg/mL 50-100 mcg/mL

> 20 > 10 >5 > 20 > 100

Drug

Peak

Trough

Amikacin (Amikin) 25-35 mcg/mL < 10 Gentamicin (Garamycin) 4-6 mcg/mL 1.016 > 3.0 g/dL > 200 U/L > 0.5 > 0.6

Replacement Fluids Fluid Na 1/2 NSS 77 NS 154 D5W D10W LR 130

K 4

Cl HCO3 77 154 109 28

Ca kcal/L Glucose (g/L) 170 50 340 100 3 9 -

HELPFUL EQUATIONS Anion Gap: Na – (Cl + HCO3) Correction: AG falls by about 2.5 mEq/L for every 1 g/dL dec. in albumin below 4 Winter’s Formula Expected PCO2 = (1.5*HCO3) + 8 +/- 2 Delta-Delta ∆ AG / ∆ HCO3 1 = metabolic alkalosis present Osmolar Gap: Osm pt – Osm calc, < 10

Osmolality: 2*Na + glucose/18 + BUN/2.8 Fractional Na Excretion (UNa * Cr serum) / (Na serum * UCr) Fractional Urea: (UUr*PCr)/(UCr*BUN) < 35 = normal/prerenal azo., > 35 = ATN Body Water Deficit: (liters) (0.6 * kg weight * Na patient – 140) / 140 Urine Anion Gap: UNa + UK – UCl + = intrinsic renal, - = normal/GI bicarb loss

Corrected Total Ca: (albumin) (0.8 * (albumin norm – albumin pt)) + Ca Corrected Na: (hyperglycemia) Na + ((glucose – 100) * 0.016)

Creatinine Clearance: (estimate of GFR) (UCr*UNa in mL) / (Cr serum*time in min) Creatinine Clearance (Cockroft-Gault) ((140 – age) * weight in kg * F) / F = 85% (72 * serum creatinine in m/dL) if female

Aa Gradient ((713 * FIO2) – (PaCO2 / 0.8)) – PaO2 Arterial Blood Gas Rule: acute (chronic) ∆ 10 mmHg PaCO2 = ∆ 0.08 pH (∆ 0.03)

Mean Arterial Pressure: (MAP) Diastolic + ((Systolic – Diastolic) / 3) Body Surface Area: (m^2) sqrt((height in cm * weight in kg) / 3600) BMI: weight in kg / (height in m)^2 BMI (18.5-25), Over 25-30, Obese > 30 Acid/Base Basics: Acidosis < 7.4, Alkalosis > 7.4. In Respiratory, pH and pCO2 are in Reverse directions. If gap meta. acidosis, Winter’s formula used for resp. compensation.

PHLEBOTOMY TUBES Red top

Chemistries, amylase, ANA, CEA, complement, Coombs, C-peptide, CPK isoenzymes, cross-match, folate, glucose tolerance, hepatitis, HIV, IgA, IgD, IgG, IgM, iron, lipase, methemoglobin, most drug levels, PSA, RPR/VDRL, thyroid Yellow top Blood cultures Green top Ammonia, chromosome and HLA analysis, thiamine Blue top PT, PTT, INR, factor assays, fibrinogen, fibrin split products Purple top CBC, ABO type, cortisol, ESR, helper T cell, renin (on ice) Gray top Ethanol, lactate (on ice), sulfa levels James Lamberg UNIT CONVERSIONS ºC = (ºF – 32) * 5/9 1 in = 2.54 cm 1 cm = 0.3937 in 37.0 ºC = 98.6 ºF 1 ft = 0.3048 m 1 m = 3.2808 fl 37.8 ºC = 100.0 ºF 1 mi = 1.6093 km 1 km = 0.6214 mi 38.0 ºC = 100.4 ºF 1 fl oz = 29.573 mL 1 mL = 0.033814 fl oz 38.3 ºC = 101.0 ºF 1 qt = 0.94633 L 1 L = 1.0567 qt 38.9 ºC = 102.0 ºF 1 gal = 3.7854 L 1 L = 0.26417 gal 39.0 ºC = 102.2 ºF 1 teaspoon = 5 mL 1 tablespoon = 15 mL 39.4 ºC = 103.0 ºF 1 oz = 28.350 g 1 g = 0.035274 oz 40.0 ºC = 104.0 ºF 1 lb = 0.45359 kg 1 kg = 2.2046 lbs ºF = (ºC * 9/5) + 32

ADMIT / TRANSFER ORDERS Admit/Transfer: floor, room, service, attending, residents Diagnosis: list in order of priority Condition: undetermined, good, fair, serious, critical (do not use “guarded” or “stable”) Vitals: q shift, routine, q 15 minutes x 4 then q 2 hours, q4h + neuro checks q4h, etc. Activity: ad lib, bed rest, up to chair, ambulate tid, assess for falls risk, etc. Diet: regular 2000 cal/day, ADA (diabetic), low sodium, clear liquid, NPO, etc. Ins & Outs: strict, routine, ad lib, etc. IV Fluids: D5NS to run at 83 mL/hr, etc. Drains: Foley to gravity, nasogastric tube to intermittent suction, etc. Meds: antibiotics, anticoagulants, antiemetics, insulin, O2, pain meds, etc. Allergies: specific medications or substances with reaction, NKDA, etc. Prophylaxis: DVT prophylaxis (e.g. Lovenox, SCDs), PUD prophylaxis (e.g. Protonix) Labs: CBC, chemistries, X-rays, CT/MRI, ECG, pulse oximetry, etc. Monitors: arterial line, noninvasive BP, CVP, pulse ox, telemetry, etc. Respiratory Care: updrafts, endotracheal suctioning, spirometry, etc. Dressing Care: dressing changes, DVT stockings, etc. House Officer Calls: Call MD/DO if SBP > 180 or < 80, HR > 150 or < 50, RR > 30 or < 8, T > 102ºF, O2 sats < 90%, etc. ON SERVICE NOTE Admit Date / Diagnosis: date, list diagnoses in order of importance Hospital Course: changes over tie, lab studies, procedures, results Physical Exam: brief, targeted Problem List: list in order of importance Assessment: based on above date Plan: medication changes, lab tests, procedures, consults, etc. PROGRESS NOTE (SOAP Note) S: patient comments or complaints, nursing comments O: Vitals: blood pressure, pulse, respirations, temp, weight, O2 sat Ins/Outs: IV fluid, PO intake, emesis, urine stools, drains Exam, Meds: physical findings, pertinent routine or new medications Labs: new laboratory or procedure results A: assessment based on above date P: medication changes, lab tests, procedures, consults, discharge DISCHARGE NOTE Admission / Discharge Dates & Diagnoses: dates, list diagnoses in order of importance Service & Referring Physician: service name, attending, residents, referring doc name Consults: physicians, services, dates Procedures: dates of surgery, lumbar punctures, angiograms, etc. History & Physical Exam: pertinent admission H&P and lab tests Course: summary of the treatment and progress during hospital stay Discharge Condition: good, fair, serious, critical (do not use “guarded” or “stable”) Disposition: discharge to home, specific nursing home, etc. Medications: discharge meds with dosage, administration, refills Instructions: activity restrictions, diet, dressing/cast care, further treatment, etc. Follow-Up: follow-up appointment, emergency phone number, etc.

