2011 07 Pharmacology Dermatologic Pharmacology 2

June 19, 2018 | Author: dtimtiman | Category: Sunscreen, Acne Vulgaris, Ultraviolet, Disinfectant, Chemical Substances
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Subject: Pharmacology Topic: Dermatologic Pharmacology 2 Lecturer: Dra. Dela Cruz Date of Lecture: 22/7/11 Transcriptionist: ior Editor: ior Pa es: 8

Antiseptics / Disinfectants

   2    1    0    2      1    1    0    2    Y    S

Lower concentration is necessary for use as Antiseptics to avoid adverse effects

Antisepsis ♦


application of chemical agents that inhibit

3%-6% H2O2 – for cleansing wounds

growth and multiplication of 

>30% H202 – for use as bleaching and oxidizing agent

microorganisms in living tissues to prevent infection ♦

applied to the skin surface or mucous membrane

generally static

Disinfection ♦

application of chemical agents to inhibit t he growth or kill microorganisms in inanimate objects

disinfectants to avoid adverse reaction

Types of Antiseptics/Disinfectants Antiseptics/Disinfectants 1. Alcohol (may either be): 

Ethyl alcohol

Isopropyl alcohol

usually stronger and too toxic to be used in living tissues

** Those with high concentrations are used as

Spectrum of activity:

generally cidal 


Sterilization ♦

Chemical or physical process that

viruses with a low probability of survival

General Uses:

No activity against spores and hydrophilic viruses

completely destroys or remove all types of  microorganisms including spores and

Bacteria, mycobacteria, fungi and and lipophilic lipophilic

Not effective for sterilization

Mechanism of Action: 

1. Cleansing of skin and wound surfaces after injury

cause cell membrane damage and rapid denaturation of proteins

2. Preparation of skin surface prior to injection or surgical procedures


3. Routine disinfection of body cavities E.g. bladder, urethra, vagina 4. Treatment of mouth and throat infection 5. Surgical scrub

Applied to the skin prior to injections

For hard surface disinfection

no residual action because they evaporate completely

6. Hand sanitizers (usually contain antiseptic) 

drying effect on the skin, may be alleviated by adding emollients or moisturizers to the formulation

highly flammable

30-90% concentration for antimicrobial activity

70% is optimum concentration for antiseptic purposes

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