GRANULACION activada humedad y fusion pptx.pptx

SEMINARIO DE FARMACOTECNIA I REALIZAR UNA COMPARACIÓN ENTRE LOS PROCESOS DE GRANULACIÓN ACTIVADA POR HUMEDAD Y GRANULACIÓN POR FUSIÓN: EXCIPIENTES EX CIPIENTES UTILIZADOS, EQUIPOS, OPERACIONES OPERACION ES QUE QUE FORMA FORMA PAR PARTE TE DEL PROCESO, PROCESO, PARÁMETROS PARÁMETROS DE CONTROL Y VENTAJAS DEL PROCESO INTEGRANTES: Bravo Ortiz, Cristina Del Pilar.  Gutiérr Gutiérrez ez Serrano, David Gustavo  ua!"n ua#lla$ua!an, %osé &uis  'au(aille Ro)as, 'a*el Edit$ &aura.  Salvador +illanueva, 'aal# &)u*isa.  S"n($ez de la Cruz, %a$ir Adol-o. 

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GRAN3&ACI4N ACTI+ADA POR 3'EDAD 3'EDAD 5 GRAN3&ACION GRAN3&ACION POR /3SI4N Celulosa

A(tivad a or $u!ed ad Por

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A*sor*en la $u!edad # la distri*u#en uni-or!e!ente

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•  T  Ter!or er!oresistentes esistentes •

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!i(ro(ristalin a Al!idon Aentes alutinantes $idro-o*os 'onoestearato de li(erilo A(ido esteari(o

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Por a(tiva(i0n de $u!edad

Por -usi0n

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E6uios ara la Granula(i0n en se(o a(tivada a( tivada or $u!edad

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&a(tose !onno$#drate Povidone Iron o8ide 9t  7 !in; •

Aua 9t  < !in;

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'i(ro(r#stallin e (ellulose 9t  < !in; Sili(on dio8ide 9t  < !in;

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Crosovidon e 9t  = !in;

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E6uios ara ranula(i0n or -usi0n: Granulador !ez(lador de alta velo(idad

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OPERACIONES QUE FORMAN PARTE DE LOS PROCESOS GRANULACIÓN ACTIVADA ACTIVADA POR HUMEDAD P.A

  &  

E8(iientes 9Alutinantes;

GRANULACIÓN POR FUSIÓN P.A

E8(iiente s

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PAR?'ETROS GRAN3&ACI4N ACTI+ADA ACTI+ADA POR &A & A 3'EDAD 3'EDAD Cara(ter@sti(as del -"r!a(o  Tio de alutinantes alutinantes Cantidad de alutinantes  Tio de ranulador ranulador  Tie!o de !ez(lado !ez(lado

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PAR?'ETROS AR?'ETROS GRAN3& GRAN3&ACI4N ACI4N POR /3SI4N •

Antes del ro(eso de ranula(i0n, se realiza el !ez(lado entre rodu(to #

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 Tener  Tener en (uenta (uenta la te!eratura de -usi0n

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GRAN3&ACI4N EN SECO ACTI+ADA POR 3'EDAD

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Pro(eso Pro(eso e1(iente #

GRAN3&ACI4N POR /3SI4N

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3so de alutinantes (on

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REFERENCIAS -I-LIOGRÁFICAS •

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&ozano. 'anual de Te(nolo@a /ar!a(éuti(a: /ar!a(éuti(a: Pro(edi!ientos ese(iales. Elsevier: 'adrid =>7=.F7. RoHe R., S$ese# P., Juinn '. and*oo and P$ar!a(euti(al E8(iients: &a(tose, 'ono$#drate.Si8t$ Edition. Kas$inton DC: P$ar!a(euti(al Press=>>L.