Board Questions in Pharmacology

BOARD QUESTIONS IN PHARMACOLOGY Questions

Answer A

Reference Goodman and Gilman 10th ed p.488

MPL 1.0

An anti-malarial agent which also exerts an amebicidal effect Chloroquine C. Primaquine Chloroguanide D. Mefloquine

A

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An anti-arrhythmic drug that predominantly block the slow calcium channels Verapamil C. Lidocaine Amiodarone D. Metoprolol Repeated exposure to which of the following anesthetic agents is most associated with liver damage A. Isoflurane C. Nitrous oxide B. Halothane D. Enflurane 5. The pharmacokinetic parameter which determines the speed of drug input that must balance the speed of drug elimination to achieve a steady state concentration clearance C. dosing rate bioavailability D. volume of distribution

A

If a drug has a high distribution volume, it indicates that: it is highly bound to plasma proteins drug is highly retained in the vascular compartment the plasma drug concentration will increase there is extensive tissue uptake

D

In what condition are the drugs phenoxybenzamine and phentolamine useful? pheochromocytoma C. essential hypertension migraine attacks D. benign prostatic hyperplasia

A

A college friend consulted you regarding the suitability of the therapy his doctor prescribed for severe hypertension. He complained of postural and exercise hypotension (“dizziness”), diarrhea and problems with ejaculation. Which of the following is most likely to produce the effects that your friend has described? Propanolol C. Hydralazine Guanethidine D. Captopril Norpepinephrine acts as a neurotransmitter at: all preganglionic neurons parasympathetic postganglionic neurons sympathetic postganglionic neurons neuromuscular junction

B

Goodman and Gilman 10th ed p.1084 Goodman and Gilman 10th ed p.949 Goodman and Gilman 10th ed p.351-352 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.34-41 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.35 & 47 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.144-146 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.166

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In the treatment of organophosphate poisoning, the mechanism of action of pralidoxime is: competitive inhibition with acetylcholine non-competitive antagonism with acetylcholine regeneration of acetylcholine regeneration of acetylcholinesterase A patient was given digitalis for heart failure, complained of nausea, vomiting, and diarrhea. PE revealed irregular cardiac rhythm. Which of the following is the most appropriate thing to do? increase the dose of digitalis

D

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.145 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.103 Basic and Clinical Pharmacol ogy 9th Ed. Katzung

Extrapyramidal adverse effect is commonly seen with the use of this antipsychotic agent: Haloperidol C. Chlorpromazine Thioridazine D. Fluoxetine

B

C

C

C

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add a beta-blocker discontinue digitalis administer potassium A 52 year old man consulted at the clinic due to hypertension (BP 190/90). Except for mild wheezing, his PE findings were unremarkable. The drug given can depress AV conduction, hence the use of beta-blocker is contraindicated. The drug that was given is: Methyldopa C. Verapamil Enalapril D. Hydrochlorothiazide A patient noted to have elevated cholesterol, LDL, and VLDL. Which among the following drugs act by blocking HMG-CoA reductase to inhibit cholesterol synthesis? Probucol C. Lovastatin Clofibrate D. Nicotinic acid A 20 year old female was treated for endometriosis for 6 months. She claims to have been given a drug with androgenic effects such as hirsutism, deepening of the voice, and acne. Which of the following drugs could have been given? GnRH agonist Combined oral contraceptive pills Danazol Medroxyprogesterone acetate A patient underwent hip replacement and was given morphine for pain relief. At present her RR was noted to be at 8 cycles/min with prolonged episodes of apnea. What will you give this patient to reverse the present condition? atropine sulfate C. Naloxone Flumazenil D. Protamine sulfate A 7-year old was admitted because of pneumonia. On routine stool exam E. histolytica cyst 5-8/hpf was noted. What will you give? Diloxanide furoate C. both A& B metronidazole D. no treatment necessary A patient with septic shock was noted to have absent urine output for the past 12 hours. Which of the following drugs would be most helpful to this patient? A. Furosemide C. Dopamine B. Norpeinephrine D. Epinephrine A 40 year old male was seen at the ER because of anaphylaxis immediately given epinephrine. Apparently, the patient has taken prazosin for his hypertension. Which of the following may be observed in this patient? He may develop hypertensive crisis. There will be no effect on his blood pressure He may develop hypotension. he may develop severe difficulty of breathing due to bronchoconstriction Two drugs A and B have the same mechanism of action. Drug A at a dose of 5 mg produce the same magnitude of effect as drug B at a dose of 500 mg. This means that drug B is less efficacious than drug A drug A is 100x more potent than drug B toxicity of drug A is less than that of drug B drug A is more effective than drug B

