Cancer Epidemiology and Pediatric Neoplasia p1-10

Epidemiology, Predispositions and Clinical Course of Cancer Learning Objectives 1. US risk and relative rank of cancer. 2. 3 most common cancer sites in men and women, mortality trends. 3. 3 patterns genetic risk and examples. 4. 4 categories of paraneoplastic syndrome. 5. Tumor stage and grade, and explain which is more important clinically.

Mon. 10/11/10 In this period we’ll answer 3 questions: Who gets cancer and what types? Are there patterns of genetic predisposition to getting cancer? And how do we predict how bad a particular case of cancer will be?

Caption: Our goal with this lecture is to equip you to answer 5 questions, which are chosen for their clinical relevance and likelihood of helping you in clinical rotations, The first is, “What is the risk of getting or dying from cancer in the US, and where does that rank among major causes of mortality?”

US Cancer Overall • 1 in 4 chance of cancer death (23%) – 1500 deaths per day – males have 1 in 2 chance of getting CA (44%) – females have 1 in 3 chance of getting CA (38%) – survival rates improved significantly since 1974 for all body sites (SEER P