Farmacología Gastrointestinal

 

 

@JGTOYJI ID GBDMGBJW FÂIBGJW TMBPDUWBIJI ID ATJRJZTBO GJUUDUJ ID CEWYDYUBGBJ

@jrfjgcocaæj BB Udsufdm8 @jrfjgcocaæj Ido Jpjrjtc Ajstrcbmtdstbmjo8 @êrfjgcs Id Oj Wdgrdgb÷m Aêstrbgj, Jmtbuogdrcscs R Ido P÷fbtc. @jrfjgcocaæj Id Oj Fctbobiji Bmtdstbmjo, Jmtbibjrrdbgc

[drtdmdgd j8 Fdojmy Mcdfb Grdspc Gjstjúdij

Icgdmtd8 Irj. Ojurj Ouac Mjzjrdmc

7; id dmdrc ido 5;5:

 

 

Oj `umgb÷m prbmgbpjo ido tuec ibadstbvc gcmsbstd dm prcpcrgbcmjr jo crajmbsfc vbvc do jidgujic sufbmbstrc id fjtdrbjo (jauj, dodgtrcobtcs, mutrbdmtds) qud mdgdsbtj pjrj jsdaurjr su prcpbc fjmtdmbfbdmtc gcfc tjo, id `crfj qud dooc od pdrfbtj cetdmdr oj dmdraæj y fjtdrbj qud, pcr su gjrêgtdr ibmêfbgc, rdqubdrd pjrj oodvjr j gjec ocs prcgdscs vbtjods, jsæ gcfc ocs id rdpcsbgb÷m dstrugturjo, grdgbfbdmtc y rdprciuggb÷m @umgbcmds Ajstrcbmtdstbmjods Bmvcougrjijs

  Wdgrdgb÷m   Fctbobiji   Jescrgb÷m

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@bsbcpjtcocaæj

@jgtcrds Jardscrds   

  Êgbic   [dpsbmj   Wjods Ebobjrds 

         

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@jgtcrds Id`dmsbvcs Fugus Ebgjrecmjtc [rcstjaojmibmjs @ouhc Wjmauæmdc @udrtds umbcmds bmtdrgdouojrds y rdgjfebc gdouojr

[jtcocaæjs Gcfumds

  Dm`drfdiji Jgbicpâptbgj   Ibjrrdj

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  Dstrdúbfbdmtc

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B.  @êrfjgcs qud jgtøjm scerd oj sdgrdgb÷m aêstrbgj :.  Idprdscrds id oj sdgrdgb÷m aêstrbgj :.: Eocqudjicrds Eocqudjicrds L5 (Gbfdtbibmj, (Gb fdtbibmj, rjmbtbibmj, `jfctbibmj, mbzjtbibmj, tbctbibmj, cxbfdtbibmj.)

       

Eudmj jescrgb÷m crjo d bmsbamb`bgjmtd bmtdr`drdmgbj b mtdr`drdmgbj pcr jobfdmtcs y jmtbêgbics.  Mc j`dgtjm oj fctbobiji. Dm icsbs jprcpbjijs8 prdsupudstj tdrjpâutbgj dqubvjodmtd. Ibsfbmuydm do vcoufdm id oj sdgrdgb÷m y oj gcmgdmtrjgb÷m id L+, pdpsbmj y `jgtcr bmtræmsdgc. Bmgrdfdmtj mbvdods id ajstrbmj (pcr=pL).   Jotdrj oj jescrgb÷m id @d mc ldfc id oj ibdtj.   D`dgtcs8 Dsgjscs8 Ibjrrdj, gd`jodj, `jtbaj, fbjoabjs y dstrdúbfbdmtc, drupgb÷m gutêmdj.   Edzcjrds, y = scerdvbij ejgtdrbjmj, `crfjgb÷m id mbtrcsjfbmjs.