p.993 C

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.235-236

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C

Goodman and Gilman 8th ed p.881-884

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C

Pharmacology 4th ed page 447

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C

Pharmacology 4th ed Rang Page 598

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A

Pharmacology 4th ed Rang Page 736

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C

Pharmacology 4th ed Rang Page 288

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C

Pharmacology 4th ed Rang Page 152

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B

Pharmacology 4th ed Rang Page 29

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A diabetic patient developed hyperlipedemia (elevated LDL, and triglycerides, normal HDL). Which of the following is least appropriate for the patient? Colestipol C. Lovastatin Gemfibrozil D. Niacin A patient with tachyarrhythmia and hypertension would be given an antihypertensive. What agent would be the best choice for this patient? Felodipine C. Nifedipine Isradipine D. Verapamil Which of the following conditions will NOT benefit from the use of vasodilators? hypertension C. angina migraine D. peripheral vascular disease A patient at the delivery room is having uterine atony after giving birth toan 8-lb baby boy. Her BP at present is 150/90 mmHg. What agent should you give her: methyergonovine maleate oxytocin carboprost ergometrine The 2nd generation cephalosporin which crosses the blood brain barrier: Cefoxime C. Cefoxitin Cefuroxime D. Cefoperazone A G2 P1 term, will be given prophylactic antibiotic prior to CS. Which of the following should be recommended? Cephalexin C. Cefazolin B. Cefoxitin D. Ceftriaxone After prolonged treatment with penicillin, the patient developed pseudomembranous colitis. What antibiotic will you give for this case? Aztreonam C. Imipenem Ceftriazone D. Vancomycin This agent inhibits topoisomerase II (DNA gyrase) Clindamycin C. Spectinomycin Ciprofloxacin D. Tetracycline

D

Pharmacology 4th ed Rang Page 308

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D

Pharmacology 4th ed Rang Page 275

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B

Pharmacology 4th ed Rang Page 290 Pharmacology 4th ed Rang Page 450

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Pharmacology 4th ed Rang Page 694 Pharmacology 4th ed Rang Page 695 Pharmacology 4th ed Rang Page 702

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A neonate was given IV antibiotics for 3 days. However, the baby developed hypothermia, diarrhea and grayish color of the skin. The baby was probably given: Amikacin C. Chloramphenicol Erythromycin D. Gentamycin The purpose of giving compound drug therapy in the treatment of tuberculosis: to rapidly eradicate the strains of tubercle bacilli to shorten the infectious phase to decrease the emergence of resistant organisms to prevent complications of tuberculosis Which of the following is NOT a first line agent in the treatment of tuberculosis? A. Ethambutol C. Rifampicin B. Pyrazinamide D. Streptomycin 32.A patient taking warfarin was also being treated for fungal infection. After 7 days,the patient developed epistaxis. Which of the following antifungal agents was given? A.Nystatin C.Flucytosine B.Ketoconazole D.Amphotericin B

C

Pharmacology 4th ed Rang Page 720 Pharmacology 4th ed Rang Page 692

C

Pharmacology 4th ed Rang Page 706

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D

Pharmacology 4th ed Rang Page 706 Pharmacology 4th ed Rang Page 317

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B

B

C

D

B

B

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33.If the physician makes a prescription order that utilizes a drug supplied by the pharmaceutical company, what class of prescription order was made? A.Extemporaneous C.Precompounded B.Compounded D.Erroneous 34. Which among these antithrombotic drugs inhibit the synthesis of thromboxane by irreversible acetylation of the enzyme cyclooxygenase? A. Abciximab C. Integrilin B. Aspirin D. Ticlopidine

C

Generics Acts of the Philippines

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Pharmacology Goodman and Gilman 10th ed. Pp 1534 Pharmacology 4th ed Rang Page 316