PRE-OPERATIVE NOTE Pre-Op Diagnosis: list Procedure & Date: planned surgery and current date Labs: CBC, chemistries, PT/PTT, urinalysis, etc. CXR: note chest x-ray findings ECG: note electrocardiogram findings Blood: not needed, type/screen or type/cross 2 units packed RBCs, etc. Orders: NPO after midnight, preop antibiotics, skin or colon preps, etc. Permit: Signed and on chart (if so)

OPERATIVE NOTE Pre-Op Diagnosis: list Post-Op Diagnosis: list Procedure & Date: surgery and date performed Surgeon: attending, residents, students who scrubbed Findings: acutely inflamed gallbladder, sigmoid colon mass, etc. Anesthesia: general endotracheal (GETA), spinal, local, etc. Fluids: amount and type (electrolytes, blood, etc. in cc or units) Estimated Blood Loss: minimal or amount in cc Drains: type and location (T-tube in RUQ) Specimens: type sent to pathology (gallbladder and cystic duct, etc.) Complications: list Condition: good, fair, serious, critical, extubated, transferred to recovery room, etc.

POST-OPERATIVE NOTE S: patient comments/complaints, nursing comments, LOC, pain control, etc. O: Vitals: blood pressure, pulse, respirations, temp, oxygen sat, etc. Ins/Outs: IV fluid, PO intake, emesis, urine, stool, drains, etc. Exam: physical findings (incision/dressing, neurovascular status, etc.) Meds: routine or new medications (antibiotics, DVT prophylaxis, etc.) Labs: results of any since surgery A: assessment based on data above P: medication changes, lab tests, procedures, consults, discharge, etc.

PROCEDURE NOTE Procedure & Date: list name and date performed Permit: procedure, benefits, risks (include those of bleeding, infection, injury, anesthesia, and allergic reaction), and alternatives explained to the patient who voiced understanding of the information. Their questions were sought and answered. Patient agreed to proceed with the (spinal tap, paracentesis, etc.). Permit signed and on chart. (if so) Indications: meningitis, ascites, etc. Physician(s): attendings, residents Description: Area prepped and draped in a sterile fashion. (Local, spinal) anesthetic administered with (mL medication). Describe technique including instruments, body location, occurrences, etc. Complications: list Estimated Blood Loss: minimal or amount in mL Disposition: Patient alert, oriented, and resting; breathing non-labored; extremities neurovascularly intact; incision clean, dry, and intact; etc.

DELIVERY NOTE On (delivery date, time), this (age, race, gravida x, para x, group B strep pos/neg) female under (epidural, pudendal, local, no) anesthesia delivered a viable (male, female) infant weighting (weight) with APGAR scores of (0-10) and (0-10). Delivery was via (SVD, LTCS, classical CS). (Nuchal cord reduced.) Infant was (bulb, DeLee) suctioned at (perineum, delivery). Cord clamped and cut and infant handed to (pediatrician, nurse) in attendance. (Cord blood sent for analysis.) (Intact, fragmented, meconium stained) placenta with (2, 3) vessel cord was delivered (spontaneously, by manual extraction) at (time). (Amount) of (carboprost, methylergonovine, oxytocin) given. (Uterus, cervix, vagina, rectum) explored and (midline episiotomy, nth degree laceration, uterus and abdominal incision) repaired in a normal fashion with (type) suture. EBL (amount). Patient taken to RR in (good, fair, serious, critical) condition. Infant taken to NBN in (good, fair, serious, critical) condition. Dr. (name) attending. NOTE: SVD = spontaneous vaginal delivery. LTCS = low transverse C-section. CS = Csection. EBL = estimated blood loss. RR = recovery room. NBN = newborn nursery.

POST-PARTUM NOTE S: patient comments/complaints, nursing comments, LOC, pain control, breast erythema/tenderness, quantity/trend of vaginal bleeding, urination, flatus, bowel movements, lower extremity swelling, ambulation, breast/bottle feed, birth control type O: Vitals: blood pressure, pulse, respirations, temp, oxygen sat, etc. Ins/Outs: IV fluid, PO intake, emesis, urine, stool, etc. Exam: breath sounds, bowel sounds, fundal height/consistency, incision/episiotomy condition, lower extremity edema, Homan sign, Pratt sign Meds: RhoGAM, pain med, iron, vitamins, laxative, contraception Labs: CBC, Rh status, rubella status A: assessment based on data above P: medications, lab tests, rubella immunization, consults, discharge, etc.

GLUCOSE TOLERANCE TEST (Oral) Adult, Non-Pregnant (75g dose) Fasting: 70-105 mg/dL (>60y, 70-115) 30 min: 110-170; 60 min: 120-170 mg/dL 90 min: 100-140; 120 min: 70-120 mg/dL Diabetes Mellitus Fasting < 140, 120 minute and one other sample (30, 60, 90 min) > 200 on more than one occasion OR random > 200 and symptoms present.

Adult Pregnant (24-28 weeks) 1 hour: 140 mg/dL (50g dose) Perform 3 hour glucose tolerance test if 140 mg/dL value is exceeded Fasting: 105 mg/dL (100g dose) 1 hour: 190; 2 hour: 165; 3 hour: 145 mg/dL Gestational Diabetes Two or more value are exceeded

FUNDAL HEIGHT DURING PREGNANCY 12 Weeks Barely palpable above pubic symphysis 15 Weeks Midpoint between pubic symphysis and umbilicus 20 Weeks At the umbilicus 28 Weeks 6cm above the umbilicus 32 Weeks 6cm below the xiphoid process 36 Weeks 2cm below the xiphoid process 40 Weeks 4cm below the xiphoid process Shortcut: After 20 weeks, pubic symphysis to fundus in cm equals weeks

OB/GYN TERMINOLOGY G (gravidity): total number of pregnancies> P (parity): total number of deliveries > 500gm or ≥ 24 weeks gestation Ab (abortion): number of pregnancies that terminate < 24 weeks gestation LC (living children): number of successful pregnancy outcomes TPAL: T = term deliveries, P = preterm deliveries, A = abortions, L = living children

ESTIMATED DELIVERY DATE (Naegele’s Rule) 1) Add 7 days to FDLMP. (e.g. August 11th, 2009 becomes 18th) 2) Subtract 3 months. (August becomes May) 3) Add 1 year. (2009 becomes 2010, estimated delivery May 18th, 2010)

PRENATAL VISITS First Visit 6-8 Weeks 16-18 Weeks 26-28 Weeks 32 Weeks 36 Weeks 38 Weeks 39 Weeks 40 Weeks

H&P, Pap, Rh, Gonorrhea & Chlamydia, Infection Screen, Genetic Screen H&P, Fetal Heart Tones, Urine, HIV Testing H&P, Fetal Exam, Pelvic Sonogram?, Amniocentesis, Triple/Quad Screen H&P, Fetal Exam, Labs (CBC, Ab, Urine), Diabetes Screen, Rhogam H&P, Fetal Exam, Urine H&P, Fetal Exam, Urine, Group B Strep Culture H&P, Fetal Exam, Urine, Cervical Exam? H&P, Fetal Exam, Urine H&P, Fetal Exam, Urine, Fetoplacental Function Tests?