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    Gbfdtbibmj8 D`dgtcs jmtbjmircaâmbgcs gcm lbpdrprcojgtbmdfbj, lbpdrprcojgtbmdfbj, abmdgcfjs abmdgcfjstbj tbj y cobac c

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jzccdspdrfbj. :.5 Jmtbgcobmârabgcs ( [brdmzdpbmj, tdodmzdpbmj)

  Jotj j`bmbiji pcr rdgdptcrds F: (f:/f7854/4;;)8 (f:/f7854/4;;)8 Fjycr sdodgtbvbiji sdodgtbv biji aojmiuojr aêstrbgj   Udiugdm oj sdgrdgb÷m aêstrbgj ejsjo y dstbfuojij dm um 4;%, 4 ;%, gcm rdtjric obadrc id oj

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dvjgujgb÷m aêstrbgj8 =pL iucidmjo iucidmjo pcr fês tbdfpc.   [cerd pdmdtrjgb÷m jo WMG   [cgcs d`dgtcs gcojtdrjods rdspdgtc j gcmaâmdrds   Fdmc d`dgtbvbiji dm rdiuggb÷m id sdgrdgb÷m êgbij qud oj gbfdtbibmj, pdrc gcm tjsjs id gurjgb÷m sdfdhjmtds id øogdrjs iucidmjods

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:.7 Bmlbebicrds id Ecfej Id prctcmds (Cfdprjzco, ojmzcprjzco, pjmtcprjzco, dscfdprjzco, rjedprjzco, rjedprjzc o, dtg.)

  Ojebobiji êgbij   Bmlbebgb÷m id oj sdgrdgb÷m êgbij iurjidrj (9-4 iæjs)   Idtdrfbmj pdqudújs d bmgcmstjmtds ibsfbmugbcmds ido vcoufdm id sdgrdgb÷m aêstrbgj, id

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 pdpsbmj y `jgtcr bmtræmsdgc.    Mc j`dgtjm oj fctbobiji   Dxpdrbfdmtjo8 lbpdrpojsbj cxæmtbgj y tufcrds gjrgbmcbids. gjrgb mcbids.

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ibsfbmuydm do 4‒% id su ebcibspcmbebobiji eb cibspcmbebobiji (idedm jifbmbstrjrsd gcm do dst÷fjac   Jobfdmtcs ibsfbmuydm

vjgæc, : lcrj jmtds ido idsjyumc idsjyumc c oj o j gdmj pjrj qud gcbmgbij gcm oj gcmgdmtrjgb÷m sjmauæmdj fêxbfj gcm oj fêxbfj sdgrdgb÷m id oj ecfej id prctcmds)   Udsuotjics dqubvjodmtds qud gcm Bmlbebicrds L5, pdrc gjofjm do icocr fês rêpbic dm øogdrj  pâptbgj.   =D`bgjgbj gcfpjrjtbvj dm dsc`jabtbs pcr rd`ouhc y dm s. id Xcoobmadr-Doobscm   D`dgtcs Gcojtdrjods8 Mêusdjs, ibjrrdj, g÷obgcs, gd`jodj, fjrdcs, scfmcodmgbj y ocs idpdmibdmtds id lbpcgocrbibj.

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BB.  @êrfjgcs qud Jgtøjm scerd gcmtdmbic 5.  Jmtbêgbics

  Udojgb÷m gbrgjibjmj   Jogjmzj um pL baujo c fjycr j 18 ibsfbmuyd prctd÷obsbs pdpsæmbgj

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5.: Ebgjrecmjtc id Wcibc

         

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Wcoueods Jescrgb÷m gcfpodtj Bmiugd jogjocsbs fdtje÷obgj jmtd `jooj rdmjo Bmgrdfdmtc id pL, ibstdmsb÷m aêstrbgj d brrbtjgb÷m b rrbtjgb÷m aêstrbgj8 d`dgtc id rdectd Jggb÷m gjrfbmjtbvj

5.5 Lbir÷xbic id fjamdsbc

  Jggb÷m rêpbij   Jgdodrj vjgbjfbdmtc aêstrbgc   D`dgtc ojxjmtd

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5.7 Lbir÷xbic id Joufbmbc

  Jggb÷m odmtj    Udtjrij do vjgbjfbdmtc aêstrbgc

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    D`dgtc gcmstbpjmtd.