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35. A 60 year old was seen at the OPD due to epistaxis which occurred thrice for the past week and easy bruising. He is taking warfarin for AF. Perinent Lab exam: INR-4.5 The INR result is brought about by which of the following? A.increased thrombin activity B.decreased platelet activity C.diminished levels of vitamin K D.decreased levels of factors II, VII,IX and X 36. A 67 year old with atrial fibrillation is currently taking warfarin and digoxin. In the event this patient develops massive bleeding, which of the following would be appropriate for him? A.give vitamin K B.change to LMWH C.give protamine sulfate D.transfuse platelets 37.A 26 year old medical student was brought to the ER for an apparent suicide poisoning due to a broken heart. The maid could not recall the medication but claimed the bottle contained medicine for headache. On PE, the physician noted cyanosis of the oral mucosal, tongue and nail beds. Which of the following is the drug most likely ingested? A.Aspirin C.Flurbiprofen B.Acetaminophen D.Meloxicam 38.A 52 year old woman was suffering from severe joint pains and was diagnosed to have Rheumatoid Arthritis. Apparently, she also appears to be suffering from acid peptic disease. Among the following, which is the safest to give her? A.Aspirin C.Celecoxib B.Ibuprofen D.Phenylbutazone 39.A 21 year old male, took a bottle of insecticide from their garden approximately 30-40 cc in amount. He later developed dizziness, visual blurring, generalized body weakness, numbness, severe epigastric pain and shortness of breath. He was found lying on the floor with stiffening of the trunk and extremities and soaked with sweat. He was rushed to the ER, pertinent findings included drooling of saliva with 3 episodes of non projectile vomiting. Which of the following should be given? A.Pilocarpine C.Atropine D.Physostigmine D.Carbachol 40.This inhibits de novo synthesis of cholesterol by inhibiting HMG CoA reductaseA.Atorvastatin C.Gemfribozil B.Colestipol D.Niacin 41.An asthmatic patient came to the ER because of generalized wheezing in the lungs. Urgent management was done. However, after a while, hypertension was noted. Which of the following medications was probably given? A.salbutamol C.terbutaline B.isoproterenol D.salmeterol

D

A

Pharmacology 4th ed Rang Page 319

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B

Pharmacology 4th ed Rang Page 232

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C

Pharmacology 4th ed Rang Page 234

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C

Pharmacology 4th ed Rang Page 122

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A

Pharmacology 4th ed Rang Page 305 Pharmacology 4th ed Rang Page 160

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B

B

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42.A flight attendant has been having allergic rhinitis. She comes to your clinic asking for medication prescription two hours prior to her flight. What will be appropriate for her? A.diphenhydramine C.loratadine B.chlorpheniramine D.promethazine 43.This acts by inhibiting the immediate phase of asthma as it prevents mediator release from mast cellsA.cromolyn sodium C.montelukast B.beclomethasone D.zileuton 44.A patient with severe persistent asthma was treated for six months now with prednisone. Which of the following would be the expected side effect. A.cushingoid facie C.hyperkalemia B.hypoglycemia D.leonine facie 45.FM, 40 year old male was seen at the clinic for check-up. He has bradykinesia, muscle rigidity, pill rolling movement, resting tremors and shuffling gait. The single most effective agent in the treatment of this disorder is: A. Levodopa C. Carbamazepine B. Baclofen D. Tacrine 46. Which of the following is a selective inhibitor of MAO-B? A. Selegeline C. Tolcapone B. Amantadine D. Bromocriptine

C

Pharmacology 4th ed Rang Page 345

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A

Pharmacology 4th ed Rang Page 347 Pharmacology 4th ed Rang Page 423

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A

Pharmacology 4th ed Rang Page 509

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A

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47. Which of the following statement is NOT true regarding Levodopa? A. It is almost always used in combination with decarboxylase inhibitors. B. It has a short half-life about 1 – 3 hrs. C. If administered with meals, its absorption is delayed. D. It has very little side effect and can be withdrawn abruptly. 48. What effect does the use of oral contraceptive (OC) have on a patient with hypothyroidism? A. Low dose OC are unlikely to affect her thyroid function tests. B. Estrogen may falsely increase TSH due to alteration in TSH secretion. C. Estrogen may falsely decrease FT4 index due to alterations in TBG D. Estrogen may falsely elevate total T4 levels due to alterations in TBG 49. If a hypothyroid patient pregnant, how might her levothyroxine replacement be affected? A. She might require an increase in dose. B. She may need a decrease in dose. C. She may need to stop the medication. D. She may have to change levothyroxine to liothyronine. 50. A 62 year old with atrial fibrillation was seen at the ER with light headedness and palpitations associated with exercise usually relieved by rest. At present his heart rate is at 140/min. Which of the following is least likely effective in controlling his heart rate? A. Digoxin C. Verapamil B. Diltiazem D. Atenolol