SAFE DRUGS IN PREGNANCY Asthma, acute exacerbation Asthma, severe Asthma, chronic, moderate Back pain/headache Intra-amniotic infection Chlamydia Gonorrhea Syphilis, early Vaginal trichomoniasis Bacterial vaginosis Candidal vaginitis Bacteriuria/Cystitis Acute pyelonephritis Bronchitis Pneumonia Tuberculosis, active Hypertension, chronic Diabetes Thromboembolism (prophylaxis)

Albuterol Methylprednisolone Beclomethasone and cromolyn sodium Acetaminophen Ampicillin and gentamycin Erythromycin or azithromycin Ceftriaxone Benzathine penicillin G T-1: Clotrimazole >T-1: Metronidazole T-1: Clindamycin cream 2% >T-1: Metronidazole Clotrimazole 1% or terconazole 0.8% Nitrofurantoin Ampicillin and gentamycin Amoxicillin-clavulanate or cefuroxime 3rd gen. cephalosporin +/- azithromycin Isoniazid and rifampin Alpha-methyldopa (labetalol can be used) Insulin, glyburide Unfractionated heparin or low-molecularweight heparin (enoxaparin)

C B C and B B B and C B B B B B B B C B B and C B B C B B B

Patient Education: Self Breast Exam, Contraception, Domestic Violence, STDs/HIV, Seatbelts, Osteoporosis, Drugs/ETOH/Tobacco, Smoke Alarms, Diet/Exercise, Vaccines

BISHOP SCORING SYSTEM Score total 8 or more means vaginal birth is likely to be successful. Dilation (cm): 0 = closed; 1 = 1-2cm; 2 = 3-4cm; 3 = 5-6cm Effacement (%): 0 = 0-30%; 1 = 40-50%; 2 = 60-70%; 3 = 80% Station: 0 = -3 station; 1 = -2 station; 2 = -1 to 0 station; 3 = +1 to +2 station Consistency: 0 = firm; 1 = medium; 2 = soft Position: 0 = posterior; 1 = midposition; 2 = anterior

APGAR SCORING EXAM For newborn infants, done at 1 minute and 5 minutes after birth. Score total 0 to 10: 7+ good; 4-6 assist, stimulate; < 4 resuscitate Appearance: 2 = Pink body; 1 = Pink body with blue extremities; 0 = Blue/pale body Pulse: 2 = > 100 beats/minute; 1 = < 100 beats/minute; 0 = Absent Grimace: 2 = Cough, sneeze, or vigorous cry; 1 = Grimace or slight cry; 0 = No response Activity: 2 = Active movement; 1 = Some movement; 0 = Limp, motionless Respirations: 2 = Strong, crying; 1 = Slow, irregular; 0 = Absent

DEVELOPMENTAL MILESTONES 2 mo 4 mo 6 mo 9 mo 12 mo 15 mo 18 mo 24 mo 3 yrs 4 yrs

smile, follow past midline, ooo/aah, head up 45º regard hand, grasp rattle, squeal/laugh, bear weight on legs feed self, reach, imitate speech sound, pull to sit with no head lag take 2 cubes, jabber, pull to stand, sit unsupported wave bye, pat-a-cake, pincer grasp, dada/mama, stand 2 sec play ball with examiner, scribbles, 2 words, walk well use spoon/fork, drink from cup, 2 cube tower, 3 words, runs remove garment, 4 cube tower, 6 body parts, walk up steps wash/dry hands, 8 cube tower, 2 adjectives, broad jump dress without help, copy circle, speech all understandable, hops

IMMUNIZATION SCHEDULE Birth 2 mo 4 mo 6 mo 12-15 mo 4-6 yrs 11-12 yrs

HepB Note: Check local schedule HepB, DTaP, Rota, Hib, IPV, PCV before administration DTaP, Rota, Hib, IPV, PCV HepB, DTaP, Rota, Hib, IPV, PCV Influenza (yearly until age 4) DTaP, Hib, MMR, VZV, PCV, HepA DTaP, IPV, MMR, HepA (2 doses) MCV4, HPV (3 doses), TdaP (Td every 10 yrs after)

OFFICE HEALTH MAINTENANCE TESTS Age 13-16 Age > 16 Age ≥ 18 Age ≥ 20 Age ≥ 21 Age ≥ 40 Age ≥ 45 Age ≥ 50 Age ≥ 55 Age ≥ 65

Tetanus/Diphtheria booster (once) Tetanus/Diphtheria booster (every 10 years) CBC, BUN, Creatinine (periodically) Cholesterol (every 5 years), Breast exams (every 3 years) Pap every 2 years until 30 then every 3 years if no CIN 2+, DES, HIV Fecal Occult Blood Testing, Mammogram (annually or periodically) Fasting Glucose (every 3 years) Sigmoidoscopy (every 5 years) or Colonoscopy (q 10 years if high risk) Influenza Vaccine (annually) TSH (every 3-5 years), Cholesterol, Urinalysis (periodically), Pneumococcal Vaccine (once)

HISTORY AND PHYSICAL EXAM Chief Complaint: health problem/complaint in patient’s own words. History of Present Illness (HPI): chronological order of time/place of symptom(s) onset, duration, frequency, location, quality, quantity/severity, aggravating/alleviating factors, associated symptoms, self treatment, relevant laboratory values, pertinent negatives. James Lamberg Past Medical History: General Health: date, type, outcome, complications of Childhood Illnesses (measles, mumps, rubella, whopping cough, chicken pox, rheumatic fever, scarlet fever, polio); Adult Illnesses; Accidents/Injuries; hospitalizations not already listed; Immunizations (DPT, MMR, polio, hepatitis B, H. influenza, S. pneumonia, varicella.); Screening Tests (hematocrit, urinalysis, tuberculin skin test, pap smear, mammogram, occult stool blood, cholesterol, dental visits). Past Surgical History: date(s), type, reason, outcome, transfusions, complications. Family History: age, health/death of parents, siblings, spouse, children; Ask About: diabetes, heart disease, hypertension, stroke, cancer, bleeding disorders, asthma, arthritis, tuberculosis, epilepsy, mental illness, symptoms of presenting illness. Social History: birthplace, education, employment, religion, marriage/divorce, living accommodations, people at home, ambulation status/ability, hobbies, diet, exercise. Tobacco, Alcohol, Drugs: type, amount, frequency, duration, reactions, treatment. Medications: name, dose, frequency, duration, reason taking, compliance, availability. Allergies: medications/substances causing reactions (rash, swelling, agitation, etc.). Review of Systems (ROS): General: weight change, fatigue, weakness, fever, chills, night sweats Skin: skin, hair, nail changes, itching, rashes, sores, lumps, moles Head: trauma, headache location/frequency, nausea, vomiting, visual changes Eyes: glasses/contacts, blurriness, diplopia, tearing, itching, acute vision loss Ears: hearing loss, tinnitus, vertigo, discharge, earache Nose: rhinorrhea, stuffiness, sneezing, itching, allergy, epistaxis Mouth: bleeding gums, hoarseness, sore throat, swollen neck Breasts: skin changes, masses/lumps, pain, discharge, self exams Cardiac: HTN, murmurs, angina, palpitations, dyspnea, orthopnea, edema, last ECG Respiratory: SOB, wheeze, cough, sputum, hemoptysis, pneumonia, asthma, last CXR GI: appetite, N/V, indigestion, dysphagia, BM changes, melena, pain, jaundice, hepatitis Urinary: frequency, hesitancy, urgency, polyuria, dysuria, hematuria, nocturia, stones Genital, male: discharge, sores, testicular pain, hernias Genital, female: menarche, period regularity, dysmenorrhea, FDLMP, itching, sores, discharge, grava/para/abortus, birth control, STD history, sex interest, sexual problems Vascular: leg edema, claudication, varicose veins, thromboses/emboli MSK: muscle weakness, pain, joint stiffness, ROM instability, redness, arthritis, gout Neuro: loss of sensation, numbness, tingling, tremors, weakness, syncope, seizures Hematologic: anemia, easy bruising/bleeding, petechiae, purpura, transfusions Endocrine: heat/cold intolerance, sweating, polyuria, polydipsia, thyroid, diabetes Psych: mood, anxiety, depression, tension, memory, suicidal ideation

