Covid Pathophysiology

 

Covid Pathophysiology (Paent-based) Modifable actor

Non modifable actor History Travel at Beijing, China Respiratory producon by human host inected by SARS-COV 2 Paent exposed to the Sars COV 2 Inhaled viruses and bind to host receptors spread directly on mucous membranes to surrounding cells Sore throat Viral contents are released inside the host cells, viral RNA enters the nucleus or replicaon. New viral parcles are made that will bound to Angiotensin-converng enzyme 2 (ACE2) and mimic ACE-2 and gain access into the cell Viral prolieraon in the ssues with more ACE 2 receptors increase inammaon leads to macrophages requirement cause vessel wall damage and ssue damage (Kidneys, Lungs, GIT, Heart, Vessels, Brain) Binds ACE-2 in trigeminal nerve leads to acvaon o trig  trigeminovascular system / (Headache, Loss o smell and apete) Increase Inammatory cytokines triggers Systemic Response/ Increased Inc reased skeletal muscle damage (Weakness/Fague) /Cytokines induce hypothalamus to release prostaglandins – increase body temperature (Colds/Chills/ever) Local response by alveolar epithelial cells releases chemo toxins into the surrounding ssue to recruit neutrophils to the site o inammaon Accumulaon o neutrophils and plasma exudate rom capillaries and alveoli/ Irritaon and aempted clearance o airways/ coughing does not have producon o phlegm/ mucus – dry cough

 

Covid Pathophysiolo Pathophysiology gy (Paent-based)

Non-modifable Factor

 

Modifable Factor

Age Traveler (Beijing, China) Gender Respiratory producon by human host inected by SARS-COV 2

Paent exposed to the Sars COV 2 Inhaled viruses and bind to host receptors spread directly on mucous membranes to surrounding cells

Sore throat

Viral contents are released inside the host cells, viral RNA e nters the nucleus nucle us or re licaon. licaon. New viral parcles are made that will bound to Angiotensin-converng enzyme 2 (ACE2) and mimic ACE-2 and gain access into the cell Viral prolieraon in the ssues with more ACE 2 receptors Increase inammaon leads to macrophages requirement cause vessel wall damage and ssue damage (Kidneys, Lungs, GIT, Heart, Vessels, Brain) Binds ACE-2 in trigeminal nerve leads to acvaon o trigeminovascular system

Headache

Increase Inammatory cytokines triggers Systemic Response

Loss o smell & appete

Cytokines induce Increased skeletal muscle damage

hypothalamus to release prostaglandins

Local response by alveolar epithelial cells releases chemo toxins into the surrounding ssue to recruit neutrophils to the site o    Accumulaon o neutrophils and plasma exudate rom capillaries and alveoli

 

Weakness/Fague

Increase body temperature

Chills

Colds

Irritaon and aempted clearance o airways

coughing does not have producon o  phlegm

Dead cells and debris build up

Fluid accumulates in alveoli

Fever Dry cough

Minimal pleural eusion