D

Pharmacology 4th ed Rang Page 511 Pharmacology 4th ed Rang Page 510

C

Pharmacology 4th ed Rang Page 630

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A

Basic and clinical Pharmacol ogy 9th Edition Katzung p 631 Pharmacology 4th ed Rang Page 265

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A

A

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51. Patients receiving insulin therapy generally require which of the following interventions with progression to end-stage renal disease? A. decrease total insulin dose B. increase total insulin dose C. increase frequency of insulin administration D. no change in insulin regimen 52. The inhibitor of GIT lipase is useful in the treatment of obesity and has minimal side effects: A. sibutramine C. orlistat B. phentermine D. glucosan 53. An experiment on GI drugs was done. The baseline gastric volume 2 cc and when tested with litmus paper, The paper remained pink. After administering drug A, the gastric volume was 2 cc and litmus paper turned blue. This means A. drug A is effective in lowering gastric pH B. drug A is effective in increasing gastric pH but no effect on volume C. The drug is effective in lowering the gastric pH and volume D. The drug has no effect on the volume and pH of gastric juice 54.A patient taking this drug came into the clinic due to visual disturbances, constipation, difficulty in urination and dry mouth. This drug could be: A.Muscarinic antagonist B.histamine H2 antagonist C.dopamine D2 antagonist D.gastrin antagonist 55.The onset and duration of action of NPH insulin are extended because: A.protamine decreases the rate at which insulin is absorbed B.protamine blocks insulin metabolism in the liver C.protamine is basic and combines with insulin by charge interactions D.protamine is slowly degraded proteolytically releasing the bound insulin 56. An estrogen receptor antagonist which is useful for postmenopausal breast cancer A. Megastrol C. Flutamide B. Tamoxifen D. Leuprolide

A

Basic and clinical Pharmacol ogy 9th Edition Katzung p 694 Pharmacology 4th ed Rang Page 407 Pharmacology 4th ed Rang Page 375

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A

Pharmacology 4th ed Rang Page 122

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B

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.697

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B

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.679 Pharmacology 5th ed Rang Page 388 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.362 Pharmacology 5th ed Rang Page 257

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57. The agent of choice in the treatment of gestational diabetes A. Sulfonylurea C. Insulin B. Biguanide D. Acarbose 58. A 40 year old bank executive sought consult due to a difficulty of going to sleep but no problem in maintaining sleep. He stopped drinking coffee, eating chocolates, and smoking a month ago. The most appropriate drug for him is: A. Diphenhydramine C. Phenobarbital B. Midazolam D. Clonazepam 59. A kidney transplant patient is given a drug for immunosuppression to prevent rejection of the allografted organ. The drug is most likely A. Cyclosprine C. Cyclophosphamide B. Azathioprine D. Vincristine

C

C

B

B

B

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0.33

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60. The preferred treatment for a patient who suffers a series without complete recovery is: A. Diazepam C. Succinylcholine B. Chlopromazine D. Ethosuximide

D

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.391 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.266 Pharmacology 5th ed Rang Page 375

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61. A company manager is suffering from allergic rhinitis. He has a series of staff meeting so he needs a medication that will not make him drowsy. Which of the following would you give? A. Chlorpheniramine C. Terfenadine B. Hydroxyzine D. Diphenhydramine 62. A patient with severe liver disease eventually developed encephalopathy. Which agent is important in the therapy of this condition? A. Lactulose C. Loperamide B. Lactate D. Lorazepam 63. A substance that enhances the probability of ovulation by blocking the inhibitory effect of estrogen and thus stimulating the release of gonadotrophin from the pituitary is: A. Clomiphene citrate C. Tamoxifen B. Danazol D. Progesterone

C

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.681 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.249 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.242