HISTORY AND PHYSICAL EXAM Physical Exam General: sex, race, state of health, development, dress, hygiene, affect Vitals: blood pressure/auscultatory gap, pulse, respirations, pain, temp, height, weight Skin: skin scars, rashes, bruises, tattoos, hair consistency, nail pitting, stippling Head: size, shape, trauma Eyes: pupil size, shape, reactivity, conjunctival injection, scleral icterus, fundal papilledema, hemorrhages, lids, extraocular movements, visual fields and acuity Ears: shape/symmetry, tenderness, discharge, external canal/tympanic membrane inflammation, gross auditory acuity via Rinne and Weber tests Nose: symmetry, tenderness, discharge, mucosa/turbinate inflammation, frontal/maxillary sinus tenderness, dullness to percussion of sinuses Mouth/Throat: hygiene, dentures, erythema, exudate, tonsillar enlargement Neck: masses, range of motion, spine/trachea deviation, thyroid size, JVD Breasts: skin changes, symmetry, tenderness, masses, dimpling, discharge Heart: rate, rhythm, murmurs, rubs, gallops, clicks, precordial movements, Allen test, PMI, heaves, hepato- or abdominojugular reflex/reflux, jugular venous pressure Lungs: chest symmetry with respirations, wheezes, crackles, vocal fremitus, whispered pectoriloquy (“Scooby Doo” or “toy boat”), percussion, diaphragmatic excursion Abdomen: shape, scars, bowel sounds, consistency (soft/firm), tenderness, rebound masses, guarding, spleen size, liver span, percussion (tympany, shifting dullness), costovertebral angle (CVA) tenderness via Lloyd punch, Murphy sign, Psoas sign, Obturator sign, Rovsing sign GU, male: rashes, ulcers, scars, nodules, induration, discharge, scrotal masses, hernias GU, female: external genitalia, vaginal mucosa/cervix, inflammation, discharge, bleeding, ulcers, nodules, masses, internal vaginal support, bimanual and rectovaginal palpation of cervix, uterus, ovaries Rectal: sphincter tone, prostate consistency, masses, occult stool blood MSK: muscle atrophy, weakness, joint ROM, instability, redness, swelling, tenderness, spine deviation, gait, Heberden and Bouchard nodes, somatic dysfunction (osteopathic) MSK, knee: anterior/posterior drawer test, varus/valgus stress test, McMurray sign, Apley grind, ballottement, patellar tracking, Thompson test (Achilles) MSK, back: straight leg raise, seated straight leg raise (malingering) MSK, wrist: Phalen sign, Tinel sign, DeQuervain test Vascular: carotid, radial, femoral, popliteal, posterior tibial, dorsalis pedis pulses, carotid bruits, jugular venous distension (JVD), edema, varicose, veins, Homan & Pratt signs Lymphatic: cervical, supra/infraclavicular, axillary, trochlear, inguinal adenopathy Neurologic: cranial nerves, sensation, strength (5/5), reflexes (+2/4), cerebellum (rapid alternating movements, finger-to-nose, pronator drift, heel-to-shin), gait (tandem walk on heels L5 or toes S1, Romberg test), Kernig and Brudzinski signs, asterixis test Labs: hematology, chemistry, urinalysis, cultures, ECG, x-rays, CT/MRI scan, etc. Code Status: determine if patient has a living will, DNR, or advance directives. Assessment/Plan: differential diagnosis, supporting history and exam, medication changes, lab tests, procedures, consults, etc. Smoking Cessation: 1-800-QUIT-NOW

NEUROLOGICAL EXAM CN I, olfactory: smell CN II, optic: visual acuity/fields and fundoscopic exam of each eye CN III/IV/VI, oculomotor/trochlear/abducens: eyelid opening, extraocular movements, SO4LR6, direct and consensual pupillary light reflexes CN V, trigeminal: corneal reflex, facial sensation, jaw opening, bite CN VII, facial: eyebrow raise, eyelid close, smile, frown, pucker, taste CN VIII, vestibulocochlear: auditory acuity, oculocephalic reflex, oculovestibular reflex CN IX/X, glossopharyngeal/vagus: palate elevation, swallowing, taste, phonation, gag CN VI, spinal accessory: lateral head rotation, neck flexion, shoulder shrug CN XII, hypoglossal: tongue protrusion and strength on lateral deviation Sensation: test and contralateral compare pain/temp, vibratory, proprioceptive (join position), stereognosis, graphesthesia, two point discrimination. Strength: Test and contralateral compare extremity muscle groups. 5/5: Movement against gravity with full resistance. 4/5: Movement against gravity with some resistance. 3/5: Movement against gravity only. 2/5: Movement with gravity eliminated. 1/5: Visible/palpable muscle contraction but no movement. 0/5: No muscle contraction. Reflexes: Test and contralateral compare triceps (C7, radial n.), biceps (C5, musculocutaneous n.), brachioradialis (C6, radial n.), patellar (L4, femoral n.), Achilles (S1, tibial n.), and Babinski sign (downward, not fanned toes). +4/4: Hyperactive with clonus (UMN) +3/4: Hyperactive +2/4: Normal +1/4: Hypoactive +0/4: No reflex (LMN)

MENTAL STATUS EXAM (Folstein) 5 pts 5 pts 3 pts

What time is it? (year, season, month, day, date) Where are we? (state, country, town, hospital, floor) Test giver names 3 objects, 1 second to say each. Ask patient to repeat all 3. Give 1 point for each correct. Repeat 3 objects until learned, note # of trials. 5 pts Serial 7’s from 100 (93, 86, 79, 72, 65) or spell “world” backwards. 3 pts Ask for 3 objects named above. 2 pts Test giver points to pen and watch, and patient names them. 1 pt Repeat the following: “No ifs, ands, or buts.” 3 pts Follow command: “Take the paper in your right hand, fold in half, place on floor.” 1 pt Read and obey the following: CLOSE YOUR EYES. 1 pt Write a sentence. 1 pt Copy design. James Lamberg GLASGOW COMA SCALE LOC continuum: alert, drowsy, stupor, coma Eye Response (E): 4 = Spontaneously, 3 = Verbal Command, 2 = Pain, 1 = No Response Verbal Response (V): 5 = Oriented & Converses, 4 = Disoriented & Converses, 3 = Inappropriate Responses, 2 = Incomprehensible Sounds, 1 = No Response Motor Response (M): 6 = Obeys Verbal Command, 5 = Localizes Pain, 4 = Withdraws From Pain, 3 = Decorticate (flex) To Pain, 2 = Decerebrate (extend) To Pain, 1 = None

DERMATOME MAP C2: posterior half of the skull cap C3: high turtle neck shirt area C4: low-collar shirt area T4: nipples T5: inframammary fold T6/T7: xiphoid process

T10: umbilicus T12: pubic bone

Decorticate (abnormal flexion): Lesion cerebral hemisphere or internal capsule. Decerebrate (abnormal extension): Lesion midbrain, brain stem, or pons. Nerve Axillary n. Musculocutaneous n. Median n. Radial n. Ulnar n. Root C5 root C6 root C7 root C8 root T1 root

Motor Action Shoulder abduction Wrist extension Wrist flexion Finger flexion Finger ab/adduction

Motor Action Shoulder abduction Elbow flexion Thumb opposition Finger extension Finger ab/adduction Sensation Lateral arm Thumb, index finger Middle finger Ring, small finger Medial arm

Sensation Lateral shoulder Lateral forearm Lateral palm Dorsolateral hand Medial hand Reflex Biceps Brachioradialis Triceps ---

Stroke Etiologies: ~75% Embolic: (artery, cardioembolic, paradoxical) or cryptogenic. ~25% Thrombotic: lacunar (arteriolar, seen in HTN & DM) or large vessel.

DERMATOME MAP

Nerve Motor Action Sensation Obturator n. Thigh adduction Medial thigh Femoral n. Knee extension Anterior thigh Sciatic n. Knee flexion Posterolateral calf Peroneal n. Toe extension Dorsal foot Tibial n. Toe flexion Plantar foot James Lamberg Root Motor Action Sensation Reflex L1 root Hip flexion (T12-L3) Below inguinal ligament -L2 root Hip adduction (L2-L4) Middle thigh -L3 root Knee extension (L2-L4) Lower thigh -L4 root Foot dorsiflex/inversion Medial leg, medial foot Patellar L5 root Toe extension Lateral leg, dorsal foot -S1 root Foot plantarflex/eversion Lateral foot Achilles Stroke Info: Embolic: rapid onset, symptoms maximum at onset. Thrombotic: progression of symptoms over hours to days, stuttering course. TIA: sudden neurological deficits caused by cerebral ischemia that resolve within 24 hours (usually within 1 hour) and are a harbinger of stroke.

