Ciclo Celular Regulacion

 

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IE]COT@E]C[2 H`h`eoui H`h`e oui @ouirrc @ouirrc Bceeiaacr Bceeiaacr Hcshi Hcshic c

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Iz` K`hmcrûe [tcvce @hcb`emrg L`s`p`et` [`h`z`r Kfristi`e Oust`vg

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T`lgs K`dcz`s Dry`e Isr`ch

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Y`pg Tglcrg K`rhgs @rich

 

KGLZHCBG[ KMN-KIKHIE@ Tcouh`e kchuh`r.

a`scs

mch

kikhg

A`ktgr A`kt gr pr prgl glgt gtgr gr mc h` litg litgsi sis s rcs rcspge pges`dhc mc quc kéhuh`s cetrce ce litgsis.

KMN0 agsa KMN0 agsagr grih ih` ` prgt prgtci cie` e`s, s, kikhie` D cs ie`ktiv`.

si sie e

@kkige mch kglphc @kkige kglphcbg bg sgdrc sgdrc sus dh`ekgs prgtikgs prgvgk` kgem kg emce ces` s`ki kiûe ûe mc krgl krgl`t `tie ie`, `, mcsi mc siet etco cor` r`ki kiûe ûe mc kudi kudicr crtt` euk eukhc` hc`rr y gro` gro`eiz eiz`ki `kiûe ûe mc fusg fusg litûtikg.

 

KGLZHCBG[ KMN-KIKHIE@ ▢

Kmn0-kikhie` D

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Kmn=-kikhie` M

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Kmn1-kikhie` M

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Kmn4-kikhie` C

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Kmn4-kikhie` @

Tcspges`dhc h` tr`esikiûe mc O4 ` A`sc L Tcspges`dhc h` tr`esikiûe mc O0 ` [

Tcspges`dhc h` tr`esikiûe mc [ ` O4

 

Zrgkcsgs sc rc`hikce kgrrckt`lc etc ZSE]G[ MC KGE]TGH

@ME eg cstc m`ð`mg.

Tcphik`kiû e mch @ME. @hiec`kiûe mc krglgsgl `s ce litgsis. Kie`s`

Zrgtcìe`s ietrìesck`s.

A`ktgrcs mc ]r`eskripki ge.

 

ZTILCT ZSE]G MC KGE]TGH 

❑ ❑

H@ ZTILCT@ QÌ@ 

Kgesistc ce h` agsagrih`kiûe mc h` prgtcìe` prgtcìe` mc rctiegdh`stgl`. Ku`emg h` prgtcìe` Td cst` fipgagsagrih`mg fipgagsagrih`mg f`kc ue kglphcbg kglphcbg kge ch C4A iefidicemghg.

❑ Ku`emg ch TD cs

agsagrih`mg pgr hgs kglphcbgs kie`s`-kik agsagrih`mg kie`s`-kikhie`, hie`, ch a`ktgr mc tr`eskripkiûe C4A 2

[c hidcr` hidcr` mch rctiegd rctiegdh`stgl` h`stgl` (Td)  [c `ktiv`  Zrglucvc h` tr`eskripkiûe mc ocecs eckcs`rigs p`r` h` rcphik`kiûe mc2 

g g 

L`tcri`h oceétikg Fistge`s

Ch kikhg kchuh`r `v`ez` mc O0 ` [ p`r` quc h` kéhuh` rcphiquc su @ME y pucm` mivimirsc ce h` a`sc L.

 

❑ @h `v`ez`r ch kikhg

kchuh`r,, h` prgtcìe` mch kchuh`r

TD2  

❑ [i

[c tgre` fipgagsagrih`mg Quchvc ` cbcrkcr su `kkiûe iefiditgri` sgdrc ch a`ktgr C4A. gkurrc lut`kiûe mch TD, ch a`ktgr C4A2

Pucm` hidrc  Ch TD picrmc h` k`p`kim`m mc kgetrgh mch 

kikhg kchuh`r  H`s kéhuh`s prghiacr`e mc l`ecr` mcskgetrgh`m`.  @p`rckce kicrtg tipg mc k`ekcrcs. 

 

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[COSEM@ QÌ@ 

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Qcriaik` ch pgsidhc m`ðg mch @ME  mch @ME , `etcs mc quc ieikic h` rcphik`kiûe ` tr`vés mc h` prgtcìe` @ prgtcìe` @]L ]L (`t`x (`t`xi`-tc i`-tch`oic h`oickt`si` kt`si` lutc lutcm). m).

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Ce k`sg mc m`ðg mch @ME  mch @ME , sc `ktiv`2 

Ch oce suprcsgr mc tulgrcs p3; tulgrcs p3; hh`l`mg ch ‘vioih`etc mch kikhg kchuh`r.“

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Zrglucvc h` tr`eskripkiûe mc p40. mc p40. Iefidc h` auekiûe mc kmn=-kikhie` M  Arce` h` tr`esikiûe mc O0 ` [. 

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] `ldiée rcouh` h` tr`eskripkiûe mc ocecs p`r` h` rcp`r`kiûe mch @ME.

