Copia de 2 Farmacocinetica

 

6. Ekrakjljngîtjk ‚ Ekrakjl`ngkank

Eërakjl4 sust. qjk. prlpnk l kdhgk kc lrikgnsal quh prl`ujh ug hehjtl thrkpîujl l tlxnjl. Ekrakjljngîtjk4 tl`ls cls prljhsls quh jlgjurrhg hg hc lrikgnsal `hs`h ck k`angnstrkjnúg

`hc eërakjl mkstk su hcnangkjnúg. Pnhgh 0 prljhsls4 ;. 6. :. 0.

Kfslrjnúg4 Kfslrjnúg4 Rksl `h vák `h `h k`angns k`angnstrkjnú trkjnúg g k jnrjuckjnúg jnrjuckjnúg @nstrnfujn @nstrnfujnúg4 úg4 Zkcn`k Zkcn`k `h `h eërakjl eërakjl k thdn`ls. thdn`ls. Rrljhs Rrljhsl l `ngëanjl. `ngëanjl. Ahtkfl Ahtkflcns cnsal4 al4 Fnltr Fnltrkgs kgselr elrakj akjnúg núg `h eërak eërakjl jl Hxjrhjnúg4 Hxjrhjnúg4 Zkcn`k Zkcn`k `h eërakjl eërakjl l ahtkflc ahtkflcntls ntls kjt l ngkjvls. ngkjvls.

Ekrakjl`ngkank4 ax `h kjjnúg `h cls eërakjls y hehjtls.

;. K Kgn gn`k `k` ` k rhj rhjhp hptl tlrh rhss 6. Kjt Kjt ngtr ngtrág ágsshjk. jk.

N.

Ekrakjljngîtjk

Jurvk fësnjk ekrakjljngîjk4    

Cki ah4 mkstk quh cchik k jnrjuckjnúg j nrjuckjnúg Jurvk ksjhg`hgth4 kfslrjnúg, eksh ; mkstk Jakx (jlgjhgtrkjnúg aëxnak) Pakx4 hapl hg quh sh kcjkgzk jlgjhgtrkjnúg aëxnak Vh`ujjnúg 82% jlgjhgtrkjnúg ah`njkahgtl 1 hapl vn`k ah`nk

;) Kfslrjnúg4 Hxnsth snhaprh y jukg`l hc ah`njkahgtl ktrkvnhsh ahafrkgk fnlcúinjk, hxtrkvksjuckr. Ah`njkahgtls HU pkskg `nrhjtkahgth, gl sh pnhr`h gk`k, fnl`nsplgnfncn`k` hs ;22%. Rlr ltrk vák vák gl hs ;22%. Uhcljn`k` `h kfslrjnúg 1 Jakx/Pakx K akylr vhcljn`k` kfslrjnúg4 ahglr hapl ckthgjnk, hehjtl aës ngthgsl y `urk`hrl (pq `halrk aës hg fkdkr `hs`h pkrth aës kctk `h ck jurvk). Ekjtlrhs quh nguyhg hg kfslrjnúg4 Rrlpnls `hc eërakjl4 k) Zlcufncn`k` Zlcufncn`k`44 jkrik `h ck alcîjuc alcîjuck. k. Cks alcîjucks alcîjucks sng sng jkrik slg slg aës cnplslcuf cnplslcufchs, chs, `k`l quh ahafrkgks fnlcúinjks slg elselcápn`ls, pkskg aës eëjnc k trkvîs `h ck ahafrkgk, sh kfslrfh ahdlr f) Pkakûl Pkakûl `lsns4 `lsns4 akylr `lsns `lsns kfslrjnúg kfslrjnúg aës aës rëpn`k, rëpn`k, pq psnjleëra psnjleërakjls kjls akylrák akylrák slg cnplslcufchs, sh kfslrfhg plr `neusnúg pksnvk. Hs rhchvkgth hg ngtlxnjkjnúg, `k`l quh kc uskr `lsns aës kctk quh thrkpîujk, thg`rë ugk jlgjhgtrkjnúg pcksaëjk aës kctk y hg ahgls hapl j) @nsljnkjnúg @nsljnkjnúg (poK)4 naplrt naplrtkgth kgth hg hg eërakjls eërakjls kj/fkshs kj/fkshs `îfnchs. `îfnchs. Ëjn`ls Ëjn`ls `îfnchs `îfnchs sh sh kfslrfhg ahdlr jlg pM kctl y fkshs `îfnchs sh kfslrfhg ahdlr jlg pM fkdl

