DIT Workbook 2013

Heart Rate goes down Eye meiosis Salivary gland secretion Bronchiolar smooth muscle CONSTRICTION Bladder wall CONSTRICTION and sphincter relaxation GU erection GI tract motility increased and spincters relaxed

Pralidoxime regenerates Achase after organophosphate poisoning

Atropine

Donepezil, Galantine, Rivastigamine

Alzheimer’s, treat with galantine, donepezil, rivastigamine

Organophosphate poisoning, treat with atropine and pralidoxime

DUMBELSS: Diarrhea, urination, meiosis, bradycardia, bronchospasm, excitation of skeletal muscle, lacrimation, sweating, salivation

Pralidoxime

Epithelial cells?

Opposite of dumbbelss, so constipation, urinary retention, tachycardia, bronchorelaxation, loss of stimualation to skeletal muscle, dry eyes/mouth, no sweat

Muscarinic Antagonist

Muscarinic Antagonist

AntiCholinesterase Direct Muscarinic Agonist

Muscarinic Antagonist

Anticholinesterase Cholinergic Agonist

Muscarinic Antagonist

Muscarinic Antagonist Muscarinic Antagonist Anticholinesterase

Anticholinesterase

Muscarinic Agonist Muscarinic Antagonist

Acetylcholinesterase Regenerator

Anticholinesterase Cholinergic Agonist Anticholinesterase Muscarinic Antagonist Muscarinic Antagonist

Ipratropium, Tiotropium

Calcium, amphetime, ephedrine, tyramine

Gq Gi Gs Gs

Gi

Gq

Gi

Gq

Gs protein Adenylcate cyclase Increased cAMP Protein Kinase C Activation =

Cutesies have 1 M&M MAD 2s

Vd = D/c

CL = Rate of elimination/Plasma concentration CL = (0.7 x Vd) x T1/2 LD (loading dose) = Css x Vd MD (Maintenance dose) = Css x CL

10.5

600 mg

Stop the infusion for one half life which as we calculated was 10.5 h

20 mg / h

LD will not change MD will change getting decreased