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5.9 Jscgbjgb÷m

         

Jggb÷m rêpbij y scstdmbij  Mc sd j`dgtj do vjgbjfbdmtc vjgbjfbdmtc aêstrbgc Dvjgujgbcmds admdrjofdmtd mcrfjods Do FaCL5 fjmtbdmd pL dodvjic (=7) pjrj jescrgb÷m id pdpsbmj jo JBCL7  Mc j`dgtj do dquboberbc dquboberbc êgbiceêsbgc    Mc rdgcfdmijic dm prc`bojxbs   D`dgtcs Gcojtdrjods8 Jogjocsbs fdtje÷obgj, jogjourbj dm usc gr÷mbgc8 Md`rcobtbjsbs, Yrjstcrmcs id fctbobiji ajstrcbmtdstbmjo, ajstrcbmtdstbmjo, edzcjrds, gcocmbzjgb÷m ejgtdrbjm ejgtdrbjmj, j, drugtcs, `ojtuodmgbjs, ibstdmsb÷m, mjusdj d bmiuggb÷m id rd`ouhc.   Bmtdrjggbcmds8 umbâmicsd umbâmicsd j ctrcs `êrfjgcs c jufdmtjmic do pL8 @d, tdtrjgbgobmj, qubmcocmjs, btrjgcmjzco, dtg.

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BBB.  Ajstrcprctdgtcrds 7.: Wugrjo`jtc8 (sugrusj+JB(CL)

  Tmb÷m sdodgtbvj scerd drcsbcmds fugusjs   Dstbfuojgb÷m ido [a y ebgjrecmjtc   Jifbmbstrjgb÷m gcm dst÷fjac vjgæc.

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7.5 Ebsfutc.

       

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Fdgjmbsfc sdfdhjmtd j sugrjo`jtc [rcejeod bmgrdfdmtc id fugus, [a y ebgjrecmjtc Jggb÷m jmtlbldoygcejgtdr y jmtbibjrrdbgj Ybmgb÷m id odmauj y ldgds

7.9 Jmêocacs id prcstjaojmibmjs Fbscprcstco Fbscprcs tco (jmêocac id [AD:)

  Dstbfuoc id `ouhc sjmauæmdc sjmauæmdc,, sdgrdgb÷m id fcgc y ebgjrecmjtc   Tsc prc`boêgtbgc y tdrjpâutbgc id ajstrcpjtæj pcr JBMDs   Jggb÷m jecrtbvj BP.  @jrfjgc @jrfjgcocaæj ocaæj id oj Fctbobiji Ajstrcbmtdstbmjo

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9.: Ojxjmtds

Fjmdhc jprcpbjic ido dstrdúbfbdmtc8   Ibdtj `bercsj    Jgtbvbiji `æsbgj   Bmadstj id oæqubics   Ojxjmtds 

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Ybpcs8 Ojxjmtds `crfjicrds `crfjicrds id E Ecoc coc

  [sbobc, fdtbogdouocsj, pcobgjre÷`boc, gcocbids lbirc`æobgcs mc ibadrbeods, gcm jggb÷m fdgêmbgj.   [udidm prciugbr `ojtuodmgbj (ibadstb÷m ejgtdrbjmj id `berjs vdadtjods)

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Jeojmijicrds id Ldgds

  Icgusjtc, aobgdrbmj (supcsbtcrbcs), jgdbtd fbmdrjo8 Jtrjdm jauj y oæpbics ljgbj ojs ldgds

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Csf÷tbgcs

Jtrjdm oæqubic ljgbj ojs ldgds. Jzøgjrds c sjods mc jescrebeods   Odgld Id Fjamdsbj8 Lbpdrfjamdsdfbj Lbpdrfjamdsdfbj dm BUG 

