Estimation of Malondialdehyde Levels in Serum and Saliva of Children Affected With Sickle Cell Anemia

 

]Bow`aolbfb grff groj dttp;//www.kisppb.eoj o` Uu`bly, Jly 58>8, IX; 7>.>5Bfplrtjf`t og Xfbobo`ties l`b Xrfvf`tivf Bf`tistry, Yf`fpoyl Bf`tla Eoaafcf, Jl`claorf, Mlr`ltlml, I`bil

LNUR^LER

Nlemcrou`b; Uiemaf efaa l`fjil (UEL) is l` i`dfritfb bisorbfr og dfjocaoni` sy`tdfsis edlrletfrizfb ny bfgorjfb frytdroeytfs. Dfjocaoni` U prfsf`t i` siemaf“sdlpfb frytdroeytfs fxdinits l` f`dl`efb rltf og luto“oxibltio` eojplrfb witd `orjla dfjocaoni` L. It probuefs jorf og rfletivf oxycf` spfeifs (^OU) wdied projotfs oxibltivfay strfssfb f`viro`jf`t. ^OU bfcrlbf tdf jfjnrl`fs og siemaf efaa frytdroeytfs eojposfb og poayu`slturltfb aipibs l`b gorj jlao`bilabfdybf (JBL) ls l ny“probuet. Lij; Rdf lij og tdf stuby is to fvlaultf l`b eojplrf tdf JBL afvfas og sfruj l`b slaivl i` UEL pltif`ts. Bfsic`; Bfsic`;   L  totla og 6 ¼ 4, rfspfetivfay,

i` Croup L l`b tdfy wfrf gou`b to nf dicdfr tdl` jfl` JBL afvfas og sfruj (6.43 ¼ 8.9>) l`b slaivl (8.>9>9 ¼ 8.87) og Croup N l`b tdf biggfrf`ef og tdfir jfl` wls gou`b to nf stltistielaay sic`iel`t. Eo`eausio`;  L sic`iel`t eorrfaltio` og tdf JBL wls Eo`eausio`; gou`b i` slaivl l`b sfruj og tdf pltif`ts witd UEL. Rdis `bi`c succfsts tdlt slaivl el` nf fggfetivfay usfb ls l `o`i`vlsivf latfr`ltivf gor lssfssi`c tdf oxibltivf strfss i` pltif`ts witd UEL.

MFYSO^BU; Jlao`bilabfdybf, slaivl, sfruj, siemaf efaa l`fjil

I`trobuetio` Uiemaf efaa l`fjil (UEL) is l` i`dfritfb bisorbfr og dfjocaoni` sy`tdfsis tdlt is lssoeiltfb witd l

 Lbbrfss gor eorrfspo`bf`ef; eorrfspo`bf`ef;  Br. Uubdi`brl Nlaicl, Bfplrtjf`t og Xfbobo`ties l`b Xrfvf`tivf Bf`tistry, Udlrlb Xlwlr Bf`tla Eoaafcf, Ulwl`ci (J), Slrbdl, Jldlrlsdtrl, I`bil. F-jlia; nlaicljsHdotjlia.eoj

Leefss tdis lrtieaf o`ai`f \uiem rfspo`sf eobf

Sfnsitf;  Sfnsitf;  www.kisppb.eoj BOI; 5 ja og naoob wls brlw` groj

leibs, l`bogtdfrfgorf, it is ]>Zl Ulaivl grfquf`tay jflsurfb niojlrmfr oxibltivf strfss. is l `lturla noby uib, wdied is leealijfb ls tdf rst bfgf`sf systfj og tdf noby l`b l`y dorjo`la, `utritio`la, l`b jftlnoaie bisturnl`efs tdlt oeeur i` sfruj is fqulaay rffetfb i` slaivl.]5Z @o`i`vlsivf l`b slgf jftdobs og slaivlry sljpaf eoaafetio`, tdf possiniaity og rfpfltfb sljpai`c, l`b ao`citubi`la jo`itori`c dlvf laa jlbf slaivlry l`laysis jorf auerltivf.]2Z Fstijltio` og oxibltivf strfss is l` fssf`tila plrt og routi`f naoob i`vfsticltio`s, wdied lrf fjpaoyfb gor jo`itori`c dflatd l`b bisflsf. Rdfrf is l alem og aitfrlturf wdied fstijltfs oxibltivf strfss usi`c slaivlry JBL, fspfeilaay i` pltif`ts witd UEL. Rdfrfgorf, tdf prfsf`t stuby wls elrrifb out to fvlaultf l`b eorrfaltf tdf JBL afvfas i` sfruj l`b slaivl i` ediabrf` witd UEL.

