All Veterinary Drugs

Compiled by: Dr. Rai M Sajid

Knowledge should be free for all ! Cattle Horse Sheep Goat

All Veterinary Drugs Drugs Salt & Dose Rates Compiled by Dr. Rai M Sajid

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Edition 1 Page 37

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Veterinarians

2012 If u can look at a dog and not feel vicarious excitement and affection , you must be a cat.

Compiled by: Dr. Rai M Sajid

Contents : Dose Rates of Penicillins: Elimination, Distribution, and Clearance of Penicillins: Drug Withdrawal and Milk Discard Times of Pencillins: Dose Rates of Cephalosporins : Elimination, Distribution, and Clearance of Cephalosporins: Drug Withdrawal and Milk Discard Times of Cephalosporins: Dose Rates of Aminoglycosides: Elimination, Distribution, and Clearance of Aminoglycosides: Dosage Modifications of Aminoglycosides in Renal Failure: Drug Withdrawal and Milk Discard Times of Aminoglycosides: Classes of Quinolones: Dose Rates of Quinolone : Dose Rates of Sulfonamides: Drug Withdrawal and Milk Discard Times of Sulfonamides: Dose Rates of Potentiated Sulfonamides: Drug Withdrawal and Milk Discard Times of Potentiated Sulfonamides: Dose Rates of Tetracyclines: Elimination, Distribution, and Clearance of Tetracyclines: Drug Withdrawal and Milk Discard Times of Tetracyclines: Dose Rates of Chloramphenicol and Florfenicol: Elimination and Distribution of Chloramphenicol and Florfenicol: Dose Rates of Macrolides: Drug Withdrawal and Milk Discard Times of Macrolides: Dose Rates of Lincosamides:

Dose Rates of Polyene Macrolide Antibiotics: Commonly Used Cardiovascular Drugs and Dosages : Drugs Used to Stimulate Appetite : Emetic Drugs : Antiemetic Drugs: Antiulcerative Drugs: Antidiarrheal Drugs: Drugs Used for Chronic Colitis: Prokinetic Drugs: Cathartic and Laxative Drugs: Dosages of Antistaphylococcal Antibiotics: Dosages of Antifungal Medications: Antihistamine Dosages: Glucocorticoids: Psychotropic Drugs Used for Skin Disorders: Competitive Nondepolarizing Agents and Antagonists: Skeletal Muscle Relaxants: Anabolic Steroids: Anticonvulsant Drugs: Drugs Used for Treatment of Status Epilepticus: Tranquilizers and Sedatives without Analgesic Effects: Analgesics: Antitussive Drugs: β-Adrenergic Receptor Agonist Drugs: Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals: Dosages of Diuretics: Drugs Used to Treat Urinary Incontinence: Dose Rates of Imidazoles: Dose Rates of Griseofulvin: Dosage Rates of Antiviral Drugs : Actions of Inflammatory Mediators: Relative Potencies of Commonly Used

Compiled by: Dr. Rai M Sajid

Corticosteroids: Mechanisms of Action, Indications, and Toxicities of Selected Antineoplastic Agents:: Natural Steroid roid Hormones for Consideration

as Growth Promoters: Synthetic Steroid Hormones for Consideration as Growth Promoters: Antibacterial Growth Promoters for Potential Use in Livestock Production:

I m happy to compiled this data, & I m sure tthis his will help you in any matter about drugs. You can get this data from every where , but in one softcopy never find. You can easily find any drug by pressing keys ( Ctrl .F ) . This effort is dedicated to all veterinarians.

“ This is only picture in which almost all class mates are together.” together. (Errors & Omissions are accepted )

Compiled by: Dr. Rai M Sajid

Dose Rates of Penicillin: Penicillin Sodium penicillin G Potassium penicillin G Procaine penicillin G Benzathine penicillin G Penicillin V Cloxacillin Ampicillin Amoxicillin Sodium carbenicillin Potassium clavulanate:amoxicillin (1:4) Probenecid (prolongs blood levels of penicillins that have short plasma half-lives or that are costly) Amoxicillin-clavulanic acid Imepenem Ticarcillin

