2011 07 Pharmacology Dermatologic Pharmacology 2

Subject: Pharmacology Topic: Dermatologic Pharmacology 2 Lecturer: Dra. Dela Cruz Date of Lecture: 22/7/11 Transcriptionist: ior Editor: ior Pa es: 8

Antiseptics / Disinfectants

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   2    1    0    2      1    1    0    2    Y    S

Lower concentration is necessary for use as Antiseptics to avoid adverse effects

Antisepsis ♦

e.g.

application of chemical agents that inhibit

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3%-6% H2O2 – for cleansing wounds

growth and multiplication of 

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>30% H202 – for use as bleaching and oxidizing agent

microorganisms in living tissues to prevent infection ♦

applied to the skin surface or mucous membrane

♦

generally static

Disinfection ♦

application of chemical agents to inhibit t he growth or kill microorganisms in inanimate objects

♦

disinfectants to avoid adverse reaction

Types of Antiseptics/Disinfectants Antiseptics/Disinfectants 1. Alcohol (may either be): 

Ethyl alcohol

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Isopropyl alcohol

usually stronger and too toxic to be used in living tissues

♦

** Those with high concentrations are used as

Spectrum of activity:

generally cidal 

viruses

Sterilization ♦

Chemical or physical process that

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viruses with a low probability of survival

General Uses:

No activity against spores and hydrophilic viruses

completely destroys or remove all types of  microorganisms including spores and

Bacteria, mycobacteria, fungi and and lipophilic lipophilic

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Not effective for sterilization

Mechanism of Action: 

1. Cleansing of skin and wound surfaces after injury

cause cell membrane damage and rapid denaturation of proteins

2. Preparation of skin surface prior to injection or surgical procedures

Uses:

3. Routine disinfection of body cavities E.g. bladder, urethra, vagina 4. Treatment of mouth and throat infection 5. Surgical scrub

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Applied to the skin prior to injections

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For hard surface disinfection

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no residual action because they evaporate completely

6. Hand sanitizers (usually contain antiseptic) 

drying effect on the skin, may be alleviated by adding emollients or moisturizers to the formulation

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highly flammable

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30-90% concentration for antimicrobial activity

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70% is optimum concentration for antiseptic purposes

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