 

`) Elrak ekrakj ekrakjîujk îujk44 Dkrkfh 7 Zusphg Zusphgsnúg snúg 7 Jkpsuck Jkpsuck 7 Jlaprna Jlaprnan`l n`l 7 Irkihks Irkihks Rrlpnls `h ck vák k) Zuphrjnh Zuphrjnh kfslrjn kfslrjnúg4 úg4 akylr akylr suphrjnh suphrjnh (hd. (hd. ngthsgl) ngthsgl) akylr akylr kfslrjnú kfslrjnúg g f) Nrrnikjnúg Nrrnikjnúg `hc thdn`l4 thdn`l4 k 7 nrrnikjnú nrrnikjnúg g 7 kfslrjnúg. kfslrjnúg. j) pM4 pOk

Akylrák psnjleërakjls sh k`angnstrkg UL. @hfn`l k kctk cnplslcufncn`k` y fkdl tkakûl. Ktrkvnhskg fkrrhrks fnlcúinjks ah`nkgth `neusnúg pksnvk sniuhg Chy `h Ecnjo4 sh kfslrfh aës anhgtrks shk aës phquhûk, cnplslcufch y akylr `hctk `h jlgjhgtrkjnúg. -Fnl`nsplgnfncn`k`4 % `h ck `lsns quh cchik ngkcthrk`k `hs`h vák `h k`angnstrkjnúg mkstk jnrjuckjnúg snstîanjk @hphg`h `h ck vák `h k`angnstrkjnúg, HU 1 ;22% ;22 % fnl`nsplgnfncn`k`, gl mky kfslrjnúg. Hd.4 @nkzhpka UL1 ;22% (phquhûk kplckr y cnplcnjk). Kjtôk auy rëpn`l, sh puh`h `hdkr ZLZ Nanprkangk 1 02% Fnl`nsplgnfncn`k` sh jkcjuck jlg hc ërhk fkdl ck jurvk HU/UL Jkusks fkdk fnl`nsplgnfncn`k` UL4    

pljl cnplslcufch jlapchdls jlg kcnahgtls PIN @hstrun`l hg PIN plr hgznaks, kj jclrmá`rnjl Rrnahr pksl mhpëjl (tl`l cl quh sh kfslrfh hg hc ngthsgl pksk prnahrl plr hc máik`l, jnrj. plrtkc, máik`l cls fnltrkgselrak. Hstl hs fuhgl hg prleërakjls, yk quh gl hgh kjt fnlcúinjk mkstk shr trkgselrak`l plr hc máik`l. Hds. Rrleërakjls4 vhgckekxngk (hg pkrth), tkalxnehgl, rnsphrn`lgk.

¼Rlr quî fkdk fnl`nsplgnfncn`k` UL2% `rliks) Xfnjk`k hg antljlg`rnk y VH eug`kahgtkcahgth `hc máik`l Elrak`l plr4 l Mhalprlthágk (J^R 082)4 ugh y jh`h L6 kc eërakjl Eckvlprlthágk (J^R082 rh`ujtksk)4 ekjncntk ck lxnihgkjnúg `hc eërakjl l

Juk`rls `h J^R4 *Gl hs ghjhskrnl quh sh kprhg`kg tl`ls cls juk`rls `h sustrktls (AHGPNVK, CLZ RVHIXGPKVK PL@LZ)4 Uhrhals :4 J^R ;K6, J^R 6@5, J^R :K0. Hs Hstëg tëg hg cnfrl `hc @r. Zncvk

 

;) J^R ;K6 (0% eërakjls) 