COMMON PRN MEDICATIONS Acetaminophen (Tylenol) 650mg PO q4h PRN temp > 101.5°F, headache Bisacodyl (Dulcolax) 10mg PO/PR qday PRN constipation Diphenhydramine (Benadryl) 25mg PO qHS PRN insomnia, allergy Lorazepam (Ativan) 1-2mg IM/IV q6h PRN anxiety, agitation Maalox 10-20mL PO q1-2h PRN dyspepsia Morphine 2mg IV q4h PRN pain Ondansetron (Zofran) 4mg IV q4h PRN nausea Promethazine (Phenergan) 25mg PO/IM/IV q4h PRN nausea

ELECTROLYTE REPLACEMENT Potassium, Oral: KCL powder (30-60 min absorption) or K-Dur 10 & 20 mEq tabs Potassium, IV: K salts, 10 mEq/hr peripheral, 20 mEq/hr central line, 20-40 mEq in 100250 mL D5W or NSS over 2-4 hours. Use acetate salt in hyperchloremic acidosis. Phosphorus, Oral: Neutra-Phos packet = 7.1 mEq K+ / 7.1 mEq Na+ / 250 mg Phos Phosphorus, IV: Na PO4 or K PO4 IV 20-40 mEq / 250 mL over 4-8 hours Magnesium, Oral: magnesium oxide 400 mg PO tid Magnesium, IV: Magnesium sulfate 1-2 g / 100 mL over 1-2 hours Calcium, Oral: calcium carbonate 500 mg PO tid Calcium, IV: Ca gluconate 1-2 g / 100 mL over 1-2 hours

ADULT ELECTROLYTE REPLACEMENT Note: applies to patients without ESRD, GFR > 50mL/min, and urine output > 30mL/h. Potassium 2.8 to 3.1 mMol/L: KCl 60mEq IV over 6h (peripheral) or 3h (central) Potassium 3.2 to 3.4 mMol/L: KCl 40mEq IV over 4h (peripheral) or 2h (central) Potassium 3.5 to 3.7 mMol/L: KCl 20mEq IV over 2h (peripheral) or 1h (central) Magnesium 1 to 1.3 mg/dL: Magnesium Sulfate 4gm IV over 4 hours Magnesium 1.4 to 1.8 mg/dL: Magnesium Sulfate 2gm IV over 2 hours Phosphorus 1.5 to 1.7 mg/dL: Sodium Phosphate 20 mMol IV over 4 hours Phosphorus 1.8 to 2 mg/dL: Sodium Phosphate 15 mMol IV over 4 hours Phosphorus 2.1 to 2.3 mg/dL: Sodium Phosphate 10 mMol IV over 4 hours ESRD Changes: Anemia, Hypocalcemia, Hyperkalemia, Hypermagnesemia, Hyperlipidemia, Hypertension, Secondary Hypoparathyroidism

ELECTROLYTE CONDUCTION DISTURBANCES Hyperkalemia: peak T waves (tall, peaked/pointed with narrow base), widening QRS, ST elevations and depressions, 1st degree AV block, conduction disturbances, P waves disappear (sine wave QRS), VT, V-fib, asystole. Hypokalemia: flat T waves, high U wave, arrhythmias Hypomagnesemia: Same as hypokalemia Hypocalcemia: prolong QT Hypercalcemia: shorten QT Hypothyroidism: sinus bradycardia, decrease voltage, prolonged PR, U wave Hyperthyroidism: no major pathognomonic changes, ?arrhythmias Pericarditis: diffuse ST elevations, PR depression Pericardial Effusion: decrease voltage, electrical alternans PE: SI, QIII, T wave inv V1-V3, sinus tachycardia Hypothermia: prominent J wave (Osborn wave)

INTRAVENTRUCULAR CONDUCTION DISTURVANCES RBBB: QRS >= 0.12; secondary R wave seen in V1 (rSR’ or rsR’ in V1 or V2), wide terminal S in I, V6. LBBB: QRS >= 0.12; Upright, Monophasic, Broad R waves in I, V6, predominantly negative QRS complexes in V1, absence of Q wave in V5 and V6. LAHB: axis > -30 (LAD); qR in I, rS III, normal QRS duration in the absence of other causes of LAD LPHB: axis > 90 (RAD); rS in I, qR in III in the absence of other causes of RAD Intraventricular conduction delay: QRS > 0.12s but no RBBB or LBBB morphology WiLLiaM MaRRoM “Rule”: If QRS > 0.12 everywhere, V1 – V6 is “W” to “M” in LBBB (WiLLiaM) and “M” to “W” in RBBB (MaRRoW).

CHAMBER HYPERTROPHY CRITERIA Left Ventricular Hypertrophy (LVH) * Sokolow and Lyon Criteria: S V1 + R V5 or V6 > 35 mm * Cornell Criteria: S V3 + R aVL > 28 mm (men), > 20 mm (women) * Framingham Criteria: - R aVL > 11 mm, R V4, V5, or V56 > 25 mm - S V1, V2, or V3 > 25 mm - R V5 or V6 > 35 mm - R I + S III > 25 mm RVH: QRS axis > + 90; dominant R V1 (R > 7mm in V1); QRS < 0.12s RAH: Peak Pointed P waves in “Pulmonary” leads (II, III, aVF) > 2.5 mm in height LAH: m-shaped (notched) and widened P wave ( > 0.12 s) in a "Mitral" lead (I, II, aVL) and/or a deep negative component to the P in lead V1 Bi-Atrial Hypertrophy: P I, II, III > 2.5 mm & > 0.12 sec; big biphasic P V1

ISCHEMIC HEART DISEASE Ischemia: T wave flattening, or symmetric inversion in contiguous leads, Injury: T wave becomes broader and peaks (“hyperacute" stage), followed by ST segment elevation, appearance of Q waves and gradual resolution of ST segment to baseline and evolution of T waves. Infarction: abnormal Q wave: > 25% R, > 0.04 sec Note: Normal Q waves seen due to activation of interventricular septum and seen in left or lateral leads; I, aVF, V5 and V6. Also, small Q waves are innocent in III and V1 if no other abnormality is seen.

LBBB AMI PREDICTION (Sgarbossa Criteria) 1) ST depression >= 1 mm that is concordant with QRS 2) ST elevation >= 1 mm in V1, V2, or V3 3) ST elevation >= 5 mm that is discordant with QRS

MI LOCALIZATION Anterior: Anterolateral Lateral High lateral Inferior Inferolateral True posterior

 

I, V2, V3, and V4 I, aVL, V5, and V6 V5 and V6 I and aVL (often with V5, V6) II, III, and aVF II, III, aVF, and V6 Reciprocal changes in V1 and V2

BODY FLUIDS (What To Order) Paracentesis: Cell count and WBC (> 250 PMNs, treat for SBP), Gram stain, culture in blood culture bottles, total protein, albumin (obtain simultaneous serum levels) If clinically indicated: amylase, cytology, LDH, culture for mycobacterium. Serum-Ascites Albumin Gradient: (SAAG): > 1.1 = portal hypertension (cirrhosis, CHF) < 1.1 = malignancy, TB peritonitis, pancreatitis, nephrotic syndrome Fluid total protein < 1 g/dL, consider SBP prophylaxis Lumbar Puncture: Cell count and WBC differential (obtain simultaneous serum levels), glucose and total protein (obtain simultaneous serum levels), Gram stain and culture If strong clinical suspicion: VDRL, MS-IgG, oligoclonal bands, myelin basic protein, AFB stain or culture, cryptococcal antigen, toxoplasma PCR, India ink. Thoracocentesis: Cell count and WBC differential, Gram stain and culture, total protein and LDH (obtain simultaneous serum levels), pH (usually in an ABG kit). Light’s Criteria for Pleural Fluid: (fluid is exudate if any criteria is met) Pleural fluid protein/serum protein > 0.5, pleural fluid LDH/serum LDH > 0.6, pleural fluid LDH > 2/3 upper limit of normal for serum. James Lamberg

