Immunology 2nd Qs - Part 2

1. One of the of  the following is a pro-apoptotic gene: A. B. C. D. E.

Bcl-2. Bcl-X5. Bcl-XL. Bcl-w. None of the of  the above.

2. The most important step in the death pathway of apoptosis of  apoptosis is: A. B. C. D. E.

Fas-Fas ligand interaction. Activation of caspase of  caspase enzyme. CAD activation. DNA fragmentation. Phagocytosis of dead of  dead cells.

3. All of the of  the following are physiological function performed through complement receptors except: A. Opsonization by C3 B. B cell stimulation. C. Transportation of fractured of  fractured immune complex by RBC's through CR1. D. Glomerular involvement in SLE through CR1 E. Immune complex clearance. 4. Deficiency in early lectin and classical pathways results in: A. B. C. D. E.

Type I hypersensitivity Type II hypersensitivity Type III hypersensitivity Type IV hypersensitivity None of the of  the above.

5. One of the of  the following proteins is not activated by the acute phase reactants. A. B. C. D. E.

CRP Ig's Fibrinogen. Somatostatin. α1- antitrypsin.

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6. All of the of  the following are phagocyte receptors except: A. B. C. D. E.

Cytokine receptors Toll-like receptors. Receptors for apoptotic cells. Complement receptors. NKG2

7. Which of the of  the following microorganism evades the immune system by the blocking of the of  the enzyme catalase? A. B. C. D. E.

Mycobacterium leprae. Pneumococci. N. meningitides. HBV S. aureus.

8. One of the of  the following is not of the of  the respiratory burst enzyme: A. B. C. D. E.

Myeloperoxidase. NADPH oxidase. Tyrosine kinase. NO synthetase. None of the of  the above.

9. Products of the of  the Arachidonic acid metabolism include all of the of  the following except: A. B. C. D. E.

Thromboxane A2 Prostaglansin E2 Platelet activating factor Chondroitin sulfate. Leukotriene.

10. One of the of  the following is inhibitory receptor on the surface of the of  the NK cells: A. B. C. D. E.

CD 28 CD 80 CD 16 CD 94 CD 34

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11. One of the of  the following is not part of the of  the membrane attack complex: attack  complex: A. B. C. D. E.

C6 C7 C9 C4 C8

12. The form of Schistosoma of  Schistosoma mansoni that lives in the portal vein is: A. B. C. D. E.

Adult worm. Eggs. Larvae. Mature female. Immature female.

13. Cytomegalovirus evades the immune system by: A. B. C. D. E.

Production of a of  a lytic enzyme. Expression of HLA-E. of  HLA-E. Waxy coat. Downregulation of MH of  MHC C expression. Upregulation of bcl-2 of  bcl-2 gene.

14. A positive Mantoux test is indicative of all of  all of the of  the following except: A. B. C. D. E.

Active TB infection. BCG vaccination. Primary exposure to TB. Immune deficiency in an unvaccinated patient. None of the of  the above.

15. The weakest type of vaccine of  vaccine is: A. B. C. D. E.

Killed organism. Viral vectors. Toxoids. Live attenuated. Recombinant subunit.

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16. C reactive protein (CRP) is produced under the influence of: A. B. C. D. E.

IL-1 TNF. IL-4 IFN-γ. Monoclonal antibody.

17. Factor B is: A. B. C. D. E.

Is the enzymatic part of the of  the C3 convertase in the alternative pathway Only component of complement of  complement pathway that circulate active enzyme Bind covalently to pathogen through thioster bond Has no potential enzymatic activity Cleavage factor D

18. Mostly affected by INF type I (INF alpha and beta): A. B. C. D. E.

Aspergellus Plasmodium Listeria bacteria Staphylococcus bacteria Influenza virus

19. Elimination of bacteria of  bacteria by opsonization is done by: A. B. C. D. E.

Neutralization of bacterial of  bacterial toxin Recognition of bacteria of  bacteria bound antibodies by Fc receptor on macrophage Prevention of bacteria of  bacteria adhesion to endothelial cell Binding antibodies Fc on bacteria Class 1 MHC MHC antigen

20. Which one is false? A. Mast cells: IL 12 B. TH2 cells: IL6 C. TH1 cells: INF gamma D. Eosinophils: IL 5

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21. About C4, which one is true? A. C4 binds and cleaves C5 B. C4 cleaves C2 C. C4a fragment anaphylatoxin D. C4 binds only C1q E. Deletion of C4 of  C4 allele is associated with SLE 22. A 10 years old boy has recurrent skin and lung infections by staphylococcus aureus, what can be found at his diagnosis? A. Low IgM, absence of B of  B cell B. Low Ig low B cell C. Low terminal complement D. Abnormal NBT test 23. Which type of Ab of  Ab is involved in SLE with recurrent mid trimester abortion and DVT and abnormal PTT PTT test? A. Anti Sm antibodies B. Anti Ds DNA antibodies C. Anti nuclear Ab D. Anti phospholipid Ab E. Rheumatic Ab 24. Recognition receptor functions as secreted receptor A. Mannan binding lectin B. CD 14 C. Toll like receptor 25. Remission state in pregnancy happens in all of the of  the conditions except: A. SLE B. Type I diabetes C. Contact dermatitis D. Arteritis

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26. M. tuberculosis is best eliminated by: A. IL-4 B. TNF alpha C. IL-5 D. IL-8 27. Complement activation a) Activate hapten b) Active C1q binds antigen-antibody complex c) C3 convertase C4bc2b d) C3 convertase C3bBb e) Regulate factor H 28. Which statement is correct? A. Cross-linkage by antigen of two of  two or more IgE molecules is required for degranulation of  sensitized mast cells. B. Damage during Type II reactions can be caused by either opsonization or complement lysis. C. dsDNA-anti-dsDNA complexes can initiate glomerulonephritis. D. Contact dermatitis due to poison ivy is an Ag-Ab complex lesion. E. Macrophages are activated non-specifically by interferon-gamma. 29. Which of the of  the following is an example of type of  type III hypersensitivity? A. B. C. D. E.

Asthma. SLE. Myasthenia gravis. Rhinitis. Contact dermatitis.

30. Immediate hypersensitivity skin reactions: A. B. C. D. E.

Exhibit a wheal due to influx of mononuclear of mononuclear cells. Exhibit a red flare due to vasodilation. Cannot be elicited by monovalent hapten. Are due to IgE antibody. All of the of  the above are correct.

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31. Graves disease is characterized by: A. B. C. D. E.

Antibodies to the thyroid stimulating hormone Antibodies to the thyroid stimulating hormone receptors. Antibodies to thyroid peroxidase. Hypothyroidism. B and C

32. The major cells in type IV hypersensitivity reactions at local reactions are: A. B. C. D. E.

Mast cells. Macrophages. Eosinophils. Cytotoxic T lymphocytes. Neutrophils

33. The enzyme changing arachidonic acid into prostaglandins is: A. B. C. D. E.

Cyclooxygenase. Lipooxygenase. Chymptryptase. Phosphatase. Phosopholipase A2

34. A test for granulocyte function is: A. B. C. D. E.

CD 14 cell count. GM-CSF level determination. PPD. CBC with differential. Nitro Blue Tetrazolium test (NBT).

35. Cytopathic and non-cytopathic forms of infection of  infection are found in: A. B. C. D. E.

Extracellular bacteria. Intracellular bacteria. Viruses. Parasites. Fungi.

Done!!

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Key answers

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

B A D C D E A C D D D A D D A B A E B A B D D A A B B D B E E B A E C

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