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Zustrktls jckvhs4 Jclzkpngk (akylrák), Jkehágk, Ecuvlxkangk, Mkclphrn`lc, Anrtkzkpngk, Lckgzkpngk (pkrjnkchs) Ng`ujtlrhs (kuahgtkrkg kjt. @hc snst hgznaëjl)4 Jkehágk, jnikrrnccl, Lahprkzlc Ngmnfn`lrhs4 Rkrlxhgk, jnprllxkjngl, Hrntrlanjngk, Ecuvlxkangk (plthgth), duil `h uvk Hd.4 Zn pkjnhgth H[T euak aujml (usukcahgth cl mkjhg) y ch hstly `kg`l Jclzkpngk, hstk sh ahtkflcnzkrë aujml aës rëpn`l quh sn gl euakrk, `hfhrî `krch aës `lsns pkrk ansal hehjtl. Hd. 64 Kc rhvîs, sn hstk uskg`l Jclzkpngk y plr kciôg alvl usk EEcuvlxkangk cuvlxkangk (kg`hprhsnvl y plthgth ngmnfn`lr `h J^R;K6), Jclzkpngk gl sh ahtkflcnzkrë jlg ansak vhcljn`k`, y kuahgtkrë jlgjhgtrkjnúg pcksaëjks y plsnfchs hehjtls k`vhrsls.

6) J^R 6@5 (:2% eërakjls)   

Zustrktls4 Jclrprlakjngk, Mkclphrn`lc, Rkrlxhgk, Prkak`lc, Pkalxnehgl Ng`ujtlrhs4 Gl hgh Ngmnfn`lrhs4 l Rlthgths4 Eculxhgk, Glrulxhgk (ahtkflcntl kjvl `h ulxhgk), Rkrlxhgk l

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Al`hrk`ls4 Jntkclprka, Hsjntkclprka, Jclrprlakjngk, Fuprlpnlg, htj. Hd.4 Zn pkjnhgth hstk uskg`l Pkalxnehgl y sh ng`njk Eculxhgk, Pkalxnehgl gl sh trkgselrak hg ahtkflcntl kjvl, plr cl tkgtl, gl rhjnfh hehjtl thrkpîujl hsphrk`l.

:) J^R :K0 (82% eërakjls) 

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Zustrktls4 Fhgzl`nkjhpngks (hxjhptl Clrkzhpka). Jkrfkakzhpngk (hsauck su prlpnl ahtkflcnsal), Hgnchstrk`nlc (hs naplrtkgth plr pkjnhgth quh puh`k hstkr uskg`l KJL y shr hpncîpjk l fnplckr sn ch `kals Jkrfkakzhpngk u ltrl kgjlgvucsnvkgth, vk k thghr rh`ujjnúg `h gnvhchs `h KJL y plr cl tkgtl puh`h quh`kr hafkrkzk`k. Ôgnjl kgjlgvucsnvkgth quh gl fkdk gnvhchs `h Hgnchstrk`nlc, sngl quh cls kuahgtk hs ck Ckaltrningk). Ng`ujtlrhs4 Jkrfkakzhpngk, Ehgntlágk, Jlrjln`hs, puh`hg ihghrkr kuahgtl `h vhcljn`k` `h ahtkflcnzkjnúg. Ngmnfn`lrhs4 l Rlthgths4 Eculxhgk, Kgeôginjls, Akjrúcn`ls. Al`hrk`ls4 Ecuvlxkangk, Prnjájcnjls l Hd.4 pkjnhgth quh hsth uskg`l akjrúcn`l, kzntrlanjngk, l mn`rlxnjclrlqungk y k`haës ch `kals Eculxhgk pq hstë `hprnan`l, kuahgtkrk jlgjhgtrkjnúg pcksaëjk `h akjrúcn`l, jlg su hehjtl tlxnjl, y jlal mn`rlxnjclrlqungk k`haës kuahgtk hg [P vkals k thghr 6 ah`njkahgtls quh kuahgtkg [P, puh`h `krch ugk tkqunjkr`nk vhgtrnjuckr y alrnr.

@nehrhgjnks Ahtkfúcnjks  

Rhrslgks quh ahtkflcnzks ah`njkahgtls `nehrhgth. Rlcnalrsals ihgîjls slg ck ppkc. jkusk `h `nehrhgjnks ahtkfúcnjks ngthrphrslgkchs.

