Aurora PPT.ppt

New Insights Into the Management of Dyslipidaemia

Global Burden of Cardiovascular Disease According to WHO estimates: • 16.6 million people die of CVD worldwide each year • CVD contributed to approximately one third of global deaths In 2001: • 7.2 million deaths from CHD • 5.5 million deaths from stroke

Adapted from International Cardiovascular Disease Statistics 2003; American Heart Association

Risk Factors for Cardiovascular Disease •

Modifiable – –

– – – – – – –

Smoking Dyslipidaemia • raised LDL cholesterol • low HDL cholesterol • raised triglycerides Raised blood pressure Diabetes mellitus Obesity Dietary factors Thrombogenic factors Lack of exercise Excess alcohol consumption

• Non-modifiable – – – –

Personal history of CHD Family history of CHD Age Gender

Levels of Risk Associated with Smoking, Hypertension and Hypercholesterolaemia Hypertension (SBP >195 mmHg)

x3 x9

x4.5

x16 Smoking

x1.6

x6

x4 Serum cholesterol level (>8.5 mmol/L, 330 mg/dL)

Adapted from Poulter N et al., 1993

Cholesterol: A Major Risk Factor • In the USA, 102 million people have elevated total cholesterol (>200 mg/dL, 5.2 mmol/L)1 • In EUROASPIRE II, 58% of patients with established CHD had elevated total cholesterol (5 mmol/L, 190 mg/dL)2

• 10% reduction in total cholesterol results in: –

15% reduction in CHD mortality (P