INSULIN FOR HOSPITALIZED PATIENTS Treatment Goals: Blood glucose < 180, 400 or < 70, call house officer. 70 – 150 No insulin 151 – 200 2 units of regular insulin or aspart SQ 201 – 250 4 units of regular insulin or aspart SQ 251 – 300 6 units of regular insulin or aspart SQ 301 – 350 8 units of regular insulin or aspart SQ 351 – 400 10 units of regular insulin or aspart SQ

CORRECTING HIGH BLOOD GLUCOSE Correction Factor: BG lowering power of 1 unit of rapid acting insulin. CF = 1700 / total daily dose (TDD). i.e. if TDD = 50 units, 1700/50 ~ 30 mg/dL per unit Correction Dose = Blood Glucose – Targeted Blood Glucose / CF, CF = 3000 / kg Example: CF = 30, lunch BG = 251, want BG at 100. (251 – 100) / 30 = 5 units.

INSULIN PRESCRIBING GUIDE Insulin Aspart (Novolog) Lispro (Humalog) Glulisine (Apidra) Regular NPH Glargine (Lantus)

Onset 15 min 15 min 15 min 30-60 min 1-3 hr 1-3 hr

Peak 1-2 hr 1-2 hr 1-2 hr 2-4 hr 4-12 hr Peakless

Duration 4 hr 4 hr 4 hr 6-8 hr 10-18 hr 24 hr

Basal: Glargine once a day at hs or alternatively NPH at AM and HS 0.5 units/kg/day normal weigh and condition 0.3 units/kg/day renal failure, old/frail, thin, gastroparesis, hepatic, severe cardiac, or cerebrovascular disease 0.7 units/kg/day obese, sick (fevers, etc.), open wounds, on steroids Prandial: Aspart, lispro, apidra 0-15 min and regular 30 min before meals 0.1 units/kg normal weight and condition 0.05 units/kg renal failure, old/frail, thin, gastroparesis, hepatic, severe cardiac, or cerebrovascular disease 0.15 units/kg obese, sick (fevers, etc.), open wounds, on steroids Patient Receiving Continuous Tube Feeds Preferred is Insulin 70/30 q8h. Alternatives are NPH bid or Glargine HS supplemented with Aspart/Regular. Example: 75kg normal pt on feeds gets 20 units q8h. 0.8 units/kg/day normal weight and condition 0.6 units/kg/day renal failure, old/frail, thin, gastroparesis, hepatic, severe cardiac, or cerebrovascular disease 1.0 units/kg/day obese, sick (fevers, etc.), open wounds, on steroids For enteral/parenteral nutrition, may use 1 unit/15 grams CHO (ask nutrition). Patient Who Is NPO: Preferred dosing schedule is glargine with supplemental aspart based on weight. 0.25 units/kg/day normal weight and condition 0.15 units/kg/day renal failure, old/frail, thin, gastroparesis, hepatic, severe cardiac, or cerebrovascular disease 0.7 units/kg/day obese, sick (fevers, etc.), open wounds, on steroids Insulin Infusion: For critical care and/or peri/postoperative patients (not DKA/HHS) Titration Schedule Adjust glargine q 2 days based on FBG 100 – 120 mg/dL + 2 units 120 – 140 mg/dL + 4 units 140 – 180 mg/dL + 6 units > 180 mg/dL + 8 units If FBG < 80 mg/dL x 3 days / week, decrease glargine by 2 units.

WOUND CLOSURE Location

Suture Size/Type

Suture Technique Interrupted in galea, single tight layer in scalp, horizontal mattress if bleeding not well controlled Close perichondrium with interrupted Vicryl and close skin with interrupted nylon

Removal

Scalp

3-0 or 4-0 nylon or polypropylene

Pinna

5-0 Vicryl/Dexon in perichondrium

Eyebrow

4-0 or 5-0 Vicryl (SQ) 6-0 nylon for skin

Layered closure

3-5 days

Eyelid

6-0 nylon

Single-layer horizontal mattress or simple interrupted

3-5 days

Lip

4-0 Vicryl (mucosa) 5-0 Vicryl (SQ or muscle) 6-0 nylon (skin)

If wound through lip, close three layers (mucosa, muscle, skin); otherwise do two-layer closure

3-5 days

Oral

4-0 Vicryl

Face

Trunk

Extremity

6-0 nylon (skin) 5-0 Vicryl (SQ) 4-0 Vicryl (SQ, fat) 4-0 or 5-0 nylon (skin) 3-0 or 4-0 Vicryl (SQ, muscle) 4-0 or 5-0 nylon (skin)

Simple interrupted or horizontal mattress if muscularis of tongue involved Simple interrupted for single layer, layered closure for fullthickness laceration

7-12 days

3-5 days

N/A

3-5 days

Single or layered closure

7-12 days

Single-layer interrupted or vertical mattress; apply splint if over a joint

10-14 days

Hands/Feet

4-0 or 5-0 nylon

Single-layer closure with simple interrupted or horizontal mattress; apply splint if over a joint

7-12 days

Nail bed

5-0 Vicryl

Meticulous placement to obtain even edges, allow to dissolve

N/A

James Lamberg This Belongs To:

Contact:

ACCIDENTAL NEEDLESTICK 1) Clean wound with alcohol-based agent (virucidal to HBV, HCV, HIV). 2) Immediately go to Emergency Department for post-exposure prophylaxis (PEP). National Clinicians' Post-Exposure Prophylaxis Hotline, PEPline: 1-888-448-4911

DISCUSSING A DNR ORDER 1) Establish an appropriate setting for the discussion. Ensure comfort and privacy. 2) Ask the patient and family what they understand about their current health situation. 3) Find out what they expect will happen and how they want things to be if they are ill. 4) Discuss a DNR order, including context. Specifically use the word “die.” Say: “If you should die despite all of our efforts, do you want us to use heroic measures to bring you back?” OR “How do you want things to be when you die?” Do Not Say: “Well, if your heart and lungs were to stop, would you want us to use shocks to start your heart and put you on a breathing machine?” 5) Respond to emotions sympathetically, which can be silently offering tissues. 6) Establish and implement the plan depending on your judgment and institution policies.

SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS) Sepsis: Infection with any two of the following SIRS criteria present. * Normal WBC with > 10% immature neutrophils (bands, stabs) * Temp grater than 38.3ºC * Temp less than 36ºC * WBC > 12,000/mm3 * WBC < 4,000/mm3 * HR > 90 bpm * Respirations > 20 breaths/minute * CPR above upper limit * PaCO2 ≤ 32 mmHg * Altered mental status * Non diabetic serum glucose > 120 * Significant edema * Positive fluid balance > 20 mL/kg/24h

PSYCH EMERGENCIES Delirium Tremens (DT): Within 2-8 days after cessation of EtOH * Delirium, agitation, fever, autonomic hyperactivity, auditory/visual hallucinations * Treat aggressively with benzodiazepines and hydration Neuroleptic Malignant Syndrome (NMS): Idiosyncratic, time-limited reaction * Fever, rigidity, autonomic instability, clouding of consciousness * Withhold neuroleptics, hydrate, consider dantrolene (Dantrium) Serotonin Syndrome: Precipitated by two 5HT-enhancing drugs (e.g. MAOI + SSRI) * Altered mental status, fever, agitation, tremor, myoclonus, hyperreflexia, ataxia, incoordination, diaphoresis, shivering, diarrhea * Discontinue offending agents, consider cyproheptadine (Periactin) Tyramine Reaction: HTN crisis precipitated by tyramine foods while on MAOIs * HTN, headache, neck stiffness, sweating, N/V, visual problems, stroke, death * Treat with phentolamine (Regitine) Acute Dystonia: Early, sudden onset of facial muscle spasm, may require intubation * Treat with benztropine (Cogentin) or diphenhydramine (Benadryl) Lithium Toxicity: May occur at any Li level, usually > 1.5 * N/V, slurred speech, ataxia, incoordination, hyperreflexia, seizures, delirium, nephro DI * Discontinue LI, hydrate aggressively, consider hemodialysis Tricyclic Antidepressant (TCA) Toxicity: CNS stimulation, depression, seizures * Anticholinergic: cardiac conduction, hypotension, respiratory depression, agitation * Monitor ECG, bicarbonate for dysrhythmias/seizures, charcoal, cathartics, supportive

DDx: Life Threatening CP Tension PTX * acute MI * tracheal deviation away from PTX * unstable angina * ipsilateral absent breath sounds * pneumothorax (PTX) * ipsilateral hyperresonant to percussion * tension PTX * severe dyspnea, tachycardia, hypotension * hemothorax Cardiac Tamponade * pulmonary embolism * Beck’s triad: JVD, hypotension, muffled heart sound * pulmonary contusion * ECG: pulsus alternans, *Echo is test of choice * pneumonia Blunt Cardiac Trauma * aortic dissection * abnormal ECG (PVCs, STach, AFib, RBBB, ST ∆s) * aortic aneurysm * hypotension * diaphragmatic trauma * abnormal wall motion on echocardiogram * Boerhaave’s Myocarditis * pericarditis * Increased cardiac enzymes * myocarditis * Increased WBC Aortic Disruption (dissection/aneurysm) * Increased ESR * CP with radiation to back ECG: * hypotension - nonspecific ST ∆s CXR findings: - conduction block * widened mediastinum - low QRS voltage * tracheal deviation/NGT/esophagus to Rt - dysrhythmias * obliteration of aortic knob CP + Fever * apical capping * pneumonia * depression of Lt mainstem broncus * myocarditis * widened paratracheal strips or paraspinal interfaces * pericarditis * Left hemothorax * pleurisy * fracture of 1st of 2nd ribs or scapula CP + hypoxemia Initial Management of Ischemic CP * pulmonary embolus * cardiac monitor, O2, chewable ASA, 12-lead ECG * pulmonary contusion * sublingual nitroglycerine (NTG) * pneumonia * nitropaste to anterior chest wall unless BP < 100/60 * pulmonary infarct * morphine 2 mg IVP if continued CP * empyema * beta-blocker if not contraindicated (e.g. metoprolol 5 mg IVP) to keep pulse ~ 60 bpm * thrombolysis for > 0.1 mV ST elevation in at least two contiguous leads or new LBBB, if not contraindicated (call cardiology consult) * PTCA if thrombolysis is contraindicated (call cardiology consult) * send blood for CPK, CK-MB, troponin, electrolytes Pulmonary Embolism Pericarditis * dyspnea, tachypnea, hypoxemia * normal CXR CXR findings: (or normal) ECG: * normal enzymes * atelectasis/consolidation * S1Q3T3 (25%) ECG stages: * patchy infiltrate * Sinus Tach (most common) - I: nl or STach * elevated hemidiaphragm Diagnosis: - II: concave ST elevation * pleural effusion * angiography - III: aVR &V1 ST depress * Hampton sign * lower extremity Doppler - IV: Lead II PR depress * Westermark sign * V/Q scan, helical CT (very specific)

COMA / UNCONSCIOUS WITH UNKNOWN ETIOLOGY Coma cocktail: “DON’T” = dextrose 1 amp, oxygen, naloxone 2 mg IV, thiamine 100 mg IV. Magnesium 1-2 g IV in alcoholics. Ceftriaxone IV if meningitis suspected. Coma Causes: AEIOU TIPS: alcohol, electrolytes, endocrine, encephalopathy, insulin, oxygen, opiates, organ failure, uremia, trauma, temperature, infection, psychogenic, stroke, subarachnoid, shock.

TOXICOLOGY (Poison Control Hotline: 1-800-222-1222) Charcoal 1 g/kg with sorbitol for unknown exposures, coma cocktail if unconscious. Toxidrome Class HR RR BP Pupils Mentation Temp Skin

Anticholinergic High High/Low High/Low Dilated Agitated Increased Dry

Cholinergic High/Low Normal High/Low Constricted Agitated Normal Diaphoretic

Sympathomimetic High Normal High Dilated Agitated Increased Diaphoretic

Opiate Low Low Low Constricted Depressed Decreased Normal

SedativeHypnotic Low Low Low Normal Depressed Normal Normal

Acetaminophen: N-Acetylcysteine if > 140 mcg/mL at 4hrs (Rumack-Matthew nomogram) or 7.5g total ingestion. Inc. PT most sensitive indicator of hepatotoxicity. Anticholinergics: Physostigmine 0.5-2.0 mg slow IV push adults, 0.02 mg/kg children. Cholinergics: Atropine 1 mg IV adults, 0.01 mg/kg IV children, up to 5 mg IV every 10 minutes until secretions dry. Pralidoxime 2 g at 0.5 g/min adult, 20-40mg/kg children. Methanol: Folic acid 50-100 mg q4-24h. Ethanol 7.5-10 ml/kg 10% IV loading then 1.41.6 mL/kg per hour of 10% ethanol in D5W. Hemodialysis if > 50 mg/dL methanol. Ethylene Glycol: Ethanol (same as for methanol tox).100 mg thiamine and 100 mg pyridoxine IV q 24h. 4-MP is treatment of choice. Hemodialysis if > 50 mg/dL. Tricyclic Antidepressant: Na bicarbonate IV push 2-3 amps (1-2 mEq/kg) then add 3-4 amps to a 1 L of D5W and run at 1-2x maintenance rate until QRS narrows or pH > 7.55. Benzodiazepines: Flumazenil 0.2 mg over 30 sec then additional 0.3 mg over 30 seconds at 1-minute intervals up to 3 mg max. Contraindicated in mixed tox. Seizure caution. Digoxin: Digibind if > 10 mg ingestion, digoxin > 5 ng/mL, or K+ > 5.5 mEq/L. Digibind # of vials = (kg weight * digoxin level) / 100. Worsened with hyper Ca. Hydrofluoric Acid: Calcium gel, mix 1 amp Ca gluconate with 2-3 packs surgilube. Nitrates: Methylene blue 1-2 mg/kg over 5 minutes, repeat if needed to max 15 mg/kg. Iron: Deferoxamine. Mild symptoms, 90 mg/kg IM. Severe, 10-15 mg/kg/hr IV. Lead: Dimercaprol 75 mg/m2 IM q4h for 2 days, then q4-12h for up to 7 days, check for peanut allergy. EDTA 50-75 mg/kg per day, avoid if renal failure. Opiates: Naloxone 0.1-0.2 mg IV, titrate gradually. Children 0.1 mg IV push. Carbon Monoxide: 100% oxygen, hyperbaric chamber if > 25% CO, > 20% if pregnant. Cyanide: Lilly Kit (amyl nitrite inhaled, sodium nitrite, sodium thiosulfate). Calcium Channel Blocker: Calcium chloride 10 mL 10% slow IV push. Beta Blocker: Glucagon 2-5 mg slow IV push, adult. Peds 50-150 mcg/kg slow IV push. Isoniazid: Pyridoxine equal to isoniazid dose up to 5 g or 70 mg/kg.

