Immunology Serology Blood Banking

 

IMMUNOLOGY-SEROLOGY & BLOOD BANKING

1.

He was said to have been given the world’s first blood

transfusion by his Jewish physician Giacomo di San Genesio, who had him drink the blood of three 10-year-old boys. 

2.

a.

Pope Innocent VII 

b.

Pope Pius I 

c.

Pope Gregory III 

d.

Pope Boniface IV 

5.

The number of H antigen structures currently identified

are: 

3.

4.

6.

a.

Type O 

b.

Type A 

c.

Type B 

d.

Type AB 

Bombay phenotype antibodies include:  

a.

 Anti-A 

b.

 Anti-B 

c.

 Anti-H 

d.

 All of the choices choices 

What type of blood should be given in an emergency

a.

Two 

b.

Four  

c.

Six 

a.

O Rh-negative, whole blood  

d.

Eight 

b.

O Rh-positive, whole blood  

Greatest amount of H antigen: 

c.

O Rh-negative, pRBCs  

a.

 A1 

d.

O Rh-positive, pRBCs 

b.

O 

7.

c.

 AB 

ancestry: 

d.

B 

transfusion when there is no time to type the recipient’s sample? 

Identify the blood type based on the following reactions: 

FORWARD GROUPING 

REVERSE GROUPING 

 Anti-A 

 Anti-B 

 A cells 

B cells 

O 

4+ 

3+ 

O 

8.

This blood group is an anthropologi anthropological cal marker in Asian

a.

Diego 

b.

Cartwright  

c.

Colton  

d.

Gerbich 

The activity of this antibody is enhanced in an acidic

environment. 

a.

 Anti-S 

 

9.

b.

 Anti-U 

a.  Decreased sample volume 

c.

 Anti-N 

b.  Improved productivity 

d.

 Anti-M 

Shelf-life of packed red blood cells obtained through

open system with ACD anticoagulant: 

10.

c.  Enhanced sensitivity  d.  Standardization 

14.

 Agglutination  Agglutinatio n reaction: “Several “Several large clumps with clumps with clear

a.

21 days 

background”   a.  4+ 

b.

35 days 

b.  3+ 

c.

42 days 

c.  2+ 

d.

None of the choices 

d.  1+ 

Indication for transfusion of neocytes:  a.  Immune thrombocytopenic purpura  b.  Hemolytic transfusion reaction  c.  Thalassemia  d.  Hydrops fetalis 

15.

This type of autologous donation occurs when blood is

collected from the patient before the start of surgery. The patient’s blood volume is returned to normal with fluids, and autologous blood blood may be returned to the t he patient after the surgery is complete.  a.  Preoperative 

11.

b.  Normovolemic hemodilutio hemodilution n 

Citrate in ACD functions as: 

c.  Intraoperative salvage 

a.  Anticoagulan  Anticoagulantt  b.  ATP source  c.  RBC membrane stabilizer   d.  Carameliza Caramelization tion inhibitor  

12.

The most common cause of transfusion-rela transfusion-related ted sepsis

16.

The anticoagulant preferred in direct antiglobulin testing

is:  a.  EDTA  b.  Heparin 

is:  a.  Whole blood  b.  Packed red blood cells  c.  Leukocyte concentrates  d.  Platelets concentrates 

13.

d.  Postoperative salvage 

Major advantage of gel technology: 

c.  Citrate  d.  Oxalate  deferred by the physician physician due to the 17.  A donor was deferred presence of bluish purple areas under the skin of the donor. This is typical of: 

 

a.  Syphilis  

18.

22.

b.  Herpes simplex 

a.  2-5% 

c.  Candidiasis  

b.  5-10% 

d.  Kaposi’s sarcoma 

c.  10-15% 

 A febrile transfusion transfusion reaction is defined defined as a rise in body

d.  75-85% 

temperature of ___ occurring in association with the transfusion of blood or components and without any other explanation.  

23.

b.  Opsonin 

b.  1oF

c.  Chemotaxin 

d.  3oF

20.