 

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Anglrák `h ck plfckjnúg sh jlaplrtk jlal ahtkflcnzk`lrhs chgtls4 rhqunhrhg `lsns ahgls `lsns, aës VKA. l Hd.4 Mnplkjvn`k` `h J^R 6@54 ;2% jkujësnjls. Chs `ks ah`njkahgtl y hghg tl`ls cls hehjtls k`vhrsls `hc aug`l Mky sudhtls jlg `upcnjkjnlghs ihgîjks ljksnlgkcahgth prl`ujhg akylr prl`ujjnúg hgznaëjk4 l Ahtkflcnzk`lrhs uctrkrrëpn`ls4 ahglr rptk jcágnjk, ahgls `lsns, ahgls VKA. Gl rhsplg`hg jlg gk`k, hstks shiurl `h `lsns y `nkigúsjl, phrl gl rhsplg`h, hstl sh skfh yk quh pjth gl thg`rë VKA. Hd. pkjnhgth quh hstk psnjújl y quh ch `ks Vnsphrn`lgk hg `lsns `h jkfkccl y gl hgh VK VKA A puh`h shr ug ahtkflcnzk`lr uctrk rëpn`l Ltrls ekjtlrhs4 l H`k`4 K`uctls akylrhs hstk prlclgik`l ahtkflcnsal eksh N, gl ksá eksh NN Nguhgjnks mlralgkchs l l Ihghrl l Ekjt. Muîsph` @nhtk l l Htgnk4 rh`ujjnúg ahtkflcnsal LM hg ksnëjls.

EKZH NN   

Jlapuhstl plr trkgsehrksks Lfdhtl hs ihghrkr ahtkflcntls ngkjvls mn`rlslcufchs pkrk plsthrnlr hcnangkjnúg Hgznaks eksh NN (prnahrks `ls cks aës naplrtkgths)4 X@R Icujurugnc trkgsehrksks (hd. ahtkflcnzk ck CAP) Vh`ujtksks (hd.4 LM-`hsmn`rlihgksks. Ck Kc`hmá`l-@hsmn`rlihgksk hs fckgjl jcágnjl `hc @nsucrka, pq ck ngmnfh, ngmnfnhg`l ahtkflcnsal `hc LM, LM quh`krk jlal kc`hmá`l y ihghrkrk ságtlaks auy `hskirk`kfchs) Zuceltrkgsehrksks Icutkúg ‚ Z- trkgsehrksk Htj.  

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8) Hxjrhjnúg Vnûúg4 prngjnpkc rhsplgskfch hxjrhjnúg. Znst. fncnkr jlgtrnfuyh y aujml ahgls ahgls cls pucalghs, chjmhúrikgl akthrgk y skcnvk. hxjrhjnúg. Vhgkc4 

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Ah`nkgth ctrkjnúg iclahruckr4 Erkjjnúg cnfrh `hc eërakjl pksk k snsthak hcnangkjnúg rhgkc4 62% @urkgth trkyhjtl plr tôfucls rhgkchs pkrth `hc eërakjl ctrk`l hs rhkfslrfn`l. Rrljhsl `hphg`hrë `h pM urngkrnl Zhjrhjnúg tufuckr (kjvk l pksnvk)4 =2%

Kcthrkjnlghs `h eugjnúg rhgkc rh`ujhg hcnangkjnúg `h eërakjls. 

Hd.4 HVJ, h`k`.

 

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Hstl hsphjnkcahgth rhchvkgth hg eërakjls mn`rlcnjls (hd. cnl, ck ôgnjk elrak quh hgh pkrk skcnr `hc juhrpl hs hc rnûúg.)

P ± H (hapl vn`k ah`nk hcnangkjnúg)   

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Hs ck vhcljn`k` hg ck jukc jlgjhgtrkjnúg pcksaëjk (Jp) sh rh`ujh 82% @hphg`h `hc Jchkrhgjh `hc eërakjl y `h ck jkpkjn`k` `h `nstrnfujnúg Hchahgtl naplrtkgth plrquh `hthrangk ck Rlslcliák P ± H akylr k 60 mrs hs hs ngghjhskrnl `lsns 7 ; x `ák. `ák. Hd.4 cnl Hquncnfrnl hstkfch (Zthk`y Ztkth4 ZZ)4 jkg`k` `h eërakjl hcnangk`l hs snanckr k `lsns k`angnstrk`k ZZ4 sh kcjkgzk hg 8-;2 P ± H l Hd.4 Cnl, KU, JFT4 kprlx. ; shakgk ah`njkahgtl cchik k hstk`l. Kgths gl snrvh ah`nrcl

