Immunology 2nd Qs - Part1

Q1. The normal autoantibody characterize  by all of  the following except? A1.has high affinity. Q2. the memory B cells characterize  by all of  the following except? A2. Has IgM receptors. Q3. The tetramer  assay is used for? A3. Determine the CD4+ and CD8+ cells. Q4. Which of  following isn’t correct about MBL? Q4. Its collagen tail  binds to C1q. Q5. Which of  the following isn’t a regulator  in complement cascade? Q5. Factor  B. Q6. Which of  the following is not in the  predonal cascade (alternative)? A6. C1 inhibitor  Q7. Which of  the following is not secreted in acute  phase response? A7. IL 4 Q8. Which of  the following is not a function of  complement? A8. Inhibit TH1 Q9. Which of  the following is not  pro inflammatory? A9. IL10 Q10. In acute  phase response the IL1 affect the hypothalamus to  produce: A10. Fever  Q11. If  the c3 is deficient which of  the following is most likely to occur? A11. SLE Q12.  NK  cells in macrophages differ  in? A12. Granzyme and  perforin mechanism of  killing Q13. Which of  the following is not apart of  chronic inflammation? A13. Increase in neutrophils

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Q14. CpG  bind to A14. TLR9 Q15. Which enzyme  protects the cytoplasm from respiratory  burst enzymes? A15. Catalase Q16. A defect in  NADPH oxidase will result in: A16. Chronic granulomatous disease Q17. Which of  the following doesn’t share in  protecting from worm? A17. TH1 Q18.which of  the following isn’t  product  by archadonic acid metabolites? A18.histamine. Q19. The receptor  that is used  by  NK  to identify the  pathogens? A19. KIR. Q20. All about the adaptive immune response is true except? A20. Use  pattern recognition molecule. Q21. The enzyme the resemble Membrane Attach Complex? A21. Perforine. Q22. Mutation in Fas-FasL will lead to? A22. Auto Immune Lymphoproliferative Syndrome (ALPS). Q23. Which is the major  contributor  that changes the acute inflammation to chronic? A23. Inability to remove the  pathogen. Q24.the major  cytokine released from TH1 is? A24. INF gamma. Q25. If  positive If  positive TB test which of  following isn’t true? A25. It might  be  because of  high PPD or  the needle is injected subcutaneous. Q26. Which of  these cells aren't found in the granuloma? A26. B cells. Q27. The major  cell that contribute defense against HBV are? A27. CD8+. -3-

Q28.what is the most likely to occur  due to delayed hypersensitivity reaction? A28.HBV. Q29. Which is not correct about cytokines? A29. Lipid components. Q30. The advantage of  ISCOM over  the other  vaccination techniques is? A30. Deliver  the Ag the APC. Q31.WE use skin test for? A31.type I and type IV hypersensitivity reaction Q32.glomeruonephritis is a disease? A32. Can result from nephritis syndrome o nephritis Q33.what is not an action of  corticosteroids? A33.inhibit the meyloperoxidase. Q34.which is not a mechanism of  developing auto immune disease? A34.intactpreviliged sites Q35.to test the  presence of  auto AB we use? A35.ELISA or  indirect immune fluorescent Q36.the relation  between IDDM and HLA DQ is explained as? A36. Inappropriate  presentation of  insulin on the HLA DQ in the thymus. Q37. The most common symptom of  celiac is? A37. Celiac diarrhea. Q38. The AB against endomysel will cause? A38. Celiac disease. Q39. The autoantibody against the transglutamase is in? A39. The celiac disease. Q40. The difference  between the graves disease and other  type II hypersensitivity is? A40. The autoantibody isn’t cytotoxic. Q41. We use coombs test for? A41. Autoimmune hemolysis. -4-

Q42. Which isn’t correct relationship? A42. The graves disease >>>> against thyroid hormones.

Q43. The  best disease which we can  plasmapheresis is? A43. Wegener`s granulomatosis.

Q44. To form immunocomplexes the Ag shouldn’t  be? A44. Monovalent.

Q45 farmer  lung is? A45. Disease caused  by hypersensitivity against mold spores.

Q46. In rheumatoid arthritis (RA) the cytokine that caused activation of  ostoclast? A46. TNF.

Q47. In the treatment of  rheumatoid arthritis (RA) and other  recently we start to use the  blocker  of? A47. TNF.

Q48. For  treatment Multiple sclerosis we use? A48. INF  beta.

Q49.the  presence of  rheumatoid factor  indicates? A49. Some autoimmune diseases use different mechanism.

Q50. The Ag that cause autoimmunity against rheumatoid arthritis (RA)?

A50. Heat shock  protein shock  protein HSP.

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