INFECTIOUS DISEASE Dental: Pen VK 500 mg qid. Clinda 300-450 mg qid. Otitis Externa: Cortisporin Otic 4 gtts tid-qid. Suspension if TM perforated. Otitis Media (50% viral): Amoxicillin 45 mg/kg/day bid x 7-10 days OR Amox-Clav 45 mg/kg bid OR azithromycin 10 mg/kg PO once, then 5 mg/kg daily x 4 days. Sinusitis (> 10 days, bacterial): Amoxicillin 1 gm PO tid. Pharyngitis: Penicillin G 1.2 million units IM OR Pen VK 500 bid x 7 days. Conjunctivitis: Erythromycin ophthalmic ointment 1/2 inch bid-tid x 5-7 days. Antipseudomonal if contacts or foreign body. Moxifloxacin 0.5% ophthalmic solution 12 gtts q2h x 2 days, then q4-8h x 5 days while awake. Cystitis: < 10yo, TMP/SMX 2 mg/kg daily x 7-10 days. > 10yo, TMP/SMX DS bid OR cipro 250 mg bid x 3-7 days. Pregnancy, nitrofurantoin 100 mg bid x 7 days. Pyelonephritis: Cipro 500 mg bid. Amox/Clav 875 mg bid. Cervicitis, Urethritis: Ceftriaxone 125 mg IM OR cefixime 400 mg PO AND azithromycin 1 g PO for chlamydia OR azithromycin 2 g PO. Cipro not first line. Pelvic Inflammatory Disease: Ceftriaxone 250 mg IM for GC AND doxycycline 100 mg bid x 14 days. Trichomonas, flagyl 2 g PO OR flagyl 500 mg PO bid x 7 days. Candida, diflucan 150 mg PO. Bacterial vaginosis, flagyl 500 mg bid x 7 days. Meningitis: < 4wks, ampicillin 50 mg/kg IV qid, cefotaxime 50 mg/kg IV tid. > 4 wks, ceftriaxone 50 mg/kg IV bid AND vanco 15 mg/kg IV bid-qid. > 50yo, ceftriaxone 2 g IV bid AND vanco 1 g IV bid-qid AND ampicillin 2 g IV 6x/day. Consider acyclovir. Add dexamethasone prior to or with antibiotic administration. Pneumonia: Neonate, ampicillin 50 mg/kg IV AND gentamicin 2.5 mg/kg IV OR cefotaxime 50 mg/kg IV. 4wk – 18yo, erythromycin 10 mg/kg PO qid x 10-14 days. Azithromycin 10 mg/kg x 1 day, then 5 mg/kg x 4 days. Adult, ceftriaxone 1-2 g IV AND azithromycin 500 mg IV. Consider fluoroquinolone for HAP. Out pt oral, Azithromycin 500 mg x 1 day, then 250 mg daily x 4 days OR doxycycline 100 mg bid x 7-10 days. Bronchitis: Symptomatic care +/- albuterol. > 1wk or smoker, consider macrolide. Sepsis: Neonate, cefotaxime 50 mg/kg IV bid AND ampicillin 50 mg/kg IV bid. 3mo – 18yo, ceftriaxone 100 mg/kg IV/IM AND gentamicin 2.5 mg/kg IV bid. Adult, imipenem 500-1,000 mg IV. Immunocompromised, ceftazidime 2 g AND gentamicin 2 mg/kg. Vascular device, add vanco 15 mg/kg max 1 gm. CNS, ceftriaxone 2 g IV bid AND vancomycin 1 g IV bid. If PCN allergy, vanco 1 g IV bid AND chloramphenicol 12.5 mg/kg IV qid AND TMP/SMX 5 mg/kg IV qid. Pulmonary (CAP), ceftriaxone 2 g IV AND moxifloxacin 400 mg IV OR azithromycin 500 mg IV. Pulmonary (HAP), cefepime 2 g IV bid AND levofloxacin 750 mg IV, consider vanco 1 g IV. Intraabdominal, piperacillin/tazobactam 4.5 mg IV tid OR flagyl 500 mg IV tid AND levofloxacin 750 mg IV OR imipenem 500 mg IV qid. GU/urosepsis, ampicillin 500 mg qid AND gentamicin 5 mg/kg. Cellulitis: Diclox 500 mg qid OR cephalexin 500 mg qid AND TMP/SMX DS bid x 5 days OR clinda qid x 5 days. Consider doxycycline or rifampin and chlorhexidine wash. Diabetic Cellulitis: Cipro 500 mg bid AND clinda 300 mg qid. Amox/Clav 875 mg bid. Animal Bites: Amox/Clav 875 mg bid 7-10 days. Up to 7 days to start rabies Rx, RIG 20 units/kg, 1/2 or more in wound, rest in deltoid AND rabies vaccine 1 mL in other deltoid. James Lamberg PCN Allergy: Cross-reactivity with 3rd gen cephalosporins is near 0%.

SPANISH TRANSLATIONS I am a paramedic/nurse/doctor. I speak a little Spanish. Is there someone here that speaks English? What is your name? I don’t understand. Can you speak more slowly please? Wake up sir/madam. Sit up please. Listen. How are you? Do you have neck or back pain? Were you unconscious? Move your fingers and toes. What day is today? Where are you? What is your telephone number/address? When were you born? Sit here please. Lie down please? Do you have pain? . . . trouble breathing? . . . weakness? Where? (hip, leg, arm, throat) Show me where it hurts with your hand. Does the pain increase when you breathe? Breath deeply through your mouth. Breath slowly. What medicines do you take? Have you been drinking? Have you taken any drugs? Do you have chest pain? Do you have heart problems? . . . diabetes? asthma? allergies? HTN? Have you had this pain before? How long ago? Are you sick to your stomach? Are you pregnant? Do you need to vomit? You will be OK. It’s not serious. It is serious. Please don’t move. What’s the matter? Do you want to go to the hospital? We are going to take you to the hospital. We are going to give you oxygen. We are going to give you an IV.

Soy paramédico/enfermera/enfermero Hablo un poco de Español. ¿Hay alguien aquí que habla inglés? ¿Cómo te llamas? No entiendo. ¿Por favor, puede hablar más despacio? Despiértate, señor/señora. Siéntate por favor. Escúchame. ¿Cómo estás? ¿Te duele el cuello o la espalda? Estuviste inconsciente? Mueva los dedos de las manos y los pies. ¿Qué dia es hoy? ¿Dónde estás? ¿Cuál es tu número de teléfono/domicilio? ¿Cuando naciste? Siéntata aquí, por favor. Acuéstate, por favor. ¿Tienes dolor? . . . dificultad para respirar? . . . débilidad? ¿Dónde? (cadera, pierna, brazo, garganta) Muéstrame con tu mano dónde te duele. ¿Te aumenta el dolor cuando respiras? Respira profundo por la boca. Respira despacio. ¿Qué medicinas tómas? ¿Has estado tomado alcohol? ¿Has tomado alguna droga? ¿Tienes dolor de pecho? ¿Tienes problemas de corazón? . . . diabétes? asma? alergias? presión alta? ¿En otra ocasión has tenido este dolor? ¿Hace cúanto tiempo? ¿Tienes nausea o asco? ¿Estás embarazada? ¿Necesitas vomitar? Todo estará bien. No es serio. Es serio. Por favor, no te muevas. ¿Qué pasa? ¿Quieres ir al hospital? Te vamos a llevar al hospital. Te vamos a dar oxígeno. Te vamos a poner suero.

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20/30 Hold Chart 6 Feet From Eyes (Foot of Bed)

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v.09Dec10