CC1 Posttest

Clinical Chemistry Post-test Choose the best answer. 1. Pathway important in RBCs for the production of 2,3-DPG/2.3-BPG a. Hexose Monophosphate Shunt b. Pentose Phosphate Pathway c. Rapoport Luebering Pathway d. Only and b are correct e. All of the above 2. Mary collected a specimen for glucose at 7:00, forgot to process it, and left it on room temperature. She was able to process and release the result of 85 mg/dl by 10:00 10: 00 am. Which is true regarding this specimen? a. The result is 21 mg/dl less than the actual glucose level. b. The result is 6 mg/dl less than the actual glucose level. c. The result is 2 mg/dl more than the actual glucose level. d. The result is 7 mg/dl more than the actual glucose level. 3. Which is true regarding hexokinase test for glucose? a. The second reaction uses G6PD b. The measured product is NADPH c. The second reaction uses peroxidase d. Only a and b are correct e. All of the above 4. All are true of Type I Diabetes Mellitus, except: a. Ketosis prone b. Insulin resistance c. Autoimmune destruction of B cells d. insulinopenia 5. Which carbohydrate can be absorbed in the intestinal brush border? a. Maltose b. Galactose c. Lactose d. sucrose 6. Which among the enzymes may cause galactosemia? a. Galactokinase b. Galactose 1- phosphate uridyltransferase c. Uridyl diphosphate -4- epimerase d. All of the above 7. A pregnant lady is to undergo OGCT. All of the following are true of OGCT except: a. Glucose load is 75g b. Must be done 24 – 28 weeks of gestation c. Requires 2 blood collection d. Must drink glucose load within 10 minutes

Prepared by: Maria Joanne Dente

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Convert FBS = 6 mmol/L to conventional unit and interpret. a. 101 mg/dl; normal b. 108 mg/dl; high c. 108 mg/dl; normal d. 101 mg/dl; high Strict glucose-requiring organs a. Brain b. Kidneys c. Muscle d. Liver All are true of glycated haemoglobin test except: a. Measured using chromatography b. Not applicable for patient with hemoglobinopathies c. For glucose measurement 2 -3 months prior to testing d. Uses serum as specimen In anaerobic glycolysis, what is the final product of the reaction? a. Pyruvate b. Lactate c. Acetyl coA d. NADPH Na-dependent glucose transporters transport a. Glucose b. Galactose c. Fructose d. A and B only e. All of the above All of these hormones are gluconeogenic, except: a. Epinephrine b. ACTH c. Thyroxine d. Growth Hormone The following is true regarding Na Fluoride tube, except: a. It is placed in gray top container b. Plasma is collected c. Na Fluoride is the antiglycolytic agent d. Na Fluoride is the anticoagulant WHO criteria for being classified as diabetic. a. FBS ≥ 110 mg/dl; 2hr post glucose load ≤ 200 g/dl b. FBS ≥ 126 mg/dl; 2hr post glucose load ≥ 200 mg/dl c. FBS ≤ 126 mg/dl; 2hr post glucose load ≥ 200 mg/dl d. FBS ≥ 126 mg/dl; 2hr post glucose load ≤ 200 mg/dl

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Clinical Chemistry Post-test 16. Which of the following is considered a cause of post-renal azotemia? a. Shock b. Tubular necrosis c. Prostatic tumor d. Nephritis

c. d. 27.

For numbers 17 – 20, match column A with column B. Column A 17. 0.357 18. 88.4 19. 0.0595 20. 0.0555

Column B a. Creatinine b. Uric acid c. Urea d. Glucose

Multiple choice. 21. In the Fearon test for urea, what are th e additives that may be used to intensify color reaction? a. Ferric ion b. Na Carbonate c. Thiosemicarbazide d. A and C only e. All of the above 22. What is the major NPN, end product of protein catabolism? a. Uric Acid b. Urea c. Creatinine d. Ammonia 23. A defect in uric acid metabolism where there is hyperuricemia and a deposition of urate crystals in the joints. a. Lesch Nyhan Syndrome b. Fanconi’s Syndrome c. Tophi d. Gout 24. Enzymatic Uricase method for uric acid m easures uric acid at what wavelength? a. 500 – 550 nm b. 440 – 460 nm c. 293 nm d. None of the above 25. What reagent is used in Jaffe reaction? a. Alkaline Picrate solution b. Janovsky complex c. Na aluminum silicate d. Magnesium aluminum silicate 26. Which is true regarding ammonia measurement? a. The patient is required to fast for 8 hours b. Plasma collected may be stored in room temperature

Prepared by: Maria Joanne Dente

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Heparinized plasma on ice as specimen The specimen need not be centrifuged immediately. What is used as indicator i n creatininase enzymatic reaction for creatinine measurement? a. Benzoquinone amine b. Tungsten Blue c. Diazine d. Nitroprusside What is an interference for o-phthaldehyde measure for urea? a. Bilirubin b. Ascorbic acid c. Sulfa drugs d. A and B only e. None of the above Which of the following are hormone secretions of the kidneys? a. Erythropoietin b. Angiotensin c. ADH d. Aldosterone The reference method for the measurement of urea? a. Fearon b. Mass Spectrometry c. Nesslerization d. Berthelot Responsible for the transport of lipids in the body? a. Apolipoprotein b. Lipoprotein c. Albumin d. None of the above Type of lipid formed from a glycerol backbone and 2 fatty acids a. Phospholipid b. Fatty acid c. Triglyceride d. Cholesterol

For 33 – 37, match column A with column B. Column A 33. Transport endogenous triglyceride 34. Transport triglyceride from liver to extrahepatic tissues 35. Highly atherogenic 36. Creamy floating

Column B a. VLDL

b.

Lp(a)

c. d.

LDL HDL

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Clinical Chemistry Post-test layer in plasma 37. With the most abundant protein

38. 39. 40. 41.

e.

Chylomicrons

For numbers 38 – 41, use the following choices: a. LDL b. VLDL c. Both LDL and VLDL d. Chylomicrons Which is elevated in Type IV hyperlipoproteinemia? Which is elevated in Type I hyperlipoproteinemia? In type IIb hyperlipoproteinemia, which is not elevated? Type IV hyperlipoproteinemia presents with turbid plasma, which is the lipoprotein elevated?

For numbers 47-50, match column A with column B. Column A 47. Apo B-100 48. Apo B-48, Apo A-IV 49. Apo B-48, Apo B-100 50. Apo E

Column B a. Type III b. Type I c.

Type IIa

d.

Type V

Multiple Choice 42. Normal value for triglyceride? a. ≥60 mg/dl b.