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64. Which of the following combination (diuretic agent and MOA) is CORRECT? A. Furosemide – inhibition of carbonic anhydrase B. Acetazolamide – osmotic effect C. Hydrochlorothiazide – inhibition of Na-Cl symport D. Indapamide – inhibition of Na-K-2Cl symport 65. Which of the following combination of diuretic and site of action on the nephron is CORRECT? A. Ethacrynic acid – thick ascending limb of loop of Henle B. Furosemide – proximal tubule C. Hydrochlorothiazide – late distal tubule D. Spironolactone – distal convoluted tubule 66. Which of the following is preferred for a pregnant woman with hyperthyroidism? A. Carbimazole C. RAI B. Methimazole D. PTU

C

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.632 Goodman and Gilman 8th ed p 53-54

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67. Drugs A and B act on the same tissue or organ through independent receptors, but with opposite effects. This is known as: A. Competitive antagonism B. Irreversible antagonism C. Physiologic antagonism D. Chemical antagonism 68. This pharmacokinetic value most reliably reflects the amount of drug reaching the target tissue after oral administration A. Volume of distribution B. Area under the blood concentration-time curve C. Peak blood concentration D. Time to peak blood concentration 69. A 3 year old patient passed out noodle-like worms and was given an appropriate anti-helminthic. The mechanism of the drug is most probably via A. interference with cell wall synthesis B. inhibition of neuromuscular transmission C. interference with cell wall division D. interference with protein synthesis

C

B

Goodman and gilman 8th edition Pp2627

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B

Goodman and gilman 8th edition pp. 969970

0.5

A

A

A

D

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70. A patient with nosocomial pneumonia is given ceftazidime and another antibiotic. The most probabale purpose for adding the second antiobiotic is to: Increase renal excretion Decrease systemic toxicity Increase oral absorption Prevent the emergence of resistant bacteria 71. About 75% of patients in this condition may suffer from vertigo, inability to perceive termination of movement and difficulty in sitting or standing without visual clues Patients allergic to penicillin Patients receiving streptomycin therapy Patients on isoniazid for tuberculosis Patients on amphotericin B 72. A kidney transplant patient is given a drug for immunosuppression to prevent rejection of the allografted organ. The most appropriate drug is: Cyclosporine Azathioprine Cyclophosphamide Vincristine 73. A hypertensive patient is treated by a doctor and experiences hemolytic anemia with a positive Coomb’s test. This is most likely caused by: A. Clonidine C. Methyldopa B. Captopril D. Prazosin 74. In a hypertensive patient who is taking insulin to treat diabetes, which of the following drugs should be used with caution? Propanolol C. Hydralazine Methyldopa D. Prazosin 75. A patient has been taking Imipramine for depression. He would most likely experience which of the following adverse effects? Seizures C. hepatotxicity anticholinergic effects D. nephrotoxicity 76. Chlorpromazine may be used not only in treating schizophrenia but is also effective in reducing nausea and vomiting as an antihistaminic as an antihypertensive agent for treating bipolar affective disorder 77. A child suffers from lapses of consciousness or vacant stares lasting about 10 secs, often in clusters. The drug which may be most helpful for his disorder is: Phenytoin C. Ethosuximide Carbamazepine D. Phenobarbital 78. Upon taking Penicillin, a patient suddenly experiences respiratory distress and circulatory collapse. Which drug would be most helpful in this situation? Norepinephrine C. Isoproterenol Epinephrine D. Atropine 79. A gout patient developed nephropathy characterized by overproduction of uric acid and extreme hyperuricemia. What agent could have helped prevent this? Cyclophosphamide C. Sodium chloride Allopurinol D. Antidiuretic hormone 80. A patient with peptic ulcer and on therapy with cimetidine may experience decreased effects of many other drugs because cimetidine is an inhibitor of A. the proton pump C. monoamine oxidase

D

Goodman and gilman 8th edition Pp1127

1.0

B

Goodman and gilman 8th edition Pp1104 1108

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B

Goodman and gilman 8th edition Pp1270

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C

DiPalma 4th ed p. 472

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A

Goodman and Gilman 8th ed p.239

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B

Goodman and Gilman 8th ed p.405-414

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A

DiPalma 4th ed p.275277

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C

Goodman and Gilman 8th p. 449 – 453

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B

Goodman and Gilman 8th ed p.198

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B

Goodman and Gilman 8th ed p.678

1.0

D

Goodman and Gilman 8th ed p.901

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B. tyrosine kinase

D. cytochrome P-450

81. The index of safety of a drug decreases as the median toxic dose: decreases and the median effective dose increases increases and the median effective dose decreases the median effective dose decreases the median effective dose increases 82. What is the major second messenger of beta receptor activation that participates in signal transduction? inositol triphosphates C. calcium cAMP D. adenylyl cyclase