Jngîjks `h hcnangkjnúg4 

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Lr`hg ;, Cnghkc l Ng`hphg`nhgth4 eërakjl sh hcnangk hg prlplrjnúg jlgstkgth. Akylrák `h psnjleërakjls sh hcnangkg ksá, tf Cnl. @k ugk jurvk clikrátanjk Lr`hg 2, Gl cnghkc, @hphg`nhgth `h `lsns4 hcnangkjnúg `h jkg`k` dk, sh tkgtls ai `h ah`njkahgtl plr ugn`k` `h hapl. Hd.4 Kciugls NZVZ (Eculxhgk, Rkrlxhgk) Jngîjk anxtk4 ah`njkahgtl `h ;hr lr`hg quh pksk k lr`hg 2, 2 , hstl pksk jukg`l cls ahjkgnsals `h hcnangkjnúg `h ;hr lr`hg sh skturkg, hs phcnirlsl pq jngîjk `h lr`hg 2 hcnangk ahgls eërakjl. Auy rhchvkgth hg ngtlxnjkjnlghs. Hd.4 ug psnjleërakjl l cnl

Zkfhr cl jcágnjkahgth rhchvkgth, pq hs naplrtkgth skfhr ahtkflcnsal `h cls J^R, pq hs naplrtkgth jlgljhr cks jngîjks `h hcnangkjnúg.

NN.  

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Ekrakjl`ngkank

Zh ljupk `hc hstu`nl `h cls ahjkgnsals `h kjjnúg `h eërakjls y sus hehjtls. Hehjtls4 l Phrkpîujls Gl `hshk`ls, VKA l Ahjkgnsals `h kjjnúg4 l Hgznaëjls (ppkchs hg psnjleërakjls)4 NAKL, @nsucrka l Alcîjucks trkgsplrtk`lrks4 Akylrák kg`hprhsnvls Jkgkchs núgnjls4 FTR, Kgjlgvucsnvkgths l l Ah`njkahgtls slfrh hxprhsnúg iîgnjk `h cks jîcucks

Ngthrkjjnúg Eërakjl-Vhjhptlr 

Hsphjnjn`k`4 jkpkjn`k` `nsjrnangkvk hgtrh alcîjucks. Zn `nshûl ug ah`njkahgtl quh shk hsphjájkahgth ug ngmnfn`lr `h ck rhjkpturk `h shrltlgngk thgil quh kshiurkrah quh hc ah`njkahgtl mkik hsl y gl ltrks jlsks. Ihghrkcahgth gl ljurrh, phrl cl naplrtkgth hs quh shk eug`kahgtkcahgth hsl. Cls ah`njkahgtls snhaprh vkg k thghr ltrks kjjnlghs, plr hdhapcl, cls NZVZ, kugquh sh cckakg shchjvls gl cl slg tkgtl, ck akylrák hgh ltrls ahjkgnsals `h kjjnúg. Hd.4 Eculxhgk gl slcl gl rhjkptk shrltlgngk, sngl tkafnîg ngmnfh ck rhjkpturk `h glrk`rhgkcngk.

 

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Kgn`k`4 Irk`l `h ktrkjjnúg y ugnúg hgtrh eërakjl-rhjhptlr hsphjnjl. Ihghrkcahgth ugnlghs slg rhvhrsnfchs. Mky kciugls gl rhvhrsnfchs, phrl slg ck anglrák, hd. NAKL gl rhvhrsnfchs, phrl yk gl sh uskg Cuhil `h phrnl`l `h ugnúg hc eërakjl sh shpkrk `h rhjhptlr4 (O`) Jlgstkgth `nsljnkjnúg. l Hstl hs naplrtkgth hg jcágnjk plr cls kgpsnjújls kpnjls. Cl quh cls mkjh kpnjls hs ugk akylr O` quh ugl pnjl. Hc kgpsnjújl pnjl sh ugh euhrthahgth k rhjhptlr `h `lpkangk, hgh ugk fkdk O`, hsl mkjh quh thgik aës hehjtls k`vhrsls ghurlcúinjls. Hc kgpsnjújl kpnjl hgh ugk O` aks kctk, plr cl quh sh ugh k rhjhptlr, phrl hstkrë hg ugk jlgstkgth ugnúg/`hsugnúg y hstl phranth rh`ujnr VKA. Kjt. Ngtrágshjk4 Hs cl quh hc ah`njkahgtl mkjh jukg`l cchik kc rhjhptlr l k snl `h kjjnúg. Jlg hstl pl`hals jcksnjkr cls ah`njkahgtls hg4 l Kilgnstks l Kilgnstk pkrjnkc l Kgtkilgnstk Kilgnstk ngvhrsl pkrjnkc l l Kilgnstk ngvhrsl

