Leanguard Clinical

 

 YOUR KEY TO NATURAL NATURAL WEIGHT MANAGEMENT SUPPORT Slim Actin with LeanGard®

  LeanGard® is an effective and clinically safe dietary supplement for weight management support.

LeanGard® is a bio-available combination of natural ingredients that addresses multiple targets in weight management: • Supports Lean Body Mass • Supports a Healthy Body • Promotes Satiety (feeling full & satisfied) • Provides Antioxidant Support The beneficial effects of LeanGard® are best obtained when the supplement is used in conjunction with a sensible diet and healthy life style measures. LeanGard® is a 100% guaranteed plant extract that conforms to current GMP standards for pesticides, allergens, GMO, microbiologics, heavy metals, and other contaminants.

Synergy of Ingredients

ForsLean®

GarCitrin®

 LeanGard® is comprised of Forslean, GarCitrin, and BioPerine   ForsLean® (Coleus Forskohlii Extract, 10% Forskolin) Forskolin helps build lean body mass and maintain healthy body composition. GarCitrin® (Garcinia Cambogia Extract) Hydroxycitric acid in combination with garcinol supports satiety, weight management, and lean body mass, and provides provides antioxidant support. It also effectively intervenes in the conversion of carbohydrates to fat through ATP citrate lyase inhibition. BioPerine® (Piper Nigrum Extract) BioPerin enhances uptake and utilization of natural actives when compared to valerian and passion flower, two of the most utilized plants in sedative pharmaceutical applications.

 BioPerine® (piper nigrum extract)

ForsLean®  • Safe, naturally derived, effective dietary ingredient composition • Patented for use in promoting lean body mass • Clinically tested in humans (multiple studies) • Kosher & Halal certified • Tried and tested ingredient that manufacturers, retailers, and consumers can have confidence in • Well tolerated and without adverse side effects*   ForsLean® is a powdered extract from the root of Coleus Forskohlii, Fors kohlii, standardized to contain 10% forskolin.

*At 500mg per per day for up to 12 weeks weeks produced produced no significant detrimental effects on chemistry, chemistry, hematological hematological parameters, parameters, blood pressure pressure,, or thyroid functions. These claims have not been evaluated by regulatory authorities. This This product is not intended to diagnose, diagnose, treat, cure, or or prevent any disease. Expert Review Report from Cantox Health Sciences International, - Ontario, Canada, August August 2004.

 

Clinical Studies on ForsLean® • Open field study (8 weeks) weeks) with 6 overweight women subjects – Dr. A. Conte, USA • Open fie field ld study (6 months) with 16 obese subjects subjects – Dr. Asano, Japan • Pilot clinical efficacy efficacy and safety study, 19 women subjects, randomized, randomized, double-blind, placebo controlled – University of Memphis TN, USA • Preclinical toxicology evaluation evaluation –  – CBPRC, Bombay  • 60 subject clinical efficacy study study –  – CBPRC, Bombay  • 24 subjects body composition composition and body weight evaluation – Northern Michigan University  • Double-blind, placebo-controlle placebo-controlled d study of 30 obese/overweight subjects subjects – Kansas State University University,, USA • • • • •

60 subject clinical efficacy study study –  – CBPRC, Bombay  6 month feeding/toxicity study study –  – India Micronucleus assay and dose effects effects studies studies – India – India Bone density and hormonal levels levels study – study – Mumbai, India Hormonal study (3 months) with 30 male subjects – subjects  – Manipal, India India

GarCitrin®  GarCitrin® is used in combination with ForsLean ® and BioPerine® to formulate LeanGard® for weight management. GarCitrin® is a safe, natural extract derived from the Garcinia Cambogia fruit containing Garcinol and Hydroxycitric Acid (HCA). Garcinol in combination with HCA supports satiety, satiety, weight management, lean body mass and provides antioxidant support. Additionally, it effectively intervenes in the conversion of carbohydrates to fat through ATP citrate lyase inhibition. The combination of the calcium salt in HCA and Garcinol reduces fatty acid and lipid synthesis and improves lean body mass much more effectively than HC. Clinical Comparison: GarCitrin® is statistically more effective than HCA alone in... • Reducing total body weight and body mass index • Reducing body fat • Increasing lean body mass and content of body water • Reducing levels of appetite perception GarCitrin® and HCA did not produce subjective or objective side effects.

Source: Plant part used:  Active constituents:  Nutraceutical benefits: 

Garcinia cambogia (Malabar Tamarind, fam. Clusiaceae) Fruits Hydroxycitric Acid (HCA), Garcinol Weight management support

Carcitrin patents:   Australia AU773081:  Europe EP1254209:  New Zealand NZ 518116: 

In addition to the U.S. patent #7,063,861 GarCitrin® was granted other international patents: Bio-available composition of natural and synthetic HCA Composition comprising Hydroxycitric Acid and Garcinol for weight loss Bio-available compositions of natural and synthetic HCA 

BioPerine®  BioPerine® is a clinically proven, natural, bio-availability enhancer for nutrients.

BioPerine® is a patented standardized extract obtained from black pepper, pepper, containing not less than 95% piperine. Possible mechanisms for increased nutrient bio-availability: • Increases blood supply to the GI tract • Increases emulsifying content of the gut • Increases active nutrient transport BioPerine® is widely patented: 1. U.S. Patent 5,536,506 2. U.S. Patent 5,744,161 3. U.S. Patent 5,972,382 4. U.S. Patent 6,054,585 5. European Patent # EP0810868 6. Japan Patent # 3953513 7. Canada Patent # 2247467.

 

The LeanGard® Clinical Trial  

Study Design: Placebo-controlled, randomized, double-blind, double-blind, parallel‐group study comparing the efficacy and safety of LeanGard®. 500mg of LeanGard® or a placebo was given twice daily to 50 over‐weight subjects, 24 men and 26 women ranging in age from 25 to 55 years. Scientific Findings:  After only 12 weeks of supplementation, 500mg 500mg two times daily. daily.   • 7.5% reduction in body weight (1.1% decrease/placebo) • 6.47% decrease in hip/weight ratio (1.89% increase/placebo) • 7.45% decrease in BMI (Body Mass Index) (1.09 decrease/place decrease/placebo bo • 8.15% decrease in body fat (1.18% decrease/placebo) • 4.36% • 4.50%

increase in lean body mass (.67% increase/placebo) decrease in BMR (Basal Metabolic Rate) (.64% decrease/placebo)

Claims: Reduces body weight in four different measured measured parameters Increases muscle and lean body mass Increases Basal Metabolic Rate Does not promote water loss Safety & Quality: No side effects were reported in the 12 week study No significant changes in blood pressure or heart rate were reported No significant changes in hematological parameters: Liver function, renal function, thyroid function, and plasma lipid levels LeanGard® is an effective and clinically safe dietary intervention for weight management support.