 

[COSEMG ZSE]G MC KGE]TGH ❑ Tcouh`

h` tr`esikiûe mc [ ` O4

❑ Qcri Qcriaik` aik` ch prgkcsg

mc rcphik`kiûe mch @ME.

❑ Ku`emg cxistc m`ðg mch @ME, lcmi`etc

ch @ ch  @]L. ]L.

Zrglucvc h` lisl` rcm lghckuh`r quc ce h` tr`esikiûe prcvi`. kikh khie ie`` C  Iefidc h` `ktivim`m mc kmn4 ‛ki  Zrgvgk` ue` p`us` ce h` prgorcsiûe mc h` rcphik`kiûe mch @ME. ❑ Ku`emg f`y m`ðg irrcp`r`dhc mch @ME, ce h` tr`esikiûe mc [ ` O4 ch @]L2 

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Zrglucvce ocecs quc kgemukce ` h` `pgptgsis kchuh`r.

 

]CTKCT ZSE]G MC KGE]TGH ❑

Tcouh` h` tr`esikiûe mc O4 ` L.

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Kglprucd` h` rcphik`kiûe kgrrckt` mch @ME.

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Kgrrioc hgs crrgrcs ce h` sìetcsis mch @ME.

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Ce kéhuh`s EG k`ekcrgs`s `etc h` ilpgsidihim`m mc rcp`r`r ch @ME

[c iefidc h` `ktivim`m mc ch kglphcbg kmn0-kikhie` D, D, pgr h` `kkiûe mc h` kie` ki e`s` s` _cc cch. h.  [c mcticec ch kikhg kchuh`r ce O4 

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Aie`hlcetc h` kéhuh` lucrc.

 

KS@T]G ZSE]G MC KGE]TGH ❑

[c l`eiaicst` mur`etc h` lct`a`sc mc H` litgsis.

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@h ku`rtg puetg mc kgetrgh sc hg kgegkc kglg kgetrgh mch fusg. fusg.

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@scour` ch kgrrcktg `ekh`bc mc hgs krglgsgl`s `h fusg litûtikg ` tr`vés mch kcetrighg.

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Zrcvicec crrgrcs ce h` scp`r`kiûe mc h`s krglàtim`s fcrl`e`s.

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H` a`hh` ce cstc puetg mc kgetrgh ticec kgesckuceki`s or`vcs ce h` scp`r`kiûe g misyuekiûe mc hgs krglgsgl`s fcrl`e`s y scorco`kiûe ` h`s kéhuh`s fib`s.

 

Ch Zuetg mc Kgetrgh mc O4 rcouh` h` cetr`m` ` Litgsis

Mcspués mc h` sìetcsis mc @ME @ ME y rcmukir pgsidhcs crrgrcs, sc kglprucd` h` rcphik`kiûe kgrrckt` mc @ME

Zuetg mc kgetrgh O4/L @ME M`ð`mg

Kie`s`s @]L Kie`s`s @]T

Mctckt`e rglpilicetgs ce k`mce`s mc @ME

Litgsis

 

Ch kglphcbg @]L/@]T prgp`o` h` scð`h mc `hcrt`

Zrgtcìe`s lcmi`mgr`s2 DTK@LKM0-

@]L/@]T Agsagrih`e ` h`s fistge`s

Zucetc lghckuh`r2 Cetrc fistge`s

(krgl`tie`)

y Zrgtcìe`s rcp`r`mgr`s (LTE)

LTE

Tcp`r` k`mce`s mc @ME

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Zuetg mc kgetrgh O4/L •

Cvit` ir ` Litgsis si f`y m`ðg krglgsûlikg Dhgquc` h` `ktivim`m mc LZA, lcmi`etc @]L-@]T

Kie`s`s iefidce ` h`s agsa`t`s`s KMK43

@ktiv`e KMK432 kglphcbg LZA ch

 

H` tr`esikiûe O4/L (cetr`m` ` litgsis)

Z`r` ch p`sg mc O4 ` A`sc L sc rcquicrc `ktiv`kiûe mch LZA

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Agsagrih` sustr`tgs litûtikgs ([cp`r`kiûe mc kcetrgsgl` kcetrgsgl`s) s) @ktiv` cezil`s rcouh`mgr`s (Kgemces`kiûe)

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Tuptur` mc h` Cevghtur` eukhc`r 

[u `ktivim`m v` mc Zrga`sc ` Lct`a`sc

 

Aie mc O4

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Kgemcesie` I

[c k`r`ktcriz` pgr h` k`ìm` ce h`s kgekcetr`kigecs kgekcetr`kige cs mch kglphcbg LZA

Kgemcesie` II

Kgeticece Zrgtcìe`s [LK kge `ktivim`m @]Z`s` y Zrgtcìe`s eg [LK

Krglgsgl`s ieiki`e ch prgkcsg mc kgemces`kiûe (Kgemcesie` (Kgemcesie` I y II)

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Kgfcsie`s2 Zcrlitce quc h`s krglàtimcs fcrl`e`s sc l`etceo`e ueim`s

Zrgtcìe`s mch puetg mc kgetrgh mc `etca`sc (Kie`s` (Kie`s ` p;6-KF p;6-KFAT) AT)

[u `ktiv`kiûe cvit` h` kgemces`kiûe mc krglgsgl`s y h` cetr`m` ` litgsis ce prcsceki` mc cstrés

 

ZSE]G MC KGE]TGH CE LC]@A@[C

 

Ch [@K [@K ([piemhc @sscldhy Kfcknpgiet) g puetg mc kgetrgh mc lget`bc mch fusg. •

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cetr`m` ` h` a`sc L Tctr`s`r h` cetr`m` ` h` @e`a`sc f`st` quc hgs krglgsgl`s sc `hiecce ce h` ph`k` lct`aàsik`, sc gricetce dice y kge tcesiûe `mcku`m`.

