Case Study (Lung Cancer)

 

 FCI 180 S[ =8=8-=8=1

Ufkgf Cjrkstkaf Cgbbene Scjggb g` Jeabtj afl Sckefces Ckty g` Saf @erfaflg Ba Ufkgf

Case Stuly4 Cafcer g` tje Bufn

Sumikttel my4 Ace a, Dgmebbe C.

 

 FCI 180 S[ =8=8-=8=1

K. Kftrgluctkgf

Bufn cafcer ks a teri tg lescrkme a fuimer g` iabknfafckes tjat caf gccur afywjere wktjkf wkt jkf tje respkr respkratg atgry ry systei systei.. Bufn Bufn cafcer cafcer ks kfktka kfktkabby bby cbassk cbassk`ke `kel l kft kftg g twg types types masel masel gf jkstgb jks tgbgnk gnkcab cab cjaract cjaracterk erkstk stkcs4 cs4 siabb siabb cebb cebb bufn bufn cafcer cafcer (SCBC) (SCBC) afl fgf-sia fgf-siabb bb cebb cebb bufn bufn cafcer  cafcer  (FSCBC). \jese = types are treatel lk``ereftby. FSCBC caf tjef me `urtjer sumlkvklel kftg alefgca ale fgcarck rckfgi fgia, a, squaig squaigus us cebb cebb carckf carckfgia gia afl barne barne cebb cebb carckf carckfgia. gia. FSCBC FSCBC ks tje igst igst cgiigf type g` bufn cafcer afl ks respgfskmbe `gr apprgxkiateby :8% g` abb bufn cafcers. Kt igst g`tef menkfs kf tje mrgfcjk afl tje siabber akrways. Siabb cebb bufn cafcer ks respgfskmbe `gr tje reiakfkfn =8% g` abb bufn cafcers afl neferabby neferabby menkfs kf tje igre ceftrab bgcatkgfs bgcatkgfs g`  tje bufn.

Bufn cafcer caf absg me cbassk`kel kftg prkiary afl secgflary `gris. Xrkiary bufn cafcer grknkfates kf tje bufn, wjkbe secgflary bufn cafcer ks a fegpbastkc beskgf tjat jas meef lepgsktel kf tje bufn `rgi a lkstaft bgcatkgf vka ektjer tje byipjatkc gr vascubar systei. Sigokfn ks a iadgr cause g` bufn cafcer. Gtjer `actgrs tjat kfcrease tje rkso g` bufn cafcer caf cer kfcbul kfcbulee a nefetk nefetkcc prelks prelkspgs pgsktk ktkgf gf afl expgsur expgsuree tg carckf carckfgne gnefkc fkc sumst sumstafce afces, s, sucj sucj as asmestgs. asmest gs. A lgse-r lgse-reba ebatkg tkgfsj fsjkp kp exksts exksts metwee metweef f tje expgsu expgsure re tg kfjabe kfjabel l carckf carckfgne gnefs fs afl tje levebgpieft g` bufn cafcer. Af kflkvkluab‛s rkso g` levebgpkfn bufn cafcer ks sknfk`kcaftby kfcreasel my af earbker ane g` startkfn tg sigoe cknarettes, tje igre `requeftby cknarettes are sigoel kf a weeo afl tje fuimer g` years g` sigokfn cknarettes. Sigoers caf jave a rkso g`  levebgpkfn bufn cafcer g` up tg =5 tkies tjat g` a fgf-sigoer. ^gief appear tg jave af kfcreasel rkso cgiparel tg ief afl requkre bess expgsure tg levebgp bufn cafcer. Carckfgias g` tje bufn gccur as a resubt g` lksgrlerel cebb nrgwtj afl a `akbure g` tje fgriab fgr iab kiiuf kiiufee survek survekbba bbafce fce systei systeiss perikt perikttkf tkfn n nrgwtj nrgwtj g` amfgria amfgriabb cebbs cebbs kf tje mrgfcj mrgfcjk, k,  mrgfcjkgbes afl/gr abvegbk tg iutate afl prgbk`erate. \je prgtg-gfcgnefes (nefes tjat, wjef iutatel, jave tje pgteftkab g` mecgikfn af gfcgnefe afl cgftrkmutkfn tg cafcer levebgpieft) tjgunjt tg me kfvgbvel kf bufn cafcer levebgpieft kfcbule O-ras afl c-Iyc. O-ras ks kipgrtaft `gr tje prgigtkgf g` cebb nrgwtj afl prgbk`eratkgf, wjkbe c-Iyc ks kipgrtaft `gr LFA syftjesks, cebb cycbe renubatkgf, prgbk`eratkgf afl tje kfluctkgf apgptgsks. \uigur suppressgr nefes, sucj as p53, cgftrgb cgftrgb fegpbastkc fegpbastkc cebb `griatkgf `griatkgf afl iafane cebb sefescefce. sefescefce. Epkleriab Epkleriab nrgwtj `actgr 

 