Dosage, Route, and Frequency 10,000-20,000 IU/kg, IV or IM, qid 25,000 IU/kg, PO, qid 10,000-30,000 IU/kg, IM or SC, sid-bid 10,000-40,000 IU/kg, IM (horses) or SC (cattle), every 48-72 hr 15,000 IU/kg or 8-10 mg/kg, PO, tid 10 mg/kg, IM or PO, qid 5-10 mg/kg, IV, IM, or SC, bid-tid 10-25 mg/kg, PO, bid-qid 4-7 mg/kg, IM, sid-bid 11 mg/kg, PO, bid (dogs) or sid-bid (cats) 10-20 mg/kg, IV or IM, bid- tid 10-20 mg/kg (amoxicillin) and 2.55 mg/kg (clavulanate), PO, bid 1-2 mg/1,000 IU penicillin G (dogs), PO, qid 10-20 mg/kg, PO, bid- tid 1-7 mg/kg, IV or IM, tid- qid 15-110 mg/kg, IM or IV, every 4-8 hr

Elimination, Distribution, and Clearance of Penicillins: Penicillin

Species

Elimination Half-life (min)

Penicillin G

Dogs Horses Dogs Cattle Dogs Cattle

30 38 48 84 48 122

Ampicillin Amoxicillin Ticarcillin Carbenicillin

Volume of Distribution (mL/kg) 156 301 270 493 347 330

Clearance (mL/kg/min) 3.6 5.5 3.9 4.0 4.9 5.5

Drug Withdrawal and Milk Discard Times of Pencillins : Penicillin

Species

Withdrawal Time (days)

Procaine penicillin G

Cattle

10 (at label dosage) 30 (at 20,000 IU/kg, bid) 9

Sheep

Milk Discard Time (days) 3

Compiled by: Dr. Rai M Sajid

Benzathine penicillin G Ampicillin

Amoxicillin *

Pigs Cattle

7 30

Cattle Preruminant calves Cattle

6 15 30

2

All administered IM

Dose Rates of Cephalosporins : Cephalosporin Dosage, Route, and Frequency 20-35 mg/kg, IM or IV, tid- qid Cephalothin 30 mg/kg, IM or IV, every 4-6 hr Cephapirin 20-25 mg/kg, IM or IV, tid- qid Cefazolin 10-30 mg/kg, PO, tid- qid Cephalexin 22 mg/kg, PO, bid Cefadroxil 1.1 mg/kg, IM, sid Ceftiofur * All for use in small animals, except ceftiofur, which is for use in cattle.

Elimination, Distribution, and Clearance of Cephalosporins: Cephalosporin Cefazolin Cefotaxime Cephalexin Cefadroxil Ceftiofur

Species Horses Sheep Dogs Dogs Cats Cattle

Elimination Halflife (min) 45 25 84 120 150-180 ~360

Volume of Distribution (mL/kg) 188 134 — — — —

Clearance (mL/kg/min) 5.5 9.0 — — — —

Drug Withdrawal and Milk Discard Times of Cephalosporins: Cephalosporin Ceftiofur Sodium cephapirin (intramammary) Benzathine cephapirin (drycow treatment)

Withdrawal Time 0 days 4 days before slaughter 42 days after latest infusion

Milk Discard Time 4 days 3 days after calving—milk not used for food

Dose Rates of Aminoglycosides: Aminoglycoside Gentamicin Kanamycin Streptomycin/dihydrostreptomycin

Dosage, Route, and Frequency 3-6 mg/kg, IM or SC, sid- bid 12-15 mg/kg, IM or SC, sid-bid 7.5-12.5 mg/kg, IM or SC, bid

Compiled by: Dr. Rai M Sajid

5-7.5 mg/kg, IM or SC, bid 3-6 mg/kg, IM or SC, sid- bid 15 mg/kg, PO, sid- bid 0.5-1 g/quarter, intramammary, sid

Amikacin Netilmicin Neomycin

Elimination, Distribution, and Clearance of Aminoglycosides: Aminoglycoside

Species

Elimination Half-life (min)

Gentamicin

Dogs Horses Foals Dogs Horses Sheep

75 110 200 60 85 110

Kanamycin

Volume of Distribution (mL / kg) 335 190 300 255 174 217

Clearance (mL / kg /min) 3.10 1.23 1.04 3.05 1.43 1.52

Dosage Modifications of Aminoglycosides in Renal Failure: Plasma creatinine (mg/dL) 5

Dose and Dosage Interval Full dose at usual dosage interval Full dose doubling the usual dosage interval Full dose tripling the usual dosage interval Half dose doubling the usual dosage interval, or full dose quadrupling the usual dosage interval Aminoglycosides contraindicated

Drug Withdrawal and Milk Discard Times of Aminoglycosides: Route Oral Parenteral Udder infusion *

Approximate Withdrawal Time (days) 20-30 (3 for neonatal pigs) 100-200 (40 for neonatal pigs [often not approved for food animals]) 2-3* (often not approved for food animals)

