Colon Cancer Pa Tho Physiology

PATHOPHYSIOLOGY OF COLON CANCER

Predisposing factors: Old age, 62 years old Non-white race Family history of oropharyngeal cancer Radiation exposure

Modifiable risk factors: High-salt diet Sedentary lifestyle Alcoholism Smoking

Abnormal growth of tissue from the oropharynx

Adenomatous polyps Malignant

Benign Untreated\ignored

Aggregation of adenomatous polyps in the colon

High Malignancy

Protooncogenes are changed to oncogenes

Enlargement of tumors

Lower and upper gastrointestinal bleeding

Occult blood in stool

Abnormal cells/cancer cells grow and divide rapidly

Cancer cells proliferates in the superficial lining of the colon

Lumen obstruction

Cancer cells has grown through the wall but not the lymph nodes

Bowel Obstruction

Cancer invades the lymph nodes Constipatio n

Abdominal pain

Abdominal distention

Vomiting Metastases to distant sites, other organs such as liver, lungs

Metastases to distant sites, other organs such as liver, lungs

Multiple destruction of organs/ MODS

DEATH

High energy utilization by the cancer cells Weight loss