 

[@K ([pie [@K ([piemhc mhc @sscldh @sscldhy y Kfcknpgiet)

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H` mcor`m`kiûe mc kikhie` D0 iefidc KMN0

ueiûe mch kga`ktgr prgtcikg mc KMK4: `ktiv`emg kglphcbg prglgtgr mc `e`a`sc/kikhgsgl` (@ZK/K)

tr`esaicrc

udikuitie`s ` h` udikuitie`s kikhie` D0 y ` scourie` Mcor`m`kiûe

Hio`s` mc udikuitie`s

scourit` sckucstr` ` h` prgtc`s` scp`r`s` hidcr`kiûe scp`r`s`, mcor`m`kiûe h` kgfcsie`

 

a`hh` ce ch `hiec`licetg krglgsûlikg

[cð`hiz`kiûe kiectgkgrg

sietctiz`r prgtcìe`s mch puetg mc kgetrgh (L@M4, DSD;, DSDT0)

mgs kglphcbgs

DSD;/DSDT0

K-L@K4/KMK4:

kglphcbg litûtikg mc kgetrgh (LKK) sckucstr` KMK4: iefidikiûe mch prgkcsg litûtikg.

 

KZK (krglgsglc Z`ssceocr kglphcx)

crrgrcs mc ueiûe mc likrgtòduhgs y kiectgkgrg Agrl`mg pgr prgtcìe`s •

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survivie`([ST) dgrc`hie`(DGT) prgtcìe` kcetrglcrik`(IEKCEZ) kcetrglcrik`(IEKCEZ) `urgr` kie`s` D(@urD)

Ocecr` h` mctckkiûe y mcscst`dihiz`kiûe mc h`s ueigecs crr`m`s, c rr`m`s, `ktiv` [@K y arce` h` litgsis.

 

Tcouh`kiûe mc h` kitgkiecsis prgkcsg mc kitgkiecsis sc ocecr` mcspués mc h` scorco`kiûe ‘prgkcsg sghg aìsikg“

gro`eiz`kiûe gro`eiz` kiûe cstruktur`h kchuh`r

auekigecs lghckuh`rcs

m`ðg g mcaikiceki`

KFN0 surkg mc scolcet`kiûe @urD

a`kihit`r h` mivisiûe

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m`ðg ce h` scorco`kiûe sc orco`kiûe krglgsûlik` rcorcsiûe mc h` kitgkiecsis dieukhc`kiûe.

 

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@ tr`vés mch hgkus mc tipg mc `p`rc`licetg Ch prgm prgmuk uktg tg TLCI TLCI pr prcv cvic icec ec tr`e tr`esk skri ripk pkiû iûe e mchh oce mc oce ILCI ILCI TC[I y ILC ILC= [O[4, ue oce cxprcs`mg t`rmc ce h` lcigsis H`s kéhuh`s sc kglprglctce ` kglphc kgl phct`r t`r h` lciût lciûtik` ik` Ocec Oc ecss SLC cb cbcr crk kce kgetr getrg gh lcmi` cmi`et etc c ch ch chcl clce cettg mc `kkiû kkiûe e ki kiss ST[ 0 Ch prgmu rgmukt ktg g mch mch oce oce ILC ILC0 cs ue` lcigs cigsis is oce oc e ILC0 ILC0 rc rcpr prili ilimg mg tc tclp lpr` r`eg eg Ch oce LCT4, sc tr`eskridc mur`etc h` litg li tgsi siss y h` lcig lcigsi siss

 

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@ktiv`kiûe y rcprcsiûe mc quie`s`s [criectfr [crie ctfrcgeie cgeie` ` quie`s` quie`s` p`r` rcprilir ch ieikig h` icrc lcigsis. Lknh t`ldiée t`ld iée scmc rcquicrc rcqu làs `mch`etc ce h` lcigsis. Kmk46 quie`s` p`r` mivisigecs eukhc`rcs. Lcnhh c Ilc4 Lcn Ilc4

 

Ce h` l`ygrì` mc hgs gro`eislgs supcrigrcs, ch prgorcsg mc h` lcigsis ce h` cspcrl`tgoéecsis t`ldiée cs kgetieug Zgr ch kgetr`rig, mur`etc h` gvgoéecsis, h`s kéhuh`s egrl`hlcetc ticece `rrcstgs ce lcigsis 0 y 4. p;= kmk4 LZA