C3b  a.  Anaphylatoxin 

a.  1oC or more  or more 

c.  3oC or more 

19.

Percentage of B cells present in the circulation 

or more 

The most severe form of HDN is associated with: 

d.  Cytokine 

24.

What is the most common complement component

deficiency? 

a.  Anti-A 

a.  C1 

b.  Anti-B 

b.  C2 

c.  Anti-K 

c.  C3 

d.  Anti-D 

d.  C4 

This is a diagnostic prenatal test in which a sample of

the baby’s blood is removed from the umbilical cord for testing: 

25.

Which of the following f ollowing is the most common congenital congenital

immonudeficiency? 

a.  Cordocentesis  b.  PUBS 

a.  Severe combined immonudeficie immonudeficiency ncy  b.  Selective IgA deficiency 

c.  Both 

c.  X-linked agammaglobu agammaglobulinemia linemia 

d.  None of the above 

d.  Common variable immunodeficien immunodeficiency cy 

26. 21.

Year of discovery of the T cell receptor gene: 

Which disease might be indicated by antibodies to

smooth muscle? 

a.  1964 

a.  Chronic active hepatitis 

b.  1974  c.  1984 

b.  Primary biliary cirrhosis 

d.  1994 

d.  Myasthenia gravis 

c.  Hashimoto’s thyroiditis 

 

27.

b.  Molecular  

The most common fungal infection for AIDS patients is

c.  Enzymatic 

caused by: 

d.  Biologic  

a.  Candida albicans 

28.

b.  Cryptococcus neoformans 

32.

c.  Blastomyces dermatitidis 

hypersensitivity? 

d.  Cryptosporidi Cryptosporidium um parvum  This dengue antigen has been detected in the serum of

Hives and itching are under what type of

a.  Type I  b.  Type II 

dengue virus infected patients as early as 1-day post onset of

c.  Type III 

symptoms (DPO), and up to 18 DPO.  

d.  Type IV 

a.  NS1 

29.

33.

Gamma counter uses these substances as labels:  

b.  C 

a.  Isotopes 

c.  E 

b.  Fluorochromes 

d.  prM 

c.  Enzymes 

These are expressed in the developing fetus and in

d.  Immune complexes 

rapidly dividing tissue, such as that associated with tumors, but

34.

that are absent in normal adult tissue: 

treponemes are immobilized. Interpret the result. 

30.

Treponema pallidum immobiliza immobilization tion (TPI) test: 10%

a.  Oncogenes 

a.  Positive 

b.  Sarcoma 

b.  Negative 

c.  Oncofetal antigens 

c.  Doubtful 

d.  Tumor specific antigen 

d.  Indeterminate 

Polymerase chain reaction (PCR) is a/an ___ assay. 

35.

a.  Chemical 

macroscopic agglutination agglutination is graded as 25%. Interpret. 

When reading for a slide agglutination for Salmonella,

b.  Molecular  

a.  Non-reactive 

c.  Enzymatic 

b.  Negative 

d.  Biologic  

c.  Positive 

Restriction Fragment Length Polymorphism (RFLP) is 31. a/an ___ assay.  a.  Chemical 

36.

d.  1+  Other name for “HCV RNA”:  a.  Viral clade 

 

b.  Surface antigen  c.  Viral load  d.  Core antigen 

37.

Not included as a Hepatitis B serologic marker:  a.  HBcAg  b.  HBeAg  c.  Anti-HBeAg  d.  Anti-HBcAg 

38.

 Autoimmune diseases diseases are mostly associated associated with which which

class of HLA?  a.  Class I  b.  Class II  c.  Class III  d.  Class IV 

39.

Which of the following activates both T and B cells?   a.  Pokeweed mitogen  b.  Lipopolysaccharide  c.  Concanavalin A  d.  Phytohemagglutinin 

40.

It is used as the receptor for the sheep red blood cells

(sRBC) for e-rosette assay:  a.  CD2  b.  CD4  c.  CD8  d.  CD12