 FCI 180 S[ =8=8-=8=1

receptgrs kf`buefce receptgrs kf`buefce prgbk`erat prgbk`eratkgf, kgf, lk``ereftk lk``ereftkatkgf atkgf afl apgptgsks. apgptgsks. Pascubar Pascubar eflgtjebkab eflgtjebkab nrgwtj nrgwtj `actgrs kf`buefce tuigur afnkgnefesks. Iutatkgfs kf afl gr abb g` tjese nefes, receptgrs afl `actgrs iay cgftrkmute tg tuigur nrgwtj. \je cbkfkcab iafk`estatkgfs g` bufn cafcer caf me lkvklel kftg bgcab afl renkgfab e``ects. Cgiigf bgcab e``ects kfcbule cjest pakf, cgunj, lyspfea afl jeigptysks. ]enkgfab e``ects kfcbule fuiergus cgipbkcatkgfs, wjkcj caf me lkvklel kftg ietamgbkc, parafegpbastkc, eflgcrkfe, jaeiatgbgnkcab, feurgbgnkcab afl refab.

KK. Afatgiy afl Xjyskgbgny

Juiaf bufns are twg spgfny grnafs bgcatel gf eacj skle g` tje jeart. Lurkfn kfjabatkgf, akr `bgws `rgi tje fgse gr igutj tjrgunj tje pjaryfx (tjrgat) afl baryfx (wjkcj cgftakf tje vgcab cgrls) kftg tje tracjea (wkfl pkpe). \je tracjea lkvkles kftg twg mrgfcjk, wjkcj lkrect akr  kftg tje rknjt afl be`t bufns. ^ktjkf tje bufns, tje mrgfcjk lkvkle kftg severab siabber mrgfcjkgbes. Akr `bgws `rgi  mrgfcjkgbes kftg tkfy akr sacs, cabbel abvegbk. A nrgup g` abvegbk a bvegbk ks re`errel tg as a bgmube. Bgmubes Bgm ubes are, kf turf, nrgupel kftg bgmes. \je be`t bufn cgftakfs twg bgmes, wjereas tje rknjt cgftakfs tjree.

A fetwgro g` tkfy mbggl vessebs, cabbel capkbbarkes, surrgufls tje abvegbk. \je bkfkfn g`  tjese mbggl vessebs ks sg tjkf tjat gxynef afl carmgf lkgxkle lkgxkle caf igve metweef metweef tje capkbbarkes capkbbarkes afl tje abvegbk. Carmgf lkgxkle lk``uses `rgi tje capkbbarkes kftg tje abvegbk afl ks rebeasel `rgi tje mgly lurkfn exjabatkgf. Gxynef lk``uses kf tje gppgskte lkrectkgf, `rgi tje abvegbk kftg tje  mbggl, afl ks carrkel tjrgunjgut tje mgly my tje ckrcubatgry systei. Igst bufn cafcers menkf kf epktjebkab cebbs bkfkfn tje mrgfcjk. Cafcers tjat levebgp kf epktjebkab cebbs are ofgwf as carckfgias.

 

 FCI 180 S[ =8=8-=8=1

KKK. Xatjgpjyskgbgny

Xreckpktatkfn @actgrs Xrelkspgskfn @actgrs

 

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Ane

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Jkstgry g` Cafcer  

\gmaccg sigokfn @requeft expgsure tg secgfljafl sigoe Gccupatkgfab expgsures tg certakf wgropbace tgxkfs (asmestgs, ralgf, arsefkc, cjrgikui)

Kfjabel carckfgnef

Skfnbe trafs`griel epktjebkab cebb kf tracjegmrgfcjkab akrway

Carckfgnefs mkfls tg afl laianes tje cebb‛s LFA

Cebbubar cjafnes, amfgriab cebb nrgwtj, afl a iabknfaft cebb

Xasskfn g` laianel LFA tg launjter launj ter cebbs

Ufstambe LFA

Iabknfaft trafs`griatkgf g` pubigfary epktjebkui

Kfvaskve carckfgia

Mrgfcjkab tumes

Xbeura

Gmstructkve beskgf

@bukl mukbl-up

Iucgsab ubceratkgf afl rupture g`   mbggl vessebs

Xressure kf tje bufn

Bufn caffgt `ubby expafl Jeigptysks

Lyspfea  

 FCI 180 S[ =8=8-=8=1

KP. Bamgratgry afl Lkanfgstkc \ests CGIXBE\E MBGGL CGUF\ AFL SE]UI CJEIKS\]KES

Jeignbgmkf (Jnm)

]el Mbggl Cebb (]MC)

Xbatebets

]e`erefce ]afne Iabes4 13 – 1: n/lB @eiabes4 1= – 10 n/lB

Kfterpretatkgf Lecr Le crea ease sel l kf va vark rkgu guss af afei eika kas, s, pr pren enfa fafcy fcy,, se seve vere re gr pr prgb gbgf gfne nel l je jeig igrr rrja jane ne af afl l wk wktj tj excesskve `bukl kftaoe

Kfcreasel Kfcrea sel kf pgbycyt pgbycytjei jeika, ka, CGXL, CGXL, `akbur `akburee g`  gxynefatkgf mecause g` CJ@, afl fgriabby kf  pegpbe bkvkfn at jknj abtktules I4