Ciclo de las Pentosas o Vía del Fosfogluconato

Ciclo de las Pentosas o Vía del Fosfogluconato.

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Recordemos: 

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Ciclo de las Pentosas •

•

Este Este ciclo ciclo revist reviste e especi especial al impor importan tancia cia en alguno algunoss tejido tejidos, s, como como eritro eritrocit citos, os, el tejido tejido adiposo, el cristalino y otros. Tiene dos funciones principales:  –   – 

•

•

Proporcionar NADPH para la biosíntesis reductora Proporcionar ribosa 5-fosfato para la biosíntesis de nucleótidos y ácidos nucleicos

La ener energí gía a que que se libe libera ra en el proc proces eso o no se cons conser erva va en form forma a de ATP, ATP, sino sino de equivalentes de reducción en forma de NADPH. Consta de 2 etapas:  –   – 

La Etapa oxidativa que va desde Glucosa 6 (P) a Ribulosa 5 (P) La Etapa No oxidativa que va desde Ribulosa 5 (P) a Fructosa 6 (P) + Gliceraldehído 3 (P)

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Utilidad: Producción de NADPH(H +), necesario para: •

 –

 –

•

Biosíntesis de ácidos grasos. Regeneración de glutatión:

Producción de ribosa-5-fosfato ribosa-5-fosfato para la l a biosíntesis de ácidos nucleicos:  –

 –

RNA, DNA, ATP, NADH, FAD, Coenzima A

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Ruta de las Pentosas Fosfato

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Regulación Ruta de las Pentosas fosfato/glicolisis •

Pode Podemo mos s estu estudi diar ar el me meta tabo bolilism smo o de la gluc glucos osa a 6 fo fosf sfat ato o en cuat cuatro ro situaciones diferentes: 1. Se nece necesita sita más Ribo Ribosa sa 5-fo 5-fosfat sfato o que NADP NADPH: H: Células en división rápida que necesitan Ribosa 5-fosfato para síntesis de nucleótidos precursores de DNA.

•

2.

Se

sita tant Ribo

5-fosfat 5-fo sfat

NADPH NAD PH

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