Milk discard time

Classes of Quinolones: Quinolone carboxylic acids: Naphthydridine carboxylic acids: Cinnoline carboxylic

Enrofloxacin, norfloxacin, ciprofloxacin, orbifloxacin, pefloxacin, danofloxacin, difloxacin, marbofloxacin, rosoxacin, acrosoxacin, oxolinic acid Enoxacin, nalidixic acid Cinoxacin

Compiled by: Dr. Rai M Sajid

acids: Pyridopyrimidine carboxylic acids: Quinolizine carboxylic acids:

Pipemidic acid, piromidic acid Ofloxacin, flumequine

Dose Rates of Quinolones : Quinolone Nalidixic acid Norfloxacin Enrofloxacin

Species Cats, dogs Dogs Cats Dogs

Beef cattle (not veal or dairy)

Marbofloxacin Difloxacin Orbifloxacin *

Pigs Preruminant calves Cats, Dogs Dogs Cats, dogs

Dosage, Route, and Frequency 3 mg/kg, PO, qid 10-20 mg/kg, PO, bid 5 mg/kg, PO, sid or divided bid 5-20 mg/kg, PO, sid or divided bid 2.5 mg/kg, SC, once then PO 7.5-12.5 mg/kg, SC, once 2.5-5 mg/kg, SC, sid 2.5-5 mg/kg, PO or IM, sid 2.5-5 mg/kg, PO or SC, sid 2.75-5.5 mg/kg, PO, sid 5-10 mg/kg, PO, sid 2.5-7.5 mg/kg, PO, sid

Use of fluorinated quinolones in food-producing animals is extra-label in the USA.

Dose Rates of Sulfonamides: Sulfonamide

Species

Sulfathiazole Sulfamethazine

Horses Cattle, sheep, pigs Cattle

Sulfadiazine Sulfadimethoxine

All All

Sulfaethoxypyridazine

Cattle Pigs

Sulfapyridine

Cattle

Dosage, Route, and Frequency 66 mg/kg, PO, tid 66 mg/kg, PO, every 4 hr 220 mg/kg, PO or IV, sid (initial dose; half for subsequent doses) 50 mg/kg, PO, bid 55 mg/kg, PO, sid (initial dose; half for subsequent doses) 55 mg/kg, PO, sid 110 mg/kg, PO, sid (initial dose, half for subsequent doses) 132 mg/kg, PO, bid (initial

Compiled by: Dr. Rai M Sajid

dose, half for subsequent doses) 160 mg/kg, PO, bid (initial dose, half for subsequent doses)

All

Succinylsulfathiazole

Drug Withdrawal and Milk Discard Times of Sulfonamides: Sulfonamide Sulfamethazine Sulfabromethazine Triple sulfonamide solution† Sulfadimethoxidine

Species Cattle Pigs Cattle Cattle

Withdrawal Time (days) * 10 14 10 10

Milk Discard Time (hr) 96

Cattle

7

60

96 96

*

28 days for slow-release bolus 8% sodium sulfamethazine, 8% sodium sulfapyridine, 8% sodium sulfathiazole

†

Dose Rates of Potentiated Sulfonamides: Combination Trimethoprim/sulfadiazine Ormetoprim/sulfadimethoxine

Dosage, Route, and Frequency 15-60 mg/kg, PO, IV, or IM, sid 55 mg/kg, PO, sid (initial dose; half for subsequent doses)

Drug Withdrawal and Milk Discard Times of Potentiated Sulfonamides: Combination Trimethoprim/sulfadiazine Trimethoprim/sulfadoxine

Withdrawal Time (days) 3 5 (PO) 28 (parenteral)

Milk Discard Time (days) 7

Dose Rates of Tetracyclines: Tetracycline

Species

Tetracycline

Cats, dogs

Oxytetracycline

Cats, dogs

Doxycycline

Cattle, sheep, pigs Calves, foals, lambs, piglets Horses Dogs

Dosage, Route, and Frequency 7 mg/kg, IM or IV, bid 20 mg/kg, PO, tid 7 mg/kg, IM or IV, bid 20 mg/kg, PO, tid 5-10 mg/kg, IM or IV, sid 10-20 mg/kg, PO, bid-tid 5 mg/kg, IV, sid-bid 5-10 mg/kg, PO, sid 5 mg/kg, IV, sid

Compiled by: Dr. Rai M Sajid

Elimination, Distribution, and Clearance of Tetracyclines: Tetracycline

Species

Oxytetracycline

Dogs Calves (