A

83. Which of the following bronchodilators is a xanthine derivative? Terbutaline C. theophylline ipratropium bromide D. salmeterol

C

84. Myelosuppression is a common side effect associated with the use of the following anticancer drugs, EXCEPT: Vincristine C. Methotrexate Cyclophosphamide D. Chlorambucil

A

85. The following anticancer drug, with its toxic effect, is correctly matched with the appropriate antidote: cyclophosphamide-induced hemorrhagic cystitis – ondansetron methotrexate-induced myelosuppression – MESNA cisplatin-induced nausea and vomiting – leucovorin doxorubicin-induced arrhythmia - dexrazoxane 86. Which of the following anticancer drugs act as a mitotic inhibitor? Methotrexate C. Bleomycin Vinblastine D. Carmustine

D

87. Radical cure for malaria is achieved by giving: Chloroquine C. Mefloquine Quinine D. Primaquine

D

88. A 3 year old was brought to the ER because of recurrent attacks of blank stares lasting for a few minutes. The anti-seizure agent that you will give the child is: Phenobarbital C. Lamotrigine Ethosuximide D. Vigabantrine 89. The mainstay drug in the treatment of all types of leprosy is: Clofazime C. Isoniazid Dapsone D. Rifampicin 90. A patient on anti-TB drug developed peripheral neuritis. This was improved by giving Pyridoxine. The drug taken must have been: Ethambutol C. Isoniazid Rifampicin D. Para-aminosalicylic acid

B

B

B

B

C

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.30 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.25-27 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.324, 325, 328 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.911 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.914

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Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.911 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.871 Goodman and Gilman 10th ed p.535

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Goodman and Gilman 10th ed p.1288 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.784

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91. A patient with elevated cholesterol level is also taking warfarin for his deep venous thrombosis. The lipid lowering agent that may enhance the effect of Warfarin is: nicotinic acid C. cholestyramine lovastatin D. gemfibrozil 92. A known diabetic patient was brought to the ER unconscious with random blood sugar of 900 mg/dl. ABG study showed metabolic acidosis. Which of the following preparation is appropriate? regular insulin insulin zinc preparation isophane zinc suspension potassium zinc insulin suspension 93. Which of the following corticosteroids has the greatest anti-inflammatory potency relative to cortisol? Prednisone C. Aldosterone Dexamehtasone D. Triamcinolone

C

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.574 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.700

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Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.647 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.138 Goodman and Gilman 10th ed p.1250

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94. A 30-year old G2P1 patient suffers experiences a regular and increasingly frequent contractions at 6 months of gestation. Which of the following agents may help in this case? Terbutaline C. Propanolol Nicotine D. Tacrine 95. The primary mechanism underlying the resistance of gram positive organism to macrolide antibiotic is: methylation of binding site on the 50S ribosomal subunits formation of esterases that hydrolyzed the lactone ring formation of drug-inactivating acetyltransferase decrease drug permeability of the cytoplasmic membrane 96. A prescription that has the generic name enclosed in a parenthesis and written below the brand name can be interpreted as: violative prescription imposiible prescription erroneous prescription correct prescription 97. The onset and duration of action NPH insulin are extended by protamine because: it decreases the rate of insulin absorption it blocks insulin metabolism in the liver it is a basic compound and combines with insulin by charge interactions it is slowly degraded proteolytically releasing the bound insulin 98. The following anti-anginal drugs are vasodilators, EXCEPT: A. Felodipine C. Metoprolol B. Nitroglycerin D. Diltiazem

A

C

Generic Act of the Philippines

0.5

B

Pharmacology 4th ed Rang Page 697

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C

Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.186 Basic and Clinical Pharmacol ogy 9th Ed. Katzung p.190

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99. Which is a direct effect of nitrates when given in the usual doses for the management of angina? increased preload increased afterload increased cardiac contractility decreased preload

D

A

B

A

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100.

A. B. C. D.

The mechanism of action of Omeprazole inhibits H+-K+ ATPase pump promotes prostaglandin formation blocks action of histamine of H2 receptors neutralizes acid by increasing the pH of gastric secretion

A

Goodman and Gilman 8th ed p.902-904

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