Kjvn`k` ngtrágshjk4 hsphjtrl kilgnstk **(jcësnjk prhiugtk hstk `nkpl) 

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Kilgns Kilg nsk k tltkc   4 Ah`njkahgtl jukg`l cchik kc rhjhptlr hs jkpkz `h kjvkrcl ihghrkg`l

rhspuhstk fnlcúinjk kc ;22%. Kgn`k` –x‑ l @lpkangk-Vhjhptlr `lpkangk. FT@ hs kilgnstk `h rhjhptlr-FT@, quh hstë hg jkgkc `h jclrl y mkjh quh hsth sh kfrk kc cchikr FT@ Kgkilgn Kgk ilgnsk sk 4 Gl hgh kjt ngtrágshjk, 2% `h rptk fnlcúinjk, gl ihghrk rhspuhstk, phrl hgh kgn`k` akylr k –x‑ Hd.4 sn thgil `lpkangk ugn`k k rhjhptlr y ch `ly kgtkilgnstk, ug kgpsnjújl, l `hspckzkrë k ck `lpkangk y gl thg`rë su kjvn`k` fnlcúinjk l Ngtlxnjkjnúg jlg FT@ `kr uakzhgnc, pq hs kgtkilgnstk. Kilgnsk Kilgns k pkrjnk pkrjnkcc4 hgh kgn`k` akylr k –x‑ y hs jkpkz `h kjvkrcl, hgh kjt ngtrágshjk, phrl ihghrk 3;22% `h rptk fnlcúinjk l Hd. jcësnjl hg psnqunktrák4 Krnpnprkzlc (r-@) Ck hc rhjhptlr `h `lpkangk kc ;22%, hc Mkc`lc `hspckzk kquh ck `lpkangk y ck`lpkangk kjvk ug kjvk 2%, l shk gl ck kjvk, y hgtrh ah`nl thghals hc Krnprnpkzlc vk k cchikr kc rhjhptlr `h `lpkangk y ck `hspckzkrk, phrl hg ugk sntukjnúg `lg`h mkyk aujmk `lpkangk, plr hd. hg hstk`l `h psnjlsns, hc Krnprnpkzlc vk jlaplrtkrsh jlal ug kgtkilgnstk Zn hc kilgnstk hstk prhshgth y `kals ug kilgnstk ki lgnstk pkrjnkc sh jlaplrtkrë jlal ug Kgtkilgnstk pq ck kjvn`k` ngtrágshjk shrë ahglr k ;22%. ;2 2%. Rhrl hg ug pkjnhgth quh gl thgik prhshgjnk `h kilgnstk, k ilgnstk, plr hdhapcl, hg ug hstk`l `h mnpl`lpkanghrink, y ch `kals Krnprnpkzlc, hc kilgnstk shrë ahglr quh kilgnstk tltkc, plr cl tkgtl, cl vk k kjvkr hg ug 82%. Zn thgákals 2%, hsh 82% hs akylr k 2, plr cl quh sh jlaplrtkrk jlal kjvkgth. Zn thgákals ;22%, hsh 82% sh jlaplrtkrë jlal kgtkilgnstk. Hc kilgnstk pkrjnkc hgh ugk kgn`k` plr hc rhjhptlr akylr kc kilgnstk, plr cl quh sá hstë hc kilgnstk cl `hspckzk, jlal hc kgtkilgnstk, phrl k `nehrhgjnk `hc kgtkilgnstk quh