 

    Wcrebtco c Ojgtuocsj8 Ojgtuocsj8 @ojtuodmgbj   [urajmtd8 jggb÷m irêstbgj

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Gjtêrtbgcs (Dstbfuojmtd)

       

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Dstbfuojm do pdrbstjotbsfc y oj sdgrdgb÷m Jmtrjmæobgcs8 jocd, gêsgjrj y sdm. @dmco`tjodbmj (rdtbrjic pcr pcsbeod gjribctcxbgbiji) Jgdbtd id gjstcr (rbgbmc). Jggb÷m irêstbgj.

9.5 @jrfjgcocaæj ido vcfbtc 9.5.: Dfâtbgcs Jpcfcr`bmj

       

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 Mc usjr dm pjgbdmtds pjgbdmtds bmgcmsgbdmtds, bmgcmsgbdmtds, mb trjs oj bmadstb÷m bmadstb÷m id sustjmg sustjmgbjs bjs gcrrcsbvjs. gcrrcsbvjs. Idrbvjic sdfbsbmtdtbgc id fcr`bmj Dstbfuoj zcmj A.Z Euoejr Jifbmbstrjgb÷m suegutêmdj, d`dgtc dm pcgcs fbmutcs

9.5.5 Jmtbdfâtbgcs ArjmbsdtrcmjArjmbsdtrc mj- Cmijmsdtrcmj

Jmtjacmbstjs sdodgtbvcs 4-LY7   P÷fbtcs prcvcgjics pcr jgtbvjgb÷m id rdgdptcrds 4-Lt7, gcfc8 @êrfjgcs dm admdrjo y jmtbgjmgdrcscs dm pjrtbguojr [rcgdscs ibadstbvcs jauics [cstcpdrjtcrbcs Ujibctdrjpbj Trdfbj   Wd jifbmbstrj vbij crjo c B.P   [csbeods gd`jodjs dm um :4%    Mc ljy ijtcs id sdaurbiji dm dfejrjzc 

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Fdtcgocprjfbij 

Jmtjacmbstj i5 j icsbs ljebtujods   P÷fbtcs ido dfejrjzc   P÷fbtcs id oj fbarjúj 

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pcr cpbêgdcs. Ibabtjobgcs, tdc`bo   P÷fbtcs Jmtjacmbstj i5 t 4-LY7j icsbs jotjs   [jrj v÷fbtcs fdibjics pcr trjmsfbsb÷m sdrctbmbmdrabgj   Udjggbcmds jivdrsjs j icsbs jotjs8 sdijgb÷m, ibjrrdj, sbamcs dxtrjpbrjfbijods (JMYB-I5)  pjrnbmscmbsfc, fcvbfbdmtcs fcvbfbdmtcs ibsgdmd ibsgdmdtbgcs. tbgcs. 

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Ctrcs @êrfjgcs8 Icfpdrbicmj, jmtbfusgjrbmbgcs jmtb fusgjrbmbgcs.. 9.7 @jrfjgcs Jmtbibjrrdbgcs Cpbjgdcs88 Ib`dmcxbojtc, ocpdrjfbij Cpbjgdcs

       

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Dstbfuojm rdgdptcrds ‟f‖ bmtdstbmjods Jufdmtj gcmtrjggbcmds gbrguojrds mc prcpuosbvj Bfpbid gcmtrjggbcmds ocmabtuibmjods prcpuosbvjs8 Lbpdrtcmc fusguojrds, fjmtdmbic

  [jrêobsbs bmtdstbmjo t÷mbgj   Fês tbdfpc pjrj rdjescrgb÷m r djescrgb÷m id jauj y dodgtrcobtcs

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Ebeobcarj`æj   H.@o÷rdz @jrfjgcocaæj Lufjmj 4ª Dibgb÷m 5;;<   Ocrdmzc [, Fcrdmc J, dt joo.Pdojzqudz. @jrfjgcocaæj Eêsbgj y Goæmbgj (