LAPORAN PRAKTIKUM ANTIKONVULSI
June 13, 2020 | Author: Anonymous | Category: N/A
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LAPORAN AKHIR PRAKTIKUM FARMAKOLOGI Pengujian Efek Antikonvulsi kelompok 2 Selasa, 07.00-10.00
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LA6ORATORIUM LA6ORATORIUM FARMAKOLOG FARMAKOLOGII FAKULTAS FARMASI UNIRSITAS PA8A8ARAN 201
Pengujian Efek Antikonvulsi
I.Tujuan
Me#/e)a$"! eek o(a) )e'$aap ko#"ls! paa $e9a# :a#/ !(e'! s)'!k#!# (e'asa'ka# pe#/ama)a# 9ak)" )!m("l#:a a# lama#:a lama#:a ko#"ls!.
II. Prinsip
1.;a) a#)!ko#"ls! :a#/ !s"#)!kka# sea! sea! ak!(a) $!poksem!a, a! !s"a)" ok"s alam o)ak :a#/ me#:e(a(ka# (a#/k!)a# pa'oks!mal. Fok"s !#! me'"paka# #e"'o# ep!lep)!k :a#/ se#s!)! )e'$aap 'a#/sa#/a# :a#/ !se(") #e"'o# ep!lep)!k. Ne"'o# !#!la$ :a#/ me#>a! s"m(e' (a#/k!)a# ep!lep)!k. Le)"pa# epola'!sas! apa) )e'>a! ! ae'a$ ko')eks. Pe#>ala'a# :a#/ )e'(a)as ! ae'a$ ko')eks aka# me#!m("lka# (a#/k!)a# pa's!al m!sal#:a ep!leps! okal >aala' ke a'ea :a#/ le(!$ l"as a# me#!m("lka# ko#"ls! "m"m =/e#e'al!@e ep!leps:?. Le)"pa# epola'!sas! ! l"a' ko')eks mo)o'!k a#)a'a la!# ko')eks se#so'!k, p"sa) s"(ko')!kal, me#!m("lka# /e>ala p'oko#"ls! a#)a'a la!# aa#:a pe#/!9aa# sela#>")#:a pe#>ala'a# ke ae'a$ ko')eks mo)o'!k me#:e(a(ka# ko#"ls!. 6e'asa'ka# )empa) asal le)"pa#
epola'!sas!, >e#!s (a#/k!)a# a# pe#>ala'a# epola'!sas! )e'se("), !ke#al (e'(a/a! (e#)"k ep!leps! =epa')eme# Fa'makolo/! a# Te'ape")!k FKUI,200+?. !samp!#/ se(a/a!
a#)!a#s!e)as,
se(a/!a#
/olo#/a#
(e#@o!a@ep!#
(e'ma#aa) se(a/a! a#)!ko#"ls! k$"s"s#:a "#)"k ep!leps!, m!sal#:a sa>a !a@epam. !a@epam )e'")ama !/"#aka# "#)"k )e'ap! ko#"ls! 'ek"'e# m!sal#:a s)a)"s ep!lep)!k"s. O(a) !#! >"/a (e'ma#aa) "#)"k )e'ap! pa's!al see'$a#a m!sal#:a (a#/k!)a# klo#!k okal a# $!psa'!)m!a :a#/ 'e'ak)e' )e'$aap )e'ap! la@!m =Ra$a'>a T>a:,2007?.
Meka#!sme ke'>a o(a) /olo#/a# 6e#@o!a@ep!# =!a@epam?. Pe#/!ka)a# GA6A =asam /ama am!#o(")!'a)? ke 'esep)o'#:a paa mem('a#e sel aka# mem("ka sal")a# klo'!a, me#!#/ka)ka# eek ko#"ks! ko'!a. Al!'a# !o# klo'!a :a#/ mas"k me#:e(a(ka# $!pe'pola'!sas! lema$ me#"'"#ka# po)e#s! pos)s!#ap)!k a'! am(a#/ le)"p a# me#!aaka# pem(e#)"ka# ke'>a po)e#s!al. 6e#@o!a@ep!# )e'!ka) paa s!s! spes!!k a# (e'a!#!)as )!#//! a'! mem('a#e sel, :a#/ )e'p!sa$ )e)ap! eka) 'esep)o' GA6A. Resep)o' (e#@o!a@ep!#e )e'apa) $a#:a paa SSP a# lokas!#:a se>a>a' e#/a# #e"'o# GA6A. Pe#!#/ka)a# (e#@o!a@ep!# memaa paa 'esep)o' ! o)ak :a#/ !se(") 'esep)o' GA6A. Hal !#! me#:e(a(ka# pelepasa# #e"'o)'a#sm!))e'
:a#/
!se(")
GA6A !
alam
o)ak.
Ne"'o)'a#sm!)e'
me'"paka# (a$a# k!m!a :a#/ !s!mpa# alam sel-sel sa'a ! o)ak a# s!s)em sa'a. Me'eka :a#/ )e'l!(a) alam )'a#sm!s! pesa# a#)a'a sel sa'a. GA6A aala$ #e"'o)'a#sm!))e' :a#/ (e'"#/s! se(a/a! alam! Bsa'a-me#e#a#/ka#B a/e#.