 

hgh kjt. ngtrágshjk `h 2%, hc kilgnstk pkrjnkc hgh ugk kjvn`k` ngtrágshjk quh hstk hgtrh hc 2 y hc ;22%, l shk gl hs 2, puh`h shr 62, 82, htj. Rhrl kcil mkjh. Hd.4 l Ck `lpkangk mkjh ;22%. Hc Mkc`lc mkjh 2%. Hc krnpnprkzlc mkjh 82%. Hgtlgjhs sn hghs aujmk `lpkangk y `ks Krnprnpkzlc vks k fkdkr `h ug hstk`l `h ug ;22% k ug 82%. Zn hghs skturk`l jlg Mkc`lc tl`l, hghs 2% y `ks Krnprnpkzlc pkskrks `h ug 2% k ug 82%, hs ug al`uck`lr hg hsh shg`l, `hphg`hrë `hc hstk`l fkskc. l

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Rlr cl ansal hc Krnprnpkzlc, sn fnhg gl hs ug fuhg kgpsnjújl pq hgh kjvkjnúg, sn tu cl `ks hg ug hstk`l hg hc jukc mkyk aujmk kjvn`k` `h @lpkangk, hc Krnprnpkzlc ck fkdkrk. Hsl ljurrh jukg`l cl `ks hg `lsns kctks. l Rhrl sn `ks Krnprnpkzlc hg hstk`l `h pljk `lpkangk, ugk `hprhsnúg, cl `ks hg `lsns fkdks y vk k shr kjvkgth plr hsth hehjtl `h kilgnstk pkrjnkc. Hstl sh vh hg jcágnjk, hs auy naplrtkgth. l Rlr hsl Krnprnpkzlc hstë kprlfk`l hg `hprhsnúg ugnplckr y hgh hvn`hgjnk, kugquh gl hstë prlfk`l, hg `hprhsnúg fnplckr, plrquh eugjnlgk jlal kjvkgth, jlal ug kilgnstk `lpkangîrinjl. Ck kjvn`k` ngtrágshjk `hc ah`njkahgtl snhaprh hs ck ansak, hs kfslcutk, sn hs 82% snhaprh cl shrë, ck `nehrhgjnk vk shr sn hstks hg prhshgjnk `h ug kilgnstk hsh 82% hs ahglr k ug ;22%, plr cl tkgtl, hc hehjtl ghtl hs `h kgtkilgnsal. K Kcc rhvîs, sn hstks kgth ug kgtkilgnstk, hc hehjtl shrë `h kilgnsal. Uk k `hphg`hr `h hg quh sntukjnúg hstîs.

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Kilgnsk Kilgns k Ngvhrs Ngvhrsl l4 Zh ugh kc rhjhptlr y `hshgjk`hgk ug hehjtl fnlcúinjl., l shk hgh

kjt. ngtrágshjk, phrl hehjtl `hshgjk`hgk`l hs lpuhstl kc `h Kilgnstk. l Hs aës eëjnc `h hgthg`hr hg ug rhjhptlr `h FTR (r-FTR). Hc r-FTR hstk hg ug jkgkc `h jclrl, jlapuhstl plr : sufugn`k`hs, kcek, fhtk y ikak, elrakg ug plrl plr hc quh pksk hc jclrl y puh`h shr hsauck`l plr `nvhrsks jlsks. Hc ikfk hs hc kilgnstk, phrl puh`h mkfhr ltrls kilgnstks jlal cks FTR, hc LM, Rrlplelc, ltrls sh`kgths. Hsth jkgkc glrakcahgth hstk kfnhrtl, phrl sh kfrh hg ngthgsn`k` y akigntu` –x‑, ch `ks ikfk l FTR y hc jkgkc sh kfrh aës y aës ejth. Ch `ks uakzhgnc quh hs kgtkilgnstk `h FTR y jkgkc vlcvhr k su hstk`l fkskc, jlal sn gl hstuvnhrk hsauck`l plr FTR. Zn mnpltîjkahgth ch `nhrks ugk sustkgjnk quh sh pu`nhrk ugnr kc jkgkc y quh cl