tdf eunitla vfi` trl`sgfrrfb og tdf afgt lrj >2“clucf Naoob wls tdf` to lwitd pali`lstfriaf nuan`ffbaf. wdied wls ijjfbiltf. Rdf supfr`ltl`t wls rfjovfb l`b ef`trigucfb lt 5888 rpj gor 2―6 ji`. Ufruj ontli`fb wls tdf` storfb lt ∞ >8¸E gor sunsfquf`t l`laysis.

Jltfrilas l`b Jftdobs

Rdf vlaufs og JBL fvlaultfb i` notd tdf stuby croups i` slaivl ls wfaa ls sfruj lrf sdow` i` Rlnaf Z.

L totla og 9¼8.8767 8.883

8.>>>>3

 

t

X

7.779

8.8888, IX; 7>.>56¼9 6.4373¼8.9>657

8.823 8.657 8.>9>9¼8.875

 

X

8.886*

*X18.86, sic`iel`t. UB:Utl`blrb bfviltio`

Oxibltivf dlsbisflsfs. nff` rfaltfb to tdf ftiopltdocf`fsis ]7Z og sfvfrla strfss edro`ie  ^OU dlvf nff` rfportfb to paly l vfry ijportl`t roaf i` efaa sic`lai`c l`b jftlnoaie proefssfs]3Z  l`b laso dlvf nff` tdoucdt to nf ijpaieltfb i` tdf pltdocf`fsis og l vlrifty og i`ljjltory bisorbfrs. Xoayu`slturltfb gltty leibs lrf tdf jost eojjo`ay i`voavfb nioaociela tlrcfts og oxibltivf strfss provibi`c JBL ls l ny“probuet o` pfroxibltio`.]4Z  JBL is lnaf to ijplir sfvfrla pdysioaociela jfedl`isjs og tdf dujl` noby tdroucd its lniaity to rflet witd joafeuafs sued ls B@L l`b protfi`s. It is, tdfrfgorf, usfgua to eo`sibfr tdis joafeuaf ls sojftdi`c jorf tdl` l aipib pfroxibltio` probuet. JBL is lssfssfb to qul`tigy tdf afvfa og oxibltivf strfss  strfss   i` vivo l`b l`b i`  i` vitro usi`c sfvfrla jftdobs. I` tdf plst >8 yflrs, JBL dls nff` rfeoc`izfb r feoc`izfb ls l rfafvl`t aipib pfroxibltio` jlrmfr, l`b ls sued, tdf jflsurfjf`t og JBL afvfas i` nioaociela sljpafs groj plrtieipl`ts lggfetfb ny sfvfrla bisflsfs dls nff` wibfay utiaizfb. ^fef`t rfsflred dls rfvflafb potf`tila lppaieltio`s og l`tioxibl`t/grff rlbiela jl`ipualtio`s i` prfvf`tio` or eo`troa og bisflsfs.]9Z Rdfrf dlvf nff` vfry gfw stubifs i`vfsticlti`c tdf JBL afvfas og slaivl. Nlsfb o` tdfsf prfaiji`lry onsfrvltio`s, wf dypotdfsizf tdlt biggfrf`efs i` JBL fxist nftwff` UEL pltif`ts l`b dflatdy eo`troas l`b tdlt i`erflsfb JBL jly nf l gflturf og notd aoela l`b pfripdfrla fxtrlefaaualr uibs i` pltif`ts witd UEL. Rdfrfgorf, tdf stuby fvlaultfb notd aoela (slaivl) l`b pfripdfrla (sfruj) afvfas og JBL i` plrtieipl`ts witd UEL l`b dflatdy eo`troas. Ufvfrla jftdobs dlvf nff` rfportfb gor jflsuri`c tdf JBL og nioaociela uibs=]3 4.94>6¼9 8.6¼8.>49¼8.87