I#! mem(a#)" me#>a/a ak)!!)as sa'a ! o)ak se!m(a#/, a# )e'l!(a) alam me#o'o#/ ka#)"k, me#/"'a#/! kea "#)"k me#/$am(a) p'oses !#!s!as! a# pe#:e(a'a# ke>a#/. Nam"# paa "m"m#:a o(a) a#)!ep!leps! le(!$ ! !a#al!s!s e#/a# Student’s t-test. a)a !sa>!ka# alam (e#)"k )a(el a)a" /'a!k . VI.Data Pengamatan dan Perhitungan
Kelompok
)0
Me#!a# eek ko#"ls! !#! !lak"ka# e#/a# !#"ks! s)'!k#!# a# o(a) :a#/ !">!ka# :a!)" !a@epam e#/a# os!s 2,* m/k/ 66 a# 5,* m/k/ 66. Pe'a#/sa#/a# s!s)em sa'a p"sa) ole$ s)'!k#!# me#:e(a(ka# #e"'o# )e'eks!)as! sampa! am(a#/ k'!)!s )e')e#)" se$!#//a me#!m("lka# eek ko#"ls! sea#/ka# !a@epam me'"paka# s"a)" o(a) a#)!ko"ls!, !ma#a (eke'>a melal"! pe#/$am(a)a# s!s)em GA6Ae'/!k e#/a# "/a aka#
(e'pe#/a'"$ paa eek o(a), maka !/"#aka# me#a#)a# se(a/a! $e9a# pe'a! kelompok :a#/ )e'!'! a'! kelompok ko#)'ol #e/a)!, kelompok o(a) ">! I a# kelompok o(a) ">! II. Lal" sem"a me#ala ke>a#/ :a#/ pe')ama, sea#/ka# death time aala$ pa#>a#/ 9ak)" a#)a'a )!m("l#:a ke>a#/ pe')ama sampa! )e'>a!#:a kema)!a#. Paa me#! I !(e'!ka# !a@epam paa os!s :a#/ le(!$ 'e#a$, sea#/ka# me#! I aka# mem(e'!ka# onset :a#/ >a"$ le(!$ lama a'!paa me#a me#/$am(a) pe#/!#"ks!
s)'!k#!#. em!k!a# p"la paa me#! I a# me#a!#:a ko#"ls! sampa! me#a e#/a# me#/a#)a/o#!s ke'>a #e"'o)'a#sm!))e' /l!s!# paa me"la sp!#al!s :a#/ me#:e(a(ka# $!pe'eks!)a(!l!)as #e"'o# se$!#//a #e"'o# )e'se(") )e'ks!)as! sampa! paa am(a#/ k'!)!s )e')e#)" :a#/ me#:e(a(ka# (e')am(a$#:a )o#"s o)o) 'a#/ka se$!#//a )e'>a! ko#"ls! a)a" ke>a#/. Te'>a!#:a ko#"ls! )e'se(") me#:e(a(ka# )e'>a!#:a /a#//"a# s!s)em ka'!oask"le'. 8a#)"#/ me#/alam! /a#//"a# alam mela#/s"#/ka# "#/s!#:a "#)"k memompa a'a$ ke sel"'"$ )"("$, ko#"k)!!)as >a#)"#/ me#"'"# se$!#//a ak$!'#:a >a#)"#/ /a/al alam memompa a'a$ a# me#:e(a(ka# kema)!a# paa me#a!#:a ko#"ls!, !ma#a !a@epam (e'!ka)a# e#/a# 'esep)o' GA6A A paa ka#al !o# 3l - :a#/ me#:e(a(ka# me#!#/ka)#:a pem("kaa# ka#al !o# 3l - se$!#//a !o# 3l - a'! l"a' sel mas"k ke alam sel :a#/ apa) me#:e(a(ka# #e"'o# )e'se(") me#/alam! $!pe'pola'!sas!. Te'>a!#:a $!pe'pola'!sas! me#:e(a(ka# pe#/$am(a)a# po)e#s!al aks!, me#"'"#ka# eks!)a(!l!)as a'! #e"'o# se$!#//a #e"'o# )!ak )e'eks!)as! sampa! am(a#/ k'!)!s. ks!)as! #e"'o# :a#/ )!ak sampa! paa am(a#/ k'!)!s )!ak me#!m("lka# ko#"ls!, se$!#//a e#/a# me#"'"##:a eks!)a(!l!)as #e"'o# )e'se(") me#:e(a(ka# p'oses ko#"ls! apa) !! !k"'a#/! ko#)'ol !(a/! 9ak)" 'a)a-'a)a ea)$ )!me ko#)'ol, $as!l )e'se(") !kal!ka# 100E. Se)ela$ !lak"ka# pe'$!)"#/a# me#//"#aka# '"m"s )e'se(") maka apa) !)e#)"ka# pe'se# !#$!(!s! death time a'! !a@epam os!s 2,* m/k/ 66 :a!)" *77,57C E, a# pe'se# !#$!(!s! death
time a'! !a@epam os!s 5,* m/k/ 66 :a!)" 12+,44 E. a'! $as!l )e'se(") apa) )e'l!$a) p"la (a$9a !a@epam mem!l!k! ak)!!)as alam mempe'pa#>a#/ death time e#/a# meka#!sme ke'>a :a#/ sama :a!)" (eke'>a paa s!s)em GA6Ae'/!k. Ha#:a os!s :a#/ mem(eaka# keeek)!a# ke'>a#:a. Semak!# (esa' os!s maka a:a !#$!(!s!#:a aka# semak!# )!#//!.
VIII. esimpulan
!a@epam apa) mem(e'! eek a#)!ko#"ls! paa $e9a# pe'
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