l l

jhrrkrk plr jlapchtl mkrák hc hehjtl tltkcahgth lpuhstl `hc Ikfk y cks FTR, hsl sh cckak –Kilgnstk ngvhrsl‑. Gl sh uskg hg ck jcágnjk, phrl hs naplrtkgth skfhrcl. Hdhapcl jlg r-FTR (rhjhptlr kjlpck`l k jkgkc `h Jc) Kilgnstk4 FTR, mkjh quh jkgkc sh kfrk aës y aës ejth Kgtkilgnstk4 Ecuakzhgnc, mkjh quh jkgkc vuhcvk k hstk`l glrakc, jlal sn gl hstuvnhrk hsauck`l. Naplrtkgth hg ngtlxnjkjnúg. Kilgnstk pkrjnkc4 Kfhrjkgncl (gl sh usk hg jcágnjk), kjtôk jlal hsphjnh `h Krnprnpkzlc, jlg kjt ngtrágshjk ahglr k kilgnstk tltkc, phrl akylr k kgtkilgnstk. Kilgnstk ngvhrsl4 @nahcahtlxnjkrflgnc-F-jkrflcngk. @nahcahtlxnjkrflgnc-F-jkrflcngk. 

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Hc hehjtl jcágnjl, sn skfhals quh hc rhjhptlr `h jclrl hs naplrtkgth pkrk hc trktkanhgtl `h cks jrnsns jlgvucsnvks y skfhals quh cks FTR slg kgjlgvucsnvkgths. Zng ug pkjnhgth hstk jlgvucsnlgkg`l l plr kciôg alvl hgh hc uafrkc jlgvucsnvkgth fkdl y ch `ks FTR hsh pkjnhgth vk k `hdkr `h jlgvucsnlgkr, pq hc jkgkc `h Jc sh kfrh, Jc hgtrk k ck ghurlgk y ck ghurlgk sh mnphrplckrnzk, y jlal ck hpnchpsnk hs ug hstk`l `h `hsplckrnzkjnúg jllr`ngk`k, hgtlgjhs jh`hrëg jlgvucsnlghs. Zn ch `nsth FTR y `hdl `h jlgvucsnlgkr, phrl hrhs akcvk`l y ch `ks  

Ecuakzhgnc4 vlcvhrë k jlgvucsnlgkr. Hc kilgnstk pkrjnkc4 puh`h quh jlgvucsnlgh, l puh`h quh gl, pq fkdkrk `hc ;22 kc 82%, sh jlaplrtk jlal kgtkilgnstk.

Zn pjth hstk jlgvucsnlgkg`l, gl ch mhals `k`l ck FTR, y ch `kals hc Kilgnstk pkrjnkc, puh`h quh `hdh `h jlgvucsnlgkr, shrë ug hehjtl ahgls hehjvl quh Clrkzhpka. Rjth quh hgh hpnchpsnk, hgh jlgvucsnlghs ejths y ch `kals ug Kilgnstk Ngvhrsl jlgvucsnlgkrk tl`l hc rktl. Hstl hs cl quh mky quh hgthg`hr `h Kjt. Ngtrágshjk, quh mky `nehrhgths alcîjucks quh puh`hg ugnrsh k ug ansal rhjhptlr, quh hghg `nehrhgths kgn`k`hs y `nehrhgths kjts ngtrágshjks.

Al`uckjnúg Kclstîrnjk.  

Jukg`l rhjhptlr hgh aës `h ug snl `h kjjnúg @hsjrntl hg rhjhptlrhs jlg 7 ; cljus `h ugnúg, hg quh ugl `h hccls rhiuck ck kjjnúg `h ltrl. Hd.4 l Jkgkc `h Jc, hc kilgnstk gkturkc hs hc IKFK. Zh ch cckak jkgkc `h jclrl kjlpck`l k rhjhptlr IKFK. Rhrl tkafnîg hgh snls `h ugnúg pkrk ltrks jlsks, jlal FTR, Rrlplelc, LM, kghstîsnjls. K hstls snls `h kjjnúg quh gl slg hc prngjnpkc sh ch cckakg snls `h Al`uckjnúg Kclstîrnjk, cl quh mkjhg hs plthgjnkr hc hehjtl. l Hd. FTR plthgjnk hehjtl `hc Ikfk, Ikfk sh ugh k jkgkc y mkjh quh sh kfrk aës y aës ejth. K hstl sh ch cckak Al`uck`lr kclstîrnjl plsnvl. Pkafnîg mky al`uck`lrhs kclstîrnjls ghikvls, quh mkjhg cl ngvhrsl. l